Pulmonary clearance of circulating endothelin-1 in dogs in vivo: Exclusive role of ET(B) receptors

Journal of Applied Physiology

Volumn 81, Issue 4, 1996, Pages 1510-1515

  Dupuis, Jocelyn ^a   Goresky, Carl A ^b   Fournier, Alain ^b  

^a MONTREAL HEART INSTITUTE   (Canada)

^b NONE

Author keywords

BQ 123; BQ 788; endothelin receptors; pulmonary metabolism

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; LUNG CLEARANCE; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION;

EID: 0029847636     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.81.4.1510     Document Type: Article

References (20)

1. Änggård, E., S. Galton, G. Rae, R. Thomas, L. McLoughlin, G. de Nucci, and J. R. Vane. The fate of radioiodinated endothelin-1 and endothelin-3 in the rat. J. Cardiovasc. Pharmacol 13,Suppl. 5: S46-S49, 1989.
2. Cody, R. J., G. J. Haas, P. F. Binkley, Q. Capers, and R. Kelley. Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure. Circulation 85: 504-509, 1992.
3. Cua, W. O., G. Basset, F. Bouchonnet, R. A. Garrick, G. Saumon, and F. P. Chinard. Endothelial and epithelial permeabilities to antipyrine in rat and dog lungs. Am. J. Physiol 258 (Heart Circ. Physiol. 27): H1321-H1333, 1990
4. Donckier, J., L. Stoleru, W. Hayashida, H. Van Mechelen, P. Selvais, L. Galanti, J. P. Clozel, J. M. Ketelslegers, and H. Pouleur. Role of endogenous endothelin-1 in experimental renal hypertension in dogs. Circulation 92: 106-113, 1995.
5. Dupuis, J., C. A. Goresky, and D. J. Stewart. Pulmonary removal and production of endothelin in the anesthetized dog. J. Appl. Physiol. 76: 694-700, 1994.
6. B receptors in rats. Biochem. Biophys. Res. Commun. 199: 1461-1465, 1994.
7. Kiowski, W., G. Sutsch, P. Hunziker, P. Muller, J. Kim, E. Oechslin, R. Schmitt, R. Jones, and O. Bertel. Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure. Lancet 346: 732-736, 1995.
8. Loffler, B. M., V. Breu, and M. Clozel. Effect of different endothelin receptor antagonists and of the novel non-peptide antagonist Ro 46-2005 on endothelin levels in rat plasma. FEBS Lett. 333: 108-110, 1993.
9. Masaki, T., S. Kimura, M. Yanagisawa, and K. Goto. Molecular and cellular mechanism of endothelin regulation: implication for vascular function. Circulation 84: 1457-1468, 1991.
10. Miyauchi, T., R. Yorikane, S. Sakai, T. Sakurai, M. Okada, M. Nishikibe, M. Yano, I. Yamaguchi, Y. Sugishita, and K. Goto. Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension. Circ. Res. 73. 887-897, 1993.
11. 1,3,11,15]ET-1. Biochem. Biophys. Res. Commun. 182: 144-150, 1992.
12. B-mediated regulation of extracellular levels of endothelin-1 in cultured human endothelial cells. Biochem Biophys. Res. Commun. 209: 483-489, 1995.
13. Perreault, T., and J. Baribeau. Characterization of endothelin receptors in newborn piglet lung. Am J. Physiol. 268 (Lung Cell Mol Physiol. 12): L607-L614, 1995.
14. Rimar, S., and C-N. Gillis. Differential uptake of endothelin-1 by the coronary and pulmonary circulations. J. Appl. Physiol. 73: 557-562, 1992.
15. Stewart, D. J., G. Kubac, K. B. Costello, and P. Cernacek. Increased plasma endothelin-1 in the early hours of acute myocardial infarction. J. Am. Coll. Cardiol. 18: 38-43, 1991.
16. Stewart, D. J., R. D. Levy, P. Cernacek, and D. Langleben. Increased plasma endothelin-1 in pulmonary hypertension' marker or mediator of disease? Ann. Intern. Med. 114: 464-469, 1991.
17. Warner, T. D., J. A. Mitchell, G. De Nucci, and J. R. Vane. Endothelin-1 and endothelin-3 release EDRF from isolated perfused arterial vessels of the rat and rabbit. J. Cardiovasc. Pharmacol. 13, Suppl. 5. S85-S88, 1989.
18. Westcott, J. Y., J. Henson, I. F. McMurtry, and R. F. O'Brien. Uptake and metabolism of endothelin in the isolated perfused rat lung. Exp. Lung Res. 16: 521-532, 1990.
19. B-receptor mRNA in the lung of rats with pulmonary hypertension. J. Cardiovasc. Pharmacol. 22, Suppl. 8: S336-S338, 1993.
20. Yoshibayashi, M., K. Nishioka, K. Nakao, Y. Saito, M. Matsumura, T. Ueda, S. Temma, G. Shirakami, H. Imura, and H. Mikawa. Plasma endothelin concentrations in patients with pulmonary hypertension associated with congenital heart defects. Circulation 84: 2280-2285,1991.