-
1
-
-
48549093414
-
-
2007 AIDS epidemic update [UNAIDS Web site].
-
2007 AIDS epidemic update [UNAIDS Web site].
-
-
-
-
2
-
-
48549097268
-
-
Accessed
-
(February 10, 2008). http://www.unaids.org/en/KnowledgeCentre/HIVData/EpiUpdate/EpiUpdArchive/2007default.asp Accessed
-
(2008)
-
-
-
3
-
-
0037367636
-
New antiretroviral drugs
-
Gulick R.M. New antiretroviral drugs. Clin Microbiol Infect 9 (2003) 186-193
-
(2003)
Clin Microbiol Infect
, vol.9
, pp. 186-193
-
-
Gulick, R.M.1
-
4
-
-
33749021387
-
Emergence of drug resistance is associated with an increased risk of death among patients first starting HAART
-
Hogg R.S., Bangsberg D.R., Lima V.D., et al. Emergence of drug resistance is associated with an increased risk of death among patients first starting HAART. PLoS Med. 3 (2006) e356
-
(2006)
PLoS Med.
, vol.3
-
-
Hogg, R.S.1
Bangsberg, D.R.2
Lima, V.D.3
-
5
-
-
9444228307
-
Time to virological failure of 3 classes of antiretrovirals after initiation of highly active antiretroviral therapy: Results from the EuroSIDA Study Group
-
for the Euro-SIDA Study Group
-
Mocroft A., Ledergerber B., Viard J.P., et al., for the Euro-SIDA Study Group. Time to virological failure of 3 classes of antiretrovirals after initiation of highly active antiretroviral therapy: Results from the EuroSIDA Study Group. J Infect Dis 190 (2004) 1947-1956
-
(2004)
J Infect Dis
, vol.190
, pp. 1947-1956
-
-
Mocroft, A.1
Ledergerber, B.2
Viard, J.P.3
-
6
-
-
0035313589
-
Human immunodeficiency virus type 1 entry inhibitors PRO 542 and T-20 are potently synergistic in blocking virus-cell and cell-cell fusion
-
Nagashima K.A., Thompson D.A., Rosenfield S.I., et al. Human immunodeficiency virus type 1 entry inhibitors PRO 542 and T-20 are potently synergistic in blocking virus-cell and cell-cell fusion. J Infect Dis 183 (2001) 1121-1125
-
(2001)
J Infect Dis
, vol.183
, pp. 1121-1125
-
-
Nagashima, K.A.1
Thompson, D.A.2
Rosenfield, S.I.3
-
7
-
-
0042376485
-
A new classification for HIV-1
-
for the HIV Network for Prevention Trials Vaccine Preparedness Protocol Team
-
Berger E.A., Doms R.W., Fenyö E.M., et al., for the HIV Network for Prevention Trials Vaccine Preparedness Protocol Team. A new classification for HIV-1. Nature 319 (1998) 240
-
(1998)
Nature
, vol.319
, pp. 240
-
-
Berger, E.A.1
Doms, R.W.2
Fenyö, E.M.3
-
8
-
-
16044373004
-
Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
-
Samson M., Libert F., Doranz B.J., et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382 (1996) 722-725
-
(1996)
Nature
, vol.382
, pp. 722-725
-
-
Samson, M.1
Libert, F.2
Doranz, B.J.3
-
9
-
-
15844388931
-
Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
-
Liu R., Paxton W.A., Choe S., et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86 (1996) 367-377
-
(1996)
Cell
, vol.86
, pp. 367-377
-
-
Liu, R.1
Paxton, W.A.2
Choe, S.3
-
10
-
-
0035881173
-
Homozygous and heterozygous CCR5-Delta32 genotypes are associated with resistance to HIV infection
-
Marmor M., Sheppard H.W., Donnell D., et al. Homozygous and heterozygous CCR5-Delta32 genotypes are associated with resistance to HIV infection. J Acquir Immune Defic Syndr 27 (2001) 472-481
-
(2001)
