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Volumn 11, Issue , 2011, Pages

Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; JANUS KINASE 2; JANUS KINASE 2 INHIBITOR; NVP BSK 805; PHENYLALANINE; PROTEIN BCL XL; PROTEIN MCL 1; SMALL INTERFERING RNA; STAT5 PROTEIN; UNCLASSIFIED DRUG; VALINE; APOPTOSIS REGULATORY PROTEIN; BCL 2 LIKE PROTEIN 11; BCL-2-LIKE PROTEIN 11; CASPASE; JAK2 PROTEIN, HUMAN; MEMBRANE PROTEIN; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; NVP BSK805; NVP-BSK805; ONCOPROTEIN; PROTEIN BCL 2; QUINOXALINE DERIVATIVE;

EID: 78651515826     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-11-24     Document Type: Article
Times cited : (22)

References (56)
  • 1
    • 30644460554 scopus 로고    scopus 로고
    • JAK2 V617F in myeloid disorders: What do we know now, and where are we headed?
    • 10.1080/10428190500301348, 16321848
    • Nelson ME, Steensma DP. JAK2 V617F in myeloid disorders: What do we know now, and where are we headed?. Leuk Lymphoma 2006, 47:177-194. 10.1080/10428190500301348, 16321848.
    • (2006) Leuk Lymphoma , vol.47 , pp. 177-194
    • Nelson, M.E.1    Steensma, D.P.2
  • 2
    • 0038371050 scopus 로고    scopus 로고
    • Autoinhibition of Jak2 Tyrosine Kinase Is Dependent on Specific Regions in Its Pseudokinase Domain
    • 10.1091/mbc.E02-06-0342, 153113, 12686600
    • Saharinen P, Vihinen M, Silvennoinen O. Autoinhibition of Jak2 Tyrosine Kinase Is Dependent on Specific Regions in Its Pseudokinase Domain. Mol Biol Cell 2003, 14:1448-1459. 10.1091/mbc.E02-06-0342, 153113, 12686600.
    • (2003) Mol Biol Cell , vol.14 , pp. 1448-1459
    • Saharinen, P.1    Vihinen, M.2    Silvennoinen, O.3
  • 3
    • 20244369569 scopus 로고    scopus 로고
    • Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
    • 10.1016/j.ccr.2005.03.023, 15837627
    • Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJP, Boggon TJ, Wlodarska I, Clark JJ, Moore S, et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 2005, 7:387-397. 10.1016/j.ccr.2005.03.023, 15837627.
    • (2005) Cancer Cell , vol.7 , pp. 387-397
    • Levine, R.L.1    Wadleigh, M.2    Cools, J.3    Ebert, B.L.4    Wernig, G.5    Huntly, B.J.P.6    Boggon, T.J.7    Wlodarska, I.8    Clark, J.J.9    Moore, S.10
  • 4
    • 70249107079 scopus 로고    scopus 로고
    • How do JAK2-inhibitors work in myelofibrosis: An alternative hypothesis
    • Vannucchi AM. How do JAK2-inhibitors work in myelofibrosis: An alternative hypothesis. Leukemia Res 2009, 33:1581-1583.
    • (2009) Leukemia Res , vol.33 , pp. 1581-1583
    • Vannucchi, A.M.1
  • 5
    • 67549114832 scopus 로고    scopus 로고
    • Hypothesis: How do JAK2-inhibitors work in myelofibrosis
    • Mesa R, Gale RP. Hypothesis: How do JAK2-inhibitors work in myelofibrosis. Leukemia Res 2009, 33:1156-1157.
    • (2009) Leukemia Res , vol.33 , pp. 1156-1157
    • Mesa, R.1    Gale, R.P.2
  • 7
    • 70449440966 scopus 로고    scopus 로고
    • Polycythemia vera erythroid precursors exhibit increased proliferation and apoptosis resistance associated with abnormal RAS and PI3K pathway activation
    • 10.1016/j.exphem.2009.09.009, 2783925, 19815050
    • Laubach JP, Fu P, Jiang X, Salter KH, Potti A, Arcasoy MO. Polycythemia vera erythroid precursors exhibit increased proliferation and apoptosis resistance associated with abnormal RAS and PI3K pathway activation. Exp Hematol 2009, 37:1411-1422. 10.1016/j.exphem.2009.09.009, 2783925, 19815050.
