The chemokine system: A possible therapeutic target in acute graft versus host disease

Current Topics in Microbiology and Immunology

Volumn 341, Issue 1, 2010, Pages 97-120

  Kittan, Nicolai A ^a   Hildebrandt, Gerhard C ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CCL1 CHEMOKINE; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR9; CHEMOKINE RECEPTOR CXCR2; CHEMOKINE RECEPTOR CXCR6; CXCL1 CHEMOKINE; CXCL11 CHEMOKINE; CXCL13 CHEMOKINE; CXCL14 CHEMOKINE; CXCL2 CHEMOKINE; CXCL3 CHEMOKINE; CXCL9 CHEMOKINE; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; FRACTALKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE CHEMOTACTIC PROTEIN 2; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; MONOCYTE CHEMOTACTIC PROTEIN 5; RANTES; STROMAL CELL DERIVED FACTOR 1;

ACUTE GRAFT VERSUS HOST DISEASE; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ARTICLE; CELL INFILTRATION; CHRONIC GRAFT VERSUS HOST DISEASE; DISEASE SEVERITY; GASTROINTESTINAL TRACT; HEMOGLOBINOPATHY; HUMAN; IMMUNE RESPONSE; IMMUNOSUPPRESSIVE TREATMENT; LEUKEMIA; LIVER; LUNG; LYMPHOCYTE; LYMPHOMA; MULTIPLE MYELOMA; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SKIN; STORAGE DISEASE; ANIMAL; DRUG ANTAGONISM; GRAFT VERSUS HOST REACTION; HEMATOLOGIC DISEASE; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY; METABOLISM; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; CHEMOKINES; GRAFT VS HOST DISEASE; HEMATOLOGIC DISEASES; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; RECEPTORS, CHEMOKINE; SIGNAL TRANSDUCTION;

EID: 78650704919     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/82-2010-23     Document Type: Article

References (162)

1. Addison CL, Daniel TO, Burdick MD, Liu H, Ehlert JE, Xue YY et al (2000) The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR + CXC chemokine-induced angiogenic activity. J Immunol 165(9):5269-5277
2. Allen SJ, Crown SE, Handel TM (2007) Chemokine: Receptor structure, interactions, and antagonism. Annu Rev Immunol 25:787-820 (Pubitemid 46697924)
3. Ambruzova Z, Mrazek F, Raida L, Jindra P, Vidan-Jeras B, Faber E et al (2009a) Association of IL6 and CCL2 gene polymorphisms with the outcome of allogeneic haematopoietic stem cell transplantation. Bone Marrow Transplant 44(4):227-235
4. Ambruzova Z, Mrazek F, Raida L, Stahelova A, Faber E, Indrak K et al (2009b) Possible impact of MADCAM1 gene single nucleotide polymorphisms to the outcome of allogeneic hematopoietic stem cell transplantation. Hum Immunol 70(6):457-460
5. Baird K, Pavletic SZ (2006) Chronic graft versus host disease. Curr Opin Hematol 13(6):426-435 (Pubitemid 44607443)
6. Barrett AJ (1997) Mechanisms of the graft-versus-leukemia reaction. Stem Cells 15(4):248-258 (Pubitemid 27315328)
7. Beilhack A, Schulz S, Baker J, Beilhack GF, Wieland CB, Herman EI et al (2005) In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets. Blood 106(3):1113-1122 (Pubitemid 41076462)
8. Belperio JA, Keane MP, Arenberg DA, Addison CL, Ehlert JE, Burdick MD et al (2000) CXC chemokines in angiogenesis. J Leukoc Biol 68(1):1-8
9. Belperio JA, Keane MP, Burdick MD, Lynch JP 3rd, Xue YY, Berlin A et al (2001) Critical role for the chemokine MCP-1/CCR2 in the pathogenesis of bronchiolitis obliterans syndrome. J Clin Invest 108(4):547-556 (Pubitemid 32777734)
10. Belperio JA, Keane MP, Burdick MD, Lynch JP 3rd, Xue YY, Li K et al (2002) Critical role for CXCR3 chemokine biology in the pathogenesis of bronchiolitis obliterans syndrome. J Immunol 169(2):1037-1049 (Pubitemid 34753464)
11. Belperio JA, Keane MP, Burdick MD, Lynch JP 3rd, Zisman DA, Xue YY et al (2003) Role of CXCL9/CXCR3 chemokine biology during pathogenesis of acute lung allograft rejection. J Immunol 171(9):4844-4852 (Pubitemid 37310606)
12. Belperio JA, Keane MP, Burdick MD, Gomperts B, Xue YY, Hong K et al (2005) Role of CXCR2/ CXCR2 ligands in vascular remodeling during bronchiolitis obliterans syndrome. J Clin Invest 115(5):1150-1162 (Pubitemid 40629034)
13. Bogunia-Kubik K, Duda D, Suchnicki K, Lange A (2006) CCR5 deletion mutation and its association with the risk of developing acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. Haematologica 91(12):1628-1634 (Pubitemid 46032960)
14. Bolanos-Meade J, Chien J (2009) Chronic graft-versus-host disease and the lung. In: Vogelsang GB, Pavletic SZ (eds) Chronic graft-versus-host disease. Cambridge University Press, UK, pp 229-237
15. Bouazzaoui A, Spacenko E, Mueller G, Miklos S, Huber E, Holler E et al (2009) Chemokine and chemokine receptor expression analysis in target organs of acute graft-versus-host disease. Genes Immun 10(8):687-701
