Selective Conversion of Big Endothelins to Tracheal Smooth Muscle-Constricting 31-Amino Acid-Length Endothelins by Chymase from Human Mast Cells

Journal of Immunology

Volumn 159, Issue 4, 1997, Pages 1987-1992

  Nakano, Ayako ^a   Kishi, Fumiko ^b   Minami, Kazushi ^a   Wakabayashi, Hideki ^a   Nakaya, Yutaka ^b   Kido, Hiroshi ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHYMASE; ENDOTHELIN; ENDOTHELIN 1; PEPTIDE FRAGMENT; PROTEIN PRECURSOR; PROTEINASE INHIBITOR; SERINE PROTEINASE;

ANIMAL; ARTICLE; DRUG EFFECT; ENZYMOLOGY; HUMAN; MALE; MAST CELL; METABOLISM; MUSCLE CONTRACTION; PH; PHYSIOLOGY; RAT; TRACHEA; WISTAR RAT;

ANIMALS; CHYMASES; ENDOTHELIN-1; ENDOTHELINS; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MAST CELLS; MUSCLE CONTRACTION; PEPTIDE FRAGMENTS; PROTEASE INHIBITORS; PROTEIN PRECURSORS; RATS; RATS, WISTAR; SERINE ENDOPEPTIDASES; TRACHEA;