    • (2009) Exp Hematol , vol.37 , pp. 1411-1422
    • Laubach, J.P.1    Fu, P.2    Jiang, X.3    Salter, K.H.4    Potti, A.5    Arcasoy, M.O.6
  • 8
    • 0032568003 scopus 로고    scopus 로고
    • Expression of Bcl-x in Erythroid Precursors from Patients with Polycythemia Vera
    • 10.1056/NEJM199802263380902, 9475763
    • Silva M, Richard C, Benito A, Sanz C, Olalla I, Fernandez-Luna JL. Expression of Bcl-x in Erythroid Precursors from Patients with Polycythemia Vera. N Engl J Med 1998, 338:564-571. 10.1056/NEJM199802263380902, 9475763.
    • (1998) N Engl J Med , vol.338 , pp. 564-571
    • Silva, M.1    Richard, C.2    Benito, A.3    Sanz, C.4    Olalla, I.5    Fernandez-Luna, J.L.6
  • 9
    • 61849143248 scopus 로고    scopus 로고
    • Activity of the BH3 mimetic ABT-737 on polycythemia vera erythroid precursor cells
    • 10.1182/blood-2008-03-143321, 19060244
    • Zeuner A, Pedini F, Francescangeli F, Signore M, Girelli G, Tafuri A, De Maria R. Activity of the BH3 mimetic ABT-737 on polycythemia vera erythroid precursor cells. Blood 2009, 113:1522-1525. 10.1182/blood-2008-03-143321, 19060244.
    • (2009) Blood , vol.113 , pp. 1522-1525
    • Zeuner, A.1    Pedini, F.2    Francescangeli, F.3    Signore, M.4    Girelli, G.5    Tafuri, A.6    De Maria, R.7
  • 10
    • 57749084579 scopus 로고    scopus 로고
    • Effects of the JAK2 Inhibitor, AZ960, on Pim/BAD/BCL-xL Survival Signaling in the Human JAK2 V617F Cell Line SET-2
    • 10.1074/jbc.M803813200, 18775810
    • Gozgit JM, Bebernitz G, Patil P, Ye M, Parmentier J, Wu J, Su N, Wang T, Ioannidis S, Davies A, et al. Effects of the JAK2 Inhibitor, AZ960, on Pim/BAD/BCL-xL Survival Signaling in the Human JAK2 V617F Cell Line SET-2. J Biol Chem 2008, 283:32334-32343. 10.1074/jbc.M803813200, 18775810.
    • (2008) J Biol Chem , vol.283 , pp. 32334-32343
    • Gozgit, J.M.1    Bebernitz, G.2    Patil, P.3    Ye, M.4    Parmentier, J.5    Wu, J.6    Su, N.7    Wang, T.8    Ioannidis, S.9    Davies, A.10
  • 11
    • 33847328289 scopus 로고    scopus 로고
    • The Bcl-2 apoptotic switch in cancer development and therapy
    • 10.1038/sj.onc.1210220, 2930981, 17322918
    • Adams JM, Cory S. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 2007, 26:1324-1337. 10.1038/sj.onc.1210220, 2930981, 17322918.
    • (2007) Oncogene , vol.26 , pp. 1324-1337
    • Adams, J.M.1    Cory, S.2
  • 12
    • 0037085778 scopus 로고    scopus 로고
    • Myeloid cell factor-1 is a critical survival factor for multiple myeloma
    • 10.1182/blood.V99.6.1885, 11877256
    • Zhang B, Gojo I, Fenton RG. Myeloid cell factor-1 is a critical survival factor for multiple myeloma. Blood 2002, 99:1885-1893. 10.1182/blood.V99.6.1885, 11877256.
