메뉴 건너뛰기




Volumn 4, Issue 9, 2008, Pages 490-501

Reversal of proteinuric renal disease and the emerging role of endothelin

Author keywords

Endothelin; Glomerulosclerosis; Podocyte; Proteinuria; Reversal

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ATRASENTAN; AVOSENTAN; BOSENTAN; CALCIUM CHANNEL BLOCKING AGENT; DARUSENTAN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; ENDOTHELIN RECEPTOR; HYDRALAZINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MINERALOCORTICOID RECEPTOR;

EID: 50249165289     PISSN: 17458323     EISSN: 17458331     Source Type: Journal    
DOI: 10.1038/ncpneph0891     Document Type: Review
Times cited : (89)

References (128)
  • 1
    • 32444451549 scopus 로고    scopus 로고
    • Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes
    • Remuzzi G et al. (2006) Mechanisms of progression and regression of renal lesions of chronic nephropathies and diabetes. J Clin Invest 116: 288-296
    • (2006) J Clin Invest , vol.116 , pp. 288-296
    • Remuzzi, G.1
  • 2
    • 29244448682 scopus 로고    scopus 로고
    • Progression of chronic kidney disease: Can it be prevented or arrested?
    • Jaber BL and Madias NE (2005) Progression of chronic kidney disease: can it be prevented or arrested? Am J Med 118: 1323-1330
    • (2005) Am J Med , vol.118 , pp. 1323-1330
    • Jaber, B.L.1    Madias, N.E.2
  • 3
    • 42549084911 scopus 로고    scopus 로고
    • Primer: Strategies for identifying genes involved in renal disease
    • de Borst MH et al. (2008) Primer: strategies for identifying genes involved in renal disease. Nat Clin Pract Nephrol 4: 265-276
    • (2008) Nat Clin Pract Nephrol , vol.4 , pp. 265-276
    • de Borst, M.H.1
  • 4
    • 19944429161 scopus 로고    scopus 로고
    • Collins AJ et al. (2005) Excerpts from the United States Renal Data System 2004 annual data report: atlas of end-stage renal disease in the United States. Am J Kidney Dis 45 (1 suppl 1): A5-A7, S1-S280
    • Collins AJ et al. (2005) Excerpts from the United States Renal Data System 2004 annual data report: atlas of end-stage renal disease in the United States. Am J Kidney Dis 45 (1 suppl 1): A5-A7, S1-S280
  • 5
    • 0035199479 scopus 로고    scopus 로고
    • Forecast of the number of patients with end-stage renal disease in the United States to the year 2010
    • Xue JL et al. (2001) Forecast of the number of patients with end-stage renal disease in the United States to the year 2010. J Am Soc Nephrol 12: 2753-2758
    • (2001) J Am Soc Nephrol , vol.12 , pp. 2753-2758
    • Xue, J.L.1
  • 6
    • 34248178511 scopus 로고    scopus 로고
    • Albuminuria is a target for renoprotective therapy independent from blood pressure in patients with type 2 diabetic nephropathy: Post hoc analysis from the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial
    • Eijkelkamp WB et al. (2007) Albuminuria is a target for renoprotective therapy independent from blood pressure in patients with type 2 diabetic nephropathy: post hoc analysis from the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial. J Am Soc Nephrol 18: 1540-1546
    • (2007) J Am Soc Nephrol , vol.18 , pp. 1540-1546
    • Eijkelkamp, W.B.1
  • 7
    • 0035132554 scopus 로고    scopus 로고
    • Progression and potential regression of glomerulosclerosis
    • Fogo AB (2001) Progression and potential regression of glomerulosclerosis. Kidney Int 59: 804-819
    • (2001) Kidney Int , vol.59 , pp. 804-819
    • Fogo, A.B.1
  • 8
    • 18844435934 scopus 로고    scopus 로고
    • New capillary growth: A contributor to regression of sclerosis?
    • Fogo AB (2005) New capillary growth: a contributor to regression of sclerosis? Curr Opin Nephrol Hypertens 14: 201-203
    • (2005) Curr Opin Nephrol Hypertens , vol.14 , pp. 201-203
    • Fogo, A.B.1
  • 9
    • 31544434502 scopus 로고    scopus 로고
    • Progression versus regression of chronic kidney disease
    • Fogo AB (2006) Progression versus regression of chronic kidney disease. Nephrol Dial Transplant 21: 281-284
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 281-284
    • Fogo, A.B.1
  • 10
    • 34250696880 scopus 로고    scopus 로고
    • Reversal of renal disease: Is it enough to inhibit the action of angiotensin II?
    • Dussaule JC and Chatziantoniou C (2007) Reversal of renal disease: is it enough to inhibit the action of angiotensin II? Cell Death Differ 14: 1343-1349
    • (2007) Cell Death Differ , vol.14 , pp. 1343-1349
    • Dussaule, J.C.1    Chatziantoniou, C.2
  • 11
    • 33745058119 scopus 로고    scopus 로고
    • The podocyte's response to injury: Role in proteinuria and glomerulosclerosis
    • Shankland SJ (2006) The podocyte's response to injury: role in proteinuria and glomerulosclerosis. Kidney Int 69: 2131-2147
    • (2006) Kidney Int , vol.69 , pp. 2131-2147
    • Shankland, S.J.1
  • 12
    • 4544377833 scopus 로고    scopus 로고
    • Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin
    • Reiser J et al. (2004) Podocyte migration during nephrotic syndrome requires a coordinated interplay between cathepsin L and alpha3 integrin. J Biol Chem 279: 34827-34832
    • (2004) J Biol Chem , vol.279 , pp. 34827-34832
    • Reiser, J.1
  • 13
    • 0031058834 scopus 로고    scopus 로고
    • Age-related glomerulosclerosis and interstitial fibrosis in Milan normotensive rats: A podocyte disease
    • Floege J et al. (1997) Age-related glomerulosclerosis and interstitial fibrosis in Milan normotensive rats: a podocyte disease. Kidney Int 51: 230-243
    • (1997) Kidney Int , vol.51 , pp. 230-243
    • Floege, J.1
  • 14
    • 33750238503 scopus 로고    scopus 로고
    • Late-onset endothelin-A receptor blockade reduces podocyte injury in homozygous Ren-2 rats despite severe hypertension
    • Opocensky M et al. (2006) Late-onset endothelin-A receptor blockade reduces podocyte injury in homozygous Ren-2 rats despite severe hypertension. Hypertension 48: 965-971
    • (2006) Hypertension , vol.48 , pp. 965-971
    • Opocensky, M.1
  • 15
    • 33744981628 scopus 로고    scopus 로고
    • Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker
    • Nagase M et al. (2006) Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker. Hypertension 47: 1084-1093
    • (2006) Hypertension , vol.47 , pp. 1084-1093
    • Nagase, M.1
  • 16
    • 33645455275 scopus 로고    scopus 로고
    • Fluvastatin ameliorates podocyte injury in proteinuric rats via modulation of excessive Rho signaling
    • Shibata S et al. (2006) Fluvastatin ameliorates podocyte injury in proteinuric rats via modulation of excessive Rho signaling. J Am Soc Nephrol 17: 754-764
    • (2006) J Am Soc Nephrol , vol.17 , pp. 754-764
    • Shibata, S.1
  • 17
    • 33846443625 scopus 로고    scopus 로고
    • Podocyte as the target for aldosterone: Roles of oxidative stress and Sgk1
    • Shibata S et al. (2007) Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1. Hypertension 49: 355-364
    • (2007) Hypertension , vol.49 , pp. 355-364
    • Shibata, S.1
  • 18
    • 0346788786 scopus 로고    scopus 로고
    • The role of podocytes in glomerular pathobiology
    • Asanuma K and Mundel P (2003) The role of podocytes in glomerular pathobiology. Clinical Exp Nephrol 7: 255-259
    • (2003) Clinical Exp Nephrol , vol.7 , pp. 255-259
    • Asanuma, K.1    Mundel, P.2
  • 19
    • 38949151661 scopus 로고    scopus 로고
    • Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy
    • Ziyadeh FN and Wolf G (2008) Pathogenesis of the podocytopathy and proteinuria in diabetic glomerulopathy. Curr Diabetes Rev 4: 39-45
    • (2008) Curr Diabetes Rev , vol.4 , pp. 39-45
    • Ziyadeh, F.N.1    Wolf, G.2
  • 20
    • 33748062325 scopus 로고    scopus 로고
    • Proteinuria with and without renal glomerular podocyte effacement
    • Kalluri R (2006) Proteinuria with and without renal glomerular podocyte effacement. J Am Soc Nephrol 17: 2383-2389
    • (2006) J Am Soc Nephrol , vol.17 , pp. 2383-2389
    • Kalluri, R.1
  • 21
    • 0022973703 scopus 로고
    • Glomerular basement membrane anionic charge site changes early in aminonucleoside nephrosis
    • Mahan JD et al. (1986) Glomerular basement membrane anionic charge site changes early in aminonucleoside nephrosis. Am J Pathol 125: 393-401
    • (1986) Am J Pathol , vol.125 , pp. 393-401
    • Mahan, J.D.1
  • 22
    • 33845670760 scopus 로고    scopus 로고
    • Glomerular podocytes contain neuron-like functional synaptic vesicles
    • Rastaldi MP et al. (2006) Glomerular podocytes contain neuron-like functional synaptic vesicles. FASEB J 20: 976-978
    • (2006) FASEB J , vol.20 , pp. 976-978
    • Rastaldi, M.P.1
  • 23
    • 9644282849 scopus 로고    scopus 로고
    • Role of podocytes for reversal of glomerulosclerosis and proteinuria in the aging kidney after endothelin inhibition
    • Ortmann J et al. (2004) Role of podocytes for reversal of glomerulosclerosis and proteinuria in the aging kidney after endothelin inhibition. Hypertension 44: 974-981
    • (2004) Hypertension , vol.44 , pp. 974-981
    • Ortmann, J.1
  • 24
    • 0141674840 scopus 로고    scopus 로고
    • Urinary podocytes: Lost and found alive
    • Mundel P (2003) Urinary podocytes: lost and found alive. Kidney Int 64: 1529-1530
    • (2003) Kidney Int , vol.64 , pp. 1529-1530
    • Mundel, P.1
  • 25
    • 34250651241 scopus 로고    scopus 로고
    • Podocyte damage resulting in podocyturia: A potential diagnostic marker to assess glomerular disease activity
    • Petermann A and Floege J (2007) Podocyte damage resulting in podocyturia: a potential diagnostic marker to assess glomerular disease activity. Nephron Clin Pract 106: c61-c66
    • (2007) Nephron Clin Pract , vol.106
    • Petermann, A.1    Floege, J.2
  • 26
    • 0035720564 scopus 로고    scopus 로고
    • Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat
    • Kim YH et al. (2001) Podocyte depletion and glomerulosclerosis have a direct relationship in the PAN-treated rat. Kidney Int 60: 957-968
    • (2001) Kidney Int , vol.60 , pp. 957-968
    • Kim, Y.H.1
  • 27
    • 33645459493 scopus 로고    scopus 로고
    • Permselective dysfunction of podocyte-podocyte contact upon angiotensin II unravels the molecular target for renoprotective intervention
    • Macconi D et al. (2006) Permselective dysfunction of podocyte-podocyte contact upon angiotensin II unravels the molecular target for renoprotective intervention. Am J Pathol 168: 1073-1085
    • (2006) Am J Pathol , vol.168 , pp. 1073-1085
    • Macconi, D.1
  • 28
    • 0038235832 scopus 로고    scopus 로고
    • ACE-inhibitors but not endothelin receptor blockers prevent podocyte loss in early diabetic nephropathy
    • Gross ML et al. (2003) ACE-inhibitors but not endothelin receptor blockers prevent podocyte loss in early diabetic nephropathy. Diabetologia 46: 856-868
    • (2003) Diabetologia , vol.46 , pp. 856-868
    • Gross, M.L.1
  • 29
    • 50249162184 scopus 로고    scopus 로고
    • Effect of a selective ETA receptor antagonist on podocyte function and permselective properties of the glomerular barrier in experimental diabetes
    • Presented at the, Bergamo, September 16-19, Bergamo, Italy
    • Gagliardini E et al. (2007) Effect of a selective ETA receptor antagonist on podocyte function and permselective properties of the glomerular barrier in experimental diabetes. Presented at the 10th International Conference on Endothelin: 2007 Bergamo, September 16-19, Bergamo, Italy
    • (2007) 10th International Conference on Endothelin
    • Gagliardini, E.1
  • 30
    • 0030764235 scopus 로고    scopus 로고
    • Podocyte alpha-actinin induction precedes foot process effacement in experimental nephrotic syndrome
    • Smoyer WE et al. (1997) Podocyte alpha-actinin induction precedes foot process effacement in experimental nephrotic syndrome. Am J Physiol 273: F150-F157
    • (1997) Am J Physiol , vol.273
    • Smoyer, W.E.1
  • 31
    • 34347357580 scopus 로고    scopus 로고
    • Podocytes in culture: Past, present, and future
    • Shankland SJ et al. (2007) Podocytes in culture: past, present, and future. Kidney Int 72: 26-36
    • (2007) Kidney Int , vol.72 , pp. 26-36
    • Shankland, S.J.1
  • 32
    • 0036080664 scopus 로고    scopus 로고