J Acquir Immune Defic Syndr
, vol.27
, pp. 472-481
-
-
Marmor, M.1
Sheppard, H.W.2
Donnell, D.3
-
11
-
-
0007643930
-
Association between CCR5 genotype and the clinical course of HIV-11 infection
-
de Roda Husman A.M., Koot M., Cornelissen M., et al. Association between CCR5 genotype and the clinical course of HIV-11 infection. Ann Intern Med 127 (1997) 882-890
-
(1997)
Ann Intern Med
, vol.127
, pp. 882-890
-
-
de Roda Husman, A.M.1
Koot, M.2
Cornelissen, M.3
-
12
-
-
34147102357
-
Assessing theoretical risk and benefit suggested by genetic association studies of CCR5: Experience in a drug development programme for maraviroc
-
Wheeler J., McHale M., Jackson V., and Penny M. Assessing theoretical risk and benefit suggested by genetic association studies of CCR5: Experience in a drug development programme for maraviroc. Antivir Ther 12 (2007) 233-245
-
(2007)
Antivir Ther
, vol.12
, pp. 233-245
-
-
Wheeler, J.1
McHale, M.2
Jackson, V.3
Penny, M.4
-
13
-
-
48549083877
-
-
Pfizer NY: Inc, New York
-
Selzentry [package insert] (2007), Pfizer NY: Inc, New York
-
(2007)
Selzentry [package insert]
-
-
-
14
-
-
0141814730
-
The entry of entry inhibitors: A fusion of science and medicine
-
Moore J.P., and Doms R.W. The entry of entry inhibitors: A fusion of science and medicine. Proc Natl Acad Sci U S A 100 (2003) 10598-10602
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 10598-10602
-
-
Moore, J.P.1
Doms, R.W.2
-
15
-
-
0037059049
-
Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics
-
Reeves J.D., Gallo S.A., Ahmad N., et al. Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics. Proc Natl Acad Sci U S A 99 (2002) 16249-16254
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 16249-16254
-
-
Reeves, J.D.1
Gallo, S.A.2
Ahmad, N.3
-
16
-
-
0037320947
-
HIV-1 cell entry and advances in viral entry inhibitor therapy
-
Cooley L.A., and Lewin S.R. HIV-1 cell entry and advances in viral entry inhibitor therapy. J Clin Virol 26 (2003) 1121-1132
-
(2003)
J Clin Virol
, vol.26
, pp. 1121-1132
-
-
Cooley, L.A.1
Lewin, S.R.2
-
17
-
-
0035145352
-
The potential for HIV fusion inhibition
-
Cammack N. The potential for HIV fusion inhibition. Curr Opin Infect Dis 14 (2001) 13-16
-
(2001)
Curr Opin Infect Dis
, vol.14
, pp. 13-16
-
-
Cammack, N.1
-
18
-
-
0034312298
-
The plasma membrane as a combat zone in the HIV battlefield
-
Doms R.W., and Trono D. The plasma membrane as a combat zone in the HIV battlefield. Genes Dev 14 (2000) 2677-2688
-
(2000)
Genes Dev
, vol.14
, pp. 2677-2688
-
-
Doms, R.W.1
Trono, D.2
-
19
-
-
27644510382
-
Maraviroc (UUK-427,857), a potent, orally bioavailable,and selective small-molecule inhibitor of chemokine receptor CCR5 with broadspectrum anti-human immunode-ficiency virus type 1 activity
-
Dorr P., Westby M., Dobbs S., et al. Maraviroc (UUK-427,857), a potent, orally bioavailable,and selective small-molecule inhibitor of chemokine receptor CCR5 with broadspectrum anti-human immunode-ficiency virus type 1 activity. Antimi-crob Agents Chemother 49 (2005) 4721-4732
-
(2005)
Antimi-crob Agents Chemother
, vol.49
, pp. 4721-4732
-
-
Dorr, P.1
Westby, M.2
Dobbs, S.3
-
20
-
-
34547642109
-
