메뉴 건너뛰기




Volumn 6, Issue 1, 2011, Pages 94-105

Silencing human cancer: Identification and uses of microRNAs

Author keywords

Cancer; Cancer diagnosis; Cancer therapy; Gene therapy; MicroRNA; MiRNA; MiRNA inhibitor; MiRNA mimic; MiRNA target; Patent; RNA interference; RNA silencing

Indexed keywords

ANTI MIRNA OLIGONUCLEOTIDE; ANTINEOPLASTIC AGENT; ANTISENSE OLIGONUCLEOTIDE; HEAT SHOCK PROTEIN 90 INHIBITOR; MICRORNA; MIR 101; MIR 16; RETINOIC ACID; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 78650927296     PISSN: 15748928     EISSN: None     Source Type: Journal    
DOI: 10.2174/157489211793980033     Document Type: Article
Times cited : (10)

References (141)
  • 2
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215-33
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 3
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993; 75: 843-54
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 5
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998; 391: 806-11
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 6
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel DP. MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell 2004; 116: 281-97
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 8
    • 0344668836 scopus 로고    scopus 로고
    • Human let-7 stem-loop precursors harbor features of RNase III cleavage products
    • Basyuk E, Suavet F, Doglio A, Bordonne R, Bertrand E. Human let-7 stem-loop precursors harbor features of RNase III cleavage products. Nucleic Acids Res 2003; 31: 6593-7
    • (2003) Nucleic Acids Res , vol.31 , pp. 6593-6597
    • Basyuk, E.1    Suavet, F.2    Doglio, A.3    Bordonne, R.4    Bertrand, E.5
  • 9
    • 4644242349 scopus 로고    scopus 로고
    • RNA silencing in plants
    • Baulcombe D. RNA silencing in plants. Nature 2004; 431: 356-63
    • (2004) Nature , vol.431 , pp. 356-363
    • Baulcombe, D.1
  • 13
    • 10344248903 scopus 로고    scopus 로고
    • The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis
    • Landthaler M, Yalcin A, Tuschl T. The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis. Curr Biol 2004; 14: 2162-7
    • (2004) Curr Biol , vol.14 , pp. 2162-2167
    • Landthaler, M.1    Yalcin, A.2    Tuschl, T.3
  • 14
    • 0141843656 scopus 로고    scopus 로고
    • The nuclear RNase III Drosha initiates microRNA processing
    • Lee Y, Ahn C, Han J, Choi H, Kim J, Yim J, et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 2003; 425: 415-9
    • (2003) Nature , vol.425 , pp. 415-419
    • Lee, Y.1    Ahn, C.2    Han, J.3    Choi, H.4    Kim, J.5    Yim, J.6
  • 15
    • 0037273432 scopus 로고    scopus 로고
    • Sequence requirements for micro RNA processing and function in human cells
    • Zeng Y, Cullen BR. Sequence requirements for micro RNA processing and function in human cells. RNA 2003; 9: 112-23
    • (2003) RNA , vol.9 , pp. 112-123
    • Zeng, Y.1    Cullen, B.R.2
  • 17
    • 0347361541 scopus 로고    scopus 로고
    • Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs
    • Yi R, Qin Y, Macara IG, Cullen BR. Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev 2003; 17: 3011-6
    • (2003) Genes Dev , vol.17 , pp. 3011-3016
    • Yi, R.1    Qin, Y.2    Macara, I.G.3    Cullen, B.R.4
  • 18
    • 28444433734 scopus 로고    scopus 로고
    • Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interferencerelated genes
    • Grishok A, Sharp PA. Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interferencerelated genes. Proc Natl Acad Sci USA 2005; 102: 17360-5
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 17360-17365
    • Grishok, A.1    Sharp, P.A.2
  • 19