    • Podocyte slit-diaphragm protein nephrin is linked to the actin cytoskeleton
    • Yuan H et al. (2002) Podocyte slit-diaphragm protein nephrin is linked to the actin cytoskeleton. Am J Physiology Renal Physiol 282: F585-F591
    • (2002) Am J Physiology Renal Physiol , vol.282
    • Yuan, H.1
  • 33
    • 0038512591 scopus 로고    scopus 로고
    • Podocyte differentiation and hereditary proteinuria/nephrotic syndromes
    • Gubler MC (2003) Podocyte differentiation and hereditary proteinuria/nephrotic syndromes. J Am Soc Nephrol 14 (suppl 1): S22-S26
    • (2003) J Am Soc Nephrol , vol.14 , Issue.SUPPL. 1
    • Gubler, M.C.1
  • 34
    • 0035126234 scopus 로고    scopus 로고
    • Podocytes respond to mechanical stress in vitro
    • Endlich N et al. (2001) Podocytes respond to mechanical stress in vitro. J Am Soc Nephrol 12: 413-422
    • (2001) J Am Soc Nephrol , vol.12 , pp. 413-422
    • Endlich, N.1
  • 35
    • 0034954343 scopus 로고    scopus 로고
    • Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton
    • Takeda T et al. (2001) Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton. J Clin Invest 108: 289-301
    • (2001) J Clin Invest , vol.108 , pp. 289-301
    • Takeda, T.1
  • 36
    • 1642337947 scopus 로고    scopus 로고
    • Changes in glomerular perm-selectivity induced by angiotensin II imply podocyte dysfunction and slit diaphragm protein rearrangement
    • Benigni A et al. (2004) Changes in glomerular perm-selectivity induced by angiotensin II imply podocyte dysfunction and slit diaphragm protein rearrangement. Semin Nephrol 24: 131-140
    • (2004) Semin Nephrol , vol.24 , pp. 131-140
    • Benigni, A.1
  • 37
    • 0019195506 scopus 로고
    • The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
    • Furchgott RF and Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 299: 373-376
    • (1980) Nature , vol.299 , pp. 373-376
    • Furchgott, R.F.1    Zawadzki, J.V.2
  • 38
    • 0023859136 scopus 로고
    • A novel potent vasoconstrictor peptide produced by vascular endothelial cells
    • Yanagisawa M et al. (1988) A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411-415
    • (1988) Nature , vol.332 , pp. 411-415
    • Yanagisawa, M.1
  • 40
    • 0027984808 scopus 로고
    • Endothelins: Molecular biology, biochemistry, pharmacology, physiology, and pathophysiology
    • Rubanyi GM and Polokoff M (1994) Endothelins: molecular biology, biochemistry, pharmacology, physiology, and pathophysiology. Pharmacol Rev 46: 325-415
    • (1994) Pharmacol Rev , vol.46 , pp. 325-415
    • Rubanyi, G.M.1    Polokoff, M.2
  • 41
    • 33845423984 scopus 로고    scopus 로고
    • Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention
    • Ge Y et al. (2006) Collecting duct-specific knockout of the endothelin B receptor causes hypertension and sodium retention. Am J Physiol Renal Physiol 291: F1274-F1280
    • (2006) Am J Physiol Renal Physiol , vol.291
    • Ge, Y.1
  • 42
    • 0034619523 scopus 로고    scopus 로고
    • Endothelins and endothelin receptor antagonists: Therapeutic considerations for a novel class of cardiovascular drugs
    • Luscher TF and Barton M (2000) Endothelins and endothelin receptor antagonists: therapeutic considerations for a novel class of cardiovascular drugs. Circulation 102: 2434-2440
    • (2000) Circulation , vol.102 , pp. 2434-2440
    • Luscher, T.F.1    Barton, M.2
  • 43
    • 33645739923 scopus 로고    scopus 로고
    • The renal medullary endothelin system in control of sodium and water excretion and systemic blood pressure
    • Kohan DE (2006) The renal medullary endothelin system in control of sodium and water excretion and systemic blood pressure. Curr Opin Nephrol Hypertens 15: 34-40
    • (2006) Curr Opin Nephrol Hypertens , vol.15 , pp. 34-40
    • Kohan, D.E.1
  • 44
    • 0027203495 scopus 로고
    • A specific endothelin subtype A receptor antagonist protects against injury in renal disease progression
    • Benigni A et al. (1993) A specific endothelin subtype A receptor antagonist protects against injury in renal disease progression. Kidney Int 44: 440-444
    • (1993) Kidney Int , vol.44 , pp. 440-444
    • Benigni, A.1
  • 45
    • 1842411863 scopus 로고    scopus 로고
    • Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension
    • Hocher B et al. (1997) Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension. J Clin Invest 99: 1380-1389
    • (1997) J Clin Invest , vol.99 , pp. 1380-1389
    • Hocher, B.1
  • 46
    • 16744362572 scopus 로고    scopus 로고
    • Dysfunctional renal nitric oxide synthase as a determinant of salt-sensitive hypertension: Mechanisms of renal artery endothelial dysfunction and role of endothelin for vascular hypertrophy and glomerulosclerosis
    • Barton M et al. (2000) Dysfunctional renal nitric oxide synthase as a determinant of salt-sensitive hypertension: mechanisms of renal artery endothelial dysfunction and role of endothelin for vascular hypertrophy and glomerulosclerosis. J Am Soc Nephrol 11: 835-845
    • (2000) J Am Soc Nephrol , vol.11 , pp. 835-845
    • Barton, M.1
  • 47
    • 43849113758 scopus 로고    scopus 로고
    • Late-onset endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats
    • Vernerová Z et al. (2008) Late-onset endothelin receptor blockade in hypertensive heterozygous REN-2 transgenic rats. Vascul Pharmacol 48: 165-173
    • (2008) Vascul Pharmacol , vol.48 , pp. 165-173
    • Vernerová, Z.1
  • 48
    • 0035090401 scopus 로고    scopus 로고
    • Regression of renal vascular fibrosis by endothelin receptor antagonism
    • Boffa JJ et al. (2001) Regression of renal vascular fibrosis by endothelin receptor antagonism. Hypertension 37: 490-496
    • (2001) Hypertension , vol.37 , pp. 490-496
    • Boffa, J.J.1
  • 49
    • 0031891447 scopus 로고    scopus 로고
    • Unselective inhibition of endothelin receptors reduces renal dysfunction in experimental diabetes
    • Benigni A et al. (1998) Unselective inhibition of endothelin receptors reduces renal dysfunction in experimental diabetes. Diabetes 47: 450-456
