Chronpharmaceutics, pulsatile drug delivery system as current trend

Asian Journal of Pharmaceutical Sciences

Volumn 5, Issue 5, 2010, Pages 204-230

  Dalvadi, Hitesh ^a   Patel, Jayvadan K ^b  

^a CKPithawalla Institute Of Pharmaceutical Science and Research   (India)

^b NOOTAN PHARMACY COLLEGE   (India)

Author keywords

Floating pulsatile; Model drug use; Multiparticulate; Stimuli induce; Time controlling

Indexed keywords

ACECLOFENAC; ALGINIC ACID; BICARBONATE; CARBOPOL 934; CARBOXYMETHYLCELLULOSE; CROSCARMELLOSE SODIUM; DICLOFENAC; DILTIAZEM; DOFETILIDE; DOXORUBICIN; ETHYL CELLULOSE; EUDRAGIT; GLUCOSE; GUAR GUM; HYDROXYPROPYLMETHYLCELLULOSE; INSULIN; KETOPROFEN; LACTOSE; MACROGOL; MAGNESIUM STEARATE; METHYLCELLULOSE; METOPROLOL TARTRATE; PARACETAMOL; POLYMER; POVIDONE; PULSINCAP; SALBUTAMOL SULFATE; THEOPHYLLINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALSARTAN; VERAPAMIL; XANTHAN;

ADSORPTION; ARTHRITIS; ARTICLE; ASTHMA; ATTENTION DEFICIT DISORDER; CARDIOVASCULAR DISEASE; CHRONPHARMACEUTICS; DRUG ABSORPTION; DRUG CAPSULE; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; ELECTROSTIMULATION; FIRST PASS EFFECT; HUMAN; HYDROGEL; HYDROPHILICITY; HYDROPHOBICITY; HYPERCHOLESTEROLEMIA; INSULIN RELEASE; LIGHT; MAGNETISM; MARKETING; MICELLE; NONHUMAN; PEPTIC ULCER; PH; PHARMACEUTICS; PULSATILE DRUG RELEASE; STIMULATION; TABLET; TEMPERATURE SENSITIVITY; ULTRASOUND;

EID: 78751479294     PISSN: 18180876     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (123)

1. S. Survase, N. Kumar. Pulsatile Drug Delivery: Current Scenario. Current Research & Infor. Pharm. Sci., 2007, 8 (2): 27-33.
2. L. X. Liu, X. C. Wang. Solubility-modulated monolithic osmotic pump tablet for atenolol delivery. Eur. J. Pharm. Biopharm., 2008, 68: 298-302.
3. U. Conte, L. Maggi. A flexible technology for the linear, pulsatile and delayed release of drugs allowing for easy accommodation of difficult in vitro targets. J. Control. Release, 2000, 64: 263-68.
4. E. S. Lee, S. W. Kim, S. H. Kim. et al. Drug release from hydrogel devices with rate-controlling barriers. J. Membr. Sci. 1980, 7: 293-303.
5. J. T. McConville, A. C. Ross, A. J. Florence, et al. Erosion characteristics of an erodible tablet incorporated in a timedelayed capsule device, Drug Dev. Ind. Pharm., 2005, 31: 79-89.
6. S. Lu, K. Anseth. Polymerization of multilaminated poly(HEMA) hydrogels for controlled release. J. Control. Release, 1999, 57: 291-300.
7. A. K. Anal. Time-Controlled Pulsatile Delivery Systems for Bioactive Compounds. Recent Patents on Drug Delivery & Formu., 2007, 1: 73-79.
8. A. Kikuchi, T. Okano. Pulsatile drug release control using hydrogels. Advan. Drug Del. Reviews, 2002, 54: 53-77.
9. B. Lemmer, The clinical relevance of chronopharmacology in therapeutics. Pharmacol. Res.1996, 33: 107-115.
10. Björm Hemmer. Circadian rhythms and drug delivery. J. Control. Release, 1991, 16:63-74.
11. B. Lemmer, Chronopharmacokinetics: implications for drug treatment, J. Pharm. Pharmacol., 1999, 51 (8): 887-890.
12. P. Roy, A. Shahiwala. Multiparticulate formulation approach to pulsatile drug delivery: current perspectives. J. Control. Release, 2009, 134:74-80.