    • 0037144546 scopus 로고    scopus 로고
    • A microRNA in a multiple-turnover RNAi enzyme complex
    • Hutvagner G, Zamore PD. A microRNA in a multiple-turnover RNAi enzyme complex. Science 2002; 297: 2056-60
    • (2002) Science , vol.297 , pp. 2056-2060
    • Hutvagner, G.1    Zamore, P.D.2
  • 21
    • 33645763485 scopus 로고    scopus 로고
    • Cleavage of the siRNA passenger strand during RISC assembly in human cells
    • Leuschner PJ, Ameres SL, Kueng S, Martinez J. Cleavage of the siRNA passenger strand during RISC assembly in human cells. EMBO Rep 2006; 7: 314-20
    • (2006) EMBO Rep , vol.7 , pp. 314-320
    • Leuschner, P.J.1    Ameres, S.L.2    Kueng, S.3    Martinez, J.4
  • 22
    • 27744590896 scopus 로고    scopus 로고
    • Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
    • Matranga C, Tomari Y, Shin C, Bartel DP, Zamore PD. Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes. Cell 2005; 123: 607-20
    • (2005) Cell , vol.123 , pp. 607-620
    • Matranga, C.1    Tomari, Y.2    Shin, C.3    Bartel, D.P.4    Zamore, P.D.5
  • 23
    • 27744506761 scopus 로고    scopus 로고
    • Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation
    • Rand TA, Petersen S, Du F, Wang X. Argonaute2 cleaves the anti-guide strand of siRNA during RISC activation. Cell 2005; 123: 621-9
    • (2005) Cell , vol.123 , pp. 621-629
    • Rand, T.A.1    Petersen, S.2    Du, F.3    Wang, X.4
  • 25
    • 0037031576 scopus 로고    scopus 로고
    • Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
    • Martinez J, Patkaniowska A, Urlaub H, Luhrmann R, Tuschl T. Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell 2002; 110: 563-74
    • (2002) Cell , vol.110 , pp. 563-574
    • Martinez, J.1    Patkaniowska, A.2    Urlaub, H.3    Luhrmann, R.4    Tuschl, T.5
  • 27
    • 0036792769 scopus 로고    scopus 로고
    • Fragile X-related protein and VIG associate with the RNA interference machinery
    • Caudy AA, Myers M, Hannon GJ, Hammond SM. Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev 2002; 16: 2491-6
    • (2002) Genes Dev , vol.16 , pp. 2491-2496
    • Caudy, A.A.1    Myers, M.2    Hannon, G.J.3    Hammond, S.M.4
  • 28
    • 0036791671 scopus 로고    scopus 로고
    • A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins
    • Ishizuka A, Siomi MC, Siomi H. A Drosophila fragile X protein interacts with components of RNAi and ribosomal proteins. Genes Dev 2002; 16: 2497-508
    • (2002) Genes Dev , vol.16 , pp. 2497-2508
    • Ishizuka, A.1    Siomi, M.C.2    Siomi, H.3
  • 29
    • 0142165224 scopus 로고    scopus 로고
    • Functional siRNAs siRNAs and miRNAs exhibit strand bias
    • Khvorova A, Reynolds A, Jayasena S.D. Functional siRNAs siRNAs and miRNAs exhibit strand bias. Cell 2003; 115: 209-16
    • (2003) Cell , vol.115 , pp. 209-216
    • Khvorova, A.1    Reynolds, A.2    Jayasena, S.D.3
  • 31
    • 0037085968 scopus 로고    scopus 로고
    • Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation
    • Seggerson K, Tang L, Moss EG. Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation. Dev Biol 2002; 243: 215-25
    • (2002) Dev Biol , vol.243 , pp. 215-225
    • Seggerson, K.1    Tang, L.2    Moss, E.G.3
  • 32
    • 28044457883 scopus 로고    scopus 로고
    • MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function
    • Humphreys DT, Westman BJ, Martin DI, Preiss T. MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function. Proc Natl Acad Sci USA 2005; 102: 16961-6
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 16961-16966
    • Humphreys, D.T.1    Westman, B.J.2    Martin, D.I.3    Preiss, T.4
  • 33
    • 34547944309 scopus 로고    scopus 로고
    • MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F
    • Mathonnet G, Fabian MR, Svitkin YV, Parsyan A, Huck L, Murata T, et al. MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science 2007; 317: 1764-7
    • (2007) Science , vol.317 , pp. 1764-1767
    • Mathonnet, G.1    Fabian, M.R.2    Svitkin, Y.V.3    Parsyan, A.4    Huck, L.5    Murata, T.6
  • 35
    • 33646522366 scopus 로고    scopus 로고
    • Recapitulation of short RNA-directed translational gene silencing in vitro
    • Wang B, Love TM, Call ME, Doench JG, Novina CD. Recapitulation of short RNA-directed translational gene silencing in vitro. Mol Cell 2006; 22: 553-60
    • (2006) Mol Cell , vol.22 , pp. 553-560
    • Wang, B.1    Love, T.M.2    Call, M.E.3    Doench, J.G.4    Novina, C.D.5
  • 36
    • 20444427566 scopus 로고    scopus 로고
    • Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies
    • Sen GL, Blau HM. Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. Nat Cell Biol 2005; 7: 633-6
    • (2005) Nat Cell Biol , vol.7 , pp. 633-636
    • Sen, G.L.1    Blau, H.M.2
  • 37
    • 22144432980 scopus 로고    scopus 로고
    • RNAi and the P-body connection
    • Rossi JJ. RNAi and the P-body connection. Nat Cell Biol 2005; 7: 643-4
    • (2005) Nat Cell Biol , vol.7 , pp. 643-644
    • Rossi, J.J.1
  • 38
    • 22144478256 scopus 로고    scopus 로고
    • MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
    • Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R. MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol 2005; 7: 719-23
    • (2005) Nat Cell Biol , vol.7 , pp. 719-723
    • Liu, J.1    Valencia-Sanchez, M.A.2    Hannon, G.J.3    Parker, R.4
  • 39
    • 3943051423 scopus 로고    scopus 로고
    • Eukaryotic mRNA decapping
    • Coller J, Parker R. Eukaryotic mRNA decapping. Annu Rev Biochem 2004; 73: 861-90
    • (2004) Annu Rev Biochem , vol.73 , pp. 861-890
    • Coller, J.1    Parker, R.2
  • 40
    • 23944514849 scopus 로고    scopus 로고
    • Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation
    • Bagga S, Bracht J, Hunter S, Massirer K, Holtz J, Eachus R, et al. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 2005; 122: 553-63
    • (2005) Cell , vol.122 , pp. 553-563
    • Bagga, S.1    Bracht, J.2    Hunter, S.3    Massirer, K.4    Holtz, J.5    Eachus, R.6
  • 41
    • 41649115420 scopus 로고    scopus 로고
    • GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay
    • Eulalio A, Huntzinger E, Izaurralde E. GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay. Nat Struct Mol Biol 2008; 15: 346-53
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 346-353
    • Eulalio, A.1    Huntzinger, E.2    Izaurralde, E.3
  • 42
    • 34250646697 scopus 로고    scopus 로고
    • Molecular mechanism of target RNA transcript recognition by Argonaute-guide complexes
    • Parker JS, Roe SM, Barford D. Molecular mechanism of target RNA transcript recognition by Argonaute-guide complexes. Cold Spring Harb Symp Quant Biol 2006; 71: 45-50
    • (2006) Cold Spring Harb Symp Quant Biol , vol.71 , pp. 45-50
    • Parker, J.S.1    Roe, S.M.2    Barford, D.3
  • 43
    • 32444436121 scopus 로고    scopus 로고
    • Short RNAs repress translation after initiation in mammalian cells
    • Petersen CP, Bordeleau ME, Pelletier J, Sharp PA. Short RNAs repress translation after initiation in mammalian cells. Mol Cell 2006; 21: 533-42
    • (2006) Mol Cell , vol.21 , pp. 533-542
    • Petersen, C.P.1    Bordeleau, M.E.2    Pelletier, J.3    Sharp, P.A.4
  • 44
    • 33748928159 scopus 로고    scopus 로고
    • The diverse functions of microRNAs in animal development and disease
