-
1
-
-
0022481133
-
Multiple nuclear factors interact with the immunoglobulin enhancer sequences
-
Sen R, Baltimore D. Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell 1986;46:705-16
-
(1986)
Cell.
, vol.46
, pp. 705-716
-
-
Sen, R.1
Baltimore, D.2
-
3
-
-
0031017618
-
MAP3K-related kinase involved in NF-kappaB induction by TNF CD95 and IL-1
-
Malinin NL, Boldin MP, Kovalenko AV, Wallach D. MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. Nature 1997;385:540-4
-
(1997)
Nature
, vol.385
, pp. 540-544
-
-
Malinin, N.L.1
Boldin, M.P.2
Kovalenko, A.V.3
Wallach, D.4
-
4
-
-
34547660308
-
Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma
-
Keats JJ, Fonseca R, Chesi M, et al. Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell 2007;12:131-44
-
(2007)
Cancer Cell.
, vol.12
, pp. 131-44
-
-
Keats, J.J.1
Fonseca, R.2
Chesi, M.3
-
5
-
-
34547562418
-
Frequent engagement of the classical and alternative NF-kappa B pathways by diverse genetic abnormalities in multiple myeloma
-
Annunziata CM, Davis RE, Demchenko Y, et al. Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell 2007;12:115-30
-
(2007)
Cancer Cell
, vol.12
, pp. 115-130
-
-
Annunziata, C.M.1
Davis, R.E.2
Demchenko, Y.3
-
6
-
-
0026066613
-
Generation of p50 subunit of NF-kappaB by processing of p105 through an ATP-dependent pathway
-
Fan CM, Maniatis T. Generation of p50 subunit of NF-kappaB by processing of p105 through an ATP-dependent pathway. Nature 1991;354:395-8
-
(1991)
Nature
, vol.354
, pp. 395-398
-
-
Fan, C.M.1
Maniatis, T.2
-
7
-
-
0027520473
-
Proteolytic degradation of MAD3 ikappa balpha and enhanced processing of the NF-kappaB precursor p105 are obligatory steps in the activation of NF-kappaB
-
Mellits KH, Hay RT, Goodbourn S. Proteolytic degradation of MAD3 (IkappaBalpha) and enhanced processing of the NF-kappaB precursor p105 are obligatory steps in the activation of NF-kappaB. Nucleic Acids Res 1993;21:5059-66
-
(1993)
Nucleic. Acids Res.
, vol.21
, pp. 5059-5066
-
-
Mellits, K.H.1
Hay, R.T.2
Goodbourn, S.3
-
8
-
-
0027243576
-
P105 and p98 precursor proteins play an active role in NF-kappaB-mediated signal transduction
-
Mercurio F, DiDonato JA, Rosette C, Karin M. p105 and p98 precursor proteins play an active role in NF-kappaB-mediated signal transduction. Genes Dev 1993;7:705-18
-
(1993)
Genes. Dev.
, vol.7
, pp. 705-718
-
-
Mercurio, F.1
DiDonato, J.A.2
Rosette, C.3
Karin, M.4
-
9
-
-
0025999203
-
Cytoplasmic retention DNA binding and processing of the NF-kappaB p50 precursor are controlled by a small region in its C-terminus
-
Blank V, Kourilsky P, Israel A. Cytoplasmic retention, DNA binding and processing of the NF-kappaB p50 precursor are controlled by a small region in its C-terminus. EMBO J 1991;10:4159-67
-
(1991)
EMBO J.
, vol.10
, pp. 4159-4167
-
-
Blank, V.1
Kourilsky, P.2
Israel, A.3
-
10
-
-
0028971289
-
Rel/NF-kappaB/IkappaB family: Intimate tales of association and dissociation
-
Verma IM, Stevenson JK, Schwarz EM, et al. Rel/NF-kappaB/IkappaB family: intimate tales of association and dissociation. Genes Dev 1995;9:2723-35
-
(1995)
Genes. Dev.
, vol.9
, pp. 2723-2735
-
-
Verma, I.M.1
Stevenson, J.K.2
Schwarz, E.M.3
-
11
-
-
17944378526
-
Activation by IKKalpha of a second evolutionary conserved NF-kappaB signaling pathway
-
Senftleben U, Cao Y, Xiao G, et al. Activation by IKKalpha of a second, evolutionary conserved, NF-kappaB signaling pathway. Science 2001;293:1495-9
-
(2001)
Science
, vol.293
, pp. 1495-1499
-
-
Senftleben, U.1
Cao, Y.2
Xiao, G.3
-
12
-
-
0023724778
-
I kappa B: A specific inhibitor of the NF-kappa B transcription factor
-
Baeuerle PA, Baltimore D. I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science 1988;242:540-6
-
(1988)
Science
, vol.242
, pp. 540-546
-
-
Baeuerle, P.A.1
Baltimore, D.2
-
13
-
-
0036144763
-
Regulatory functions of ubiquitination in the immune system
-
Ben-Neriah Y. Regulatory functions of ubiquitination in the immune system. Nat Immunol 2002;3:20-6
-
(2002)
Nat. Immunol.