16. Breathnach SM, Katz SI (1987) Immunopathology of cutaneous graft-versus-host disease. Am J Dermatopathol 9(4):343-348 (Pubitemid 17155097)
17. Broxmeyer HE (2008) Chemokines in hematopoiesis. Curr Opin Hematol 15(1):49-58 (Pubitemid 350191028)
18. Cahn JY, Klein JP, Lee SJ, Milpied N, Blaise D, Antin JH et al (2005) Prospective evaluation of 2 acute graft-versus-host (GVHD) grading systems: A joint Societe Francaise de Greffe de Moelle et Therapie Cellulaire (SFGM-TC), Dana Farber Cancer Institute (DFCI), and International Bone Marrow Transplant Registry (IBMTR) prospective study. Blood 106 (4):1495-1500 (Pubitemid 41129621)
19. Campbell JJ, Hedrick J, Zlotnik A, Siani MA, Thompson DA, Butcher EC (1998) Chemokines and the arrest of lymphocytes rolling under flow conditions. Science 279(5349):381-384 (Pubitemid 28063373)
20. Champlin RE, Schmitz N, Horowitz MM, Chapuis B, Chopra R, Cornelissen JJ et al (2000) Blood stem cells compared with bone marrow as a source of hematopoietic cells for allogeneic transplantation. IBMTR Histocompatibility and Stem Cell Sources Working Committee and the European Group for Blood and Marrow Transplantation (EBMT). Blood 95(12):3702-3709 (Pubitemid 30412840)
21. Choi SW, Hildebrandt GC, Olkiewicz KM, Hanauer DA, Chaudhary MN, Silva IA et al (2007) CCR1/CCL5 (RANTES) receptor-ligand interactions modulate allogeneic T-cell responses and graft-versus-host disease following stem-cell transplantation. Blood 110(9):3447-3455 (Pubitemid 350106341)
22. Chu YW, Gress RE (2008) Murine models of chronic graft-versus-host disease: Insights and unresolved issues. Biol Blood Marrow Transplant 14(4):365-378
23. Clark J, Hansen J, Hertz M, Parkman R, Jensen L, Peavy H (1993) Idiopathic pneumonia syndrome after bone marrow transplantation. Am Rev Respir Dis 147:1601-1606 (Pubitemid 23160570)
24. Clark JG, Madtes DK, Hackman RC, Chen W, Cheever MA, Martin PJ (1998) Lung injury induced by alloreactive Th1 cells is characterized by host-derived mononuclear cell inflammation and activation of alveolar macrophages. J Immunol 161:1913-1920 (Pubitemid 28387614)
25. Constantin G, Majeed M, Giagulli C, Piccio L, Kim JY, Butcher EC et al (2000) Chemokines trigger immediate beta2 integrin affinity and mobility changes: Differential regulation and roles in lymphocyte arrest under flow. Immunity 13(6):759-769 (Pubitemid 32041799)
26. Cooke KR, Hildebrandt GC (2006) Pulmonary toxicity following hematopoietic cell transplantation: Is the lung a target organ of graft-versus-host disease? Curr Opin Organ Transplant 11 (1):69-77
27. Cooke KR, Krenger W, Hill G, Martin TR, Kobzik L, Brewer J et al (1998) Host reactive donor T cells are associated with lung injury after experimental allogeneic bone marrow transplantation. Blood 92(7):2571-2580 (Pubitemid 28453002)
28. Cooke KR, Hill GR, Gerbitz A, Kobzik L, Martin TR, Crawford JM et al (2000) Hyporesponsiveness of donor cells to lipopolysaccharide stimulation reduces the severity of experimental idiopathic pneumonia syndrome: Potential role for a gut-lung axis of inflammation. J Immunol 165(11):6612-6619
29. Crawford S, Hackman R (1993) Clinical course of idiopathic pneumonia after bone marrow transplantation. Am Rev Respir Dis 147:1393
30. Crawford S, Longton G, Storb R (1993) Acute graft-versus-host disease and the risks for idiopathic pneumonia after marrow transplantation for severe aplastic anemia. Bone Marrow Transplant 12:225
31. Cutler C, Giri S, Jeyapalan S, Paniagua D, Viswanathan A, Antin JH (2001) Acute and chronic graft-versus-host disease after allogeneic peripheral-blood stem-cell and bone marrow transplantation: A meta-analysis. J Clin Oncol 19(16):3685-3691 (Pubitemid 32786281)
32. Czermak BJ, Sarma V, Bless NM, Schmal H, Friedl HP, Ward PA (1999) In vitro and in vivo dependency of chemokine generation on C5a and TNF-alpha. J Immunol 162(4):2321-2325 (Pubitemid 29288857)
33. Datta AR, Barrett AJ, Jiang YZ, Guimaraes A, Mavroudis DA (1994) Distant T cell populations distinguish chronic myeloid leulaemia cells from lymphocytes in the same individual: A model for separating GVHD from GVL reactions. Bone Marrow Transplant 14:517-524 (Pubitemid 24338476)
34. Derk CT, Jimenez SA (2003) Systemic sclerosis: Current views of its pathogenesis. Autoimmun Rev 2(4):181-191 (Pubitemid 36798101)
35. Duffner U, Lu B, Hildebrandt GC, Teshima T, Williams DL, Reddy P et al (2003) Role of CXCR3-induced donor T-cell migration in acute GVHD. Exp Hematol 31(10):897-902 (Pubitemid 37211374)