    • (2002) Blood , vol.99 , pp. 1885-1893
    • Zhang, B.1    Gojo, I.2    Fenton, R.G.3
  • 15
    • 9244237013 scopus 로고    scopus 로고
    • The imbalance between Bim and Mcl-1 expression controls the survival of human myeloma cells
    • 10.1002/eji.200424981, 15459900
    • Gomez-Bougie P, Bataille R, Amiot M. The imbalance between Bim and Mcl-1 expression controls the survival of human myeloma cells. Eur J Immunol 2004, 34:3156-3164. 10.1002/eji.200424981, 15459900.
    • (2004) Eur J Immunol , vol.34 , pp. 3156-3164
    • Gomez-Bougie, P.1    Bataille, R.2    Amiot, M.3
  • 18
    • 0033967383 scopus 로고    scopus 로고
    • Establishment and characterization of a new human megakaryoblastic cell line (SET-2) that spontaneously matures to megakaryocytes and produces platelet-like particles
    • 10.1038/sj.leu.2401608, 10637490
    • Uozumi K, Otsuka M, Ohno N, Moriyama T, Suzuki S, Shimotakahara S, Matsumura I, Hanada S, Arima T. Establishment and characterization of a new human megakaryoblastic cell line (SET-2) that spontaneously matures to megakaryocytes and produces platelet-like particles. Leukemia 2000, 14:142-152. 10.1038/sj.leu.2401608, 10637490.
    • (2000) Leukemia , vol.14 , pp. 142-152
    • Uozumi, K.1    Otsuka, M.2    Ohno, N.3    Moriyama, T.4    Suzuki, S.5    Shimotakahara, S.6    Matsumura, I.7    Hanada, S.8    Arima, T.9
  • 19
    • 0025719947 scopus 로고
    • Granulocyte-macrophage colony-stimulating factor-dependent growth and erythropoietin-induced differentiation of a human cell line MB-02
    • Morgan DA, Gumucio DL, Brodsky I. Granulocyte-macrophage colony-stimulating factor-dependent growth and erythropoietin-induced differentiation of a human cell line MB-02. Blood 1991, 78:2860-2871.
    • (1991) Blood , vol.78 , pp. 2860-2871
    • Morgan, D.A.1    Gumucio, D.L.2    Brodsky, I.3
  • 20
    • 0142027948 scopus 로고    scopus 로고
    • Ways of dying: multiple pathways to apoptosis
    • 10.1101/gad.1126903, 14561771
    • Adams JM. Ways of dying: multiple pathways to apoptosis. Genes Dev 2003, 17:2481-2495. 10.1101/gad.1126903, 14561771.
    • (2003) Genes Dev , vol.17 , pp. 2481-2495
    • Adams, J.M.1
  • 21
    • 77951041842 scopus 로고    scopus 로고
    • Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells
    • 10.1182/blood-2009-03-209544, 20160166
    • Will B, Siddiqi T, Jorda MA, Shimamura T, Luptakova K, Staber PB, Costa DB, Steidl U, Tenen DG, Kobayashi S. Apoptosis induced by JAK2 inhibition is mediated by Bim and enhanced by the BH3 mimetic ABT-737 in JAK2 mutant human erythroid cells. Blood 2010, 115:2901-2909. 10.1182/blood-2009-03-209544, 20160166.
    • (2010) Blood , vol.115 , pp. 2901-2909
    • Will, B.1    Siddiqi, T.2    Jorda, M.A.3    Shimamura, T.4    Luptakova, K.5    Staber, P.B.6    Costa, D.B.7    Steidl, U.8    Tenen, D.G.9    Kobayashi, S.10
  • 22
    • 0031876318 scopus 로고    scopus 로고
    • Mcl-1 Is an Immediate-Early Gene Activated by the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Signaling Pathway and Is One Component of the GM-CSF Viability Response
    • 109073, 9671497
    • Chao J-R, Wang J-M, Lee S-F, Peng H-W, Lin Y-H, Chou C-H, Li J-C, Huang H-M, Chou C-K, Kuo M-L, et al. mcl-1 Is an Immediate-Early Gene Activated by the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Signaling Pathway and Is One Component of the GM-CSF Viability Response. Mol Cell Biol 1998, 18:4883-4898. 109073, 9671497.