, vol.3
, pp. 20-26
-
-
Ben-Neriah, Y.1
-
14
-
-
0033537719
-
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation
-
Delhase M, Hayakawa M, Chen Y, Karin M. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 1999;284:309-13
-
(1999)
Science
, vol.284
, pp. 309-313
-
-
Delhase, M.1
Hayakawa, M.2
Chen, Y.3
Karin, M.4
-
15
-
-
33750443289
-
IkappaB kinase complexes: Gateways to NF-kappaB activation and transcription
-
Scheidereit C. IkappaB kinase complexes: gateways to NF-kappaB activation and transcription. Oncogene 2006;25:6685-705
-
(2006)
Oncogene
, vol.25
, pp. 6685-6705
-
-
Scheidereit, C.1
-
16
-
-
0037107399
-
CD40 regulates the processing of NF-kappaB2 p100 to p52
-
Coope HJ, Atkinson PG, Huhse B, et al. CD40 regulates the processing of NF-kappaB2 p100 to p52. EMBO J 2002;21:5375-85
-
(2002)
EMBO J.
, vol.21
, pp. 5375-5385
-
-
Coope, H.J.1
Atkinson, P.G.2
Huhse, B.3
-
17
-
-
0031714501
-
Molecular determinants of NF-kappaB-inducing kinase action
-
Lin X, Mu Y, Cunningham ET Jr, et al. Molecular determinants of NF-kappaB-inducing kinase action. Mol Cell Biol 1998;18:5899-907
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 5899-5907
-
-
Lin, X.1
Mu, Y.2
Cunningham Jr., E.T.3
-
18
-
-
0034745420
-
NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100
-
Xiao G, Harhaj EW, Sun SC. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol Cell 2001;7:401-9
-
(2001)
Mol. Cell
, vol.7
, pp. 401-409
-
-
Xiao, G.1
Harhaj, E.W.2
Sun, S.C.3
-
19
-
-
0032583947
-
NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176
-
USA
-
Ling L, Cao Z, Goeddel DV. NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Proc Natl Acad Sci USA 1998;95:3792-7
-
(1998)
Proc. Natl. Acad. Sci.
, vol.95
, pp. 3792-3797
-
-
Ling, L.1
Cao, Z.2
Goeddel, D.V.3
-
20
-
-
3142663912
-
Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha IKKalpha to p100 and IKKalpha-mediated phosphorylation
-
Xiao G, Fong A, Sun SC. Induction of p100 processing by NF-kappaB-inducing kinase involves docking IkappaB kinase alpha (IKKalpha) to p100 and IKKalpha-mediated phosphorylation. J Biol Chem 2004;279:30099-105
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 30099-30105
-
-
Xiao, G.1
Fong, A.2
Sun, S.C.3
-
21
-
-
33646336615
-
Beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870
-
Liang C, Zhang M, Sun SC. Beta-TrCP binding and processing of NF-kappaB2/p100 involve its phosphorylation at serines 866 and 870. Cell Signal 2006;18:1309-17
-
(2006)
Cell. Signal
, vol.18
, pp. 1309-1317
-
-
Liang, C.1
Zhang, M.2
Sun, S.C.3
-
22
-
-
0038771214
-
Modulation of NF-kappaB activity by exchange of dimers
-
Saccani S, Pantano S, Natoli G. Modulation of NF-kappaB activity by exchange of dimers. Mol Cell 2003;11:1563-74
-
(2003)
Mol. Cell
, vol.11
, pp. 1563-1574
-
-
Saccani, S.1
Pantano, S.2
Natoli, G.3
-
23
-
-
33749265867
-
The alternative NF-kappaB pathway from biochemistry to biology: Pitfalls and promises for future drug development
-
Dejardin E. The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development. Biochem Pharmacol 2006;72:1161-79
-
(2006)
Biochem. Pharmacol.
, vol.72
, pp. 1161-1179
-
-
Dejardin, E.1
-
24
-
-
12644272789
-
Tumor necrosis factor TNF-mediated kinase cascades: Bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase JNK/SAPK pathways at TNF receptor-associated factor 2
-
USA
-
Song HY, Regnier CH, Kirschning CJ, et al. Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. Proc Natl Acad Sci USA 1997;94:9792-6
-
(1997)
Proc. Natl. Acad. Sci.