36. Emile JF, Haddad E, Fraitag S, Canioni D, Fischer A, Brousse N (1997) Detection of donorderived Langerhans cells in MHC class II immunodeficient patients after allogeneic bone marrow transplantation. Br J Haematol 98(2):480-484 (Pubitemid 27345131)
37. Faaij CM, Lankester AC, Spierings E, Hoogeboom M, Bowman EP, Bierings M et al (2006) A possible role for CCL27/CTACK-CCR10 interaction in recruiting CD4 T cells to skin in human graft-versus-host disease. Br J Haematol 133(5):538-549
38. Ferrara JL, Levine JE, Reddy P, Holler E (2009) Graft-versus-host disease. Lancet 373 (9674):1550-1561
39. Filipovich AH, Weisdorf D, Pavletic S, Socie G, Wingard JR, Lee SJ et al (2005) National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biol Blood Marrow Transplant 11(12):945-956 (Pubitemid 41754712)
40. Flier J, Boorsma DM, van Beek PJ, Nieboer C, Stoof TJ, Willemze R et al (2001) Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation. J Pathol 194(4):398-405 (Pubitemid 32782663)
41. Forster R, Davalos-Misslitz AC, Rot A (2008) CCR7 and its ligands: Balancing immunity and tolerance. Nat Rev 8(5):362-371 (Pubitemid 351595218)
42. Fowler DH, Gress RE (2000) Th2 and Tc2 cells in the regulation of GVHD, GVL, and graft rejection: Considerations for the allogeneic transplantation therapy of leukemia and lymphoma. Leuk Lymphoma 38(3-4):221-234 (Pubitemid 30303657)
43. Fowler DH, Breglio J, Nagel G, Eckhaus MA, Gress RE (1996) Allospecific CD8+ Tc1 and Tc2 populations in GVL and GVHD. J Immunol 157:4811
44. Fowler DH, Breglio J, Nagel G, Gress RE (1997) Allospecific CD4+ Th1/Th2 and CD8+ Tc1/Tc2 populations in murine GVL: Type I cells generate GVL, type II cells abrogate GVL. Biol Blood Marrow Transplant 2:118
45. Fox DJ, Reckless J, Lingard H, Warren S, Grainger DJ (2009) Highly potent, orally available antiinflammatory broad-spectrum chemokine inhibitors. J Med Chem 52(11):3591-3595
46. Freudenberger TD, Madtes DK, Curtis JR, Cummings P, Storer BE, Hackman RC (2003) Association between acute and chronic graft-versus-host disease and bronchiolitis obliterans organizing pneumonia in recipients of hematopoietic stem cell transplants. Blood 102 (10):3822-3828 (Pubitemid 37409407)
47. Goker H, Haznedaroglu IC, Chao NJ (2001) Acute graft-vs-host disease: Pathobiology and management. Exp Hematol 29(3):259-277 (Pubitemid 32223460)
48. Goulmy E, Schipper R, Pool J, Blokland E, Falkenburg F (1996) Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantation. N Engl J Med 334(5): 281-285 (Pubitemid 26033083)
49. Grainger DJ, Reckless J (2003) Broad-spectrum chemokine inhibitors (BSCIs) and their antiinflammatory effects in vivo. Biochem Pharmacol 65(7):1027-1034 (Pubitemid 36349742)
50. Gruhn B, Intek J, Pfaffendorf N, Zell R, Corbacioglu S, Zintl F et al (2009) Polymorphism of interleukin-23 receptor gene but not of NOD2/CARD15 is associated with graft-versus-host disease after hematopoietic stem cell transplantation in children. Biol Blood Marrow Transplant 15(12):1571-1577
51. Hadeiba H, Sato T, Habtezion A, Oderup C, Pan J, Butcher EC (2008) CCR9 expression defines tolerogenic plasmacytoid dendritic cells able to suppress acute graft-versus-host disease. Nat Immunol 9(11):1253-1260
52. Hancock WW, Lu B, Gao W, Csizmadia V, Faia K, King JA et al (2000) Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J Exp Med 192(10):1515-1520
53. Hasegawa H, Inoue A, Kohno M, Lei J, Miyazaki T, Yoshie O et al (2008) Therapeutic effect of CXCR3-expressing regulatory T cells on liver, lung and intestinal damages in a murine acute GVHD model. Gene Ther 15(3):171-182 (Pubitemid 351175219)
54. He S, Cao Q, Qiu Y, Mi J, Zhang JZ, Jin M et al (2008) A new approach to the blocking of alloreactive T cell-mediated graft-versus-host disease by in vivo administration of anti-CXCR3 neutralizing antibody. J Immunol 181(11):7581-7592
55. Higman MA, Vogelsang GB (2004) Chronic graft-versus-host disease. Br J Haematol 125(4): 435-454
56. Hildebrandt GC, Olkiewitz KO, Corrion LA, Chang Y, Liu C, Ferrara JLM et al (2003) Secretion of TNF-alpha by donor effector cells is critical in the development of Idiopathic Pneumonia Syndrome after allogeneic stem cell transplantation. Blood 102(11):3529
57. Hildebrandt GC, Corrion LA, Olkiewicz KM, Lu B, Lowler K, Duffner UA et al (2004a) Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome. J Immunol 173(3):2050-2059 (Pubitemid 38971642)
58. Hildebrandt GC, Duffner UA, Olkiewicz KM, Corrion LA, Willmarth NE, Williams DL et al (2004b) A critical role for CCR2/MCP-1 interactions in the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. Blood 103(6):2417-2426 (Pubitemid 38326269)