    • (1998) Mol Cell Biol , vol.18 , pp. 4883-4898
    • Chao, J.-R.1    Wang, J.-M.2    Lee, S.-F.3    Peng, H.-W.4    Lin, Y.-H.5    Chou, C.-H.6    Li, J.-C.7    Huang, H.-M.8    Chou, C.-K.9    Kuo, M.-L.10
  • 23
    • 33644855216 scopus 로고    scopus 로고
    • Glycogen Synthase Kinase-3 Regulates Mitochondrial Outer Membrane Permeabilization and Apoptosis by Destabilization of MCL-1
    • 10.1016/j.molcel.2006.02.009, 16543145
    • Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR. Glycogen Synthase Kinase-3 Regulates Mitochondrial Outer Membrane Permeabilization and Apoptosis by Destabilization of MCL-1. Mol Cell 2006, 21:749-760. 10.1016/j.molcel.2006.02.009, 16543145.
    • (2006) Mol Cell , vol.21 , pp. 749-760
    • Maurer, U.1    Charvet, C.2    Wagman, A.S.3    Dejardin, E.4    Green, D.R.5
  • 24
    • 21244472965 scopus 로고    scopus 로고
    • Mule/ARF-BP1, a BH3-Only E3 Ubiquitin Ligase, Catalyzes the Polyubiquitination of Mcl-1 and Regulates Apoptosis
    • 10.1016/j.cell.2005.06.009, 15989957
    • Zhong Q, Gao W, Du F, Wang X. Mule/ARF-BP1, a BH3-Only E3 Ubiquitin Ligase, Catalyzes the Polyubiquitination of Mcl-1 and Regulates Apoptosis. Cell 2005, 121:1085-1095. 10.1016/j.cell.2005.06.009, 15989957.
    • (2005) Cell , vol.121 , pp. 1085-1095
    • Zhong, Q.1    Gao, W.2    Du, F.3    Wang, X.4
  • 25
    • 0032189802 scopus 로고    scopus 로고
    • Mcl-1 Expression in Human Neutrophils: Regulation by Cytokines and Correlation With Cell Survival
    • Moulding DA, Quayle JA, Hart CA, Edwards SW. Mcl-1 Expression in Human Neutrophils: Regulation by Cytokines and Correlation With Cell Survival. Blood 1998, 92:2495-2502.
    • (1998) Blood , vol.92 , pp. 2495-2502
    • Moulding, D.A.1    Quayle, J.A.2    Hart, C.A.3    Edwards, S.W.4
  • 26
    • 7444243152 scopus 로고    scopus 로고
    • Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity
    • 10.1073/pnas.0406837101, 524459, 15486085
    • Harada H, Quearry B, Ruiz-Vela A, Korsmeyer SJ. Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proc Natl Acad Sci USA 2004, 101:15313-15317. 10.1073/pnas.0406837101, 524459, 15486085.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 15313-15317
    • Harada, H.1    Quearry, B.2    Ruiz-Vela, A.3    Korsmeyer, S.J.4
  • 27
    • 33748206336 scopus 로고    scopus 로고
    • Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cells
    • 10.1182/blood-2005-10-009514, 16684963
    • Garcon L, Rivat C, James C, Lacout C, Camara-Clayette V, Ugo V, Lecluse Y, Bennaceur-Griscelli A, Vainchenker W. Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cells. Blood 2006, 108:1551-1554. 10.1182/blood-2005-10-009514, 16684963.
    • (2006) Blood , vol.108 , pp. 1551-1554
    • Garcon, L.1    Rivat, C.2    James, C.3    Lacout, C.4    Camara-Clayette, V.5    Ugo, V.6    Lecluse, Y.7    Bennaceur-Griscelli, A.8    Vainchenker, W.9
  • 28
    • 58149089846 scopus 로고    scopus 로고
    • Inhibition of the Bcl-xL Deamidation Pathway in Myeloproliferative Disorders
    • 10.1056/NEJMoa0804953, 19109573
    • Zhao R, Follows GA, Beer PA, Scott LM, Huntly BJP, Green AR, Alexander DR. Inhibition of the Bcl-xL Deamidation Pathway in Myeloproliferative Disorders. N Engl J Med 2008, 359:2778-2789. 10.1056/NEJMoa0804953, 19109573.