    • (1998) Diabetes , vol.47 , pp. 450-456
    • Benigni, A.1
  • 50
    • 0141590203 scopus 로고    scopus 로고
    • Renal damage in the SHR/N-cp type 2 diabetes model: Comparison of an angiotensin-converting enzyme inhibitor and endothelin receptor blocker
    • Gross ML et al. (2003) Renal damage in the SHR/N-cp type 2 diabetes model: comparison of an angiotensin-converting enzyme inhibitor and endothelin receptor blocker. Lab Invest 83: 1267-1277
    • (2003) Lab Invest , vol.83 , pp. 1267-1277
    • Gross, M.L.1
  • 51
    • 0035155949 scopus 로고    scopus 로고
    • How renal cytokines and growth factors contribute to renal disease progression
    • Benigni A and Remuzzi G (2001) How renal cytokines and growth factors contribute to renal disease progression. Am J Kidney Dis 37: S21-S24
    • (2001) Am J Kidney Dis , vol.37
    • Benigni, A.1    Remuzzi, G.2
  • 52
    • 0029953117 scopus 로고    scopus 로고
    • Endothelin-1 induces loss of proteoglycans and enhances fibronectin and collagen production in cultured rabbit synovial cells
    • Gutierrez S et al. (1996) Endothelin-1 induces loss of proteoglycans and enhances fibronectin and collagen production in cultured rabbit synovial cells. Eur J Pharmacol 302: 191-197
    • (1996) Eur J Pharmacol , vol.302 , pp. 191-197
    • Gutierrez, S.1
  • 53
    • 33846981161 scopus 로고    scopus 로고
    • Effects of endothelin-1 on thymidine uptake and fibronectin production of diabetic glomeruli
    • Chang JM et al. (2007) Effects of endothelin-1 on thymidine uptake and fibronectin production of diabetic glomeruli. Nephrology (Carlton) 12: 62-66
    • (2007) Nephrology (Carlton) , vol.12 , pp. 62-66
    • Chang, J.M.1
  • 54
    • 34447109827 scopus 로고    scopus 로고
    • Shigatoxin-induced endothelin-1 expression in cultured podocytes autocrinally mediates actin remodeling
    • Morigi M et al. (2006) Shigatoxin-induced endothelin-1 expression in cultured podocytes autocrinally mediates actin remodeling. Am J Pathol 169: 1965-1975
    • (2006) Am J Pathol , vol.169 , pp. 1965-1975
    • Morigi, M.1
  • 55
    • 20944437139 scopus 로고    scopus 로고
    • In response to protein load podocytes reorganize cytoskeleton and modulate endothelin-1 gene: Implication for permselective dysfunction of chronic nephropathies
    • Morigi M et al. (2005) In response to protein load podocytes reorganize cytoskeleton and modulate endothelin-1 gene: implication for permselective dysfunction of chronic nephropathies. Am J Pathol 166: 1309-1320
    • (2005) Am J Pathol , vol.166 , pp. 1309-1320
    • Morigi, M.1
  • 56
    • 39049160165 scopus 로고    scopus 로고
    • Recent developments on endothelin antagonists as immunomodulatory drugs-from infection to transplantation medicine
    • Nett PC et al. (2006) Recent developments on endothelin antagonists as immunomodulatory drugs-from infection to transplantation medicine. Recent Patents Cardiovasc Drug Discov 1: 265-276
    • (2006) Recent Patents Cardiovasc Drug Discov , vol.1 , pp. 265-276
    • Nett, P.C.1
  • 57
    • 20244377044 scopus 로고    scopus 로고
    • Activation of proinflammatory and anti-inflammatory cytokines in host organs during chronic allograft rejection: Role of endothelin receptor signaling
    • Lattmann T et al. (2005) Activation of proinflammatory and anti-inflammatory cytokines in host organs during chronic allograft rejection: role of endothelin receptor signaling. Am J Transplant 5: 1042-1049
    • (2005) Am J Transplant , vol.5 , pp. 1042-1049
    • Lattmann, T.1
  • 58
    • 33845979878 scopus 로고    scopus 로고
    • Endothelin A receptor blockade reduces diabetic renal injury via an anti-inflammatory mechanism
    • Sasser JM et al. (2007) Endothelin A receptor blockade reduces diabetic renal injury via an anti-inflammatory mechanism. J Am Soc Nephrol 18: 143-154
    • (2007) J Am Soc Nephrol , vol.18 , pp. 143-154
    • Sasser, J.M.1
  • 59
    • 33748952130 scopus 로고    scopus 로고
    • Up-regulated inflammatory factors endothelin, NFkappaB, TNFalpha and iNOS involved in exaggerated cardiac arrhythmias in l-thyroxine-induced cardiomyopathy are suppressed by darusentan in rats
    • Xia HJ et al. (2006) Up-regulated inflammatory factors endothelin, NFkappaB, TNFalpha and iNOS involved in exaggerated cardiac arrhythmias in l-thyroxine-induced cardiomyopathy are suppressed by darusentan in rats. Life Sci 79: 1812-1819
    • (2006) Life Sci , vol.79 , pp. 1812-1819
    • Xia, H.J.1
  • 60
    • 0029658588 scopus 로고    scopus 로고
    • An orally active ETA/ETB receptor antagonist ameliorates proteinuria and glomerular lesions in rats with proliferative nephritis
    • Gomez-Garre D et al. (1996) An orally active ETA/ETB receptor antagonist ameliorates proteinuria and glomerular lesions in rats with proliferative nephritis. Kidney Int 50: 962-972
    • (1996) Kidney Int , vol.50 , pp. 962-972
    • Gomez-Garre, D.1
  • 61
    • 0025079136 scopus 로고
    • Endothelin stimulates angiotensin I to angiotensin II conversion in cultured pulmonary artery endothelial cells
    • Kawaguchi H et al. (1990) Endothelin stimulates angiotensin I to angiotensin II conversion in cultured pulmonary artery endothelial cells. J Mol Cell Cardiol 22: 839-842
    • (1990) J Mol Cell Cardiol , vol.22 , pp. 839-842
    • Kawaguchi, H.1
  • 62
    • 0033984070 scopus 로고    scopus 로고
    • Obesity is associated with tissue-specific activation of renal angiotensin-converting enzyme in vivo: Evidence for a regulatory role of endothelin
    • Barton M et al. (2000) Obesity is associated with tissue-specific activation of renal angiotensin-converting enzyme in vivo: evidence for a regulatory role of endothelin. Hypertension 35: 329-336
    • (2000) Hypertension , vol.35 , pp. 329-336
    • Barton, M.1
  • 63
    • 0031590298 scopus 로고    scopus 로고
    • Angiotensin II increases vascular and renal endothelin-1 and functional endothelin converting enzyme activity in vivo: Role of ETA receptors for endothelin regulation