13. R. Gurny, H. E. Junginger, N. Peppas, Eds., In; Pulsatile Drug Delivery: Current Application and Future Trends, WissenscheflicheVerlagsgesellschaft, Stuttgart, Germany, 1993, 36.
14. M. M. Massin, K. Maeyns, N. Withofs, et al. Circadian rhythm of heart rate and heart rate variability. Arch. Dis. Child., 2000, 83: 179-182.
15. J. Qureshi, Mohd. Amir, Alka Ahuja e t al. Chronomodulated Drug Delivery System of Salbutamol Sulphate for the Treatment of Nocturnal Asthma. Indian J. of Pharm. Sci. 2008, 351-356.
16. P. Roy, A. Shahiwala. Statistical optimization of ranitidine HCl floating pulsatile delivery system for chronotherapy of nocturnal acid breakthrough. Eur. J. Pharm. Sci., 2009, 37: 363-369.
17. M. H. Smolensky, N. A. Peppas, Chronobiology, drug delivery, and chronotherapeutics, Adv. Drug Del. Reviews, 2007, 59: 828-851.
18. S. Cohen, H. Bernstein (Eds). Microparticulate systems for the delivery of proteins and vaccines. New York, Marcel Dekker, Inc. 1995.
19. X. Liu, G. J. Pettway, L. K. McCauley et al. Pulsatile Release of Parathyroid Hormone from an Implantable Delivery System. Biomaterials. 2007, 28(28): 4124-4131.
20. H. Zou, X. Jiang, L. Kong et al. Design and Evaluation of a Dry Coated Drug Delivery System With Floating-Pulsatile Release, J. Pharm. Sci., 2008, 97 (1): 263-273.
21. Y. Watanabe, B. Mukai, K. Kawamura, et al. Preparation and evaluation of press-coated aminophylline tablet using crystalline cellulose and polyethylene glycol in the outer shell for timed-release dosage forms, Yakugaku Zasshi (The Pharmaceutical Society of Japan). 2002, 122(2): 157-162.
22. M. Efentakis, S. Koligliati, M. Vlachou. Design and evaluation of a dry coated drug delivery system with an impermeable cup, swellable top layer and pulsatile release, Int. J. Pharm., 2006, 311: 147-156.
23. L. Zema, A. Maroni, A. Foppoli et al. Different HPMC viscosity grades as coating agents for an oral time and/or site-controlled delivery system: an investigation into the mechanisms governing drug release, J. Pharm Sci., 2007, 96(6): 1527-1536.
24. M.E. Sangalli, A. Maroni, A. Foppoli et al. Different HPMC viscosity grades as coating agents for an oral time and/or site-controlled delivery system: a study on process parameters and in vitro performances, Eur. J. Pharm. Sci., 2004, 22: 469-476.
25. E. Karavas, E. Georgarakis, D. Bikiaris. Application of PVP/HPMC miscible blends with enhanced mucoadhesive properties for adjusting drug release in predictable pulsatile chronotherapeutics, Eur. J. Pharm. Biopharm., 2006, 64: 115-126.
26. C. Guse, S. Koennings, T. Blunk, J. Siepmann, A. Goepferich. Programmable implants - From pulsatile to controlled release. Int. J. Pharm., 2006, 314: 161-169.
27. M. Ghimire, F. J. McInnes, D. G. Watson et al. In-vitro/invivo correlation of pulsatile drug release from press-coated tablet formulations: A pharmacoscintigraphic study in the beagle dog. Eur. J. Pharm. Biopharma., 2007, 67: 515-523.
28. H. L. Lin, S. Yi Lin, Y. Ku Lin, et al. Release characteristics and in vitro-in vivo correlation of pulsatile pattern for a pulsatile drug delivery system activated by membrane rupture via osmotic pressure and swelling. Eur. J. Pharma. Biopharm., 2008, 70: 289-301.
29. H. A. El-Maradny. Modulation of a pulsatile release drug delivery system using different swellable/rupturable materials. Drug Delivery, 2007, 14: 539-546.