    • (2008) N Engl J Med , vol.359 , pp. 2778-2789
    • Zhao, R.1    Follows, G.A.2    Beer, P.A.3    Scott, L.M.4    Huntly, B.J.P.5    Green, A.R.6    Alexander, D.R.7
  • 29
    • 22244464818 scopus 로고    scopus 로고
    • Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins
    • 10.1101/gad.1304105, 1142553, 15901672
    • Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DCS. Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev 2005, 19:1294-1305. 10.1101/gad.1304105, 1142553, 15901672.
    • (2005) Genes Dev , vol.19 , pp. 1294-1305
    • Willis, S.N.1    Chen, L.2    Dewson, G.3    Wei, A.4    Naik, E.5    Fletcher, J.I.6    Adams, J.M.7    Huang, D.C.S.8
  • 30
    • 0242521470 scopus 로고    scopus 로고
    • Phosphorylation of Bim-EL by Erk1//2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function
    • 10.1038/sj.onc.1206792, 14555991
    • Luciano F, Jacquel A, Colosetti P, Herrant M, Cagnol S, Pages G, Auberger P. Phosphorylation of Bim-EL by Erk1//2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. Oncogene 2003, 22:6785-6793. 10.1038/sj.onc.1206792, 14555991.
    • (2003) Oncogene , vol.22 , pp. 6785-6793
    • Luciano, F.1    Jacquel, A.2    Colosetti, P.3    Herrant, M.4    Cagnol, S.5    Pages, G.6    Auberger, P.7
  • 31
    • 35148870200 scopus 로고    scopus 로고
    • C-Cbl is not required for ERK1/2-dependent degradation of BimEL
    • 10.1016/j.cellsig.2007.08.008, 2707770, 17884340
    • Wiggins CM, Band H, Cook SJ. c-Cbl is not required for ERK1/2-dependent degradation of BimEL. Cell Signal 2007, 19:2605-2611. 10.1016/j.cellsig.2007.08.008, 2707770, 17884340.
    • (2007) Cell Signal , vol.19 , pp. 2605-2611
    • Wiggins, C.M.1    Band, H.2    Cook, S.J.3
  • 34
    • 0033607506 scopus 로고    scopus 로고
    • Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity
    • 10.1126/science.286.5445.1735, 10576740
    • Bouillet P, Metcalf D, Huang DC, Tarlinton DM, Kay TW, Köntgen F, Adams JM, Strasser A. Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity. Science 1999, 286:1735-1738. 10.1126/science.286.5445.1735, 10576740.
    • (1999) Science , vol.286 , pp. 1735-1738
    • Bouillet, P.1    Metcalf, D.2    Huang, D.C.3    Tarlinton, D.M.4    Kay, T.W.5    Köntgen, F.6    Adams, J.M.7    Strasser, A.8
  • 35
    • 58149204019 scopus 로고    scopus 로고
    • Erythropoietin-induced phosphorylation/degradation of BIM contributes to survival of erythroid cells
    • 10.1016/j.exphem.2008.10.008, 2656114, 19100675
    • Abutin RM, Chen J, Lung TK, Lloyd JA, Sawyer ST, Harada H. Erythropoietin-induced phosphorylation/degradation of BIM contributes to survival of erythroid cells. Exp Hematol 2009, 37:151-158. 10.1016/j.exphem.2008.10.008, 2656114, 19100675.
    • (2009) Exp Hematol , vol.37 , pp. 151-158
    • Abutin, R.M.1    Chen, J.2    Lung, T.K.3    Lloyd, J.A.4    Sawyer, S.T.5    Harada, H.6
  • 36
    • 0034609737 scopus 로고    scopus 로고
    • Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
    • 10.1016/S0960-9822(00)00728-4, 11050388
    • Dijkers PF, Medema RH, Lammers J-W, Koenderman L, Coffer PJ. Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr Biol 2000, 10:1201-1204. 10.1016/S0960-9822(00)00728-4, 11050388.