Maraviroc, a chemokine CCR5 receptor antagonist for the treatment of HIV infection and AIDS
-
Meanwell N.A., and Kadow J.F. Maraviroc, a chemokine CCR5 receptor antagonist for the treatment of HIV infection and AIDS. Curr Opin Investig Drugs 8 (2007) 669-681
-
(2007)
Curr Opin Investig Drugs
, vol.8
, pp. 669-681
-
-
Meanwell, N.A.1
Kadow, J.F.2
-
21
-
-
30744447460
-
Efficacy of shortterm monotherapy with maraviroc, a new CCR5 ntagonist, n patients infected with HIV-1
-
Fätkenheuer G., Pozniak A.L., Johnson M.A., et al. Efficacy of shortterm monotherapy with maraviroc, a new CCR5 ntagonist, n patients infected with HIV-1. Nat Med 11 (2005) 1170-1172
-
(2005)
Nat Med
, vol.11
, pp. 1170-1172
-
-
Fätkenheuer, G.1
Pozniak, A.L.2
Johnson, M.A.3
-
22
-
-
34249711352
-
Access denied? The status of coreceptor inhibition to counter HIV entry
-
Biswas P., Tambussi G., and Lazzarin A. Access denied? The status of coreceptor inhibition to counter HIV entry. Expert Opin Pharmacother 8 (2007) 923-933
-
(2007)
Expert Opin Pharmacother
, vol.8
, pp. 923-933
-
-
Biswas, P.1
Tambussi, G.2
Lazzarin, A.3
-
23
-
-
40549135975
-
Assessment of the pharmaco-kinetics, safety and tolerability of maraviroc, a novel CCR5 antagonist, in healthy volunteers
-
Abel S., van der Ryst E., Rosario M.C., et al. Assessment of the pharmaco-kinetics, safety and tolerability of maraviroc, a novel CCR5 antagonist, in healthy volunteers. Br J Clin Pharmacol 65 1 (2008) 5-18
-
(2008)
Br J Clin Pharmacol
, vol.65
, Issue.1
, pp. 5-18
-
-
Abel, S.1
van der Ryst, E.2
Rosario, M.C.3
-
24
-
-
48549095315
-
-
Dumond JB, Patterson KB, Pecha A, et al. Maraviroc pharmacokinetics in blood plasma, genital tract fluid and tissue in healthy female volunteers. Presented at: 15th Conference on Retroviruses and Opportunistic Infections; Febreary 3-6, 2008; Boston, Mass. Abstract 135LB.
-
Dumond JB, Patterson KB, Pecha A, et al. Maraviroc pharmacokinetics in blood plasma, genital tract fluid and tissue in healthy female volunteers. Presented at: 15th Conference on Retroviruses and Opportunistic Infections; Febreary 3-6, 2008; Boston, Mass. Abstract 135LB.
-
-
-
-
25
-
-
48549098418
-
-
Lalezari J, Goodrich J, DeJesus E, et al, for the MOTIVATE 1 Study Team. Efficacy and safety of maraviroc in antiretroviral-experienced patients infected with CCR5-tropic HIV-1: 48-Weeks results of MOTIVATE-1 Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 17-20, 2007; Chicago, Ill. Abstract 104bLB.
-
Lalezari J, Goodrich J, DeJesus E, et al, for the MOTIVATE 1 Study Team. Efficacy and safety of maraviroc in antiretroviral-experienced patients infected with CCR5-tropic HIV-1: 48-Weeks results of MOTIVATE-1 Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 17-20, 2007; Chicago, Ill. Abstract 104bLB.
-
-
-
-
26
-
-
48549095627
-
-
Fatkenheuer G, Konourina I, Nelson M, et al, for the MOTIVATE 2 Study Team. Efficacy and safety of maraviroc (MVC) plus optimized background therapy (OBT)in viraemic, antiretroviral treatment-experienced patients infected with CCR5-ttropic (R5)HIV-1 in Europe, Australia and North America (MMOTIVATE 2): 48-Week results. Presented at: 11th European Conference; October 24-27, 2007; Madrid, Spain. Abstract PS3/5.
