Application of PVP/HPMC miscible blends with enhanced mucoadhesive properties for adjusting drug release in predictable pulsatile chronotherapeutics

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 64, Issue 1, 2006, Pages 115-126

  Karavas, Evangelos ^a,b   Georgarakis, Emmanouel ^b   Bikiaris, Dimitrios ^b  

^a Pharmaceutical Industry   (Greece)

^b ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Felodipine; Hydroxypropyl methyl cellulose; Miscible blends; Mucoadhesive polymers; Poly(vinyl pyrrolidone); Pulsatile chronotherapeutics

Indexed keywords

CARBONYL DERIVATIVE; FELODIPINE; HYDROXYL GROUP; HYDROXYPROPYLMETHYLCELLULOSE; POLYMER; POVIDONE;

ADHESION; ARTICLE; CHEMICAL COMPOSITION; CHEMICAL INTERACTION; CHRONOTHERAPY; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DISSOLUTION; DRUG COATING; DRUG FORMULATION; DRUG RELEASE; EXPOSURE; ISCHEMIC HEART DISEASE; MATHEMATICAL COMPUTING; MISCIBILITY; PREDICTION; PULSATILE DRUG RELEASE; SOLID; TABLET;

CALORIMETRY, DIFFERENTIAL SCANNING; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; FELODIPINE; METHYLCELLULOSE; MODELS, CHEMICAL; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; POLYMERS; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE;

EID: 33746740091     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2005.12.013     Document Type: Article

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