    • (2000) Curr Biol , vol.10 , pp. 1201-1204
    • Dijkers, P.F.1    Medema, R.H.2    Lammers, J.-W.3    Koenderman, L.4    Coffer, P.J.5
  • 37
    • 17444405985 scopus 로고    scopus 로고
    • Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells
    • 10.1038/sj.onc.1208421, 15688014
    • Essafi A, Fernandez de Mattos S, Hassen YAM, Soeiro I, Mufti GJ, Thomas NSB, Medema RH, Lam EWF. Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. Oncogene 2005, 24:2317-2329. 10.1038/sj.onc.1208421, 15688014.
    • (2005) Oncogene , vol.24 , pp. 2317-2329
    • Essafi, A.1    Fernandez de Mattos, S.2    Hassen, Y.A.M.3    Soeiro, I.4    Mufti, G.J.5    Thomas, N.S.B.6    Medema, R.H.7    Lam, E.W.F.8
  • 38
    • 70350061670 scopus 로고    scopus 로고
    • LRF Is an Essential Downstream Target of GATA1 in Erythroid Development and Regulates BIM-Dependent Apoptosis
    • 10.1016/j.devcel.2009.09.005, 19853566
    • Maeda T, Ito K, Merghoub T, Poliseno L, Hobbs RM, Wang G, Dong L, Maeda M, Dore LC, Zelent A, et al. LRF Is an Essential Downstream Target of GATA1 in Erythroid Development and Regulates BIM-Dependent Apoptosis. Dev Cell 2009, 17:527-540. 10.1016/j.devcel.2009.09.005, 19853566.
    • (2009) Dev Cell , vol.17 , pp. 527-540
    • Maeda, T.1    Ito, K.2    Merghoub, T.3    Poliseno, L.4    Hobbs, R.M.5    Wang, G.6    Dong, L.7    Maeda, M.8    Dore, L.C.9    Zelent, A.10
  • 39
    • 22344456263 scopus 로고    scopus 로고
    • BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis
    • Gélinas C, White E. BH3-only proteins in control: specificity regulates MCL-1 and BAK-mediated apoptosis. Genes Dev 2005, 19:1263-1268.
    • (2005) Genes Dev , vol.19 , pp. 1263-1268
    • Gélinas, C.1    White, E.2
  • 40
    • 13844319184 scopus 로고    scopus 로고
    • Obligate Role of Anti-Apoptotic MCL-1 in the Survival of Hematopoietic Stem Cells
    • 10.1126/science.1106114, 15718471
    • Opferman JT, Iwasaki H, Ong CC, Suh H, Mizuno S, Akashi K, Korsmeyer SJ. Obligate Role of Anti-Apoptotic MCL-1 in the Survival of Hematopoietic Stem Cells. Science 2005, 307:1101-1104. 10.1126/science.1106114, 15718471.
    • (2005) Science , vol.307 , pp. 1101-1104
    • Opferman, J.T.1    Iwasaki, H.2    Ong, C.C.3    Suh, H.4    Mizuno, S.5    Akashi, K.6    Korsmeyer, S.J.7
  • 43
    • 14744299761 scopus 로고    scopus 로고
    • Turning cells red: signal transduction mediated by erythropoietin
    • 10.1016/j.tcb.2005.01.007, 15752978
    • Richmond TD, Chohan M, Barber DL. Turning cells red: signal transduction mediated by erythropoietin. Trends Cell Biol 2005, 15:146-155. 10.1016/j.tcb.2005.01.007, 15752978.
    • (2005) Trends Cell Biol , vol.15 , pp. 146-155
    • Richmond, T.D.1    Chohan, M.2    Barber, D.L.3
  • 44
    • 0032522453 scopus 로고    scopus 로고
    • Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways
    • 10.1101/gad.12.8.1099, 316716, 9553040
    • Quelle FW, Wang J, Feng J, Wang D, Cleveland JL, Ihle JN, Zambetti GP. Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct Jak kinase signaling pathways. Genes Dev 1998, 12:1099-1107. 10.1101/gad.12.8.1099, 316716, 9553040.