-
Fatkenheuer G, Konourina I, Nelson M, et al, for the MOTIVATE 2 Study Team. Efficacy and safety of maraviroc (MVC) plus optimized background therapy (OBT)in viraemic, antiretroviral treatment-experienced patients infected with CCR5-ttropic (R5)HIV-1 in Europe, Australia and North America (MMOTIVATE 2): 48-Week results. Presented at: 11th European Conference; October 24-27, 2007; Madrid, Spain. Abstract PS3/5.
-
-
-
-
27
-
-
15344350690
-
Species differences in the disposition of the CCR5 antagonist, UK-4427,857, a new potential treatment for HIV
-
Walker D.K., Abel S., Comby P., et al. Species differences in the disposition of the CCR5 antagonist, UK-4427,857, a new potential treatment for HIV. Drug Metab Dispos 33 (2005) 587-595
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 587-595
-
-
Walker, D.K.1
Abel, S.2
Comby, P.3
-
28
-
-
48549101175
-
-
Maraviroc tablets NDA 22-128 [briefing document] [US Food and Drug Administration Web site].
-
Maraviroc tablets NDA 22-128 [briefing document] [US Food and Drug Administration Web site].
-
-
-
-
29
-
-
48549089549
-
-
February 10, Accessed
-
(2008). http://wwww.fda.gov/ohrms/dockets/ac/007/briefing/2007-4283b1-01-Pfizer.pdf February 10, Accessed
-
(2008)
-
-
-
30
-
-
48549087976
-
-
Hoepelman IM, Ayoub A, Heera J, et al. The incidence of severe liver enzyme abnormalities and hepatic adverse events in the maraviroc clinical development programme. Presented at: 11th European AIDS Conference; 24-27, 2007; Madrid, Spain. Abstract LBP7.99/1.
-
Hoepelman IM, Ayoub A, Heera J, et al. The incidence of severe liver enzyme abnormalities and hepatic adverse events in the maraviroc clinical development programme. Presented at: 11th European AIDS Conference; 24-27, 2007; Madrid, Spain. Abstract LBP7.99/1.
-
-
-
-
31
-
-
33847237614
-
Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bbound receptor for entry
-
Westby M., Smith-Burchnell C., Mori J., et al. Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bbound receptor for entry. J Virol 81 (2007) 2359-2371
-
(2007)
J Virol
, vol.81
, pp. 2359-2371
-
-
Westby, M.1
Smith-Burchnell, C.2
Mori, J.3
-
32
-
-
48549090574
-
-
Naeger LK. Resistance and tropism-maraviroc.
-
Naeger LK. Resistance and tropism-maraviroc.
-
-
-
-
33
-
-
48549097658
-
-
Accessed
-
(July 10, 2008). http://www.scribd.com/doc/1118185/US-Food-and-Drug-Administration-20074283s10204FDA-Naeger Accessed
-
(2008)
-
-
-
34
-
-
48549095176
-
-
McFadyen L, Jacqmin P, Wade JR, et al. Maraviroc (MVC) exposure-efficacy relationship in treatment-experienced HIV-1-infected patients. Presented at: 11th European Conference; October 24-27, 2007; Madrid, Spain. Abstract P4.1/06.
-
McFadyen L, Jacqmin P, Wade JR, et al. Maraviroc (MVC) exposure-efficacy relationship in treatment-experienced HIV-1-infected patients. Presented at: 11th European Conference; October 24-27, 2007; Madrid, Spain. Abstract P4.1/06.
-
-
-
-
35
-
-
48549105653
-
-
Saag M, Ive P, Heera J, et al. A multicenter, randomized, double-bblind, comparative trial of a novel CCR5 antagonist, maraviroc, versus efavirenz, both in combination with combivir (zidovudine [ZDV]/lamivudine [3TC]), for the treatment of antiretroviral naive subjects infected with R5 HIV-1: Week 48 results of the MERIT study. Presented at: 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; July 22-25, 2007; Sydney, Australia. Abstract WESS104.