59. Hildebrandt GC, Olkiewicz KM, Corrion LA, Chang Y, Clouthier SG, Liu C et al (2004c) Donorderived TNF-alpha regulates pulmonary chemokine expression and the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. Blood 104(2):586-593 (Pubitemid 38900046)
60. Hildebrandt GC, Olkiewicz KM, Choi S, Corrion LA, Clouthier SG, Liu C et al (2005) Donor T-cell production of RANTES significantly contributes to the development of idiopathic pneumonia syndrome after allogeneic stem cell transplantation. Blood 105(6):2249-2257 (Pubitemid 40387015)
61. Hildebrandt GC, Olkiewicz KM, Corrion L, Clouthier SG, Pierce EM, Liu C et al (2008) A role for TNF receptor type II in leukocyte infiltration into the lung during experimental idiopathic pneumonia syndrome. Biol Blood Marrow Transplant 14(4):385-396 (Pubitemid 351372746)
62. Hill GR, Crawford JM, Cooke KR, Brinson YS, Pan L, Ferrara JL (1997) Total body irradiation and acute graft-versus-host disease: The role of gastrointestinal damage and inflammatory cytokines. Blood 90(8):3204-3213 (Pubitemid 27444217)
63. Holler E, Rogler G, Herfarth H, Brenmoehl J, Wild PJ, Hahn J et al (2004) Both donor and recipient NOD2/CARD15 mutations associate with transplant-related mortality and GvHD following allogeneic stem cell transplantation. Blood 104(3):889-894 (Pubitemid 38970589)
64. Holler E, Rogler G, Brenmoehl J, Hahn J, Herfarth H, Greinix H et al (2006) Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: Effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination. Blood 107(10):4189-4193 (Pubitemid 43726832)
65. Hori T, Naishiro Y, Sohma H, Suzuki N, Hatakeyama N, Yamamoto M et al (2008) CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease. Blood 111 (8):4403-4412
66. Ichiba T, Teshima T, Kuick R, Misek DE, Liu C, Takada Y et al (2003) Early changes in gene expression profiles of hepatic GVHD uncovered by oligonucleotide microarrays. Blood 102(2):763-771 (Pubitemid 36842004)
67. Inamoto Y, Murata M, Katsumi A, Kuwatsuka Y, Tsujimura A, Ishikawa Y et al (2009) Donor single nucleotide polymorphism in the CCR9 gene affects the incidence of skin GVHD. Bone Marrow Transplant 45(2):363-369
68. Jaksch M, Remberger M, Mattsson J (2005) Increased gene expression of chemokine receptors is correlated with acute graft-versus-host disease after allogeneic stem cell transplantation. Biol Blood Marrow Transplant 11(4):280-287 (Pubitemid 40450755)
69. Kantrow SP, Hackman RC, Boeckh M, Myerson D, Crawford SW (1997) Idiopathic pneumonia syndrome: Changing spectrum of lung injury after marrow transplantation. Transplantation 63 (8):1079-1086 (Pubitemid 27190970)
70. Kaplan DH, Anderson BE, McNiff JM, Jain D, Shlomchik MJ, Shlomchik WD (2004) Target antigens determine graft-versus-host disease phenotype. J Immunol 173(9):5467-5475 (Pubitemid 39392131)
71. Kataoka Y, Iwasaki T, Kuroiwa T, Seto Y, Iwata N, Hashimoto N et al (2001) The role of donor T cells for target organ injuries in acute and chronic graft-versus-host disease. Immunology 103 (3):310-318 (Pubitemid 32626179)
72. Kim DH, Jung HD, Lee NY, Sohn SK (2007) Single nucleotide polymorphism of CC chemokine ligand 5 promoter gene in recipients may predict the risk of chronic graft-versus-host disease and its severity after allogeneic transplantation. Transplantation 84(7):917-925 (Pubitemid 351338954)
73. Koenecke C, Forster R (2009) CCR9 and inflammatory bowel disease. Expert Opin Ther Targets 13(3):297-306
74. Kolb HJ, Schmid C, Barrett AJ, Schendel DJ (2003) Graft-versus-leukemia reactions in allogeneic chimeras. Blood 103(3):767-776 (Pubitemid 38129531)
75. Kraetzel K, Stoelcker B, Eissner G, Multhoff G, Pfeifer M, Holler E et al (2008) NKG2Ddependent effector function of bronchial epithelium-activated alloreactive T-cells. Eur Respir J 32(3):563-570
76. Krowka MJ, Rosenow EC 3rd, Hoagland HC (1985) Pulmonary complications of bone marrow transplantation. Chest 87(2):237-246 (Pubitemid 15174060)
77. Lee SJ (2005) New approaches for preventing and treating chronic graft-versus-host disease. Blood 105(11):4200-4206 (Pubitemid 40720763)
78. Lieberman-Blum SS, Fung HB, Bandres JC (2008) Maraviroc: A CCR5-receptor antagonist for the treatment of HIV-1 infection. Clin Ther 30(7):1228-1250
79. Mackay CR (2001) Chemokines: Immunology's high impact factors. Nat Immunol 2(2):95-101 (Pubitemid 33707925)
80. MacMillan ML, Radloff GA, DeFor TE, Weisdorf DJ, Davies SM (2003a) Interleukin-1 genotype and outcome of unrelated donor bone marrow transplantation. Br J Haematol 121(4):597-604 (Pubitemid 36645381)