, vol.94
, pp. 9792-9796
-
-
Song, H.Y.1
Regnier, C.H.2
Kirschning, C.J.3
-
25
-
-
0035896422
-
Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice
-
Yin L, Wu L, Wesche H, et al. Defective lymphotoxin-beta receptor-induced NF-kappaB transcriptional activity in NIK-deficient mice. Science 2001;291:2162-5
-
(2001)
Science
, vol.291
, pp. 2162-2165
-
-
Yin, L.1
Wu, L.2
Wesche, H.3
-
26
-
-
27544434183
-
Essential function for the kinase TAK1 in innate and adaptive immune responses
-
Sato S, Sanjo H, Takeda K, et al. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol 2005;6:1087-95
-
(2005)
Nat. Immunol.
, vol.6
, pp. 1087-1095
-
-
Sato, S.1
Sanjo, H.2
Takeda, K.3
-
27
-
-
0032930861
-
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappab-inducing kinase
-
Shinkura R, Kitada K, Matsuda F, et al. Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappab-inducing kinase. Nat Genet 1999;22:74-7
-
(1999)
Nat. Genet.
, vol.22
, pp. 74-77
-
-
Shinkura, R.1
Kitada, K.2
Matsuda, F.3
-
28
-
-
0033621618
-
Activation of the heterodimeric IkappaB kinase alpha IKKalpha-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions
-
OMahony A, Lin X, Geleziunas R, Greene WC. Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions. Mol Cell Biol 2000;20:1170-8
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 1170-1178
-
-
O'Mahony, A.1
Lin, X.2
Geleziunas, R.3
Greene, W.C.4
-
29
-
-
43249103860
-
NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation
-
Wittwer T, Schmitz ML. NIK and Cot cooperate to trigger NF-kappaB p65 phosphorylation. Biochem Biophys Res Commun 2008;371:294-7
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.371
, pp. 294-297
-
-
Wittwer, T.1
Schmitz, M.L.2
-
30
-
-
33645785083
-
NF-kappaB-inducing kinase is involved in the activation of the CD28 responsive element through phosphorylation of c-Rel and regulation of its transactivating activity
-
Sanchez-Valdepenas C, Martin AG, Ramakrishnan P, et al. NF-kappaB-inducing kinase is involved in the activation of the CD28 responsive element through phosphorylation of c-Rel and regulation of its transactivating activity. J Immunol 2006;176:4666-74
-
(2006)
J. Immunol.
, vol.176
, pp. 4666-4674
-
-
Sanchez-Valdepenas, C.1
Martin, A.G.2
Ramakrishnan, P.3
-
31
-
-
33846233038
-
Differential regulation of p65 and c-Rel NF-kappaB transactivating activity by Cot protein kinase C zeta and NIK protein kinases in CD3/CD28 activated T cells
-
Sanchez-Valdepenas C, Punzon C, San-Antonio B, et al. Differential regulation of p65 and c-Rel NF-kappaB transactivating activity by Cot, protein kinase C zeta and NIK protein kinases in CD3/CD28 activated T cells. Cell Signal 2007;19:528-37
-
(2007)
Cell. Signal
, vol.19
, pp. 528-537
-
-
Sanchez-Valdepenas, C.1
Punzon, C.2
San-Antonio, B.3
-
32
-
-
2442693082
-
NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway
-
Je JH, Lee JY, Jung KJ, et al. NF-kappaB activation mechanism of 4-hydroxyhexenal via NIK/IKK and p38 MAPK pathway. FEBS Lett 2004;566:183-9
-
(2004)
FEBS Lett.
, vol.566
, pp. 183-189
-
-
Je, J.H.1
Lee, J.Y.2
Jung, K.J.3
-
33
-
-
85047690577
-
NF-kappaB inducing kinase activates NF-kappaB transcriptional activity independently of IkappaB kinase gamma through a p38 MAPK-dependent RelA phosphorylation pathway
-
Jijon H, Allard B, Jobin C. NF-kappaB inducing kinase activates NF-kappaB transcriptional activity independently of IkappaB kinase gamma through a p38 MAPK-dependent RelA phosphorylation pathway. Cell Signal 2004;16:1023-32
-
(2004)
Cell. Signal
, vol.16
, pp. 1023-1032
-
-
Jijon, H.1
Allard, B.2
Jobin, C.3
-
34
-
-
0037428385
-
The NF-kappaB activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536
-
Jiang X, Takahashi N, Matsui N, et al. The NF-kappaB activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536. J Biol Chem 2003;278:919-26
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 919-926
-
-
Jiang, X.1
Takahashi, N.2
Matsui, N.3
-
35
-
-
0034677019
-
Lineage-restricted function of nuclear factor kappaB-inducing kinase NIK in transducing signals via CD40
-
Garceau N, Kosaka Y, Masters S, et al. Lineage-restricted function of nuclear factor kappaB-inducing kinase (NIK) in transducing signals via CD40. J Exp Med 2000;191:381-6
-
(2000)