-
Saag M, Ive P, Heera J, et al. A multicenter, randomized, double-bblind, comparative trial of a novel CCR5 antagonist, maraviroc, versus efavirenz, both in combination with combivir (zidovudine [ZDV]/lamivudine [3TC]), for the treatment of antiretroviral naive subjects infected with R5 HIV-1: Week 48 results of the MERIT study. Presented at: 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; July 22-25, 2007; Sydney, Australia. Abstract WESS104.
-
-
-
-
36
-
-
48549098419
-
-
van der Ryst E, Cooper D, Konourina I, et al. Efficacy of maraviroc in combination with at least one other potent new antiretroviral drug: 24-Week combined analysis of the MOTIVATE 1 and 2 studies. Presented at: 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; July 22-25, 2007; Sydney, Australia. Abstract WEPEB115LB.
-
van der Ryst E, Cooper D, Konourina I, et al. Efficacy of maraviroc in combination with at least one other potent new antiretroviral drug: 24-Week combined analysis of the MOTIVATE 1 and 2 studies. Presented at: 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; July 22-25, 2007; Sydney, Australia. Abstract WEPEB115LB.
-
-
-
-
37
-
-
48549092111
-
-
Gulick RM, van der Ryst E, Lampiris H, et al. Efficacy and safety of once-daily (QD) compared with twicedaily (BID) maraviroc plus optimized background therapy (OBT) in treatment-experienced patients infected with CCR5-tropic HIV-1: 24-Week combined analysis of the MOTIVATE 1 and 2 studies. Presented at: 4th International AIDS Society Conference on HIV Pathogenesis, Prevention; July 22-25, 2007; Sydney, Australia. Abstract WEPEB116LB.
-
Gulick RM, van der Ryst E, Lampiris H, et al. Efficacy and safety of once-daily (QD) compared with twicedaily (BID) maraviroc plus optimized background therapy (OBT) in treatment-experienced patients infected with CCR5-tropic HIV-1: 24-Week combined analysis of the MOTIVATE 1 and 2 studies. Presented at: 4th International AIDS Society Conference on HIV Pathogenesis, Prevention; July 22-25, 2007; Sydney, Australia. Abstract WEPEB116LB.
-
-
-
-
38
-
-
48549090416
-
-
Hardy D, Reynes J, Konourina I, et al. Efficacy and safety of maraviroc plus optimized background therapy in treatment-experienced patients infected with CCR5-ttropic HIV-1: 48-Week combined analysis of the MOTIVATE studies. Presented at: 15th Conference on Retroviruses Infections; February 3-6, 2008; Boston, Mass. Abstract 792.
-
Hardy D, Reynes J, Konourina I, et al. Efficacy and safety of maraviroc plus optimized background therapy in treatment-experienced patients infected with CCR5-ttropic HIV-1: 48-Week combined analysis of the MOTIVATE studies. Presented at: 15th Conference on Retroviruses Infections; February 3-6, 2008; Boston, Mass. Abstract 792.
-
-
-
-
39
-
-
48549097803
-
-
Mayer H, van der Ryst E, Saag M, et al. Safety and efficacy of maraviroc, a novel CCR5 antagonist, when used in combination with optimized background therapy for the treatment of antiretroviral-experienced subjects infected with dual/mixed-tropic HIV-1: 24-Week results of a Phase 2b exploratory trial. Presented at: 16th International AIDS Conference; August 13-18, 2006; Toronto, Canada. Abstract TH HLB 0215.
-
Mayer H, van der Ryst E, Saag M, et al. Safety and efficacy of maraviroc, a novel CCR5 antagonist, when used in combination with optimized background therapy for the treatment of antiretroviral-experienced subjects infected with dual/mixed-tropic HIV-1: 24-Week results of a Phase 2b exploratory trial. Presented at: 16th International AIDS Conference; August 13-18, 2006; Toronto, Canada. Abstract TH HLB 0215.