81. MacMillan ML, Radloff GA, Kiffmeyer WR, DeFor TE, Weisdorf DJ, Davies SM (2003b) Highproducer interleukin-2 genotype increases risk for acute graft-versus-host disease after unrelated donor bone marrow transplantation. Transplantation 76(12):1758-1762 (Pubitemid 38032426)
82. Mapara MY, Kim YM, Marx J, Sykes M (2003) Donor lymphocyte infusion-mediated graftversus- leukemia effects in mixed chimeras established with a nonmyeloablative conditioning regimen: Extinction of graft-versus- leukemia effects after conversion to full donor chimerism. Transplantation 76(2):297-305 (Pubitemid 36927988)
83. Mapara MY, Leng C, Kim YM, Bronson R, Lokshin A, Luster A et al (2006) Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR. Biol Blood Marrow Transplant 12(6):623-634
84. Markey KA, MacDonald KP, Hill GR (2008) Impact of cytokine gene polymorphisms on graft-vshost disease. Tissue Antigens 72(6):507-516
85. Martin PJ (2008) Biology of chronic graft-versus-host disease: Implications for a future therapeutic approach. Keio J Med 57(4):177-183
86. Merad M, Manz MG, Karsunky H, Wagers A, Peters W, Charo I et al (2002) Langerhans cells renew in the skin throughout life under steady-state conditions. Nat Immunol 3(12):1135-1141 (Pubitemid 35469697)
87. Merad M, Hoffmann P, Ranheim E, Slaymaker S, Manz MG, Lira SA et al (2004) Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graftversus- host disease. Nat Med 10(5):510-517 (Pubitemid 38667910)
88. Middleton PG, Taylor PR, Jackson G, Proctor SJ, Dickinson AM (1998) Cytokine gene polymorphisms associating with severe acute graft-versus-host disease in HLA-identical sibling transplants. Blood 92(10):3943-3948 (Pubitemid 28525221)
89. Miklos S, Mueller G, Chang Y, Schubert TE, Holler E, Hildebrandt GC (2008) Pulmonary function changes in experimental graft-versus-host disease of the lung. Biol Blood Marrow Transplant 14(9):1004-1016
90. Miklos S, Mueller G, Chang Y, Bouazzaoui A, Spacenko E, Schubert TE et al (2009) Preventive usage of broad spectrum chemokine inhibitor NR58-3.14.3 reduces the severity of pulmonary and hepatic graft-versus-host disease. Int J Hematol 89(3):383-397
91. Morita NI, Matsumura Y, Morita K, Miyachi Y (2007) Expression of CCR5 in graft-versus-host disease (GVHD) of the skin: Immunohistochemical staining of 38 cases. J Dermatol 34(4):254-257 (Pubitemid 46365247)
92. Moser B, Wolf M, Walz A, Loetscher P (2004) Chemokines: Multiple levels of leukocyte migration control. Trends Immunol 25(2):75-84 (Pubitemid 38167488)
93. Muller G, Hopken UE, Lipp M (2003) The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity. Immunol Rev 195:117-135 (Pubitemid 37153458)
94. Murai M, Yoneyama H, Harada A, Yi Z, Vestergaard C, Guo B et al (1999) Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease. J Clin Invest 104(1):49-57 (Pubitemid 29534344)
95. Murai M, Yoneyama H, Ezaki T, Suematsu M, Terashima Y, Harada A et al (2003) Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. Nat Immunol 4(2):154-160 (Pubitemid 36193017)
96. Murphy PM (2002) International Union of Pharmacology. XXX. Update on chemokine receptor nomenclature. Pharmacol Rev 54(2):227-229 (Pubitemid 34575712)
97. Murphy PM, Baggiolini M, Charo IF, Hebert CA, Horuk R, Matsushima K et al (2000) International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol Rev 52(1):145-176 (Pubitemid 30127598)
98. Nash RA, Storb R (1996) Graft-versus-host effect after allogeneic hematopoietic stem cell transplantation: GVHD and GVL. Curr Opin Immunol 8:674-680 (Pubitemid 26385397)
99. New JY, Li B, Koh WP, Ng HK, Tan SY, Yap EH et al (2002) T cell infiltration and chemokine expression: Relevance to the disease localization in murine graft-versus-host disease. Bone Marrow Transplant 29(12):979-986 (Pubitemid 34845953)
100. Nishimura M, Kuboi Y, Muramoto K, Kawano T, Imai T (2009) Chemokines as novel therapeutic targets for inflammatory bowel disease. Ann N Y Acad Sci 1173:350-356
101. Nishio N, Yagasaki H, Takahashi Y, Muramatsu H, Hama A, Tanaka M et al (2009) Late-onset non-infectious pulmonary complications following allogeneic hematopoietic stem cell transplantation in children. Bone Marrow Transplant 44(5):303-308
102. Oettel KR, Wesly OH, Albertini MR, Hank JA, Iliopolis O, Sosman JA et al (1994) Allogeneic T-cell clones able to selectively destroy Philadelphia chromosome-bearing (Ph1+) human leukemia lines can also recognize Ph1- cells from the same patient. Blood 83:3390-3402