    • Kloosterman WP, Plasterk RH. The diverse functions of microRNAs in animal development and disease. Dev Cell 2006; 11: 441-50
    • (2006) Dev Cell , vol.11 , pp. 441-450
    • Kloosterman, W.P.1    Plasterk, R.H.2
  • 45
    • 40349100260 scopus 로고    scopus 로고
    • MicroRNAs and cancer
    • Dalmay T. MicroRNAs and cancer. J Intern Med 2008; 263: 366-75
    • (2008) J Intern Med , vol.263 , pp. 366-375
    • Dalmay, T.1
  • 46
    • 73349125465 scopus 로고    scopus 로고
    • MicroRNAs in cancer: Small molecules with a huge impact
    • Iorio MV, Croce CM. MicroRNAs in cancer: Small molecules with a huge impact. J Clin Oncol 2009; 27: 5848-56
    • (2009) J Clin Oncol , vol.27 , pp. 5848-5856
    • Iorio, M.V.1    Croce, C.M.2
  • 48
    • 34547116839 scopus 로고    scopus 로고
    • Defining embryonic stem cell identity using differentiation-related microRNAs and their potential targets
    • Chen C, Ridzon D, Lee CT, Blake J, Sun Y, Strauss WM. Defining embryonic stem cell identity using differentiation-related microRNAs and their potential targets. Mamm Genome. Mamm Genome 2007; 18: 316-27
    • (2007) Mamm Genome , vol.18 , pp. 316-327
    • Chen, C.1    Ridzon, D.2    Lee, C.T.3    Blake, J.4    Sun, Y.5    Strauss, W.M.6
  • 51
    • 41749113108 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    • Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Allgayer H. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008; 27: 2128-36
    • (2008) Oncogene , vol.27 , pp. 2128-2136
    • Asangani, I.A.1    Rasheed, S.A.2    Nikolova, D.A.3    Leupold, J.H.4    Colburn, N.H.5    Allgayer, H.6
  • 52
    • 58149240996 scopus 로고    scopus 로고
    • The inhibition of the highly expressed miR221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice
    • Mercatelli N, Coppola V, Bonci D, Miele F, Costantini A, Guadagnoli M, et al. The inhibition of the highly expressed miR221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice. PLoS ONE 2008; 3: e4029
    • (2008) PLoS ONE , vol.3
    • Mercatelli, N.1    Coppola, V.2    Bonci, D.3    Miele, F.4    Costantini, A.5    Guadagnoli, M.6
  • 54
    • 33644819964 scopus 로고    scopus 로고
    • Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
    • Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K, Yi M, et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006; 9: 189-98
    • (2006) Cancer Cell , vol.9 , pp. 189-198
    • Yanaihara, N.1    Caplen, N.2    Bowman, E.3    Seike, M.4    Kumamoto, K.5    Yi, M.6
  • 55
    • 38749089854 scopus 로고    scopus 로고
    • MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma
    • Schetter AJ, Leung SY, Sohn JJ, Zanetti KA, Bowman ED, Yanaihara N, et al. MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA 2008; 299: 425-36
    • (2008) JAMA , vol.299 , pp. 425-436
    • Schetter, A.J.1    Leung, S.Y.2    Sohn, J.J.3    Zanetti, K.A.4    Bowman, E.D.5    Yanaihara, N.6
  • 56
    • 78349293460 scopus 로고    scopus 로고
    • Biomarker assessment in nutritional modulation of oxidative stress-induced cancer development by lipid-related bioactive molecules
    • Defago MD, Soria EA. Biomarker assessment in nutritional modulation of oxidative stress-induced cancer development by lipid-related bioactive molecules. Recent Pat Anticancer Drug Discov 2010; 5(3): 188-96
    • (2010) Recent Pat Anticancer Drug Discov , vol.5 , Issue.3 , pp. 188-196
    • Defago, M.D.1    Soria, E.A.2
  • 79
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2002; 99: 15524-9
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3    Bichi, R.4    Zupo, S.5    Noch, E.6
  • 82
    • 2142654329 scopus 로고    scopus 로고
    • MicroRNA-directed cleavage of HOXB8 mRNA
