Endothelin system: The double-edged sword in health and disease

Annual Review of Pharmacology and Toxicology

Volumn 41, Issue , 2001, Pages 851-876

  Kedzierski, R M ^a   Yanagisawa, M ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Basal vascular tone; Cardiac hypertrophy; Central cardiorespiratory regulation; Embryonic development; Renal salt handling

Indexed keywords

2 [[2 [[2 [[(HEXAHYDRO 1H AZEPIN 1 YL)CARBONYL]AMINO] 4 METHYLPENTANOYL]AMINO] 3 (1 METHYL 1H INDOL 3 YL)PROPIONYL]AMINO] 3 (2 PYRIDYL)PROPIONIC ACID; 4 (4 METHOXYPHENYL) 2 (3,4 METHYLENEDIOXYPHENYL) 4 OXO 3 (3,4,5 TRIMETHOXYBENZYL) 2 BUTENOIC ACID; 5 DIMETHYLAMINO N (3,4 DIMETHYL 5 ISOXAZOLYL) 1 NAPHTHALENESULFONAMIDE; BOSENTAN; CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); DARUSENTAN; EMD 94246; ENDOTHELIN; ENDOTHELIN RECEPTOR ANTAGONIST; G PROTEIN COUPLED RECEPTOR; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; PEPTIDASE; PEPTIDE; RES 701 1; TAK 044; UNCLASSIFIED DRUG;

ATHEROSCLEROSIS; CHRONOTROPISM; DIURESIS; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HUMAN; HYPERTENSION; INOTROPISM; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; REVIEW; SODIUM EXCRETION; SUBARACHNOID HEMORRHAGE; VASOCONSTRICTION; VASOSPASM;

ANIMALS; ENDOTHELINS; HUMANS; RECEPTORS, ENDOTHELIN;

RODENTIA;

EID: 0035040924     PISSN: 03621642     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.pharmtox.41.1.851     Document Type: Review

References (165)