103. Ohl L, Henning G, Krautwald S, Lipp M, Hardtke S, Bernhardt G et al (2003) Cooperating mechanisms of CXCR5 and CCR7 in development and organization of secondary lymphoid organs. J Exp Med 197(9):1199-1204 (Pubitemid 36570075)
104. Okamoto I, Kohno K, Tanimoto T, Iwaki K, Ishihara T, Akamatsu S et al (2000) IL-18 prevents the development of chronic graft-versus-host disease in mice. J Immunol 164(11):6067-6074 (Pubitemid 30389857)
105. Ota A, Yamamoto M, Hori T, Miyai S, Naishiro Y, Sohma H et al (2009) Upregulation of plasma CCL8 in mouse model of graft-vs-host disease. Exp Hematol 37(4):525-531
106. Palmer LA, Sale GE, Balogun JI, Li D, Jones D, Molldrem JJ et al (2009) Chemokine receptor CCR5 mediates allo-immune responses in Graft-vs-Host Disease. Biol Blood Marrow Transplant 16(3):311-319
107. Panoskaltsis-Mortari A, Taylor PA, Yaegar TM, Wangensteen OD, Bitterman PB, Ingbar DH et al (1997) The critical early proinflammatory events associated with idiopathic pneumonia syndrome in irradiated murine allogenic recipients are due to donor T cell infusion and potentiated by cyclophoshamide. J Clin Invest 100(5):1015-1027 (Pubitemid 27386285)
108. Panoskaltsis-Mortari A, Strieter RM, Hermanson JR, Fegeding KV, Murphy WJ, Farrell CL et al (2000) Induction of monocyte- and T-cell-attracting chemokines in the lung during the generation of idiopathic pneumonia syndrome following allogeneic murine bone marrow transplantation. Blood 96(3):834-839 (Pubitemid 30616843)
109. Panoskaltsis-Mortari A, Hermanson JR, Haddad IY, Wange nsteen OD, Blazar BR (2001) Intercellular adhesion molecule-I (ICAM-I, CD54) deficiency segregates the unique pathophysiological requirements for generating idiopathic pneumonia syndrome (IPS) versus graftversus- host disease following allogeneic murine bone marrow transplantation. Biol Blood Marrow Transplant 7(7):368-377 (Pubitemid 32799054)
110. Panoskaltsis-Mortari A, Hermanson JR, Taras E, Wangensteen OD, Serody JS, Blazar BR (2003) Acceleration of idiopathic pneumonia syndrome (IPS) in the absence of donor MIP-1 alpha (CCL3) after allogeneic BMT in mice. Blood 101(9):3714-3721 (Pubitemid 36857964)
111. Panoskaltsis-Mortari A, Hermanson JR, Taras E, Wangensteen OD, Charo IF, Rollins BJ et al (2004) Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells. Am J Physiol Lung Cell Mol Physiol 286(2):L284-L292 (Pubitemid 38129509)
112. Panoskaltsis-Mortari A, Tram KV, Price AP, Wendt CH, Blazar BR (2007) A new murine model for bronchiolitis obliterans post-bone marrow transplant. Am J Respir Crit Care Med 176 (7):713-723 (Pubitemid 47503080)
113. Papadakis KA, Prehn J, Moreno ST, Cheng L, Kouroumalis EA, Deem R et al (2001) CCR9- positive lymphocytes and thymus-expressed chemokine distinguish small bowel from colonic Crohn's disease. Gastroenterology 121(2):246-254 (Pubitemid 32729371)
114. Patriarca F, Skert C, Sperotto A, Damiani D, Cerno M, Geromin A et al (2004) Incidence, outcome, and risk factors of late-onset noninfectious pulmonary complications after unrelated donor stem cell transplantation. Bone Marrow Transplant 33(7):751-758 (Pubitemid 38499931)
115. Pavletic SZ, Lee SJ, Socie G, Vogelsang G (2006a) Chronic graft-versus-host disease: Implications of the National Institutes of Health consensus development project on criteria for clinical trials. Bone Marrow Transplant 38(10):645-651 (Pubitemid 44669678)
116. Pavletic SZ, Martin P, Lee SJ, Mitchell S, Jacobsohn D, Cowen EW et al (2006b) Measuring therapeutic response in chronic graft-versus-host disease: National Institute of Health Consensus Development Project on criteria for clinical trials in chronic graft-versus-host disease: IV. Response criteria working group report. Biol Blood Marrow Transpl 12:252-266 (Pubitemid 43273710)
117. Pease JE, Horuk R (2009) Chemokine receptor antagonists: Part 2. Expert Opin Ther Pat 19 (2):199-221
118. Pease JE, Williams TJ (2006) The attraction of chemokines as a target for specific anti-inflammatory therapy. Br J Pharmacol 147(Suppl 1):S212-S221 (Pubitemid 43077279)
119. Piper KP, Horlock C, Curnow SJ, Arrazi J, Nicholls S, Mahendra P et al (2007) CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation. Blood 110(12):3827-3832 (Pubitemid 350248437)
120. Rao AR, Quinones MP, Garavito E, Kalkonde Y, Jimenez F, Gibbons C et al (2003) CC chemokine receptor 2 expression in donor cells serves an essential role in graft-versus-hostdisease. J Immunol 171(9):4875-4885 (Pubitemid 37310610)
121. Reckless J, Tatalick LM, Grainger DJ (2001) The pan-chemokine inhibitor NR58-3.14.3 abolishes tumour necrosis factor-alpha accumulation and leucocyte recruitment induced by lipopolysaccharide in vivo. Immunology 103(2):244-254 (Pubitemid 32521354)
