Pulsatile drug release from an insoluble capsule body controlled by an erodible plug

Pharmaceutical Research

Volumn 15, Issue 3, 1998, Pages 474-481

  Krögel, Ina ^a   Bodmeier, Roland ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Controlled release; Erosion; Hydroxypropyl methylcellulose; Lag time; Pulsatile release

Indexed keywords

CALCIUM PHOSPHATE DIBASIC; CHLORPHENIRAMINE; CROSCARMELLOSE SODIUM; DODECYL SULFATE SODIUM; EXCIPIENT; GELUCIRE; GLYCEROL OLEATE; HYDROXYPROPYLMETHYLCELLULOSE; IBUPROFEN; LACTOSE; MACROGOL; MANNITOL; METHOCEL E 3; METHYLCELLULOSE; POLOXAMER; POLYMER; POLYOX K100; POLYOX K8000; POLYSORBATE 60; POLYSORBATE 80; POLYVINYL ALCOHOL; SURFACTANT; UNCLASSIFIED DRUG;

ARTICLE; DRUG CAPSULE; DRUG DELIVERY SYSTEM; DRUG MANUFACTURE; DRUG SOLUBILITY; ERODIBLE PLUG; HARDNESS; IN VITRO STUDY; KINETICS; MATERIALS; MOLECULAR WEIGHT; PRIORITY JOURNAL; PULSATILE DRUG RELEASE; SPECTROPHOTOMETRY; TECHNIQUE; TEMPERATURE; THICKNESS;

CAPSULES; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; EXCIPIENTS; MOLECULAR WEIGHT; PHARMACOKINETICS; POLYMERS; SOLUBILITY;

EID: 0031946803     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011940718534     Document Type: Article

References (31)

