A novel pH- and time-dependent system for colonic drug delivery

Drug Development and Industrial Pharmacy

Volumn 29, Issue 6, 2003, Pages 661-667

  Qi, Meiling ^a,c   Wang, Peng ^b   Wu, Dezheng ^a  

^a North Taiping Road Hospital   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c BEIJING INSTITUTE OF TECHNOLOGY   (China)

Author keywords

Colonic drug delivery; Film coating; Gamma scintigraphy; Press coating; Tablets

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; OPADRY;

ARTICLE; COLON; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG RELEASE; GAMMA SCINTIGRAPHY; PH; TABLET HARDNESS; TIME; VISCOSITY;

ADULT; COLON; EXCIPIENTS; HARDNESS; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; METHYLCELLULOSE; SOLUBILITY; STARCH; TABLETS, ENTERIC-COATED; TIME FACTORS; TINIDAZOLE; VISCOSITY;

EID: 0038155213     PISSN: 03639045     EISSN: None     Source Type: Journal    
DOI: 10.1081/DDC-120021315     Document Type: Article

References (20)

1. Ashford, M.; Fell, J.T. Targeting drugs to the colon: delivery systems for oral administration. J. Drug Target. 1994, 2, 241-257.
2. Friend, D.R. Colon-specific drug delivery. Adv. Drug Del. Rev. 1991, 7, 149-199.
3. Kinget, R.; Kalala, W.; Vervoort, L.; van den Mooter, G. Colonic drug targeting. J. Drug Target. 1998, 6, 129-149.
4. Qi, M.L.; Wu, D.Z. Design and in vivo evaluation of colonic drug delivery systems. Chinese J. Clin. Pharm. 2000, 16, 150-154.
5. Rubinstein, A. Approaches and opportunities in colon-specific drug delivery. Crit. Rev. Ther. Drug Carrier Syst. 1995, 12, 101-149.
6. Shiha, V.R.; Kumria, R. Polysaccharides in colon-specific drug delivery. Int. J. Pharm. 2001, 224, 19-38.
7. Watts, P.J.; Illum, L. Colonic drug delivery. Drug Dev. Ind. Pharm. 1997, 23, 893-913.
8. Ahrabi, S.F.; Madsen, G.; Dyrstad, K.; Sande, S.A.; Graffner, C. Development of pectin matrix tablets for colonic delivery of model drug ropivacaine. Eur. J. Pharm. Sci. 2000, 10, 43-52.
9. Lorenzo-Lamosa, M.L.; Remunan-Lopez, C.; Vila-Jato, J.L. Design of micro-encapsulate chitosan microspheres for colonic drug delivery. J. Contrl. Release 1998, 52, 109-118.
10. Macleod, G.S.; Fell, J.T.; Collett, J.H.; Sharma, H.L.; Smith, A.M. Selective drug delivery to the colon using pectin: chitosan: hydroxypropylmethylcellulose film coated tablets. Int. J. Pharm. 1999, 187, 251-257.
11. McLeod, A.D.; Friend, D.R.; Tozer, T.N. Glucocorticoid-dextran conjugates as potential prodrugs for colon-specific delivery: hydrolysis in rat gastrointestinal tract contents. J. Pharm. Sci. 1994, 83, 1284-1289.
12. McLeod, A.D.; Tolentino, L.; Tozer, T.N. Glucocorticoid-dextran conjugates as potential prodrugs for colon-specific delivery: steady-state pharmacokinetics in the rat. Biopharm. Drug Dispos. 1994, 15, 151-161.
13. Pozzi, F.; Furlani, P.; Gazzaniga, A. The TIME CLOCK system: a new oral dosage form for fast and complete release of drug after a predetermined lag time. J. Control. Release 1994, 31, 99-108.
14. Rodriguez, M.; Vila-Jato, J.L.; Torres, D. Design of a new multiparticulate system for potential site-specific and controlled drug delivery to the colonic region. J. Control. Release 1998, 55, 67-77.
15. Wilding, I.R.; Davis, S.S.; Pozzi, F. Enteric coated timed release system for colonic targeting. Int. J. Pharm. 1994, 111, 99-102.
16. Haeberlin, B.; Friend, D.R. Anatomy and physiology of the gastrointestinal tract: implications for colonic drug delivery. In Oral Colon-Specific Drug Delivery; Friend, D.R., Ed., CRC Press: Boca Raton, FL, 1992; 1-44 pp.
17. Kaus, L.C.; Fell, J.T.; Sharman, H.; Taylor, D.C. On the intestinal transit of a single non-disintegrating object. Int. J. Pharm. 1984, 14, 143-148.
18. Davis, S.S.; Hardy, J.G.; Newman, S.P. Gamma scintigraphy in the evaluation of pharmaceutical dosage forms. Eur. J. Nuc. Med. 1992, 19, 971-986.
19. Wilding, I.R.; Coupe, A.J.; Davis, S.S. The role of γ-scintigraphy in oral drug delivery. Adv. Drug Del. Rev. 1991, 7, 87-117.
20. Wilson, C.G. In-vivo monitoring of dosage forms. J. Pharm. Pharmacol. 1998, 50, 383-386