J. Exp. Med.
, vol.191
, pp. 381-386
-
-
Garceau, N.1
Kosaka, Y.2
Masters, S.3
-
36
-
-
5644302162
-
Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase
-
Ramakrishnan P, Wang W, Wallach D. Receptor-specific signaling for both the alternative and the canonical NF-kappaB activation pathways by NF-kappaB-inducing kinase. Immunity 2004;21:477-89
-
(2004)
Immunity
, vol.21
, pp. 477-489
-
-
Ramakrishnan, P.1
Wang, W.2
Wallach, D.3
-
37
-
-
0035889229
-
NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts
-
Smith C, Andreakos E, Crawley JB, et al. NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts. J Immunol 2001;167:5895-903
-
(2001)
J. Immunol.
, vol.167
, pp. 5895-5903
-
-
Smith, C.1
Andreakos, E.2
Crawley, J.B.3
-
38
-
-
42149110830
-
Control of canonical NF-kappaB activation through the NIK-IKK complex pathway
-
USA
-
Zarnegar B, Yamazaki S, He JQ, Cheng G. Control of canonical NF-kappaB activation through the NIK-IKK complex pathway. Proc Natl Acad Sci USA 2008;105:3503-8
-
(2008)
Proc. Natl. Acad. Sci.
, vol.105
, pp. 3503-3508
-
-
Zarnegar, B.1
Yamazaki, S.2
He, J.Q.3
Cheng, G.4
-
39
-
-
77951719556
-
Classical and/or alternative NF-kappaB pathway activation in multiple myeloma
-
Demchenko YN, Glebov OK, Zingone A, et al. Classical and/or alternative NF-kappaB pathway activation in multiple myeloma. Blood 2010;115:3541-52
-
(2010)
Blood
, Issue.115
, pp. 3541-3552
-
-
Demchenko, Y.N.1
Glebov, O.K.2
Zingone, A.3
-
40
-
-
0001033803
-
Structural basis for self-association and receptor recognition of human TRAF2
-
Park YC, Burkitt V, Villa AR, et al. Structural basis for self-association and receptor recognition of human TRAF2. Nature 1999;398:533-8
-
(1999)
Nature
, vol.398
, pp. 533-538
-
-
Park, Y.C.1
Burkitt, V.2
Villa, A.R.3
-
41
-
-
0029786304
-
Anatomy of TRAF2 distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins
-
Takeuchi M, Rothe M, Goeddel DV. Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins. J Biol Chem 1996;271:19935-42
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 19935-19942
-
-
Takeuchi, M.1
Rothe, M.2
Goeddel, D.V.3
-
42
-
-
0038150358
-
Tumor necrosis factor TNF-induced germinal center kinase-related GCKR and stress-activated protein kinase SAPK activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 TRAF2
-
Shi CS, Kehrl JH. Tumor necrosis factor (TNF)-induced germinal center kinase-related (GCKR) and stress-activated protein kinase (SAPK) activation depends upon the E2/E3 complex Ubc13-Uev1A/TNF receptor-associated factor 2 (TRAF2). J Biol Chem 2003;278:15429-34
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 15429-15434
-
-
Shi, C.S.1
Kehrl, J.H.2
-
43
-
-
0034644474
-
Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
-
Deng L, Wang C, Spencer E, et al. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 2000;103:351-61
-
(2000)
Cell.
, vol.103
, pp. 351-361
-
-
Deng, L.1
Wang, C.2
Spencer, E.3
-
44
-
-
14544286868
-
TNF receptor TNFR-associated factor TRAF 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs
-
USA
-
Hauer J, Puschner S, Ramakrishnan P, et al. TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-kappaB pathway by TRAF-binding TNFRs. Proc Natl Acad Sci USA 2005;102:2874-9
-
(2005)
Proc. Natl. Acad. Sci.
, vol.102
, pp. 2874-2879
-
-
Hauer, J.1
Puschner, S.2
Ramakrishnan, P.3
-
45
-
-
0029595282
-
The TNFR2 - TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
-
Rothe M, Pan MG, Henzel WJ, et al. The TNFR2 - TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 1995;83:1243-52
-
(1995)
Cell.
, vol.83
, pp. 1243-1252
-
-
Rothe, M.1
Pan, M.G.2
Henzel, W.J.3
-
46
-
-
44949240664
-
Ciap1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
-
Bertrand MJ, Milutinovic S, Dickson KM, et al. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell 2008;30:689-700
-
(2008)
Mol. Cell.
, vol.30
, pp. 689-700
-
-
Bertrand, M.J.1
Milutinovic, S.2
Dickson, K.M.3
-
47
-
-
58249086500
-
Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2
-
Blankenship JW, Varfolomeev E, Goncharov T, et al. Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2. Biochem J 2009;417:149-60
-
(2009)
Biochem. J.