    • (1998) Genes Dev , vol.12 , pp. 1099-1107
    • Quelle, F.W.1    Wang, J.2    Feng, J.3    Wang, D.4    Cleveland, J.L.5    Ihle, J.N.6    Zambetti, G.P.7
  • 45
    • 0032711250 scopus 로고    scopus 로고
    • IL-6 up-regulates Mcl-1 in human myeloma cells through JAK/STAT rather than Ras/MAP kinase pathway
    • 10.1002/(SICI)1521-4141(199912)29:12<3945::AID-IMMU3945>3.0.CO;2-O, 10602002
    • Puthier D, Bataille R, Amiot M. IL-6 up-regulates Mcl-1 in human myeloma cells through JAK/STAT rather than Ras/MAP kinase pathway. Eur J Immunol 1999, 29:3945-3950. 10.1002/(SICI)1521-4141(199912)29:12<3945::AID-IMMU3945>3.0.CO;2-O, 10602002.
    • (1999) Eur J Immunol , vol.29 , pp. 3945-3950
    • Puthier, D.1    Bataille, R.2    Amiot, M.3
  • 46
    • 3042707495 scopus 로고    scopus 로고
    • Roles of Bim in Apoptosis of Normal and Bcr-Abl-Expressing Hematopoietic Progenitors
    • 10.1128/MCB.24.14.6172-6183.2004, 434248, 15226421
    • Kuribara R, Honda H, Matsui H, Shinjyo T, Inukai T, Sugita K, Nakazawa S, Hirai H, Ozawa K, Inaba T. Roles of Bim in Apoptosis of Normal and Bcr-Abl-Expressing Hematopoietic Progenitors. Mol Cell Biol 2004, 24:6172-6183. 10.1128/MCB.24.14.6172-6183.2004, 434248, 15226421.
    • (2004) Mol Cell Biol , vol.24 , pp. 6172-6183
    • Kuribara, R.1    Honda, H.2    Matsui, H.3    Shinjyo, T.4    Inukai, T.5    Sugita, K.6    Nakazawa, S.7    Hirai, H.8    Ozawa, K.9    Inaba, T.10
  • 47
    • 27144515283 scopus 로고    scopus 로고
    • Low-Level Expression of Proapoptotic Bcl-2-Interacting Mediator in Leukemic Cells in Patients with Chronic Myeloid Leukemia: Role of BCR/ABL, Characterization of Underlying Signaling Pathways, and Reexpression by Novel Pharmacologic Compounds
    • 10.1158/0008-5472.CAN-05-0972, 16230407
    • Aichberger KJ, Mayerhofer M, Krauth M-T, Vales A, Kondo R, Derdak S, Pickl WF, Selzer E, Deininger M, Druker BJ, et al. Low-Level Expression of Proapoptotic Bcl-2-Interacting Mediator in Leukemic Cells in Patients with Chronic Myeloid Leukemia: Role of BCR/ABL, Characterization of Underlying Signaling Pathways, and Reexpression by Novel Pharmacologic Compounds. Cancer Res 2005, 65:9436-9444. 10.1158/0008-5472.CAN-05-0972, 16230407.
    • (2005) Cancer Res , vol.65 , pp. 9436-9444
    • Aichberger, K.J.1    Mayerhofer, M.2    Krauth, M.-T.3    Vales, A.4    Kondo, R.5    Derdak, S.6    Pickl, W.F.7    Selzer, E.8    Deininger, M.9    Druker, B.J.10
  • 48
    • 33749510073 scopus 로고    scopus 로고
    • Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic
    • 10.1073/pnas.0606176103, 1595449, 16997913
    • Kuroda J, Puthalakath H, Cragg MS, Kelly PN, Bouillet P, Huang DCS, Kimura S, Ottmann OG, Druker BJ, Villunger A, et al. Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic. Proc Natl Acad Sci USA 2006, 103:14907-14912. 10.1073/pnas.0606176103, 1595449, 16997913.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 14907-14912
    • Kuroda, J.1    Puthalakath, H.2    Cragg, M.S.3    Kelly, P.N.4    Bouillet, P.5    Huang, D.C.S.6    Kimura, S.7    Ottmann, O.G.8    Druker, B.J.9    Villunger, A.10
  • 49
    • 64049095817 scopus 로고    scopus 로고
    • BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3
    • 10.1182/blood-2008-07-167023, 19064725
    • Nordigarden A, Kraft M, Eliasson P, Labi V, Lam EWF, Villunger A, Jonsson J-I. BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3. Blood 2009, 113:2302-2311. 10.1182/blood-2008-07-167023, 19064725.