EID: 0031571260     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Maggi, C. A., R. Patacchini, S. Giuliani, and A. Meli. 1989. Potent contractile effect of endothelin in the isolated guinea pig airway. Eur. J. Pharmacol. 160: 179.
2. Uchida, Y., H. Ninomiya, M. Saotome, A. Nomura, M. Ohtsuka, M. Yanagisawa, K. Goto, T. Masaki, and S. Hasegawa. 1988. Endothelin, a novel vasoconstrictor as a potent bronchoconstrictor. Eur. J. Pharmacol. 154:227.
3. Yanagisawa, M., H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Matsui, Y. Yazaki, K. Goto, and T. Masaki. 1988. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332:411.
4. Huggins, J. P., J. T. Pelton, and R. C. Miller. 1993. The structure and specificity of endothelin receptors: their importance in physiology and medicine. Pharmacol. Ther. 59:55.
5. Yanagisawa, M., and T. Masaki. 1989. Molecular biology and biochemistry of the endothelins. Trends Pharmacol. Sci. 10:374.
6. Black, P. N., M. A. Ghatei, K. Takahashi, D. Bretherton-Watt, T. Krausz, C. T. Dollery, and S. R. Bloom. 1989. Formation of endothelin by cultured airway epithelial cells. FEBS Lett. 255:129.
7. Sawamura, T., S. Kimura, O. Y. Sugita, M. Yanagisawa, and T. Masaki. 1989. Analysis of endothelin related peptide in culture supernatant of porcine aortic endothelial cells: evidence for biosynthetic pathway of endothelin-1. Biochem. Biophys. Res. Commun. 162:1287.
8. Suzuki, N., H. Matsumoto, C. Kitada, S. Kimura, and M. Fujino. 1989. Production of endothelin-1 and big-endothelin-1 by tumor cells with epithelial-like morphology. J. Biochem. 106:736.
9. Springall, D. R., P. H. Howarth, H. Counihan, R. Djukanovic, S. T. Holgate, and J. M. Polak. 1991. Endothelin immunoreactivity of the airway epithelium in asthmatic patients. Lancet 337:697.
10. Wypij, D. M., J. S. Nichols, P. J. Novak, L. Stacy, J. Berman, and J. S. Wiseman. 1992. Role of mast cell chymase in the extracellular processing of big-endothelin-1 to endothelin-1 in the perfused rat lung. Biochem. Pharmacol. 43:845.
11. Nomura, A., Y. Uchida, M. Kameyama, M. Saotome, K. Oki, and S. Hasegawa. 1989. Endothelin and bronchial asthma. Lancet ii:747.
12. Mattoli, S., M. Soloperto, M. Marini, and A. Fasoli. 1991. Levels of endothelin in the bronchoalveolar lavage fluid of patients with symptomatic asthma and reversible airflow obstruction. J. Allergy Clin. Immunol. 378:376.
13. Watanabe, A., M. Kameyama, M. Saotome, A. Nomura, H. Ninomiya, H. Ohse, Y. Uchida, and S. Hasegawa. 1991. Increased plasma level of endothelin-1 during asthmatic attacks. In Advances in Asthmology 1990. S. Kobayashi and J. A. Bellanti, eds. Elsevier Science Publishers, New York, p. 479.
14. Caughey, G. H. 1995. Mast cell chymases and tryptases: phylogeny, family relations, and biogenesis. In Mast Cell Proteases in Immunology and Biology. G. H. Caughey, ed. Marcel Dekker, New York, p. 305.
15. Urata, H., A. Kinoshita, K. S. Misono, F. M. Bumpus, and A. Husain. 1990. Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart. J. Biol. Chem. 265:22348.
16. Reilly, C. F., D. A. Tewksbury, N. M. Schechter, and J. J. Travis. 1982. Rapid conversion of angiotensin I to angiotensin II by neutrophil and mast cell proteinases. J. Biol. Chem. 257:8619.
17. Le Trong, H., H. Neurath, and R. G. Woodbury. 1987. Substrate specificity of the chymotrypsin-type protease in secretory granules isolated from rat mast cells. Proc. Natl. Acad. Sci. USA 84:364.
18. Sukenaga, Y., H. Kido, A. Neki, M. Enomoto, K. Ishida, K. Takagi, and N. Katunuma. 1993. Purification and molecular cloning of chymase from human tonsils. FEBS Lett. 323:119.
19. Kido, H., N. Fukusen, and N. Katunuma. 1984. A simple method for the purification of chymase from rat tongue and rat peritoneal cells. Anal. Biochem. 137: 449.
20. Kutunuma, N., E. Kominami, K. Kobayashi, Y. Banno, K. Suzuki, K. Chichibu, Y. Hamaguchi, and T. Kalsunuma. 1975. Studies on new intracellular proteases in various organs of the rat: purification and comparison of their properties. Eur. J. Biochem. 52:37.
21. Chandrasekharan, U. M., S. Sanker, M. J. Glynias, S. S. Karnik, and A. Husain. 1996. Angiotensin II-forming activity in a reconstructed ancestral chymase. Science 271:502.
22. Galli, S. J. 1993. New concepts about mast cell. N. Engl. J. Med. 328:257.
23. 84 bond by mast cell chymase. J. Biol. Chem. 269:18134.
24. Xu, D., N. Emoto, A. Giaid, C. Slaughter, S. Kaw, D. deWit, and M. Yanagisawa. 1994. ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell 78:473.
25. Emoto, N., and M. Yanagisawa. 1995. Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with an acidic pH optimum. J. Biol. Chem. 270:15262.
26. Advenier, C., V. Lagente, Y. Zhang, and E. Naline. 1992. Contractile activity of big endothelin-1 on the human isolated bronchus. Br. J. Pharmacol. 106:883.
27. Sokolovsky, M., R. Galron, Y. Kloog, A. Bdolah, F. E. Indig, S. Blumberg, and G. Fleminger. 1990. Endothelins are more sensitive than sarafotoxins to neutral endopeptidase: possible physiological significance. Proc. Natl. Acad. Sci. USA 87:4702.
28. Yamaguchi, T., H. Kido, and N. Katunuma. 1992. A membrane-bound metalloendopeptidase from rat kidney: characteristics of its hydrolysis of peptide hormones and neuropeptides. Eur. J. Biochem. 204:547.
29. Peto, H., R. Corder, R. W. Janes, and B. A. Wallace. 1996. A molecular model for human big-endothelin-1 (big ET-1). FEBS Lett. 394:191.
30. Sayama, S., R. V. Iozzo, and N. M. Schlechter. 1987. Human skin chymotrypsin-like proteinase: subcellular localization to mast cell granules and interaction with heparin and other glycosaminoglycans. J. Biol. Chem. 268:9023.
31. Sali, A., R. Matsumoto, H. P. McNeil, M. Karplus, and R. L. Stevens. 1993. Three-dimensional models of four mast cell chymases: identification of proteoglycan binding regions and protease-specific antigenic epitopes. J. Biol. Chem. 268:9023.
32. Kovanen, P. T., and J. O. Kokkonen. 1991. Modification of low density lipoproteins by secretory granules of rat serosal mast cells. J. Biol. Chem. 266:4430.
33. Schechter, N. M. 1995. Chymotrypsin-like proteinases of human skin mast cells. In Clinical Allergy and Immunology, Vol. 6. M. A. Kaliner, ed. Marcel Dekker, Inc., New York, p. 47.
34. Kaartinen, M., A. Penttilä, and P. T. Kovanen. 1994. Accumulation of activated mast cells in the shoulder region of human coronary atheromas, the predilection site of atheromatous rupture. Circulation 90:1669.
35. Kovanen, P. T., M. Kaartinen, and T. Paavonen. 1995. Infiltrates of activated mast cells at the site of coronary atheromatous erosion or rupture in myocardial infarction. Circulation 92:1084.