A new index, the core erosion ratio, of compression-coated timed-release tablets predicts the bioavailability of acetaminophen

International Journal of Pharmaceutics

Volumn 265, Issue 1-2, 2003, Pages 55-63

  Sawada, T ^a   Sako, K ^a   Fukui, M ^a   Yokohama, S ^a   Hayashi, M ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Acetaminophen; Compression coated tablets; Core erosion ratio; Dogs; Timed release formulation

Indexed keywords

BLUE DEXTRAN; EXCIPIENT; LACTOSE; MACROGOL 6000; PARACETAMOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; COLON; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG UPTAKE; GASTROINTESTINAL TRANSIT; ILEUM; MALE; NONHUMAN; PRIORITY JOURNAL; TABLET; TISSUE LEVEL;

EID: 0141867768     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(03)00405-8     Document Type: Article

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