    • Barton M et al. (1997) Angiotensin II increases vascular and renal endothelin-1 and functional endothelin converting enzyme activity in vivo: role of ETA receptors for endothelin regulation. Biochem Biophys Res Commun 238: 861-865
    • (1997) Biochem Biophys Res Commun , vol.238 , pp. 861-865
    • Barton, M.1
  • 64
    • 0026509658 scopus 로고
    • Functional endothelin 1 receptors on human glomerular podocytes and mesangial cells
    • Rebibou JM et al. (1992) Functional endothelin 1 receptors on human glomerular podocytes and mesangial cells. Nephrol Dial Transplant 7: 288-292
    • (1992) Nephrol Dial Transplant , vol.7 , pp. 288-292
    • Rebibou, J.M.1
  • 65
    • 41849096667 scopus 로고    scopus 로고
    • Angiotensin II infusion induces nephrin expression changes and podocyte apoptosis
    • Jia J et al. (2008) Angiotensin II infusion induces nephrin expression changes and podocyte apoptosis. Am J Nephrol 28: 500-507
    • (2008) Am J Nephrol , vol.28 , pp. 500-507
    • Jia, J.1
  • 66
    • 0032750718 scopus 로고    scopus 로고
    • Protein overload activates proximal tubular cells to release vasoactive and inflammatory mediators
    • Zoja C et al. (1999) Protein overload activates proximal tubular cells to release vasoactive and inflammatory mediators. Exp Nephrol 7: 420-428
    • (1999) Exp Nephrol , vol.7 , pp. 420-428
    • Zoja, C.1
  • 67
    • 33846470135 scopus 로고    scopus 로고
    • Dietary protein induces endothelin-mediated kidney injury through enhanced intrinsic acid production
    • Wesson DE et al. (2007) Dietary protein induces endothelin-mediated kidney injury through enhanced intrinsic acid production. Kidney Int 71: 210-217
    • (2007) Kidney Int , vol.71 , pp. 210-217
    • Wesson, D.E.1
  • 68
    • 33745821648 scopus 로고    scopus 로고
    • Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth
    • Liang XB et al. (2006) Angiotensin type 1 receptor blocker restores podocyte potential to promote glomerular endothelial cell growth. J Am Soc Nephrol 17: 1886-1895
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1886-1895
    • Liang, X.B.1
  • 69
    • 8844284400 scopus 로고    scopus 로고
    • The potential of endothelin antagonism as a therapeutic approach
    • Benigni A et al. (2004) The potential of endothelin antagonism as a therapeutic approach. Expert Opin Investig Drugs 13: 1419-1435
    • (2004) Expert Opin Investig Drugs , vol.13 , pp. 1419-1435
    • Benigni, A.1
  • 70
    • 2342557182 scopus 로고    scopus 로고
    • Progression of renal disease: New insights into risk factors and pathomechanisms
    • Gross ML and Amann K (2004) Progression of renal disease: new insights into risk factors and pathomechanisms. Curr Opin Nephrol Hypertens 13: 307-312
    • (2004) Curr Opin Nephrol Hypertens , vol.13 , pp. 307-312
    • Gross, M.L.1    Amann, K.2
  • 71
    • 41749086422 scopus 로고    scopus 로고
    • Endothelin-1 levels and albuminuria in patients with type 2 diabetes mellitus
    • Zanatta CM et al. (2008) Endothelin-1 levels and albuminuria in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract 80: 299-304
    • (2008) Diabetes Res Clin Pract , vol.80 , pp. 299-304
    • Zanatta, C.M.1
  • 72
    • 0035072569 scopus 로고    scopus 로고
    • Plasma and urinary endothelin-1 in focal segmental glomerulosclerosis
    • Chen HC et al. (2001) Plasma and urinary endothelin-1 in focal segmental glomerulosclerosis. J Clin Lab Anal 15: 59-63
    • (2001) J Clin Lab Anal , vol.15 , pp. 59-63
    • Chen, H.C.1
  • 73
    • 33644783770 scopus 로고    scopus 로고
    • Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy
    • Susztak K et al. (2006) Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy. Diabetes 55: 225-233
    • (2006) Diabetes , vol.55 , pp. 225-233
    • Susztak, K.1
  • 74
    • 0029088469 scopus 로고
    • High glucose alters actin assembly in glomerular mesangial and epithelial cells
    • Zhou X et al. (1995) High glucose alters actin assembly in glomerular mesangial and epithelial cells. Lab Invest 73: 372-383
    • (1995) Lab Invest , vol.73 , pp. 372-383
    • Zhou, X.1
  • 75
    • 12444302841 scopus 로고    scopus 로고
    • Podocytes that detach in experimental membranous nephropathy are viable
    • Petermann AT et al. (2003) Podocytes that detach in experimental membranous nephropathy are viable. Kidney Int 64: 1222-1231
    • (2003) Kidney Int , vol.64 , pp. 1222-1231
    • Petermann, A.T.1
  • 76
    • 45149133361 scopus 로고    scopus 로고
    • Preeclamptic sera induce nephrin shedding from podocytes through endothelin-1 release by endothelial glomerular cells
    • Collino F et al. (2008) Preeclamptic sera induce nephrin shedding from podocytes through endothelin-1 release by endothelial glomerular cells. Am J Physiol Renal Physiol 294: F1185-F1194
    • (2008) Am J Physiol Renal Physiol , vol.294
    • Collino, F.1
  • 77
    • 33750059766 scopus 로고    scopus 로고
    • Podocyte lesions in patients with obesity-related glomerulopathy
    • Chen HM et al. (2006) Podocyte lesions in patients with obesity-related glomerulopathy. Am J Kidney Dis 48: 772-779
    • (2006) Am J Kidney Dis , vol.48 , pp. 772-779
    • Chen, H.M.1
  • 78
    • 47949121132 scopus 로고    scopus 로고
    • Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes
    • Saraheimo M et al. (2008) Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes. Diabetes Care 31: 1165-1169
    • (2008) Diabetes Care , vol.31 , pp. 1165-1169
    • Saraheimo, M.1
  • 79
    • 43049095682 scopus 로고    scopus 로고
    • Adiponectin regulates albuminuria and podocyte function in mice
    • Sharma K et al. (2008) Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest 188: 1645-1656
    • (2008) J Clin Invest , vol.188 , pp. 1645-1656
    • Sharma, K.1
  • 80
    • 0037409319 scopus 로고    scopus 로고
    • Obesity-associated activation of angiotensin and endothelin in the cardiovascular system
    • Barton M et al. (2003) Obesity-associated activation of angiotensin and endothelin in the cardiovascular system. Int J Biochem Cell Biol 35: 826-837
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 826-837