, vol.417
, pp. 149-160
-
-
Blankenship, J.W.1
Varfolomeev, E.2
Goncharov, T.3
-
48
-
-
2942731516
-
Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation
-
Liao G, Zhang M, Harhaj EW, Sun SC. Regulation of the NF-kappaB-inducing kinase by tumor necrosis factor receptor-associated factor 3-induced degradation. J Biol Chem 2004;279:26243-50
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 26243-26250
-
-
Liao, G.1
Zhang, M.2
Harhaj, E.W.3
Sun, S.C.4
-
49
-
-
0037149542
-
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
-
Li X, Yang Y, Ashwell JD. TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature 2002;416:345-7
-
(2002)
Nature
, vol.416
, pp. 345-347
-
-
Li, X.1
Yang, Y.2
Ashwell, J.D.3
-
50
-
-
0030828690
-
CD30-dependent degradation of TRAF2: Implications for negative regulation of TRAF signaling and the control of cell survival
-
Duckett CS, Thompson CB. CD30-dependent degradation of TRAF2: implications for negative regulation of TRAF signaling and the control of cell survival. Genes Dev 1997;11:2810-21
-
(1997)
Genes. Dev.
, vol.11
, pp. 2810-2821
-
-
Duckett, C.S.1
Thompson, C.B.2
-
51
-
-
0035896734
-
Differential signaling and tumor necrosis factor receptor-associated factor TRAF degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 LMP1
-
Brown KD, Hostager BS, Bishop GA. Differential signaling and tumor necrosis factor receptor-associated factor (TRAF) degradation mediated by CD40 and the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1). J Exp Med 2001;193:943-54
-
(2001)
J. Exp. Med.
, vol.193
, pp. 943-954
-
-
Brown, K.D.1
Hostager, B.S.2
Bishop, G.A.3
-
52
-
-
33750494135
-
Rescue of TRAF3-null mice by p100 NF-kappaB deficiency
-
He JQ, Zarnegar B, Oganesyan G, et al. Rescue of TRAF3-null mice by p100 NF-kappaB deficiency. J Exp Med 2006;203:2413-18
-
(2006)
J. Exp. Med.
, vol.203
, pp. 2413-2418
-
-
He, J.Q.1
Zarnegar, B.2
Oganesyan, G.3
-
53
-
-
56349164239
-
Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1 cIAP2 TRAF2 and TRAF3 and the kinase NIK
-
Zarnegar BJ, Wang Y, Mahoney DJ, et al. Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol 2008;9:1371-8
-
(2008)
Nat. Immunol.
, vol.9
, pp. 1371-1378
-
-
Zarnegar, B.J.1
Wang, Y.2
Mahoney, D.J.3
-
54
-
-
56349164232
-
Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling
-
Vallabhapurapu S, Matsuzawa A, Zhang W, et al. Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol 2008;9:1364-70
-
(2008)
Nat. Immunol.
, vol.9
, pp. 1364-1370
-
-
Vallabhapurapu, S.1
Matsuzawa, A.2
Zhang, W.3
-
55
-
-
8444220390
-
TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells
-
Grech AP, Amesbury M, Chan T, et al. TRAF2 differentially regulates the canonical and noncanonical pathways of NF-kappaB activation in mature B cells. Immunity 2004;21:629-42
-
(2004)
Immunity
, vol.21
, pp. 629-642
-
-
Grech, A.P.1
Amesbury, M.2
Chan, T.3
-
56
-
-
0031463025
-
Early lethality, functional NF-kappaB activation and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice
-
Yeh WC, Shahinian A, Speiser D, et al. Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity 1997;7:715-25
-
(1997)
Immunity
, vol.7
, pp. 715-725
-
-
Yeh, W.C.1
Shahinian, A.2
Speiser, D.3
-
57
-
-
0033198702
-
TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses
-
Nguyen LT, Duncan GS, Mirtsos C, et al. TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses. Immunity 1999;11:379-89
-
(1999)
Immunity
, vol.11
, pp. 379-389
-
-
Nguyen, L.T.1
Duncan, G.S.2
Mirtsos, C.3
-
58
-
-
1542380581
-
Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB
-
Habelhah H, Takahashi S, Cho SG, et al. Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB. EMBO J 2004;23:322-32
-
(2004)
EMBO J.
, vol.23
, pp. 322-332
-
-
Habelhah, H.1
Takahashi, S.2
Cho, S.G.3
-
59
-
-
74049136127
-
Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines
-
Tseng PH, Matsuzawa A, Zhang W, et al. Different modes of ubiquitination of the adaptor TRAF3 selectively activate the expression of type I interferons and proinflammatory cytokines. Nat Immunol 2010;11:70-5
-
(2010)
Nat. Immunol.
, vol.11
, pp. 70-75
-
-
Tseng, P.H.1
Matsuzawa, A.2
Zhang, W.3
-
60
-
-
36048999753
-
IAP antagonists induce autoubiquitination of c-IAPs NF-kappaB activation and TNFalpha-dependent apoptosis
-
Varfolomeev E, Blankenship JW, Wayson SM, et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 2007;131:669-81
-
(2007)
Cell.
