Short-term haemodynamic effects of BQ-123, a selective endothelin ET(A)-receptor antagonist, in chronic heart failure

Lancet

Volumn 352, Issue 9123, 1998, Pages 201-202

  Cowburn, Peter J ^b   Cleland, John G F ^a   McArthur, John D ^b   Maclean, Margaret R ^b   McMurray, John J V ^b   Dargie, Henry J ^b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; ENDOTHELIN A RECEPTOR ANTAGONIST;

ARTICLE; BRADYCARDIA; CAPILLARY RESISTANCE; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFECT; HEART FAILURE; HEART INDEX; HEART LEFT VENTRICLE CONTRACTION; HEMODYNAMICS; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MEAN ARTERIAL PRESSURE; PRIORITY JOURNAL; SYNCOPE; VASODILATATION;

EID: 0032543936     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(05)77807-7     Document Type: Article

References (5)

1. 1 Dupuis J, Goresky CA, Fournier A Pulmonary clearance of circulationg endothelin-1 in dogs in vivo: Exclusive role of ET(B) receptors. J Appl Physiol 1996; 81: 1510-15.
2. 2 Kiowski W, Sutsch G, Hunziker P, et al. Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure. Lancet 1995; 346: 732-36.
3. 3 Sakai S, Miyauchi T, Kobayashi M, Yamaguchi I, Goto K, Sugishita Y. Inhibition of myocardial endothelin pathway improves long-term survival in heart failure. Nature 1996; 384: 353-55.
4. 4 Cowburn PJ, Cleland JGF, McArthur JD, et al. Endothelin-1 has haemodynamic effects at pathophysiological concentrations in patients with left ventricular dysfunction. Cardiovasc Res 1998 (in press).
5. 5 Cleland JGF, Dargie HJ, McAlpine H, et al. Severe hypotension after first dose of enalapril in heart failure. BMJ 1985; 291: 1309-12.