30. S. Y. Lin, K. H. Lin, M. J. Li. Micronized ethylcellulose used for designing a directly compressed time-controlled disintegration tablet. J. Control. Release, 2007, 70: 321-328.
31. Ying Zhu, Liangyuan Zheng. Development and Mathematical Simulation of Theophylline Pulsatile Release Tablets. Drug Deve. and Ind. Pharm., 2005, 31:1009-1017.
32. S. Sungthongjeen, S. Puttipipatkhachorn, O. Paeratakul, et al. Development of pulsatile release tablets with swelling and rupturable layers, J. Control. Release, 2004, 95: 147-159.
33. T. Bussemer, A. Dashevsky, R. Bodmeier. A pulsatile drug delivery system based on rupturable coated hard gelatin capsules, J. Control. Release, 2003, 93: 331-339.
34. A. Mohamad, A. Dashevsky. pH-independent pulsatile drug delivery system based on hard gelatin capsules and coated with aqueous dispersion Aquacoat® ECD, Eur. J. of Pharm. Biopharm., 2006 64: 173-179.
35. T. Bussemer, N.A. Peppas, R. Bodmeier, Evaluation of the swelling, hydration and rupturing properties of the swelling layer of a rupturable pulsatile drug delivery system, Eur. J. Pharm. Biopharm., 2003, 56: 261-270.
36. A. Dashevsky, T. Bussemer, A. Mohamad, et al. Process and formulation variables affecting the performance of a rupturable capsule-based drug delivery system with pulsatile drug release. Drug Dev. Ind. Pharm., 2004, 30(2): 171-179.
37. T. Bussemer, R. Bodmeier. Formulation parameters affecting the performance of coated gelatin capsules with pulsatile release profiles. Int. J. Pharm., 2003, 267: 59-68.
38. U. Y. Nayak, G. V. Shavi, Y. Nayak, et al. Chronotherapeutic drug delivery for early morning surge in blood pressure: A programmable delivery system. J. Control. Release, 2009, 136: 125-131.
39. Hao Zou, Xuetao Jiang, Lingshan Kong, Shen Gao. Design and Gamma-Scintigraphic Evaluation of a Floating and Pulsatile Drug Delivery System Based on an Impermeable Cylinder. Chem. Pharm. Bull., 2007, 55(4): 580 - 585.
40. J. T. McConville, A. C. Ross, A. R. Chambers, G. Smith, et al. The effect of wet granulation on the erosion behaviour of an HPMC-lactose tablet, used as a rate-controlling component in a pulsatile drug delivery capsule formulation. Eur. J. Pharm. Biopharm., 2004, 57: 541-549.
41. Bin Li, Jia Bi Zhu, Chun Li Zheng, Wen Gong. A novel system for three-pulse drug release based on "tablets in capsule" device. Int. J. Pharm., 2007, xxx (2007) xxx-xxx.
42. Jonathan C.D. Sutch, A. C. Ross, W. Köckenberger, R. W. Bowtell, et al. Investigating the coating-dependent release mechanism of a pulsatile capsule using NMR microscopy. J. Control. Release, 2003, 92: 341-347.
43. M. C. Gohel, M. G. Sumitra. Modulation of active pharmaceutical material release from a novel 'tablet in capsule system' containing an effervescent blend. J. Control. Release, 2002, 79: 157-164.
44. A. C. Ross, R. J. Macrae, M. Walther, Howard N. E Stevens. Chronpharmaceutical drug delivery from pulsatile capsule device based on programmable erosion. J. Pharm. Pharmacol., 2000, 52: 903-909.
45. Howard N.E. Stevens, C. G. Wilson, P. G. Welling, M. Bakhshaee, et al. Evaluation of Pulsincap( to provide regional delivery of dofetilide to the human GI tract. Int. J. Pharm., 2002, 236: 27-34.
46. Ina Krögel, Roland Bodmeier. Pulsatile drug release from an insoluble capsule body controlled by an erodible plug. Pharm. Res., 1998, 15(3): 474 - 481.
47. R. Löbenberga, J. S. Kim, G. L. Amidon. Pharmacokinetics of an immediate release, a controlled release and a two pulse dosage form in dogs. Eur. J. Pharm. Biopharm., 2005, 60: 17-23.