1. Characterization of a coronary vasoconstrictor produced by cultured endothelial cells
2. Endothelial cells in culture produce a vasoconstrictor substance
3. A novel vasoconstrictor peptide produced by vascular endothelial cells
4. The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes
5. ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
6. Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum
7. Disruption of ECE-1 and ECE-2 reveals a role for endothelin converting enzyme-2 in murine cardiac development
8. Role of neutral endopeptidase in the metabolism of endothelin
9. Clearance of circulating endothelin-1 by ETB receptor in rats
10. Cloning and expression of a cDNA encoding an endothelin receptor
11. Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
12. Signal transduction mechanisms mediating vascular actions of endothelin
13. Use of the endothelin antagonists BQ-123 and PD 142893 to reveal three endothelin receptors mediating smooth muscle cell contraction and the release of EDRF
14. Endothelins
15. Inhibition of myocardial endothelin pathway improves long-term survival in heart failure
16. Endothelin: Visualization of mRNAs by in situ hybridization provides evidence for local action
17. Endothelins, peptides with potent vasoconstrictive properties, are produced by human macrophages
18. Localization of endothelin peptides in human kidney
19. Endothelin synthesis by rabbit renal tubule cells
20. Topographical localisation of endothelin mRNA and peptide immunoreactivity in neurones of the human brain
21. Expression of the potent vasoconstrictor endothelin in human central nervous system
22. Endothelin in human brain and pituitary gland: Comparison with the rat
23. Endothelial cell-specific knock-out of the endothelin-1 gene in mice
24. Abundance of endothelin-3 in rat intestine, pituitary gland and brain
25. Severe growth retardation and juvenille lethality in ET-2 knockout mice
26. Cellular mechanism of thrombin on endothelin-1 biosynthesis and release in bovine endothelial cell
27. Transforming growth factor-beta stimulates the expression of endothelin mRNA by vascular endothelial cells
28. Endothelin-1 gene suppression by shear stress: Pharmacological evaluation of the role of tyrosine kinase, intracellular calcium, cytoskeleton, and mechanosensitive channels
29. Effect of carbon dioxide and oxygen on endothelin production by cultured porcine cerebral endothelial cells
30. Release of endothelin from the porcine aorta. Inhibition by endothelium derived nitric oxide
31. Prostaglandin E2 and prostacyclin inhibit the production and secretion of endothelin from cultured endothelial cells
32. C-type natriuretic peptide inhibits thrombin and angiotensin II-stimulated endothelin release via cyclic guanosine 3′,5′-mono-phosphate
33. Insulin stimulates endothelin binding and action on cultured vascular smooth muscle cells
34. Regulation of endothelin receptors by nitric oxide in cultured rat vascular smooth muscle cells
35. Regulation of endothelin-B receptor mRNA expression in human endothelial cells by cytokines and growth factors
36. Biology of disease. Endothelins: Circulatory plasma levels and presence in other biologic fluids
37. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons
38. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice
39. Dual genetic pathways of endothelin-mediated intracellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene
40. Cranial and cardiac neural crest defects in endothelin-A receptor deficient mice
41. Elevated blood pressure and craniofacial abnormalities in mice deficient in endothelin-1
42. Signaling pathways crucial for development revealed by endothelin-A-receptors-deficient mice
43. Aortic arch malformation and ventricular septal defects in mice deficient in endothelin-1
44. Role of endothelin-1/endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice
45. ET-3 provides environmental signals for development of two ETB expressing neural crest derivatives
46. Endothelin-3 promotes neural crest proliferation and mediates a vast increase in melanocyte number in cell culture
47. The temporal requirement for endothelin receptor-B signaling during neural crest development
48. Mammalian enteric nervous system development
49. Endothelin receptor-mediated signaling in Hirschsprung disease
50. Mutation of the endothelin-3 gene in Waardenburg-Hirschsprung disease
51. Pulmonary and cardiac expression of preproendothelin-1 mRNA are increased in heart failure after myocardial infarction in rats. Localization of preproendothelin-1 mRNA and endothelin peptide
52. Polar secretion of endothelin-1 by cultured endothelial cells
53. Anatomical localization and pharmacological activity of mature endothelins and their precursors in human vascular tissue
54. ETB receptors on aortic smooth muscle cells of spontaneously hypertensive rats
55. Vasoconstrictor effect of endothelin-1 in human skin: Role of ETA and ETB receptors
56. Regional vasodilation is a prominent feature of the haemodynamic response to endothelin in anesthetized spontaneously hypertensive rats
57. Vascular responses to endothelin-1 following inhibition of nitric oxide synthesis in the conscious rats
58. Nitric oxide and prostacyclin influence coronary vasomotor tone in perfused rabbit heart and modulate endothelin-1 activity
59. Effects of endothelin receptor antagonist BQ-123 on initial and delayed vascular responses induced by ET-1 in concious, normotensive rats
