Erythropoietin-induced phosphorylation/degradation of BIM contributes to survival of erythroid cells

Experimental Hematology

Volumn 37, Issue 2, 2009, Pages 151-158

  Abutin, Randolph M ^a   Chen, Jingchun ^a   Lung, Tina K ^a   Lloyd, Joyce A ^a   Sawyer, Stephen T ^a   Harada, Hisashi ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BIM PROTEIN; ERYTHROPOIETIN; SERINE; SHORT HAIRPIN RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; ERYTHROCYTE; ERYTHROID CELL; FLOW CYTOMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; RETICULOCYTE; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE; CELL SURVIVAL; ERYTHROID CELLS; ERYTHROPOIETIN; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS;

MURINAE; MUS;

EID: 58149204019     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2008.10.008     Document Type: Article

References (35)

1. Koury M.J., Sawyer S.T., and Brandt S.J. New insights into erythropoiesis. Curr Opin Hematol 9 (2002) 93-100
2. Richmond T.D., Chohan M., and Barber D.L. Turning cells red: signal transduction mediated by erythropoietin. Trends Cell Biol 15 (2005) 146-155
3. Adams J.M., and Cory S. The Bcl-2 apoptotic switch in cancer development and therapy. Oncogene 26 (2007) 1324-1337
4. Danial N.N., and Korsmeyer S.J. Cell death: critical control points. Cell 116 (2004) 205-219
5. O'Connor L., Strasser A., O'Reilly L.A., et al. Bim: a novel member of the Bcl-2 family that promotes apoptosis. EMBO J 17 (1998) 384-395
6. Strasser A. The role of BH3-only proteins in the immune system. Nat Rev Immunol 5 (2005) 189-200
7. Bouillet P., Metcalf D., Huang D.C., et al. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. Science 286 (1999) 1735-1738
8. Ley R., Ewings K.E., Hadfield K., and Cook S.J. Regulatory phosphorylation of Bim: sorting out the ERK from the JNK. Cell Death Differ 12 (2005) 1008-1014
9. Dijkers P.F., Birkenkamp K.U., Lam E.W., et al. FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J Cell Biol 156 (2002) 531-542
10. Whitfield J., Neame S.J., Paquet L., Bernard O., and Ham J. Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron 29 (2001) 629-643
11. Harada H., Quearry B., Ruiz-Vela A., and Korsmeyer S.J. Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proc Natl Acad Sci U S A 101 (2004) 15313-15317
12. Puthalakath H., Huang D.C., O'Reilly L.A., King S.M., and Strasser A. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Mol Cell 3 (1999) 287-296
13. Sawyer S.T., and Jacobs-Helber S.M. Unraveling distinct intracellular signals that promote survival and proliferation: study of erythropoietin, stem cell factor, and constitutive signaling in leukemic cells. J Hematother Stem Cell Res 9 (2000) 21-29
14. Bao H., Jacobs-Helber S.M., Lawson A.E., et al. Protein kinase B (c-Akt), phosphatidylinositol 3-kinase, and STAT5 are activated by erythropoietin (EPO) in HCD57 erythroid cells but are constitutively active in an EPO-independent, apoptosis-resistant subclone (HCD57-SREI cells). Blood 93 (1999) 3757-3773
15. Jacobs-Helber S.M., Penta K., Sun Z., Lawson A., and Sawyer S.T. Distinct signaling from stem cell factor and erythropoietin in HCD57 cells. J Biol Chem 272 (1997) 6850-6853
16. Menon M.P., Fang J., and Wojchowski D.M. Core erythropoietin receptor signals for late erythroblast development. Blood 107 (2006) 2662-2672
17. Socolovsky M., Fallon A.E., Wang S., Brugnara C., and Lodish H.F. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell 98 (1999) 181-191
18. Jacobs-Helber S.M., and Sawyer S.T. Jun N-terminal kinase promotes proliferation of immature erythroid cells and erythropoietin-dependent cell lines. Blood 104 (2004) 696-703
19. Zhang L., and Insel P.A. The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells. J Biol Chem 279 (2004) 20858-20865
20. Takeuchi O., Fisher J., Suh H., et al. Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proc Natl Acad Sci U S A 102 (2005) 11272-11277
21. Hara H., and Ogawa M. Erythropoietic precursors in mice under erythropoietic stimulation and suppression. Exp Hematol 5 (1977) 141-148
22. Jeffers J.R., Parganas E., Lee Y., et al. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell 4 (2003) 321-328
23. Villunger A., Michalak E.M., Coultas L., et al. p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa. Science 302 (2003) 1036-1038
24. Erlacher M., Labi V., Manzl C., et al. Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction. J Exp Med 203 (2006) 2939-2951
25. Sathyanarayana P., Dev A., Fang J., et al. EPO receptor circuits for primary erythroblast survival. Blood 111 (2008) 5390-5399
26. Rhodes M.M., Kopsombut P., Bondurant M.C., Price J.O., and Koury M.J. Bcl-x(L) prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin. Blood 106 (2005) 1857-1863
27. Diwan A., Koesters A.G., Odley A.M., et al. Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc Natl Acad Sci U S A 104 (2007) 6794-6799
28. Schweers R.L., Zhang J., Randall M.S., et al. NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci U S A 104 (2007) 19500-19505
29. Sandoval H., Thiagarajan P., Dasgupta S.K., et al. Essential role for Nix in autophagic maturation of erythroid cells. Nature 454 (2008) 232-235
30. Kannel W.B., Gordon T., Wolf P.A., and McNamara P. Hemoglobin and the risk of cerebral infarction: the Framingham Study. Stroke 3 (1972) 409-420
31. Harrison M.J., Pollock S., Kendall B.E., and Marshall J. Effect of haematocrit on carotid stenosis and cerebral infarction. Lancet 2 (1981) 114-115
32. Wannamethee G., Perry I.J., and Shaper A.G. Haematocrit, hypertension and risk of stroke. J Intern Med 235 (1994) 163-168
33. Socolovsky M., Nam H., Fleming M.D., et al. Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood 98 (2001) 3261-3273
34. Halupa A., Bailey M.L., Huang K., et al. A novel role for STAT1 in regulating murine erythropoiesis: deletion of STAT1 results in overall reduction of erythroid progenitors and alters their distribution. Blood 105 (2005) 552-561
35. Jacobs-Helber S.M., Wickrema A., Birrer M.J., and Sawyer S.T. AP1 regulation of proliferation and initiation of apoptosis in erythropoietin-dependent erythroid cells. Mol Cell Biol 18 (1998) 3699-3707