122. Reiss Y, Proudfoot AE, Power CA, Campbell JJ, Butcher EC (2001) CC chemokine receptor (CCR)4 and the CCR10 ligand cutaneous T cell-attracting chemokine (CTACK) in lymphocyte trafficking to inflamed skin. J Exp Med 194(10):1541-1547 (Pubitemid 33081528)
123. Riddell SR, Murata M, Bryant S, Warren EH (2002) Minor histocompatibility antigens-targets of graft-versus-leukemia responses. Int J Hematol 76(Suppl 2):155-161
124. Rollins BJ (1997) Chemokines. Blood 90(3):909-928 (Pubitemid 27314123)
125. Rot A, Von Andrian UH (2004) Chemokines in Innate and Adaptive Host Defense: Basic Chemokinese Grammar for Immune Cells. Annu Rev Immunol 22:891-928 (Pubitemid 38680444)
126. Sakaida E, Nakaseko C, Harima A, Yokota A, Cho R, Saito Y et al (2003) Late-onset noninfectious pulmonary complications after allogeneic stem cell transplantation are significantly associated with chronic graft-versus-host disease and with the graft-versus-leukemia effect. Blood 102(12):4236-4242 (Pubitemid 37487013)
127. Sakoda Y, Hashimoto D, Asakura S, Takeuchi K, Harada M, Tanimoto M et al (2007) Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease. Blood 109 (4):1756-1764 (Pubitemid 46239612)
128. Saruta M, Yu QT, Avanesyan A, Fleshner PR, Targan SR, Papadakis KA (2007) Phenotype and effector function of CC chemokine receptor 9-expressing lymphocytes in small intestinal Crohn's disease. J Immunol 178(5):3293-3300 (Pubitemid 46333214)
129. Sasaki M, Hasegawa H, Kohno M, Inoue A, Ito MR, Fujita S (2003) Antagonist of secondary lymphoid-tissue chemokine (CCR ligand 21) prevents the development of chronic graftversus- host disease in mice. J Immunol 170(1):588-596 (Pubitemid 36026187)
130. Sato T, Thorlacius H, Johnston B, Staton TL, Xiang W, Littman DR et al (2005) Role for CXCR6 in recruitment of activated CD8+ lymphocytes to inflamed liver. J Immunol 174(1):277-283 (Pubitemid 40007414)
131. Savani BN, Montero A, Srinivasan R, Singh A, Shenoy A, Mielke S et al (2006) Chronic GVHD and pretransplantation abnormalities in pulmonary function are the main determinants predicting worsening pulmonary function in long-term survivors after stem cell transplantation. Biol Blood Marrow Transplant 12(12):1261-1269 (Pubitemid 44858271)
132. Serody JS, Burkett SE, Panoskaltsis-Mortari A, Ng-Cashin J, McMahon E, Matsushima GK et al (2000) T-lymphocyte production of macrophage inflammatory protein-1alpha is critical to the recruitment of CD8(+) T cells to the liver, lung, and spleen during graft-versus-host disease. Blood 96(9):2973-2980
133. Shinoda H, Tasaka S, Fujishima S, Yamasawa W, Miyamoto K, Nakano Y et al (2009) Elevated CC chemokine level in bronchoalveolar lavage fluid is predictive of a poor outcome of idiopathic pulmonary fibrosis. Respiration 78(3):285-292
134. Shlomchik WD, Couzens MS, Tang CB, McNiff J, Robert ME, Liu J et al (1999) Prevention of graft-versus-host disease by inactivation of host antigen-presenting cells. Science 285(5426):412-415 (Pubitemid 29343964)
135. Shulman HM, Sale GE, Lerner KG, Barker EA, Weiden PL, Sullivan K et al (1978) Chronic cutaneous graft-versus-host disease in man. Am J Pathol 91(3):545-570 (Pubitemid 8354900)
136. Slavin S, Naparstek E, Nagler A et al (1993) Graft vs leukemia (GVL) effects with controlled GVHD by cell mediated immunotherapy (CMI) following allogeneic bone marrow transplantation (BMT). Blood 82:423a
137. Strieter RM, Burdick MD, Gomperts BN, Belperio JA, Keane MP (2005) CXC chemokines in angiogenesis. Cytokine Growth Factor Rev 16(6):593-609 (Pubitemid 41505519)
138. Sugerman PB, Faber SB, Willis LM, Petrovic A, Murphy GF, Pappo J et al
139. Sullivan KM, Parkman R (1983) The pathophysiology and treatment of graft-versus-host disease. Clin Haematol 12(3):775-789
140. Sun Y, Tawara I, Toubai T, Reddy P (2007) Pathophysiology of acute graft-versus-host disease: Recent advances. Transl Res 150(4):197-214 (Pubitemid 47444613)
141. Takahashi H, Furukawa T, Hashimoto S, Suzuki N, Kuroha T, Yamazaki F et al (2000) Contribution of TNF-alpha and IL-10 gene polymorphisms to graft-versus-host disease following allohematopoietic stem cell transplantation. Bone Marrow Transplant 26(12):1317-1323 (Pubitemid 32098051)
142. Terwey TH, Kim TD, Kochman AA, Hubbard VM, Lu S, Zakrzewski JL et al (2005) CCR2 is required for CD8-induced graft-versus-host disease. Blood 106(9):3322-3330 (Pubitemid 41565936)
143. Teshima T, Ordemann R, Reddy P, Gagin S, Liu C, Cooke KR et al (2002) Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nat Med 8(6):575-581 (Pubitemid 34633434)
