Human pulmonary circulation is an important site for both clearance and production of endothelin-1

Circulation

Volumn 94, Issue 7, 1996, Pages 1578-1584

  Dupuis, Jocelyn ^a   Stewart, Duncan J ^b   Cernacek, Peter ^b   Gosselin, Gilbert ^b  

^a MONTREAL HEART INSTITUTE   (Canada)

^b NONE

Author keywords

circulation; endothelin; endothelium; metabolism

Indexed keywords

ENDOTHELIN 1;

ADULT; AGED; ANGINA PECTORIS; AORTA; ARTICLE; CLEARANCE; CLINICAL ARTICLE; CONTROLLED STUDY; DILUTION; EXTRACTION; FEMALE; HUMAN; LUNG ARTERY; LUNG CIRCULATION; MALE; PRIORITY JOURNAL;

EID: 0029741347     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.94.7.1578     Document Type: Article

References (30)

1. Yanagisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, Yazaki Y, Goto K, Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988; 332:411-415.
2. Lerman A, Hildebrand FL Jr, Margulies KB, O'Murchu B, Perrella MA, Heublein DM, Schwab TR, Burnett JC Jr. Endothelin: a new cardiovascular regulatory peptide. Mayo Clin Proc. 1990;65:1441-1455.
3. Dupuis J, Goresky CA, Stewart DJ. Pulmonary removal and production of endothelin in the anesthetized dog. J Appl Physiol. 1994; 76:694-700.
4. de Nucci G, Thomas R, D'Orleans-Juste P, Antunes E, Walder C, Warner TD, Vane JR. Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc Natl Acad Sci U S A. 1988;85:9797-9800.
5. 125I-endothelin in the rat: importance of pulmonary clearance. Biochem Biophys Res Commun. 1990;167: 1191-1195.
6. Shiba R, Yanagisawa M, Miyauchi T, Ishii Y, Kimura S, Uchiyama Y, Masaki T, Goto K. Elimination of intravenously injected endothelin-1 from the circulation of the rat. J Cardiovasc Pharmacol. 1989;13(suppl 5):S98-S101.
7. Änggård E, Galton S, Rae G, Thomas R, McLoughlin L, de Nucci G, Vane JR. The fate of radioiodinated endothelin-1 and endothelin-3 in the rat. J Cardiovasc Pharmacol. 1989;13(suppl 5):S46-S49.
8. Westcott JY, Henson J, McMurtry TF, O'Brien RF. Uptake and metabolism of endothelin in the isolated perfused rat lung. Exp Lung Res. 1990;16:521-532.
9. Rimar S, Gillis CN. Differential uptake of endothelin-1 by the coronary and pulmonary circulations. J Appl Physiol. 1992;73: 557-562.
10. Firth JD, Ratcliffe PJ. Organ distribution of the three rat endothelin messenger RNAs and the effects of ischemia on renal gene expression. J Clin Invest. 1992;90:1023-1031.
11. Nunez DJR, Brown MJ, Davenport AP, Neylon CB, Schofield JP, Wyse RK. Endothelin-1 mRNA is widely expressed in porcine and human tissues. J Clin Invest. 1990;85:1537-1541.
12. Ray SG, McMurray JJ, Morton JJ, Dargie HJ. Circulating endothelin is not extracted by the pulmonary circulation in man. Chest. 1992; 102:1143-1144.
13. Eaton GM, Bush CA, VanFossen DB, Kelley RE, Cody RJ. Absence of pulmonary endothelin gradient in patients with normal or elevated circulating endothelin. Am J Cardiol. 1994;73:1015-1016.
14. Stewart DJ, Levy RD, Cemacek P, Langleben D. Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease? Ann Intern Med. 1991;114:464-469.
15. Yoshibayashi M, Nishioka K, Nakao K, Saito Y, Matsumura M, Ueda T, Temma S, Shirakami G, Imura H, Mikawa H. Plasma endothelin concentrations in patients with pulmonary hypertension associated with congenital heart defects: evidence for increased production of endothelin in pulmonary circulation. Circulation. 1991;84:2280-2285.
16. Miyauchi T, Yorikane R, Sakai S, Sakurai T, Okada M, Nishikibe M, Yano M, Yamaguchi I, Sugishita Y, Goto K. Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension. Circ Res. 1993;73:887-897.
17. Cacoub P, Dorent R, Maistre G, Nataf P, Carayon A, Piette JC, Godeau P, Cabrol C, Gandjbakhch I. Endothelin-1 in primary pulmonary hypertension and the Eisenmenger syndrome. Am J Cardiol. 1993;71:448-450.
18. Stewart DJ. Endothelin in cardiopulmonary disease: factor paracrine vs neurohumoral. Eur Heart J. 1993;14(suppl I):48-54.
19. Cody RJ, Haas GJ, Binkley PF, Capers Q, Kelley R. Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure. Circulation. 1992; 85:504-509.
20. Rodeheffer RJ, Lerman A, Heublein DM, Burnett JC Jr. Increased plasma concentrations of endothelin in congestive heart failure in humans. Mayo Clin Proc. 1992;67:719-724.
21. Tsutamoto T, Wada A, Maeda Y, Adachi T, Kinoshita M. Relation between endothelin-1 spillover in the lungs and pulmonary vascular resistance in patients with chronic heart failure. J Am Coll Cardiol. 1994;23:1427-1433.
22. Dupuis J, Goresky CA, Ryan JW, Rouleau JL, Bach GG. Pulmonary angiotensin-converting enzyme substrate hydrolysis during exercise. J Appl Physiol. 1992;72:1868-1886.
23. Dupuis J, Goresky CA, Juneau C, Calderone A, Rouleau JL, Rose CP, Goresky S. Use of norepinephrine uptake to measure lung capillary recruitment with exercise. J Appl Physiol. 1990;68: 700-713.
24. Rickaby DA, Linehan JH, Bronikowski TA, Dawson CA. Kinetics of serotonin uptake in the dog lung. J Appl Physiol. 1981;51: 405-414.
25. B receptors in rats. Biochem Biophys Res Commun. 1994;199:1461-1465.
26. Giaid A, Yanagisawa M, Langleben D, Michel RP, Levy R, Shennib H, Kimura S, Masaki T, Duguid WP, Stewart DJ. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med. 1993;328:1732-1739.
27. Lerman A, Hildebrand FL Jr, Aarhus LL, Burnett JC Jr. Endothelin has biological actions at pathophysiological concentrations. Circulation. 1991;83:1808-1814.
28. Donckier JE, Hanet C. Berbinschi A, Galanti L, Robert A, Van Mechelen H, Pouleur H, Ketelslegers JM. Cardiovascular and endocrine effects of endothelin-1 at pathophysiological and pharmacological plasma concentrations in conscious dogs. Circulation. 1991;84: 2476-2484.
29. B-receptor mRNA in the lung of rats with pulmonary hypertension. J Cardiovasc Pharmacol. 1993; 22(suppl 8):S36-S338.
30. Donckier J, Stoleru L, Hayashida W, Van Mechelen H, Selvais P, Galanti L, Clozel JP, Ketelslegers JM, Pouleur H. Role of endogenous endothelin-1 in experimental renal hypertension in dogs. Circulation. 1995;92:106-113.