48. K. S. Soppimath, T. M. Aminabhavi, A. M. Dave, S. G. Kumbar, et al. Stimulus-Responsive "Smart" Hydrogels as Novel Drug Delivery Systems. Drug Dev. Ind. Pharm., 2002, 28(8): 957-974.
49. T. Okano, N. Yui, M. Yokoyama, R. Yoshida. Advances in Polymeric Systems for Drug Delivery, Gordon and Breach, Yverdon, Switzerland, 1994.
50. Y.H. Bae, T. Okano, S.W. Kim. 'On-off' thermocontrol of solute transport. II. Solute release from thermosensitive hydrogels. Pharm. Res., 1991, 8 (5): 624-628.
51. L. C. Dong, A.S. Hoffman. Synthesis and application of thermally reversible heterogels for drug delivery. J. Control. Release, 1990, 13: 21-31.
52. D.C. Coughlan, F.P. Quilty, O.I. Corrigan. Effect of drug physicochemical properties on swelling/deswelling kinetics and pulsatile drug release from thermoresponsive poly(Nisopropylacrylamide) hydrogels, J. Control. Release, 2004, 98: 97-114.
53. J. R. Santos, N. M. Alves, J. F. Mano. New Thermoresponsive hydrogels based on poly (n-isopropylacrylamide)/hyaluronic acid semi-interpenetrated polymer networks: swelling properties and drug release studies, J. Bioactive Compatible Pol., 2010, 25: 169-184.
54. G. Lewis, D. C. Coughlan, M. E. Lane, O. I. Corrigan. Preparation and release of model drugs from thermally sensitive poly(N-isopropylacrylamide) based macrospheres J. of Microencapsulation, 2006, 23(6): 677-685.
55. L.-Y. Chu, S. H. Park, T. Yamaguchi, S. Nakao. Preparation of thermo-responsive core-shell microcapsules with a porous membrane and poly(N-isopropylacrylamide) gates. J. Membrane Sci., 2001, 192: 27-39.
56. S. I. Jeong, Y. M. Lee, J. Lee, Y. M. Shin, et al. Preparation and Characterization of Temperature-Sensitive Poly(Nisopropylacrylamide)-g-Poly(L-lactide-co-ε-caprolactone) Nanofibers. Macromolecular Res., 2008, 16(2): 139-148.
57. M. Khorram, E. V. Farahani, N. G. Ebrahimi. Fast Responsive Thermosensitive Hydrogels as Drug Delivery Systems. Iran. Poly. J., 2003, 12 (4): 315-322.
58. R. Yoshida, Y. Kanekob, K. Sakaib, T. Okanoa, et al. Positive thertnosensitive pulsatile drug release using negative thermosensitive hydrogels. J. Control. Release, 1994, 32: 97-102.
59. Kim, S.W. Temperature Sensitive Polymers for Delivery of Macromolecular Drugs. In Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems; Ogata, N., Kim, S.W., Feijen, J., Eds.; Springer: Tokyo, 1996; 126-133.
60. J. X. Zhang, L. Y Qiu, Y. Jin, et al. Thermally responsive polymeric micelles self-assembled by amphiphilic polyphosphazene with poly(Nisopropylacrylamide) and ethyl glycinate as side groups: Polymer synthesis, characterization, and in vitro drug release study, J. Biomed. Mater. Res., 2006, 76A: 773-780.
61. H. Yan, K. Tsujii. Potential application of poly(Nsopropylacrylamide) gel containing polymeric micelles to drug delivery systems, Colloids and Surfaces B: Biointerfaces, 2005, 46: 142-146.
62. C. L. Lo, C. K. Huang, K. M. Lin, et al. Mixed micelles formed from graft and diblock copolymers for application in intracellular drug delivery. Biomaterials, 2007, 28: 1225-1235.
63. K. Kataoka, H. Miyazaki, M. Bunya, et al. Totally synthetic polymer gels responding to external glucose concentration: their preparation and application to on-off egulation of insulin release. J. Am. Chem. Soc. 1998, 120: 12694-12695.