, vol.131
, pp. 669-681
-
-
Varfolomeev, E.1
Blankenship, J.W.2
Wayson, S.M.3
-
61
-
-
36148954336
-
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
-
Vince JE, Wong WW, Khan N, et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 2007;131:682-93
-
(2007)
Cell.
, vol.131
, pp. 682-693
-
-
Vince, J.E.1
Wong, W.W.2
Khan, N.3
-
62
-
-
40249115896
-
TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor
-
Gardam S, Sierro F, Basten A, et al. TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity 2008;28:391-401
-
(2008)
Immunity
, vol.28
, pp. 391-401
-
-
Gardam, S.1
Sierro, F.2
Basten, A.3
-
63
-
-
34548014506
-
Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs
-
Xie P, Stunz LL, Larison KD, et al. Tumor necrosis factor receptor-associated factor 3 is a critical regulator of B cell homeostasis in secondary lymphoid organs. Immunity 2007;27:253-67
-
(2007)
Immunity
, vol.27
, pp. 253-267
-
-
Xie, P.1
Stunz, L.L.2
Larison, K.D.3
-
64
-
-
77953824286
-
Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation
-
ra41
-
Razani B, Zarnegar B, Ytterberg AJ, et al. Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation. Sci Signal 2010;3:ra41
-
(2010)
Sci. Signal
, pp. 3
-
-
Razani, B.1
Zarnegar, B.2
Ytterberg, A.J.3
-
65
-
-
33846473862
-
Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes
-
Lich JD, Williams KL, Moore CB, et al. Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes. J Immunol 2007;178:1256-60
-
(2007)
J. Immunol.
, vol.178
, pp. 1256-1260
-
-
Lich, J.D.1
Williams, K.L.2
Moore, C.B.3
-
66
-
-
40749132603
-
ATP binding by monarch-1/NLRP12 is critical for its inhibitory function
-
Ye Z, Lich JD, Moore CB, et al. ATP binding by monarch-1/NLRP12 is critical for its inhibitory function. Mol Cell Biol 2008;28:1841-50
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 1841-1850
-
-
Ye, Z.1
Lich, J.D.2
Moore, C.B.3
-
67
-
-
38449087767
-
Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase
-
Arthur JC, Lich JD, Aziz RK, et al. Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase. J Immunol 2007;179:6291-6
-
(2007)
J. Immunol.
, vol.179
, pp. 6291-6296
-
-
Arthur, J.C.1
Lich, J.D.2
Aziz, R.K.3
-
68
-
-
34250886966
-
Hsp90 regulates processing of NF-kappaB2 p100 involving protection of NF-kappaB-inducing kinase NIK from autophagy-mediated degradation
-
Qing G, Yan P, Qu Z, et al. Hsp90 regulates processing of NF-kappaB2 p100 involving protection of NF-kappaB-inducing kinase (NIK) from autophagy-mediated degradation. Cell Res 2007;17:520-30
-
(2007)
Cell.. Res.
, vol.17
, pp. 520-530
-
-
Qing, G.1
Yan, P.2
Qu, Z.3
-
69
-
-
4143144401
-
TNAP a novel repressor of NF-kappaB-inducing kinase suppresses NF-kappaB activation
-
Hu WH, Mo XM, Walters WM, et al. TNAP, a novel repressor of NF-kappaB-inducing kinase, suppresses NF-kappaB activation. J Biol Chem 2004;279:35975-83
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 35975-3583
-
-
Hu, W.H.1
Mo, X.M.2
Walters, W.M.3
-
70
-
-
0034791116
-
Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation
-
Yeung KC, Rose DW, Dhillon AS, et al. Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. Mol Cell Biol 2001;21:7207-17
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 7207-7217
-
-
Yeung, K.C.1
Rose, D.W.2
Dhillon, A.S.3
-
71
-
-
0033082990
-
The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases
-
Lin X, Cunningham ET Jr, Mu Y, et al. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases. Immunity 1999;10:271-80
-
(1999)
Immunity
, vol.10
, pp. 271-280
-
-
Lin, X.1
Cunningham Jr., E.T.2
Mu, Y.3
-
72
-
-
77958086967
-
Lipopolysaccharide-induced activation of NF-kappaB non-canonical pathway requires BCL10 serine 138 and NIK phosphorylations
-
Bhattacharyya S, Borthakur A, Dudeja PK, Tobacman JK. Lipopolysaccharide-induced activation of NF-kappaB non-canonical pathway requires BCL10 serine 138 and NIK phosphorylations. Exp Cell Res 2010;316:3317-27
-
(2010)
Exp. Cell. Res.