60. Hemodynamic and coronary effects of the endothelin antagonist bosentan in patients with coronary artery disease
61. Contribution of endogenous generation of endothelin-1 to basal vascular tone
62. Systemic endothelin receptor blockade decreases peripheral vascular resistance and blood pressure in humans
63. Endothelin plays a role in maintenance of blood pressure in normotensive guinea pigs
64. Phosphoramidon blocks the pressor activity of big endothelin(1-39) and lowers blood pressure in spontaneously hypertensive rats
65. The effect of phosphoramidon on the regional haemodynamic responses to human proendothelin in conscious rats
66. Potential role of endothelin in hypertension. Controversy on endothelin in hypertension
67. Hypertension associated with endothelin-secreting malignant hemangioendothelioma
68. The effect of an endothelin-receptor antagonist, bosentan, on blood pressure in patients with essential hypertension
69. ETA receptor blockade attenuates the hypertension but not renal dysfunction in DOCA-salt rats
70. Endothelin-A receptor antagonism attenuates the hypertension and renal injury in Dahl salt-sensitive rats
71. Raised plasma endothelin in aneurysmal subarachnoid hemorrhage
72. BQ-123, a peptide endothelin A receptor antagonist prevents the early cerebral vasospasm following subarachnoid hemorrhage
73. Endothelin in cerebral vasospasm. Clinical and experimental results
74. Suppression of endothelin-1-induced mitogenic responses of human aortic smooth muscle cells by interleukin-1 beta
75. Stimulation of the hydrolysis of phosphotidylinositol-4,5-bisphosphate and phosphotidylcholine by endothelin, a complete mitogen for Rat-1 fibroblasts
76. Endothelin-1 stimulates the biosynthesis of tumor necrosis factor in macrophages: ET receptors, signal transduction and inhibition by dexamethasone
77. Expression of soluble and insoluble fibronectin in rat aorta: Effects of angiotensin II and endothelin-1
78. Oxidized low density lipoproteins induce mRNA expression and release of endothelin from human and porcine endothelium
79. Modified low density lipoproteins activate human macrophages to secrete immunoreactive endothelin
80. Increases of vascular endothelin-converting enzyme activity and endothelin-1 level on atherosclerotic lesions in hyperlipidemic rabbits
81. Polyclonal 111In-IgG, 125I-LDL, 125I endothelin-1 accumulation in experimental arterial wall injury
82. (125I) Endothelin-1 binding to vasa vasorum and regions of neovascularization in human and porcine blood vessels: A possible role for endothelin in intimal hyperplasia and atherosclerosis
83. Selective blockade of endothelin subtype A receptor decreases early atherosclerosis in hamsters fed cholesterol
84. Endothelin ETA receptor blockade restores NO-mediated endothelial function and inhibits atherosclerosis in apolipoprotein E-deficient mice
85. Myocardial infarction mediated by endothelin receptor signaling in hypercholesterolemic mice
86. Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta 1 and endothelin-1 from fibroblasts
87. Endothelin-1 and angiotensin II receptors in cells from rat hypertrophied heart. Receptor regulation and intracellular Ca+ modulation
88. Positive inotropic action of novel vasoconstrictor peptide endothelin on guinea pig atria
89. Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide
90. Endothelin-A receptor mediates cardiac inhibition by regulating calcium and potassium currents
91. Inhibition of the cardiac protein kinase A-dependent chloride conductance by endothelin-1
92. Desensitization of ET(A)endothelin receptor-mediated negative chronotropic response in right atria-species difference and intracellular mechanism
93. In vivo haemodynamic and inotropic effects of the endothelin B agonist IRL 1620
94. Contrasting inotropic effects of endogenous endothelin in the normal and failing heart: Studies with an intracoronary ET(A) receptor antagonist
95. Lethal ischemia due to intracoronary endothelin in pigs
96. Increased plasma endothelin-1 in early hours of acute myocardial infarction
97. The endothelin-1 receptor antagonist BQ-123 reduces the infarct size in canine model of coronary occlusion and reperfusion
98. Plasma endothelin in chronic heart failure
99. Increased production of endothelin-1 in the hypertrophied rat heart due to pressure overload
100. Expression of endothelin-1, endothelin-converting enzyme, and endothelin receptors in chronic heart failure
101. Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes
102. Role of endogenous endothelin in chronic heart failure: Effect of long-term treatment with an endothlin antagonist on survival, haemodynamics, and cardiac remodeling
103. Comparison of the effects of selective endothelin ETA and ETB receptor antagonists in congestive heart failure
104. Aggravation of left ventricular remodelin by a novel specific endothelin ET(A) antagonist EMD94246 in rats with experimental myocardial infarction
105. Endothelin A receptor blockade causes adverse left ventricular remodeling but improves pulmonary artery pressure after infarction in the rat
106. Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure
107. Short-term haemodynamic effects of BQ-123, a selective endothelin A receptor antagonist, chronic heart failure
108. Endothelin-1 receptor density, distribution, and function in human isolated asthmatic airways
109. Characterization of endothelin receptor subtypes on airway smooth muscle cells