    • Barton, M.1
  • 81
    • 33646400605 scopus 로고    scopus 로고
    • Endothelin-1 inhibits adiponectin secretion through a phosphatidylinositol 4,5-bisphosphate/actin-dependent mechanism
    • Bedi D et al. (2006) Endothelin-1 inhibits adiponectin secretion through a phosphatidylinositol 4,5-bisphosphate/actin-dependent mechanism. Biochem Biophys Res Commun 345: 332-339
    • (2006) Biochem Biophys Res Commun , vol.345 , pp. 332-339
    • Bedi, D.1
  • 82
    • 6044230923 scopus 로고    scopus 로고
    • Insulin infusion induces endothelin-1-dependent hypertension in rats
    • Juan CC et al. (2004) Insulin infusion induces endothelin-1-dependent hypertension in rats. Am J Physiol Endocrinol Metab 287: E948-E954
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Juan, C.C.1
  • 83
    • 39149133153 scopus 로고    scopus 로고
    • Stimulation of endothelin-1 gene expression by insulin via phosphoinositide-3 kinase-glycogen synthase kinase-3beta signaling in endothelial cells
    • Yang Z and Li JC (2008) Stimulation of endothelin-1 gene expression by insulin via phosphoinositide-3 kinase-glycogen synthase kinase-3beta signaling in endothelial cells. Life Sci 82: 512-518
    • (2008) Life Sci , vol.82 , pp. 512-518
    • Yang, Z.1    Li, J.C.2
  • 84
    • 0035894074 scopus 로고    scopus 로고
    • Tissue- and time-dependent effects of endothelin-1 on insulin-stimulated glucose uptake
    • Idris I et al. (2001) Tissue- and time-dependent effects of endothelin-1 on insulin-stimulated glucose uptake. Biochem Pharmacol 62: 1705-1708
    • (2001) Biochem Pharmacol , vol.62 , pp. 1705-1708
    • Idris, I.1
  • 85
    • 0034809972 scopus 로고    scopus 로고
    • Changes in the expression of nephrin gene and protein in experimental diabetic nephropathy
    • Aaltonen P et al. (2001) Changes in the expression of nephrin gene and protein in experimental diabetic nephropathy. Lab Invest 81: 1185-1190
    • (2001) Lab Invest , vol.81 , pp. 1185-1190
    • Aaltonen, P.1
  • 86
    • 22144484132 scopus 로고    scopus 로고
    • Endothelin inhibition delays onset of hyperglycemia and associated vascular injury in type I diabetes: Evidence for endothelin release by pancreatic islet beta-cells
    • Ortmann J et al. (2005) Endothelin inhibition delays onset of hyperglycemia and associated vascular injury in type I diabetes: evidence for endothelin release by pancreatic islet beta-cells. Biochem Biophys Res Commun 334: 689-695
    • (2005) Biochem Biophys Res Commun , vol.334 , pp. 689-695
    • Ortmann, J.1
  • 87
    • 0016197953 scopus 로고
    • Pancreatic islet transplantation. Effects on the glomerular lesions of experimental diabetes in the rat
    • Mauer SM et al. (1974) Pancreatic islet transplantation. Effects on the glomerular lesions of experimental diabetes in the rat. Diabetes 23: 748-753
    • (1974) Diabetes , vol.23 , pp. 748-753
    • Mauer, S.M.1
  • 88
    • 0015975221 scopus 로고
    • Renal transplantation in diabetes mellitus in rats
    • Lee CS et al. (1974) Renal transplantation in diabetes mellitus in rats. J Exp Med 139: 793-800
    • (1974) J Exp Med , vol.139 , pp. 793-800
    • Lee, C.S.1
  • 89
    • 0021032603 scopus 로고
    • Reversal of diabetic nephropathy in human cadaveric kidneys after transplantation into non-diabetic recipients
    • Abouna GM et al. (1983) Reversal of diabetic nephropathy in human cadaveric kidneys after transplantation into non-diabetic recipients. Lancet 2: 1274-1276
    • (1983) Lancet , vol.2 , pp. 1274-1276
    • Abouna, G.M.1
  • 90
    • 0032499911 scopus 로고    scopus 로고
    • Reversal of lesions of diabetic nephropathy after pancreas transplantation
    • Fioretto P et al. (1998) Reversal of lesions of diabetic nephropathy after pancreas transplantation. N Engl J Med 339: 69-75
    • (1998) N Engl J Med , vol.339 , pp. 69-75
    • Fioretto, P.1
  • 91
    • 0025099354 scopus 로고
    • Enalapril and low protein reverse chronic puromycin aminonucleoside nephropathy
    • Marinides GN et al. (1990) Enalapril and low protein reverse chronic puromycin aminonucleoside nephropathy. Kidney Int 37: 749-757
    • (1990) Kidney Int , vol.37 , pp. 749-757
    • Marinides, G.N.1
  • 92
    • 0026511399 scopus 로고
    • Renal protective effect of angiotensin-converting enzyme inhibition in aging rats
    • Zoja C et al. (1992) Renal protective effect of angiotensin-converting enzyme inhibition in aging rats. Am J Med 92: 60S-63S
    • (1992) Am J Med , vol.92
    • Zoja, C.1
  • 93
    • 32444440002 scopus 로고    scopus 로고
    • ACE inhibition reduces glomerulosclerosis and regenerates glomerular tissue in a model of progressive renal disease
    • Remuzzi A et al. (2006) ACE inhibition reduces glomerulosclerosis and regenerates glomerular tissue in a model of progressive renal disease. Kidney Int 69: 1124-1130
    • (2006) Kidney Int , vol.69 , pp. 1124-1130
    • Remuzzi, A.1
  • 94
    • 36749047471 scopus 로고    scopus 로고
    • Antiproteinuric effect of the calcium channel blocker cilnidipine added to renin-angiotensin inhibition in hypertensive patients with chronic renal disease
    • Fujita T et al. (2007) Antiproteinuric effect of the calcium channel blocker cilnidipine added to renin-angiotensin inhibition in hypertensive patients with chronic renal disease. Kidney Int 72: 1543-1549
    • (2007) Kidney Int , vol.72 , pp. 1543-1549
    • Fujita, T.1
  • 95
    • 0025883896 scopus 로고
    • Cause of variable therapeutic efficiency of angiotensin converting enzyme inhibitor on glomerular lesions
    • Ikoma M et al. (1991) Cause of variable therapeutic efficiency of angiotensin converting enzyme inhibitor on glomerular lesions. Kidney Int 40: 195-202
    • (1991) Kidney Int , vol.40 , pp. 195-202
    • Ikoma, M.1
  • 96
    • 0032589378 scopus 로고    scopus 로고
    • VEGF(165) mediates glomerular endothelial repair
    • Ostendorf T et al. (1999) VEGF(165) mediates glomerular endothelial repair. J Clin Invest 104: 913-923
    • (1999) J Clin Invest , vol.104 , pp. 913-923
    • Ostendorf, T.1
  • 97
    • 0037716348 scopus 로고    scopus 로고