144. Teshima T, Reddy P, Liu C, Williams D, Cooke KR, Ferrara JL (2003) Impaired thymic negative selection causes autoimmune graft-versus-host disease. Blood 102(2):429-435 (Pubitemid 36841956)
145. Tichelli A, Rovo A, Gratwohl A (2008) Late pulmonary, cardiovascular, and renal complications after hematopoietic stem cell transplantation and recommended screening practices. Hematology Am Soc Hematol Educ Program 1:125-133
146. Truitt RL, Atasoylu AA (1991a) Impact of pretransplant conditioning and donor T cells on chimerism, graft-versus-host disease, graft-versus-leukemia reactivity, and tolerance after bone marrow transplantation. Blood 77:2515-2523
147. Truitt RL, Atasoylu AA (1991b) Contribution of CD4+ and CD8+ T cells to graft-versus-host disease and graft-versus-leukemia reactivity after transplantation of MHC-compatible bone marrow. Bone Marrow Transplant 8:51-58
148. Tseng LH, Storer B, Petersdorf E, Lin MT, Chien JW, Grogan BM et al (2009) IL10 and IL10 receptor gene variation and outcomes after unrelated and related hematopoietic cell transplantation. Transplantation 87(5):704-710
149. Uderzo C, Pillon M, Corti P, Tridello G, Tana F, Zintl F et al (2007) Impact of cumulative anthracycline dose, preparative regimen and chronic graft-versus-host disease on pulmonary and cardiac function in children 5 years after allogeneic hematopoietic stem cell transplantation: A prospective evaluation on behalf of the EBMT Pediatric Diseases and Late Effects Working Parties. Bone Marrow Transplant 39(11):667-675 (Pubitemid 46813583)
150. Ueha S, Murai M, Yoneyama H, Kitabatake M, Imai T, Shimaoka T et al (2007) Intervention of MAdCAM-1 or fractalkine alleviates graft-versus-host reaction associated intestinal injury while preserving graft-versus-tumor effects. J Leukoc Biol 81(1):176-185 (Pubitemid 46021267)
151. Varona R, Cadenas V, Gomez L, Martinez AC, Marquez G (2005) CCR6 regulates CD4+ T-cellmediated acute graft-versus-host disease responses. Blood 106(1):18-26 (Pubitemid 40967169)
152. Varona R, Cadenas V, Lozano M, Moreno-Ortiz MC, Kremer L, Martinez AC et al (2006) CCR6 regulates the function of alloreactive and regulatory CD4+ T cells during acute graft-versushost disease. Leuk Lymphoma 47(8):1469-1476 (Pubitemid 44364009)
153. Viola A, Luster AD (2008) Chemokines and their receptors: Drug targets in immunity and inflammation. Annu Rev Pharmacol Toxicol 48:171-197 (Pubitemid 351756361)
154. Weiner RS, Mortimer MB, Gale RP, Gluckman E, Kay HEM, Kolb JJ et al (1986) Interstitial pneumonitis after bone marrow transplantation. Ann Intern Med 104:168-175 (Pubitemid 16134699)
155. Weninger W, Crowley MA, Manjunath N, von Andrian UH (2001) Migratory properties of naive, effector, and memory CD8(+) T cells. J Exp Med 194(7):953-966 (Pubitemid 32953264)
156. Wysocki CA, Burkett SB, Panoskaltsis-Mortari A, Kirby SL, Luster AD, McKinnon K et al (2004) Differential roles for CCR5 expression on donor T cells during graft-versus-host disease based on pretransplant conditioning. J Immunol 173(2):845-854 (Pubitemid 38930812)
157. Wysocki CA, Jiang Q, Panoskaltsis-Mortari A, Taylor PA, McKinnon KP, Su L et al (2005a) Critical role for CCR5 in the function of donor CD4 + CD25+ regulatory T cells during acute graft-versus-host disease. Blood 106(9):3300-3307 (Pubitemid 41565933)
158. Wysocki CA, Panoskaltsis-Mortari A, Blazar BR, Serody JS (2005b) Leukocyte migration and graft-versus-host disease. Blood 105(11):4191-4199 (Pubitemid 40720762)
159. Yakoub-Agha I, Saule P, Depil S, Micol JB, Grutzmacher C, Boulanger-Villard F et al (2006) A high proportion of donor CD4+ T cells expressing the lymph node-homing chemokine receptor CCR7 increases incidence and severity of acute graft-versus-host disease in patients undergoing allogeneic stem cell transplantation for hematological malignancy. Leukemia 20(9):1557-1565 (Pubitemid 44264099)
160. Zhang Y, McCormick LL, Desai SR, Wu C, Gilliam AC (2002) Murine sclerodermatous graftversus- host disease, a model for human scleroderma: Cutaneous cytokines, chemokines, and immune cell activation. J Immunol 168(6):3088-3098 (Pubitemid 34211692)
161. Zhou L, Askew D, Wu C, Gilliam AC (2007) Cutaneous gene expression by DNA microarray in murine sclerodermatous graft-versus-host disease, a model for human scleroderma. J Invest Dermatol 127(2):281-292 (Pubitemid 46106903)
162. Zlotnik A, Yoshie O (2000) Chemokines: A new classification system and their role in immunity. Immunity 12(2):121-127 (Pubitemid 30398626)