    • Yekta S, Shih IH, Bartel DP. MicroRNA-directed cleavage of HOXB8 mRNA. Science 2004; 304: 594-6
    • (2004) Science , vol.304 , pp. 594-596
    • Yekta, S.1    Shih, I.H.2    Bartel, D.P.3
  • 88
    • 33750318273 scopus 로고    scopus 로고
    • A guide through present computational approaches for the identification of mammalian microRNA targets
    • Sethupathy P, Megraw M, Hatzigeorgiou AG. A guide through present computational approaches for the identification of mammalian microRNA targets. Nat Methods 2006; 3: 881-6
    • (2006) Nat Methods , vol.3 , pp. 881-886
    • Sethupathy, P.1    Megraw, M.2    Hatzigeorgiou, A.G.3
  • 89
    • 40249106014 scopus 로고    scopus 로고
    • Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver
    • Elmen J, Lindow M, Silahtaroglu A, Bak M, Christensen M, Lind-Thomsen A, et al. Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver. Nucleic Acids Res 2008; 36: 1153-62
    • (2008) Nucleic Acids Res , vol.36 , pp. 1153-1162
    • Elmen, J.1    Lindow, M.2    Silahtaroglu, A.3    Bak, M.4    Christensen, M.5    Lind-Thomsen, A.6
  • 90
    • 37649021046 scopus 로고    scopus 로고
    • Identification of human microRNA targets from isolated argonaute protein complexes
    • Beitzinger M, Peters L, Zhu JY, Kremmer E, Meister G. Identification of human microRNA targets from isolated argonaute protein complexes. RNA Biol 2007; 4: 76-84
    • (2007) RNA Biol , vol.4 , pp. 76-84
    • Beitzinger, M.1    Peters, L.2    Zhu, J.Y.3    Kremmer, E.4    Meister, G.5
  • 98
    • 33745599493 scopus 로고    scopus 로고
    • GTI-2501, an antisense agent targeting R1, the large subunit of human ribonucleotide reductase, shows potent anti-tumor activity against a variety of tumors
    • Lee Y, Vassilakos A, Feng N, Jin H, Wang M, Xiong K, et al. GTI-2501, an antisense agent targeting R1, the large subunit of human ribonucleotide reductase, shows potent anti-tumor activity against a variety of tumors. Int J Oncol 2006; 28: 469-78
    • (2006) Int J Oncol , vol.28 , pp. 469-478
    • Lee, Y.1    Vassilakos, A.2    Feng, N.3    Jin, H.4    Wang, M.5    Xiong, K.6
  • 99
    • 0033780376 scopus 로고    scopus 로고
    • Effective targeted gene 'knockdown' in zebrafish
    • Nasevicius A, Ekker SC. Effective targeted gene 'knockdown' in zebrafish. Nat Genet 2000; 26: 216-20
    • (2000) Nat Genet , vol.26 , pp. 216-220
    • Nasevicius, A.1    Ekker, S.C.2
  • 100
    • 0034721317 scopus 로고    scopus 로고
    • Inhibition of Craf expression by antisense oligonucleotides extends heart allograft survival in rats
    • Stepkowski SM, Qu X, Wang ME, Tian L, Chen W, Wancewicz EV, et al. Inhibition of Craf expression by antisense oligonucleotides extends heart allograft survival in rats. Transplantation 2000; 70: 656-61
    • (2000) Transplantation , vol.70 , pp. 656-661
    • Stepkowski, S.M.1    Qu, X.2    Wang, M.E.3    Tian, L.4    Chen, W.5    Wancewicz, E.V.6
  • 101
    • 20044384728 scopus 로고    scopus 로고
    • Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism
    • Watts LM, Manchem VP, Leedom TA, Rivard AL, McKay RA, Bao D, et al. Reduction of hepatic and adipose tissue glucocorticoid receptor expression with antisense oligonucleotides improves hyperglycemia and hyperlipidemia in diabetic rodents without causing systemic glucocorticoid antagonism. Diabetes 2005; 54: 1846-53
    • (2005) Diabetes , vol.54 , pp. 1846-1853
    • Watts, L.M.1    Manchem, V.P.2    Leedom, T.A.3    Rivard, A.L.4    McKay, R.A.5    Bao, D.6
  • 102
    • 23044450772 scopus 로고    scopus 로고
    • Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice
    • Yu XX, Murray SF, Pandey SK, Booten SL, Bao D, Song XZ, et al. Antisense oligonucleotide reduction of DGAT2 expression improves hepatic steatosis and hyperlipidemia in obese mice. Hepatology 2005; 42: 362-71
    • (2005) Hepatology , vol.42 , pp. 362-371
    • Yu, X.X.1    Murray, S.F.2    Pandey, S.K.3    Booten, S.L.4    Bao, D.5    Song, X.Z.6
  • 105
    • 13944282215 scopus 로고    scopus 로고
    • Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    • Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM, Castle J, et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 2005; 433: 769-73
    • (2005) Nature , vol.433 , pp. 769-773
    • Lim, L.P.1    Lau, N.C.2    Garrett-Engele, P.3    Grimson, A.4    Schelter, J.M.5    Castle, J.6
  • 115
    • 67649403741 scopus 로고    scopus 로고
    • RNA Interference (RNAi) Patents and human health related applications of RNAi
    • Alexander E. RNA Interference (RNAi) Patents and human health related applications of RNAi. Recent Pat DNA Gene Seq 2007; 1: 128-33
    • (2007) Recent Pat DNA Gene Seq , vol.1 , pp. 128-133
    • Alexander, E.1
  • 116
    • 42249115702 scopus 로고    scopus 로고
    • Recent patents relating to siRNAs and therapeutic strategies for genetic diseases
    • Grinberg D. Recent patents relating to siRNAs and therapeutic strategies for genetic diseases. Recent Pat DNA Gene Seq 2008; 2: 40-3
    • (2008) Recent Pat DNA Gene Seq , vol.2 , pp. 40-43
    • Grinberg, D.1
  • 117
    • 67649409312 scopus 로고    scopus 로고
    • Recent patents on the identification and clinical application of microRNAs and target genes
    • Wang M, Xie H, Mi S, Chen J. Recent patents on the identification and clinical application of microRNAs and target genes. Recent Pat DNA Gene Seq 2007; 1: 116-24
    • (2007) Recent Pat DNA Gene Seq , vol.1 , pp. 116-124
    • Wang, M.1    Xie, H.2    Mi, S.3    Chen, J.4
  • 118
    • 67649407882 scopus 로고    scopus 로고
    • Potential of recombinant SV40-based vectors for gene therapy
    • Buscail L, Cordelier P. Potential of recombinant SV40-based vectors for gene therapy. Recent Pat DNA Gene Seq 2007; 1: 93-9
    • (2007) Recent Pat DNA Gene Seq , vol.1 , pp. 93-99
    • Buscail, L.1    Cordelier, P.2
  • 121
    • 2542626605 scopus 로고    scopus 로고
    • Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival
    • Takamizawa J, Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, et al. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res 2004; 64: 3753-6
    • (2004) Cancer Res , vol.64 , pp. 3753-3756
    • Takamizawa, J.1    Konishi, H.2    Yanagisawa, K.3    Tomida, S.4    Osada, H.5    Endoh, H.6
  • 123
    • 27544495514 scopus 로고    scopus 로고
    • A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation
    • Hayashita Y, Osada H, Tatematsu Y, Yamada H, Yanagisawa K, Tomida S, et al. A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferation. Cancer Res 2005; 65: 9628-32
    • (2005) Cancer Res , vol.65 , pp. 9628-9632
    • Hayashita, Y.1    Osada, H.2    Tatematsu, Y.3    Yamada, H.4    Yanagisawa, K.5    Tomida, S.6
  • 129
    • 22244467087 scopus 로고    scopus 로고
    • MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    • Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 2005; 65: 6029-33
    • (2005) Cancer Res , vol.65 , pp. 6029-6033
    • Chan, J.A.1    Krichevsky, A.M.2    Kosik, K.S.3
  • 131
    • 35148886434 scopus 로고    scopus 로고
    • Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    • Ma L, Teruya-Feldstein J, Weinberg RA. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007; 449: 682-8
    • (2007) Nature , vol.449 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.