    • Chronic endothelin receptor blockade prevents both early hyperfiltration and late overt diabetic nephropathy in the rat
    • Ding SS et al. (2003) Chronic endothelin receptor blockade prevents both early hyperfiltration and late overt diabetic nephropathy in the rat. J Cardiovasc Pharmacol 42: 48-54
    • (2003) J Cardiovasc Pharmacol , vol.42 , pp. 48-54
    • Ding, S.S.1
  • 98
    • 0035103048 scopus 로고    scopus 로고
    • Effects of endothelin receptor antagonists on the progression of diabetic nephropathy
    • Hocher B et al. (2001) Effects of endothelin receptor antagonists on the progression of diabetic nephropathy. Nephron 87: 161-169
    • (2001) Nephron , vol.87 , pp. 161-169
    • Hocher, B.1
  • 99
    • 0034021275 scopus 로고    scopus 로고
    • Effects of endothelin or angiotensin II receptor blockade on diabetes in the transgenic (mRen-2)27 rat
    • Kelly DJ et al. (2000) Effects of endothelin or angiotensin II receptor blockade on diabetes in the transgenic (mRen-2)27 rat. Kidney Int 57: 1882-1894
    • (2000) Kidney Int , vol.57 , pp. 1882-1894
    • Kelly, D.J.1
  • 100
    • 0032731997 scopus 로고    scopus 로고
    • State-of-the-Art lecture. Role of endothelin-1 in hypertension
    • Schiffrin EL (1999) State-of-the-Art lecture. Role of endothelin-1 in hypertension. Hypertension 34: 876-881
    • (1999) Hypertension , vol.34 , pp. 876-881
    • Schiffrin, E.L.1
  • 101
    • 33645281135 scopus 로고    scopus 로고
    • Reversal of renal lesions following interruption of nitric oxide synthesis inhibition in transgenic mice
    • Placier S et al. (2006) Reversal of renal lesions following interruption of nitric oxide synthesis inhibition in transgenic mice. Nephrol Dial Transplant 21: 881-888
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 881-888
    • Placier, S.1
  • 102
    • 0031613530 scopus 로고    scopus 로고
    • ETA receptor blockade prevents increased tissue endothelin-1, vascular hypertrophy and endothelial dysfunction in salt-sensitive hypertension
    • Barton M et al. (1998) ETA receptor blockade prevents increased tissue endothelin-1, vascular hypertrophy and endothelial dysfunction in salt-sensitive hypertension. Hypertension 31: 499-504
    • (1998) Hypertension , vol.31 , pp. 499-504
    • Barton, M.1
  • 103
    • 1542564748 scopus 로고    scopus 로고
    • ABT-627, a selective ETA-receptor anatagonist, reduces proteinuria in patients with diabetes mellitus
    • thesis] Utrecht: Elinkwijk BV
    • Honing MLH et al. (2000) ABT-627, a selective ETA-receptor anatagonist, reduces proteinuria in patients with diabetes mellitus. In: Regulation of Vascular Tone in Humans by Endothelium-derived Mediators [thesis] Utrecht: Elinkwijk BV
    • (2000) Regulation of Vascular Tone in Humans by Endothelium-derived Mediators
    • Honing, M.L.H.1
  • 104
    • 50249133312 scopus 로고    scopus 로고
    • The ETA-selective antagonist SPP301 on top of standard treatment reduces urinary albumin excretion rate in patients with diabetic nephropathy [abstract F-FC093]
    • Presented at, November 8-13, Philadelphia, PA, USA
    • Wenzel RR et al. (2005) The ETA-selective antagonist SPP301 on top of standard treatment reduces urinary albumin excretion rate in patients with diabetic nephropathy [abstract F-FC093]. Presented at ASN Renal Week: 2005 November 8-13, Philadelphia, PA, USA
    • (2005) ASN Renal Week
    • Wenzel, R.R.1
  • 106
    • 50249171901 scopus 로고    scopus 로고
    • Viberti G (online 2008) SPP301 (Avosentan) ASCEND clinical results. [www.speedel.com/assets/2008_SPP301ASCENDStudy.pdf] (accessed 5 June 2008)
    • Viberti G (online 2008) SPP301 (Avosentan) ASCEND clinical results. [www.speedel.com/assets/2008_SPP301ASCENDStudy.pdf] (accessed 5 June 2008)
  • 107
    • 50249132759 scopus 로고    scopus 로고
    • ClinicalTrials.gov (online 2005) [http://clinicaltrials.gov/ct2/show/ NCT00120328?term=NCT00120328&rank=1] (accessed 5 June 2008)
    • ClinicalTrials.gov (online 2005) [http://clinicaltrials.gov/ct2/show/ NCT00120328?term=NCT00120328&rank=1] (accessed 5 June 2008)
  • 108
    • 33750233432 scopus 로고    scopus 로고
    • Role of endothelin receptors for renal protection and survival in hypertension: Waiting for clinical trials
    • Barton M et al. (2006) Role of endothelin receptors for renal protection and survival in hypertension: waiting for clinical trials. Hypertension 48: 834-837
    • (2006) Hypertension , vol.48 , pp. 834-837
    • Barton, M.1
  • 109
    • 43049099531 scopus 로고    scopus 로고
    • Efficacy and safety of darusentan in patients with resistant hypertension: Results from a randomized, double-blind, placebo-controlled dose-ranging study
    • Black HR et al. (2007) Efficacy and safety of darusentan in patients with resistant hypertension: results from a randomized, double-blind, placebo-controlled dose-ranging study. J Clin Hypertens (Greenwich) 9: 760-769
    • (2007) J Clin Hypertens (Greenwich) , vol.9 , pp. 760-769
    • Black, H.R.1
  • 110
    • 0346736491 scopus 로고    scopus 로고
    • Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells
    • Hernandez-Perera O et al. (1998) Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. J Clin Invest 101: 2711-2719
    • (1998) J Clin Invest , vol.101 , pp. 2711-2719
    • Hernandez-Perera, O.1
  • 111
    • 38549135458 scopus 로고    scopus 로고
    • Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment
    • Whaley-Connell A et al. (2008) Attenuation of NADPH oxidase activation and glomerular filtration barrier remodeling with statin treatment. Hypertension 51: 474-480
    • (2008) Hypertension , vol.51 , pp. 474-480
    • Whaley-Connell, A.1
  • 112
    • 33846857348 scopus 로고    scopus 로고
    • Statin-sensitive endocytosis of albumin by glomerular podocytes
    • Eyre J et al. (2007) Statin-sensitive endocytosis of albumin by glomerular podocytes. Am J Physiol Renal Physiol 292: F674-F681
    • (2007) Am J Physiol Renal Physiol , vol.292
    • Eyre, J.1
  • 113
    • 0037062481 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: Implications for diabetic nephropathy
