The effect of wet granulation on the erosion behaviour of an HPMC-lactose tablet, used as a rate-controlling component in a pulsatile drug delivery capsule formulation

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 57, Issue 3, 2004, Pages 541-549

  McConville, Jason T ^a,c   Ross, Alistair C ^a   Chambers, Alan R ^a   Smith, Geoff ^b   Florence, Alastair J ^a   Stevens, Howard N E ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^b DE MONTFORT UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Erosion; High shear granulation; HPMC; Lag time; Microwave dielectric analysis; Pulsatile delivery

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; LACTOSE; METHYLCELLULOSE; PROPRANOLOL;

ARTICLE; COMPRESSION; DIELECTRIC CONSTANT; DRUG CAPSULE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SOLUBILITY; MICROWAVE RADIATION; PHYSICAL CHEMISTRY; PULSATILE DRUG RELEASE; TABLET FORMULATION;

CAPSULES; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; LACTOSE; METHYLCELLULOSE; OXAZINES; RHEOLOGY; TABLETS; TECHNOLOGY, PHARMACEUTICAL;

EID: 1842861702     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2004.01.004     Document Type: Article

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