64. M.R.Aguilar, C. Elvira, A. Gallardo, et al. Smart Polymers and Their Applications as Biomaterials, Topics in Tissue Engi., vol. 3: Eds. N Ashammakhi, R Reis & E Chiellini, 2007.
65. S. I. Kang, Y. H. Bae. A sulfonamide based glucoseresponsive hydrogel with covalently immobilized glucose oxidase and catalase, J. Control. Release, 2003, 86: 115-121.
66. H. Li, R. Luo, E. Birgersson, K.Y. Lam. A chemo-electromechanical model for simulation of responsive deformation of glucose-sensitive hydrogels with the effect of enzyme catalysis. J. Mechanics Physics Solids, 2009, 57: 369-382.
67. J. J. Kim, K. Park. Modulated insulin delivery from glucose-sensitive hydrogel dosage forms. J. Control. Release, 2001, 77: 39-47.
68. R.C.A. Schellekens, F. Stellaard, D. Mitrovic, et al. Pulsatile drug delivery to ileo-colonic segments by structured incorporation of disintegrants in pH-responsive polymer coatings. J. Control. Release, 2008, 132: 91-98.
69. V.S. Mastiholimath, P.M. Dandagi, S. S. Jain, et al. Time and pH dependent colon specific, pulsatile delivery of theophylline for nocturnal asthma. Int. J. Pharm., 2007, 328: 49-56.
70. Cui Fude, Yang Lei, Jin Jie, Piao Hongze, et al. Preparation and in vitro evaluation of pH, time-based and enzymedegradable pellets for colonic drug delivery, Drug Dev. Ind. Pharm., 2007, 33: 999-1007.
71. H. N. Shivakumar, S. Suresh, B. G. Desai. Design and evaluation of pH sensitive minitablets for chronotherapeutic delivery of theophylline, Indian J. Pharma. Sci., 2007, 69 (1):73-79.
72. Meiling Qi, Peng Wang, Dezheng Wu. A novel pH- and time-dependent system for colonic drug delivery. Drug Dev. Ind. Pharm., 2003, 29(6): 661-667.
73. H. Liu, T. Sun, F. Yu, et al. The investigation of the pharmacokinetics of pulsatile-release salbutamol sulfate with ph-sensitive ion exchange resin as the carriers in beagle dogs. Chem. Pharm. Bull., 2007, 55(3): 480-481.
74. L.Y. Qiu, K.J. Zhu, Design of a core-shelled polymer cylinder for potential programmable drug delivery, Int. J. Pharm., 2001, 219(1): 151-160.
75. N. Yui, J. Nihira, T. Okano, Y. Sakurai. Regulated release of drug microspheres from inflammation responsive degradable matrices of crosslinked hyaluronic acid. J. Control. Release, 1993, 25: 133-143.
76. P. Kiser, G. Wilson, D. Needham. Lipid-coated microgels for the triggered release of doxorubicin. J Control. Rel., 2000, 68(1): 9-22.
77. C. S. Brazel. Magnetothermally-responsive Nanomaterials: Combining Magnetic Nanostructures and Thermallysensitive polymers for triggered drug release. Pharm. Res., 2009, 26(3): 644-656.
78. T. Y. Liu, S.H. Hu, T. Y. Liu, et al. Magnetic-sensitive behavior of intelligent ferrogels for controlled release of drug. Langmuir, 2006, 22: 5974-5978.
79. K. Cai, Z. Luo, Y. Hu, et al. Magnetically triggered reversible controlled drug delivery from microfabricated polymeric multireservoir devices. Adv. Mater., 2009, 21: 4045-4049.
80. T. Y. Liu, S. H. Hu, K. H. Liu, et al. Preparation and characterization of smart magnetic hydrogels and its use for drug release, J. Magnetism Magnetic Materi., 2006, 304: e397-e399.
81. O. Saslawski, C. Weigarten, J. P. Beniot, et al. Magnetically responsive microspheres for pulsed delivery of insulin. Life Sci., 1988; 42(16):1521-1528.
82. G. A. Husseini, W. G. Pitt. The use of ultrasound and micelles in cancer treatment, J Nanosci Nanotechnol., 2008, 8(5): 2205-2215.