, vol.316
, pp. 3317-3327
-
-
Bhattacharyya, S.1
Borthakur, A.2
Dudeja, P.K.3
Tobacman, J.K.4
-
73
-
-
73649119184
-
B-cell CLL/lymphoma 10 BCL10 is required for NF-kappaB production by both canonical and noncanonical pathways and for NF-kappaB-inducing kinase NIK phosphorylation
-
Bhattacharyya S, Borthakur A, Tyagi S, et al. B-cell CLL/lymphoma 10 (BCL10) is required for NF-kappaB production by both canonical and noncanonical pathways and for NF-kappaB-inducing kinase (NIK) phosphorylation. J Biol Chem 2010;285:522-30
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 522-530
-
-
Bhattacharyya, S.1
Borthakur, A.2
Tyagi, S.3
-
74
-
-
23844541707
-
NIBP, a novel NIK and IKKbeta-binding protein that enhances NF-kappaB activation
-
Hu WH, Pendergast JS, Mo XM, et al. NIBP, a novel NIK and IKKbeta-binding protein that enhances NF-kappaB activation. J Biol Chem 2005;280:29233-41
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 29233-29241
-
-
Hu, W.H.1
Pendergast, J.S.2
Mo, X.M.3
-
75
-
-
77957279397
-
An atypical E3 ligase Zinc Finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via K63-linked ubiquitination
-
published online 3 August 2010 doi:10.1074/jbc.M110.129551
-
Jin X, Jin HR, Jung HS, et al. An atypical E3 ligase Zinc Finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via K63-linked ubiquitination. J Biol Chem 2010: published online 3 August 2010, doi:10.1074/jbc.M110.129551
-
(2010)
J. Biol. Chem.
-
-
Jin, X.1
Jin, H.R.2
Jung, H.S.3
-
76
-
-
77957281070
-
Zinc finger protein 91 plays a key role in LIGHT-induced activation of noncanonical NF-kappaB pathway
-
Jin HR, Jin X, Lee JJ. Zinc finger protein 91 plays a key role in LIGHT-induced activation of noncanonical NF-kappaB pathway. Biochem Biophys Res Commun 2010;400:581-6
-
(2010)
Biochem. Biophys. Res. Commun.
, vol.400
, pp. 581-586
-
-
Jin, H.R.1
Jin, X.2
Lee, J.J.3
-
77
-
-
77951218912
-
TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor
-
Bista P, Zeng W, Ryan S, et al. TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor. J Biol Chem 2010;285:12971-8
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 12971-12978
-
-
Bista, P.1
Zeng, W.2
Ryan, S.3
-
78
-
-
49449098218
-
NIK overexpression amplifies whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells
-
USA
-
Sasaki Y, Calado DP, Derudder E, et al. NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells. Proc Natl Acad Sci USA 2008;105:10883-8
-
(2008)
Proc. Natl. Acad. Sci.
, vol.105
, pp. 10883-10888
-
-
Sasaki, Y.1
Calado, D.P.2
Derudder, E.3
-
79
-
-
0032508414
-
NF-kappaB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
-
Wang CY, Mayo MW, Korneluk RG, et al. NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 1998;281:1680-3
-
(1998)
Science
, vol.281
, pp. 1680-1683
-
-
Wang, C.Y.1
Mayo, M.W.2
Korneluk, R.G.3
-
80
-
-
0342656129
-
Negative regulation of the nuclear factor kappaB-inducing kinase by a cis-acting domain
-
Xiao G, Sun SC. Negative regulation of the nuclear factor kappaB-inducing kinase by a cis-acting domain. J Biol Chem 2000;275:21081-5
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 21081-21085
-
-
Xiao, G.1
Sun, S.C.2
-
81
-
-
33746358830
-
State of the art therapy in multiple myeloma and future perspectives
-
Denz U, Haas PS, Wasch R, et al. State of the art therapy in multiple myeloma and future perspectives. Eur J Cancer 2006;42:1591-600
-
(2006)
Eur. J. Cancer
, vol.42
, pp. 1591-1600
-
-
Denz, U.1
Haas, P.S.2
Wasch, R.3
-
82
-
-
77649186276
-
Pyrazolo[4,3-c]isoquinolines as potential inhibitors of NF-kappaB activation
-
Mortier J, Frederick R, Ganeff C, et al. Pyrazolo[4,3-c]isoquinolines as potential inhibitors of NF-kappaB activation. Biochem Pharmacol 2010;79:1462-72
-
(2010)
Biochem. Pharmacol.
, vol.79
, pp. 1462-1472
-
-
Mortier, J.1
Frederick, R.2
Ganeff, C.3
-
83
-
-
38049018155
-
A quantitative analysis of kinase inhibitor selectivity
-
Karaman MW, Herrgard S, Treiber DK, et al. A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol 2008;26:127-32
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 127-132
-
-
Karaman, M.W.1
Herrgard, S.2
Treiber, D.K.3
-
84
-
-
77955426473
-
NF-kappaB inducing kinase NIK inhibitors: Identification of new scaffolds using virtual screening
-
Mortier J, Masereel B, Remouchamps C, et al. NF-kappaB inducing kinase (NIK) inhibitors: identification of new scaffolds using virtual screening. Bioorg Med Chem Lett 2010;20:4515-20
-
(2010)
Bioorg. Med. Chem. Lett.