110. Predominance of endothelin A receptors in ovine airway smooth muscle and their mediation of ET-1 induced contraction
111. Endothelin-1 (ET-1) induced contraction in rat isolated trachea: Involvement of ETA and ETB receptors and multiple signal transduction systems
112. Contraction of smooth muscle by activation of endothelin receptors on autonomic neurons
113. Effects of endothelin-1 on airway and parenchymal mechanics in guinea-pigs
114. Pulmonary fibrosis and chronic lung inflammation in ET-1 transgenic mice
115. Experimental bronchiolitis obliterans induced by in vivo HVJ-liposome-mediated endothelin-1 gene transfer
116. Involvement of endothelins in immediate and late asthmatic responses of guinea pigs
117. Increased endothelin-like immunoreactive material in bronchoalveolar lavage fluid from patients with bronchial asthma and patients with interstitial lung disease
118. Endothelin-1-induced bronchoconstriction in asthma
119. Mechanism of action of endothelin-1 in the canine pulmonary circulation
120. Endothelin-1 causes pulmonary vasodilation in rats
121. The endothelin antagonist bosentan and hemodyanamic effects during normoxia and hypoxic pulmonary hypertension in pigs
122. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
123. Increased plasma endothelin-1 in pulmonary hypertension: Marker or mediator of disease?
124. Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension
125. Endothelin receptor antagonists in beagle model of pulmonary hypertension: Contribution to possible potential therapy?
126. Endothelin receptor mRNA expression in renal medulla identified by in situ RT-PCR
127. Different localization of two types of endothelin receptor mRNA in microdissected rat nephron segments using reverse transcription and polymerase chain reaction assay
128. Renal haemodynamic effects of endothelin-1 and the ETA/ETB antagonist TAK-044 in anaesthetized rabbits
129. ETA receptor mediated responses to endothelin-1 and big endothelin-1 in the rat kidney
130. Endothelin inhibits vasopression action in rat inner medullary collecting duct via ETB receptor
131. Elevation of blood pressure by genetic and pharmacologic disruption of ETB receptor in mice
132. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglinosis in rat model of Hirschsprung disease
133. Salt-sensitive hypertension in endothelin-B receptor-deficient mice due to impaired renal salt excretion
134. Salt-sensitive hypertension in endothelin-B receptor-deficient rats
135. The role of endothelin (ET) and the ETB receptor in acid-base homeostasis
136. ETB receptor contributes to acidosis induced activation of the renal cortical apical membrane Na+/H+ antiporter
137. Chronic metabolic acidosis increases NHE3 protein abundance in rat kidney
138. Endothelin B receptor activates NHE-3 By a Ca-dependent pathway in OKP cells
139. Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension
140. Renal endothelin gene expression is increased in remant kidney and correlates with disease progression
141. A specific endothelin subtype A receptor antagonist protects against injury in renal disease progression
142. Effect of an endothelin-receptor antagonist on ischemic acute renal failure
143. Reversal of postischemic acute renal failure with a selective endothelin A receptor antagonist in the rat
144. Macrophage and myofibroblast involvement in ischemic acute renal failure is attenuated by endothelin receptor antagonist
145. Endothelin: A novel peptide in the posterior pituitary system
146. Histochemical studies on endothelin and the endothelin-A receptor in the hypothalamus
147. Distribution of endothelin-B receptor-like immunoreactivity in rat brain, kidney, and pancreas
148. Physiological role of brain endothelin in the central autonomic control: From neuron to knockout mouse
149. Central effect of endothelin-1 on vasopression release, blood pressure, and renal solute excretion
150. Cardiovascular effects of centrally administered endothelin-1 and its relationship to changes in cerebral blood flow
151. Endothelin-sensitive areas in the ventral surface of the rat medulla
152. Endothelin as a neuropeptide
153. Cardiovascular and respiratory effects of endothelin in the ventrolateral medulla of the normotensive rat
154. Renal sympathetic nerve activity in mice: Comparison between mice and rats and between normal and endothelin-1 deficient mice
155. Central effects of endothelin on respiratory output during development
156. Impaired ventilatory responses to hypoxia and hypercapnia in mutant mice deficient in endothelin-1
157. Abnormal central respiratory mechanism in endothelin-1 deficient mice: A study in medulla spinal cord preparations
158. Endothelin-3 inhibits prolactin and stimulates LH, FSH, TSH secretion from pituitary cell culture
159. Endothelin stimulation of cytosolic calcium and gonadotropin secretion in anterior pituitary cells
160. Endothelin-1 stimulates the in vitro release of neurohypophyseal hormones, but not corticotropin-releasing hormone, via ET A receptors
161. Dose-related potent brain stimulation by the neuropeptide endothelin-1 after intraventricular administration in conscious rats
162. Endothelin-1 in periaqueductal gray area of mice induces analgesia via glutamatergic receptors
163. Central nervous system action of endothelin-3 to inhibit water drinking in the rat
164. Behavioural, autonomic and endocrine responses associated with C-fos expression in the forebrain and brainstem after intracerebroventricular infusion of endothelins