1. R. Gurny, H. E. Junginger, and N. A. Peppas. Pulsatile Drug Delivery; Current Applications and Future Trends, Wissenschaftliche Verlagsgesellschaft, Stuttgart, 1993.
2. G. Van den Mooter, C. Samyn, and R. Kinget. The relation between swelling properties and enzymatic degradation of azo polymers designed for colon-specific drug delivery. Pharm. Res. 11:1737-1741 (1994).
3. A. Rubinstein, B. Tirosh, M. Baluom, T. Nassar, A. David, R. Radai, I. Gliko-Kabir, and M. Friedman. The rationale for peptide drug delivery to the colon and the potential of polymeric carriers as effective tools. J. Control. Release 46:59-73 (1997).
4. Y. Hirakawa, H. Yoshino, E. Fukui, and T. Hanamori. EP 0,671,168, Pharmaceutical preparation controlled to release medicinal active ingredient at targeted site in intestinal tract, Sep. 13, 1995.
5. W. Phuapradit, A. Railkar, and N. H. Shah. EP 0,673,645, Pharmaceutical composition, Sep. 27, 1995.
6. S. Poli, C. Busetti, and L. Moro. EP 0,572,942, Oral pharmaceutical compositions for specific colon delivery, Dec. 8, 1993.
7. T. Siriä, M. Mäkimartti, S. Liukko-Sipi, and M. Marvola. Development and biopharmaceutical evaluations of a new press-coated prolonged-release salbutamol sulphate tablet in man. Eur. J. Pharm. Sciences 1:195-201 (1994).
8. I. Krögel and R. Bodmeier. Evaluation of the floating properties of coated drug delivery systems containing effervescent excipients. Eur. J. Pharm. Biopharm. 42(Suppl.):21 (1996).
9. I. Krögel and R. Bodmeier. Development of floating or pulsatile DDS based on effervescent cores. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 24:237-238 (1997).
10. S. Ueda, T. Hata, S. Asakura, H. Yamaguchi, M. Kotani, and Y. Ueda. Development of a novel drug release system, time-controlled explosion system (TES). I. Concept and design. J. Drug Targeting 2:35-44 (1994).
11. S. Ueda, H. Yamaguchi, M. Kotani, S. Kimura, Y. Tokunaga, A. Kagayama, and T. Hata. Development of a novel drug release system, lime-controlled explosion system (TES). II. Design of multiparticulate TES and in vitro drug release properties. Chem. Pharm. Bull. 42:359-363 (1994).
12. S. Ueda, R. Ibuki, S. Kimura, S. Murata, T. Takahashi, Y. Tokunaga, and T. Hata. Development of a novel drug release system, time-controlled explosion system (TES). III. Relation between lag time and membrane thickness. Chem. Pharm. Bull. 42:364-367 (1994).
13. U. Conte, A. La Manna, and P. Colombo. US Patent 4,865,849, Tablet for pharmaceutical use able to release active substances at successive times. Sep. 12, 1989.
14. M. E. McNeil, A. Rashid, and H. N. E. Stevens. WO 90/09168, Dispensing device. Aug. 23, 1990.
15. I. R. Wilding, S. S. Davis, M. Bakhshaee, H. N. E. Stevens, R. A. Sparrow, and J. Brennan. Gastrointestinal transit and systemic absorption of captopril from a pulsed-release formulation. Pharm. Res. 9:654-657 (1992).
16. P. J. Gilchrist, J. M. Hebden, C. G. Wilson, R. C. Spiller, A. C. Perkins, and J. S. Binns. Regional differences in colonic absorption? - A study using the Pulsincap™ delivery system. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 22:206-207 (1995).
17. J. Binns, H. N. E Stevens, J. McEwen, G. Pritchard, F. M. Brewer, A. Clarke, E. S. Johnson, and I. McMillan. The tolerability of multiple oral doses of Pulsincap™ capsules in healthy volunteers. J. Control. Release 38:151-158 (1996).
18. J. R. Crison, P. R. Siersma, M. D. Taylor, and G. L. Amidon. Programmable oral release technology, Port Systems®: A novel dosage form for time and site specific oral drug delivery. Proceed. Intern. Symp. Control. Rel. Bioact. Mater. 22:278-279 (1995).
19. P. S.-L. Wong, F. Theeuwes, S. D. Larsen, and L. C. Dong. Osmotic device for delayed delivery of agent, Jul. 2, 1996.
20. R. Bodmeier and I. Krögel. Release device with progammable drug release, German patent application # 196 19 050, May (1996).
21. H. N. E. Stevens, A. Rashid, and M. Bakhshaee. PCT WO 91/ 12795, Dispensing Device, Sep. 5, 1991.
22. R. Bodmeier and O. Paeratakul. Mechanical properties of dry and wet cellulosic and acrylic polymer films prepared from aqueous colloidal polymer dispersions. Pharm. Res. 11:882-888 (1994).
23. R. Bodmeier and O. Paeratakul. Dry and wet strength of polymeric films prepared from an aqueous colloidal polymer dispersion, Eudragit® RS30D. Int. J. Pharm. 96:129-138 (1993).
24. F. Kuppler, M. Wesseling, and R. Bodmeier. Development of a method for measuring the tackiness of acrylic and cellulosic polymer coatings. Eur. J. Pharm. Biopharm. 42(Suppl.):14 (1996).
25. I. Krögel and R. Bodmeier. Evaluation of a pulsatile drug delivery system based on an erodible plug within an insoluble capsule body. Pharm. Res. 13(Suppl.):304 (1996).
26. D. A. Alderman. A review of cellulose ethers in hydrophilic matrices for oral controlled-release dosage forms. Pharm. Tech. & Prod. Mfr. 5:1-9 (1984).
27. J. L. Ford, M. H. Rubinstein, and J. E. Hogan. Formulation of sustained release promethazine hydrochloride tablets using hydroxypropyl methylcellulose matrices. Int. J. Pharm. 24:327-338 (1985).
28. L. W. S. Cheong, P. W. S. Heng, and L. F Wong. Relationship between polymer viscosity and drug release from a matrix system. Pharm. Res 9:1510-1514 (1992).
29. J. Gustafsson, H. Ljusber-Wahren, M. Almgren, and K. Larsson. Cubic lipid-water phase dispersed into submicron particles. Langmuir 12:4611-4613 (1996).
30. H. Ljusberg-Wahren, L. Nyberg, and K. Larsson. Dispersion of the cubic liquid crystalline phase - structure, preparation and functionality aspects. Chemistry Today 6 (1996).
31. C. -M. Chang and R. Bodmeier. Effect of dissolution media and additives on the drug release from cubic phase delivery systems. J. Contr. Release 46:215-222 (1997).