83. Nyborg Wesley L. Biological effects of ultrasound: Development of safety guidelines. Part II: General review. Ultrasound Med Biol 2001, 27(3): 301-333.
84. R. V. Kulkarni, S. A. Biswanath. Electroresponsive polyacrylamide-grafted-xanthan hydrogels for drug delivery, J. Bioactive Compatible Poly., 2009, 24: 368-384.
85. A. C. Richards Grayson, R. S. Shawgo, Y. Li, M. J. Cima. Electronic MEMS for triggered delivery, Adv. Drug Del. Reviews, 2004, 56: 173-184.
86. S. Murdan. Electro-responsive drug delivery from hydrogels. J. Control. Release, 2003, 92: 1-17.
87. J. S. Park, K. Park, H. T. Moon, D. G. Woo, et al. Electrical Pulsed Stimulation of Surfaces Homogeneously Coated with Gold Nanoparticles to Induce Neurite Outgrowth of PC12 Cells, Langmuir 2009, 25: 451-457.
88. S. H. Yuk, S. Hang, H. B. Lee. Electric Current-Sensitive Drug delivery system using Sodium Alginate/Polyacrylic acid composites. Pharm. Res., 1992, 9(7): 955-957.
89. Y. Qiu, K. Park. Environment-sensitive hydrogels for drug delivery. Adv. Drug Del. Reviews, 2001, 53: 321-339.
90. Richard D. Averitt, Sarah L. Westcott, Naomi J. Halas. Linear optical properties of gold nanoshells, J. opt Soc. Amer. B., 1999, 16(10): 1824-1832.
91. N. S. Dey, S Majumdar, M.E.B. Rao. Multiparticulate drug delivery systems for controlled release, Tropi. J. Pharm. Res., 2008, 7 (3): 1067-1075.
92. A. Dashevsky, A. Mohamad. Development of pulsatile multiparticulate drug delivery system coated with aqueous dispersion Aquacoat® ECD. Int. J. Pharm., 2006, 318: 124-131.
93. A. Mohamad and A. Dashevsky, In vitro and in vivo performance of a multiparticulate pulsatile drug delivery system. Drug Dev. Ind. Pharm., 2007, 33:113-119.
94. G. V. Shavi, U. Nayak, R. K. Averineni, K. Arumugam, et al. Multiparticulate drug delivery system of aceclofenac: development and in vitro studies. Drug Dev. Ind. Pharm., 2009, 35: 252-258.
95. C. Sun, H. Liu, S. Zhang, et al. Preparation of novel cationic copolymer microspheres and evaluation of their function by in vitro and in vivo tests as pH-sensitive drug carrier systems. Drug Dev. Ind. Pharm., 2006, 32: 929-940.
96. F. Atyabi, R. Vahabzadeh, R. Dinarvand. Preparation of ethylcellulose coated gelatin microspheres as a multiparticulate colonic delivery system for 5-aminosalicilic Acid. Iran. J. Pharma. Res., 2004, 2: 81-86.
97. M. Rodríguez, J. L. Vila-Jato, D. Torres. Design of a new multiparticulate system for potential site-specific and controlled drug delivery to the colonic region. J. Control. Release, 1998, 55: 67-77.
98. Y. Liu, S. Liu, Q. Dai. Design and Evaluation of pHindependent pulsatile release pellets containing isosorbide-5-mononitrate. Chem. Pharm. Bull., 2009, 57(1): 55-60.
99. S. Jessy, P. Vishal. Novel Floating Pulsatile Approach for Chronotherapeutic Release of Indomethacin, Dhaka Univ. J. Pharm. Sci., 2007, 6(1): 37-41.
100. S. S. Badve, P. Sher, A. Korde, A. P. Pawar. Development of hollow/porous calcium pectinate beads for floatingpulsatile drug delivery. Eur. J. Pharm. Biopharm., 2007, 65: 85-93.
101. V. G. Somani, S. R. Shahi, Y. K. Udavant, S. C. Atram, et al. A floating pulsatile drug delivery system based on hollow calcium pectinate beads, Asian J. Pharma., 2009, 120-124.