, vol.20
, pp. 4515-4520
-
-
Mortier, J.1
Masereel, B.2
Remouchamps, C.3
-
87
-
-
0033788693
-
Immunodeficiency of alymphoplasia mice aly/aly in vivo: Structural defect of secondary lymphoid organs and functional B cell defect
-
Karrer U, Althage A, Odermatt B, et al. Immunodeficiency of alymphoplasia mice (aly/aly) in vivo: structural defect of secondary lymphoid organs and functional B cell defect. Eur J Immunol 2000;30:2799-807
-
(2000)
Eur. J. Immunol.
, vol.30
, pp. 2799-2807
-
-
Karrer, U.1
Althage, A.2
Odermatt, B.3
-
88
-
-
77952555902
-
How best to use new therapies in multiple myeloma
-
Dingli D, Rajkumar SV. How best to use new therapies in multiple myeloma. Blood Rev 2010;24:91-100
-
(2010)
Blood Rev.
, vol.24
, pp. 91-100
-
-
Dingli, D.1
Rajkumar, S.V.2
-
89
-
-
0035933772
-
Inhibition of NF-kappaB activity by thalidomide through suppression of IkappaB kinase activity
-
Keifer JA, Guttridge DC, Ashburner BP, Baldwin AS Jr. Inhibition of NF-kappaB activity by thalidomide through suppression of IkappaB kinase activity. J Biol Chem 2001;276:22382-7
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 22382-22387
-
-
Keifer, J.A.1
Guttridge, D.C.2
Ashburner, B.P.3
Baldwin Jr., A.S.4
-
90
-
-
17944375043
-
TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease impaired B cell maturation in mice lacking BLyS
-
Gross JA, Dillon SR, Mudri S, et al. TACI-Ig neutralizes molecules critical for B cell development and autoimmune disease. impaired B cell maturation in mice lacking BLyS. Immunity 2001;15:289-302
-
(2001)
Immunity
, vol.15
, pp. 289-302
-
-
Gross, J.A.1
Dillon, S.R.2
Mudri, S.3
-
91
-
-
0347285357
-
BCMA is essential for the survival of long-lived bone marrow plasma cells
-
OConnor BP, Raman VS, Erickson LD, et al. BCMA is essential for the survival of long-lived bone marrow plasma cells. J Exp Med 2004;199:91-8
-
(2004)
J. Exp. Med.
, vol.199
, pp. 91-98
-
-
O'Connor, B.P.1
Raman, V.S.2
Erickson, L.D.3
-
92
-
-
70349675652
-
Atacicept in relapsed/refractory multiple myeloma or active waldenstroms macroglobulinemia: A phase I study
-
Rossi JF, Moreaux J, Hose D, et al. Atacicept in relapsed/refractory multiple myeloma or active Waldenstroms macroglobulinemia: a phase I study. Br J Cancer 2009;101:1051-8
-
(2009)
Br. J. Cancer
, vol.101
, pp. 1051-1058
-
-
Rossi, J.F.1
Moreaux, J.2
Hose, D.3
-
93
-
-
33846878524
-
Targeting mitochondrial factor Smac/ DIABLO as therapy for multiple myeloma MM
-
Chauhan D, Neri P, Velankar M, et al. Targeting mitochondrial factor Smac/ DIABLO as therapy for multiple myeloma (MM). Blood 2007;109:1220-7
-
(2007)
Blood
, vol.109
, pp. 1220-1227
-
-
Chauhan, D.1
Neri, P.2
Velankar, M.3
-
94
-
-
34548225362
-
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
-
Greten FR, Arkan MC, Bollrath J, et al. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell 2007;130:918-31
-
(2007)
Cell.
, vol.130
, pp. 918-931
-
-
Greten, F.R.1
Arkan, M.C.2
Bollrath, J.3
-
95
-
-
58549104540
-
Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen
-
USA
-
Lam LT, Davis RE, Ngo VN, et al. Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen. Proc Natl Acad Sci USA 2008;105:20798-803
-
(2008)
Proc. Natl. Acad. Sci.
, vol.105
, pp. 20798-20803
-
-
Lam, L.T.1
Davis, R.E.2
Ngo, V.N.3
-
96
-
-
67149089043
-
Biologic sequelae of IkappaB kinase IKK inhibition in multiple myeloma: Therapeutic implications
-
Hideshima T, Chauhan D, Kiziltepe T, et al. Biologic sequelae of IkappaB kinase (IKK) inhibition in multiple myeloma: therapeutic implications. Blood 2009;113:5228-36
-
(2009)
Blood
, vol.113
, pp. 5228-5236
-
-
Hideshima, T.1
Chauhan, D.2
Kiziltepe, T.3
|