    • (2009) Blood , vol.113 , pp. 2302-2311
    • Nordigarden, A.1    Kraft, M.2    Eliasson, P.3    Labi, V.4    Lam, E.W.F.5    Villunger, A.6    Jonsson, J.-I.7
  • 50
    • 34248202709 scopus 로고    scopus 로고
    • Targeting Multiple Arms of the Apoptotic Regulatory Machinery
    • 10.1158/0008-5472.CAN-07-0082, 17409392
    • Dai Y, Grant S. Targeting Multiple Arms of the Apoptotic Regulatory Machinery. Cancer Res 2007, 67:2908-2911. 10.1158/0008-5472.CAN-07-0082, 17409392.
    • (2007) Cancer Res , vol.67 , pp. 2908-2911
    • Dai, Y.1    Grant, S.2
  • 51
    • 0348148880 scopus 로고    scopus 로고
    • Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1
    • 10.1038/nature02067, 14668867
    • Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature 2003, 426:671-676. 10.1038/nature02067, 14668867.
    • (2003) Nature , vol.426 , pp. 671-676
    • Opferman, J.T.1    Letai, A.2    Beard, C.3    Sorcinelli, M.D.4    Ong, C.C.5    Korsmeyer, S.J.6
  • 53
    • 41249099841 scopus 로고    scopus 로고
    • Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera
    • 10.1016/j.ccr.2008.02.009, 18394554
    • Wernig G, Kharas MG, Okabe R, Moore SA, Leeman DS, Cullen DE, Gozo M, McDowell EP, Levine RL, Doukas J, et al. Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera. Cancer Cell 2008, 13:311-320. 10.1016/j.ccr.2008.02.009, 18394554.
    • (2008) Cancer Cell , vol.13 , pp. 311-320
    • Wernig, G.1    Kharas, M.G.2    Okabe, R.3    Moore, S.A.4    Leeman, D.S.5    Cullen, D.E.6    Gozo, M.7    McDowell, E.P.8    Levine, R.L.9    Doukas, J.10
  • 54
    • 33746437130 scopus 로고    scopus 로고
    • MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia
    • 10.1371/journal.pmed.0030270, 1502153, 16834459
    • Pikman Y, Lee BH, Mercher T, McDowell E, Ebert BL, Gozo M, Cuker A, Wernig G, Moore S, Galinsky I, et al. MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia. PLoS Med 2006, 3:e270. 10.1371/journal.pmed.0030270, 1502153, 16834459.
    • (2006) PLoS Med , vol.3
    • Pikman, Y.1    Lee, B.H.2    Mercher, T.3    McDowell, E.4    Ebert, B.L.5    Gozo, M.6    Cuker, A.7    Wernig, G.8    Moore, S.9    Galinsky, I.10
  • 55
    • 77950647838 scopus 로고    scopus 로고
    • Therapeutic Potential of Janus-activated Kinase-2 Inhibitors for the Management of Myelofibrosis
    • 10.1158/1078-0432.CCR-09-2836, 20215535
    • Verstovsek S. Therapeutic Potential of Janus-activated Kinase-2 Inhibitors for the Management of Myelofibrosis. Clin Cancer Res 2010, 16:1988-1996. 10.1158/1078-0432.CCR-09-2836, 20215535.
    • (2010) Clin Cancer Res , vol.16 , pp. 1988-1996
    • Verstovsek, S.1
  • 56
    • 57049157033 scopus 로고    scopus 로고
    • BCL-2 family antagonists for cancer therapy
    • 10.1038/nrd2658, 19043450
    • Lessene G, Czabotar PE, Colman PM. BCL-2 family antagonists for cancer therapy. Nat Rev Drug Discov 2008, 7:989-1000. 10.1038/nrd2658, 19043450.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 989-1000
    • Lessene, G.1    Czabotar, P.E.2    Colman, P.M.3


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