102. S. Sharma, A. Pawar, Low density multiparticulate system for pulsatile release of meloxicam, Int. J. Pharm., 2006, 313: 150-158.
103. R. Ishino, Absorption of DZ in beaglo dog from pulsatile release tablet. Chem. Pharm. Bull., 1992, 40: 3094-3096.
104. T. Sawada, K. Sako, M. Fukui, S. Yokohama, M. Hayashi. A new index, the core erosion ratio, of compressioncoated timed-release tablets predicts the bioavailability of acetaminophen. Int. J. Pharm., 2003, 265: 55-63.
105. M.E. Sangalli, A. Maroni, L. Zema, et al. In vitro and in vivo evaluation of an oral system for time and/or sitespecific drug delivery. J. Control. Release, 2001, 73: 103-110.
106. T.Y. Fan, S.L. Wei, W.W. Yan, et al An investigation of pulsatile release tablets with ethylcellulose and Eudragit L as film coating materials and cross-linked polyvinylpyrrolidone in the core tablets. J. Control. Release, 2001, 77: 245-251.
107. K. Kaneko, K. Kanada, M. Miyagi, et al. Formation of water-insoluble gel in dry-coated tablets for the controlled release of theophylline. Chem. Pharm. Bull., 1998, 46(4): 728-729.
108. R. Ishino, H. Yoshino, Y. Hirakawa, K. Noda. Design and Preparation of pulsatile release tablet as a new oral drug delivery system. Chem. Pharm. Bull., 1992, 40(1): 3036-3041.
109. T. Sawada, H. Kondo, H. Nakashima, et al, Time-release compression-coated core tablet containing nifedipine for chronopharmacotherapy. Int. J. Pharm., 2004, 280: 103-111.
110. Ina Krögel, Roland Bodmeier. Floating or pulsatile drug delivery systems based on coated effervescent cores. Int. J. Pharm., 1999, 187: 175-184.
111. M.E. Sangalli, A. Maroni, L. Zema, et al. In vitro and in vivo evaluation of an oral system for time and/or sitespecific drug delivery, J. Control. Release, 2001, 73: 103-110.
112. K. C. Waterman, M. B. Fergione. Press-coating of immediate release powders onto coated controlled release tablets with adhesives. J. Control. Release, 2003, 89: 387-395.
113. Y. H. Li, J. B. Zhu. Modulation of combined-release behaviors from a novel "tablets-in-capsule system", J. Control. Release, 2004, 95: 381-389.
114. G. Cheng, F. An, M. Zou, J. Sun, X. Hao, Y. He. Timeand pH-dependent colon-specific drug delivery for orally administered diclofenac sodium and 5-aminosalicylic acid. World J Gastroenterol, 2004, 10(12): 1769-1774.
115. A. B. Rane, S. G. Gattani, V. D. Kadam, et al. Formulation and evaluation of press coated tablets for pulsatile drug delivery using hydrophilic and hydrophobic polymers. Chem. Pharm. Bull., 2009, 57(11): 1213-1217.
116. S. Narisawa, M. Nagata, T. Ito, et al. Drug release behavior in gastrointestinal tract of beagle dogs from multiple unit type rate-controlled or time-controlled release preparations coated with insoluble polymer-based film, J. Control. Release, 1995, 33: 253-260.
117. C. M. Nolan, M. J. Serpe, L. A. Lyon. Thermally modulated insulin release from microgel thin films, Biomacromolecules, 2004, 5, 1940-1946.
118. Y. Luo, K. R. Kirker, G. D. Prestwich. Cross-linked hyaluronic acid hydrogel films: new biomaterials for drug delivery. J. Control. Release, 2000, 69: 169-184.
119. PULSYS™ in multiparticulate drug delivery, US patent, WO 2005/016311 A1/.
120. http://www.penw.com/timerx.html.
121. http://www.elandrugtechnologies.com/nav/56/.
122. Diffucaps in multiparticulate drug delivery, Eurand S.P.A. Corporation, U.S. Patent 72329344, Feb29, 1972.
123. M. E. McNeill, A. Rashid, S. N. E. Howard. Dispensing device. GBPatent No., GB2230442, 1993.