    • Danesh FR et al. (2002) 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: implications for diabetic nephropathy. Proc Natl Acad Sci USA 99: 8301-8305
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8301-8305
    • Danesh, F.R.1
  • 114
    • 36249017958 scopus 로고    scopus 로고
    • Insulin resistance, oxidative stress, and podocyte injury: Role of rosuvastatin modulation of filtration barrier injury
    • Whaley-Connell A et al. (2008) Insulin resistance, oxidative stress, and podocyte injury: role of rosuvastatin modulation of filtration barrier injury. Am J Nephrol 28: 67-75
    • (2008) Am J Nephrol , vol.28 , pp. 67-75
    • Whaley-Connell, A.1
  • 115
    • 34247893910 scopus 로고    scopus 로고
    • Rosuvastatin treatment prevents progressive kidney inflammation and fibrosis in stroke-prone rats
    • Gianella A et al. (2007) Rosuvastatin treatment prevents progressive kidney inflammation and fibrosis in stroke-prone rats. Am J Pathol 170: 1165-1177
    • (2007) Am J Pathol , vol.170 , pp. 1165-1177
    • Gianella, A.1
  • 116
    • 31544448314 scopus 로고    scopus 로고
    • Regression of existing glomerulosclerosis by inhibition of aldosterone
    • Aldigier JC et al. (2005) Regression of existing glomerulosclerosis by inhibition of aldosterone. J Am Soc Nephrol 16: 3306-3314
    • (2005) J Am Soc Nephrol , vol.16 , pp. 3306-3314
    • Aldigier, J.C.1
  • 117
    • 0026568514 scopus 로고
    • Endothelin stimulates aldosterone secretion in vitro from normal adrenocortical tissue, but not adenoma tissue, in primary aldosteronism
    • Zeng ZP et al. (1992) Endothelin stimulates aldosterone secretion in vitro from normal adrenocortical tissue, but not adenoma tissue, in primary aldosteronism. J Clin Endocrinol Metab 74: 874-878
    • (1992) J Clin Endocrinol Metab , vol.74 , pp. 874-878
    • Zeng, Z.P.1
  • 118
    • 9844235911 scopus 로고    scopus 로고
    • Autocrine-paracrine role of endothelin-1 in the regulation of aldosterone synthase expression and intracellular Ca2+ in human adrenocortical carcinoma NCI-H295 cells
    • Rossi GP et al. (1997) Autocrine-paracrine role of endothelin-1 in the regulation of aldosterone synthase expression and intracellular Ca2+ in human adrenocortical carcinoma NCI-H295 cells. Endocrinology 138: 4421-4426
    • (1997) Endocrinology , vol.138 , pp. 4421-4426
    • Rossi, G.P.1
  • 119
    • 0037648482 scopus 로고    scopus 로고
    • Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy
    • Wang S et al. (2003) Bone morphogenic protein-7 (BMP-7), a novel therapy for diabetic nephropathy. Kidney Int 63: 2037-2049
    • (2003) Kidney Int , vol.63 , pp. 2037-2049
    • Wang, S.1
  • 120
    • 0038717407 scopus 로고    scopus 로고
    • BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury
    • Zeisberg M et al. (2003) BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 9: 964-968
    • (2003) Nat Med , vol.9 , pp. 964-968
    • Zeisberg, M.1
  • 121
    • 0030786521 scopus 로고    scopus 로고
    • Osteogenic protein-1 downregulates endothelin A receptors in primary rat osteoblasts
    • Kitten AM et al. (1997) Osteogenic protein-1 downregulates endothelin A receptors in primary rat osteoblasts. Am J Physiol 272: E967-E975
    • (1997) Am J Physiol , vol.272
    • Kitten, A.M.1
  • 122
    • 36749101547 scopus 로고    scopus 로고
    • Bone morphogenetic protein-7 delays podocyte injury due to high glucose
    • De Petris L et al. (2007) Bone morphogenetic protein-7 delays podocyte injury due to high glucose. Nephrol Dial Transplant 22: 3442-3450
    • (2007) Nephrol Dial Transplant , vol.22 , pp. 3442-3450
    • De Petris, L.1
  • 123
    • 36049022526 scopus 로고    scopus 로고
    • BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury
    • Mitu GM et al. (2007) BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury. Am Journal Physiol 293: F1641-F1648
    • (2007) Am Journal Physiol , vol.293
    • Mitu, G.M.1
  • 124
    • 44349159591 scopus 로고    scopus 로고
    • BMP in podocytes is essential for normal glomerular capillary formation
    • Ueda H et al. (2008) BMP in podocytes is essential for normal glomerular capillary formation. J Am Soc Nephrol 19: 685-694
    • (2008) J Am Soc Nephrol , vol.19 , pp. 685-694
    • Ueda, H.1
  • 125
    • 44849114597 scopus 로고    scopus 로고
    • Aliskiren combined with losartan in type 2 diabetes and nephropathy
    • Parving HH et al. (2008) Aliskiren combined with losartan in type 2 diabetes and nephropathy. N Engl J Med 358: 2433-2446
    • (2008) N Engl J Med , vol.358 , pp. 2433-2446
    • Parving, H.H.1
  • 126
    • 0031757454 scopus 로고    scopus 로고
    • Novel strategies to retard renal disease progression: Combining ACE inhibition with endothelin receptor blocking?
    • Benigni A and Remuzzi G (1998) Novel strategies to retard renal disease progression: combining ACE inhibition with endothelin receptor blocking? Nephrol Dial Transplant 13: 2734-2738
    • (1998) Nephrol Dial Transplant , vol.13 , pp. 2734-2738
    • Benigni, A.1    Remuzzi, G.2
  • 127
    • 34247568331 scopus 로고    scopus 로고
    • What new drugs can nephrologists look forward to in the next year or two?
    • Harman C (2007) What new drugs can nephrologists look forward to in the next year or two? Nat Clin Pract Nephrol 3: 235
    • (2007) Nat Clin Pract Nephrol , vol.3 , pp. 235
    • Harman, C.1
  • 128
    • 50249089749 scopus 로고    scopus 로고
    • The SNP5333 gene polymorphism of endothelin A receptor is independently associated with increased albuminuria in type 2 diabetes
    • Presented at the, Bergamo, September 16-19, Bergamo, Italy
    • Orisio S et al. (2007) The SNP5333 gene polymorphism of endothelin A receptor is independently associated with increased albuminuria in type 2 diabetes. Presented at the 10th International Conference on Endothelin: 2007 Bergamo, September 16-19, Bergamo, Italy
    • (2007) 10th International Conference on Endothelin
    • Orisio, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.