Transactivation of the epidermal growth factor receptor in endothelin-1-induced mitogenic signaling in human ovarian carcinoma cells

Cancer Research

Volumn 60, Issue 18, 2000, Pages 5310-5317

  Vacca, F ^a   Bagnato, A ^a   Cart, K J ^a   Tecce, R ^a  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIN 1; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGENIC AGENT; TYRPHOSTIN; WORTMANNIN;

ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MITOGENESIS; OVARY CANCER; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSACTIVATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; CELL DIVISION; ENDOTHELIN-1; ENZYME ACTIVATION; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; FEMALE; HUMAN; MAP KINASE SIGNALING SYSTEM; OVARIAN NEOPLASMS; P42 MAP KINASE; PEPTIDES, CYCLIC; PHOSPHORYLATION; PROTEIN KINASE C; PROTEINS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ENDOTHELIN; SUPPORT, NON-U.S. GOV'T; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED; TYROSINE; TYRPHOSTINS;

EID: 0034665584     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. A novel potent vasoconstrictor peptide produced by vascular endothelial cells
2. The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes
3. Endothelins: Molecular biology, biochemistry, pharmacology, physiology and pathophysiology
4. Structural basis of G protein specificity of human endothelin receptors
5. Endothelin stimulates c-fos and c-myc expression and proliferation of vascular smooth muscle cells
6. Endothelin-1 stimulates DNA synthesis and anchorage-independent growth of Rat-1 fibroblasts through a protein kinase C-dependent mechanism
7. A novel vasoactive peptide endothelin stimulates mitogenesis through inositol lipid turnover in Swiss 3T3 fibroblasts
8. + exchange, c-fos expression, and mitogenesis in rat mesangial cells
9. Effects of endothelins on signal transduction and proliferation in human melanocytes
10. Identification of the ET(A) receptor subtype that mediates endothelin induced autocrine proliferation of normal human keratinocytes
11. Endothelin in brain: Receptors, mitogenesis, and biosynthesis in glial cells
12. Endothelin is an autocrine/paracrine growth factor for human cancer cell lines
13. Autocrine actions of endothelin-1 as a growth factor in human ovarian carcinoma cells
14. Endothelin expression and responsiveness in human ovarian carcinoma cell lines
15. Identification of endothelin-1 in the pathophysiology of metastatic adenocarcinoma of the prostate
16. Endothelin-1 production and decreased endothelin B receptor expression in advanced prostate cancer
17. Endothelin induces transcription of fos/jun family genes: A prominent role for calcium ion
18. Stimulation of phosphatidylinositol hydrolysis, diacylglycerol release, and gene expression in response to endothelin, a potent new agonist for fibroblasts and smooth muscle cells
19. Endothelin-1 activates phospholipase D and thymidine incorporation in fibroblasts overexpressing protein kinase C β1
20. Suppression of endothelin-1-induced mitogenic responses of human aortic smooth muscle cells by interleukin-1β
21. Bombesin, vasopressin, and endothelin rapidly stimulate tyrosine phosphorylation in intact Swiss 3T3 cells
22. Protein kinase C and protein tyrosine kinase activity contribute to mitogenic signaling by endothelin-1. Cross-talk between G protein-coupled receptors and pp60c-src
23. Mitogenic signaling via G-protein-coupled receptors
24. Endothelin rapidly stimulates mitogen-activated protein kinase activity in rat mesangial cells
25. 2-terminal kinase groups of mitogen-activated protein kinases
26. Activation of multiple mitogen-activated protein kinase signal transduction pathways by the endothelin B receptor requires the cytoplasmic tail
27. Nuclear signaling by endothelin-1. A Ras pathway for activation of the c-fos serum response element
28. Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytes
29. Coupling of ETB endothelin receptor to mitogen-activated protein kinase stimulation and DNA synthesis in primary cultures of rat astrocytes
30. Nuclear signaling by endothelin-1 requires Src protein-tyrosine kinase
31. Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate
32. Endothelin-1-induced mitogenic responses of Chinese hamster ovary cells expressing human endothelinA: The role of a wortmannin-sensitive signaling pathway
33. Role of the transactivation of the EGF receptor in signaling by G-protein-coupled receptors
34. Activation of mitogenic signaling by endothelin 1 in ovarian carcinoma cells
35. Tyrosine kinase inhibition: An approach to drug development
36. A novel ET(A) antagonist (BQ123) inhibits endothelin-1 induced phosphoinositide breakdown and DNA synthesis in rat vascular smooth muscle cells
37. Botulinum C3 exoenzyme blocks the tyrosine phosphorylation of p125FAK and paxillin induced by bombesin and endothelin
38. G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts. Shc phosphorylation and receptor endocytosis correlate with activation of Erk kinases
39. Biphasic activation of p21ras by endothelin-1 sequentially activates the ERK cascade and phosphatidylinositol 3-kinase
40. Distinct pathways of G(i)- and G(q)-mediated mitogen-activated protein kinase activation
41. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
42. Phosphatidylinositol 3-kinase is an early intermediate in the G βγ-mediated mitogen-activated protein kinase signaling pathway
43. Convergence of angiotensin II and platelet-derived growth factor receptor signaling cascades in vascular smooth muscle cells
44. Gβγ subunits mediate Src-dependent phosphorylation of the epidermal growth factor receptor
45. The m1 muscarinic acetylcholine receptor transactivate the EGF receptor to modulate ion channel activity
46. Signal characteristics of G protein-transactivated EGF receptor
47. Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma: Evidence for an autocrine role in tumor growth
48. Human astrocytoma U138MG cells express predominantly type-A endothelin receptor
49. 125I-ET-1) binding to human meningiomas and antagonizes ET-1-induced proliferation of meningioma cells
50. Human melanoma cells express functional endothelin-1 receptors
51. The expression of EGF receptors, EGF-like factors and c-myc in ovarian and cervical carcinomas and their potential clinical significance
52. Prognostic relevance of epidermal growth factor receptor (EGF-R) and c-neu/erbB2 expression in glioblastomas (GBMs)
53. Expression of transforming growth factor α in human gliomas
54. Epidermal growth factor receptor mRNA levels in human prostatic tumors and cell lines
55. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer
56. Endothelin-stimulated ERK activation in airway smooth-muscle cells requires calcium influx and Raf activation
57. Endothelin-1 and fibroblast growth factors stimulate the mitogen-activated protein kinase signaling cascade in cardiac myocytes. The potential role of the cascade in the integration of two signaling pathways leading to myocyte hypertrophy
58. Endothelin-dependent actions in cultured AT-1 cardiac myocytes. The role of the epsilon isoform of protein kinase C
59. Bombesin and neuromedin B stimulate the activation of p42(mapk) and p74(raf-1) via a protein kinase C-independent pathway in Rat-1 cells
60. On the mechanism of cytosolic phospholipase A2 activation in CHO cells carrying somatostatin receptor: Wortmannin-sensitive pathway to activate mitogen-activated protein kinase
61. Role of phosphoinositide 3-kinase in activation of ras and mitogen-activated protein kinase by epidermal growth factor