-
-
-
-
40
-
-
48549100276
-
-
Goodrich JM, Saag M, van der Ryst E, et al. 48-Week safety and efficacy of maraviroc, a novel CCR5 antagonist, in combination with optimized background therapy (OBT) for the treatment of antiretroviral-experienced patients infected with dual/mixed-tropic HIV-1. Presented at: 45th Annual Meeting of Infectious Diseases Society of America; October 4-7, 2007; Diego, Calif. Abstract LB-22.
-
Goodrich JM, Saag M, van der Ryst E, et al. 48-Week safety and efficacy of maraviroc, a novel CCR5 antagonist, in combination with optimized background therapy (OBT) for the treatment of antiretroviral-experienced patients infected with dual/mixed-tropic HIV-1. Presented at: 45th Annual Meeting of Infectious Diseases Society of America; October 4-7, 2007; Diego, Calif. Abstract LB-22.
-
-
-
-
41
-
-
48549103726
-
-
McHale M, Abel S, Russell D, et al. Overview of Phase 1 and 2a safety and efficacy data of maraviroc (UK-427,857). Presented at: 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment; July 24-27, 2005; Rio de Janeiro, Brazil. Abstract TuOa 0204.
-
McHale M, Abel S, Russell D, et al. Overview of Phase 1 and 2a safety and efficacy data of maraviroc (UK-427,857). Presented at: 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment; July 24-27, 2005; Rio de Janeiro, Brazil. Abstract TuOa 0204.
-
-
-
-
42
-
-
40549135640
-
Effect of single doses of maraviroc on the QT/QTc interval in healthy subjects
-
Davis J.D., Hackman F., Layton G., et al. Effect of single doses of maraviroc on the QT/QTc interval in healthy subjects. Br J Clin Pharmacol 65 Suppl 1 (2008) 68-75
-
(2008)
Br J Clin Pharmacol
, vol.65
, Issue.SUPPL. 1
, pp. 68-75
-
-
Davis, J.D.1
Hackman, F.2
Layton, G.3
-
44
-
-
40549127134
-
Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers
-
Abel S., Russell D., Taylor-Worth R.J., et al. Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. Br J Clin Pharmacol 65 Suppl 1 (2008) 27-37
-
(2008)
Br J Clin Pharmacol
, vol.65
, Issue.SUPPL. 1
, pp. 27-37
-
-
Abel, S.1
Russell, D.2
Taylor-Worth, R.J.3
-
45
-
-
48549088706
-
-
Abel S, Ridgway C, Hamlin J, et al. An open, randomized, 2-way cross-over study to investigate the effect of darunavir/ritonavir on the pharmacokinetics of maraviroc in healthy subjects. Presented at: 16th International HIV Drug Resistance Workshop; July 12-16, 2007; Barbados, West Indies. Abstract 55.
-
Abel S, Ridgway C, Hamlin J, et al. An open, randomized, 2-way cross-over study to investigate the effect of darunavir/ritonavir on the pharmacokinetics of maraviroc in healthy subjects. Presented at: 16th International HIV Drug Resistance Workshop; July 12-16, 2007; Barbados, West Indies. Abstract 55.
-
-
-
-
46
-
-
40549086936
-
Effects of CYP3A4 inducers with and without CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers
-
Abel S., Jenkins T.M., Whitlock L.A., et al. Effects of CYP3A4 inducers with and without CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. Br J Clin Pharmacol 65 Suppl 1 (2008) 38-46
-
(2008)
Br J Clin Pharmacol
, vol.65
, Issue.SUPPL. 1
, pp. 38-46
-
-
Abel, S.1
Jenkins, T.M.2
Whitlock, L.A.3
-
47
-
-
48549088227
-
-
Davis J, Scholler-GGyyre M, Kakuda TN, et al. An open, randomized, two-period, crossover study in two cohorts to investigate the effect of steady-state TMC125 (etravirine) and the combination of TMC125/darunavir/ritonavir on the steady-state pharmacokinetics of oral maraviroc in healthy subjects. Presented at: 11th European AIDS Conference; October 24-27, 2007; Madrid, Spain. Abstract P4.33/02.
-
Davis J, Scholler-GGyyre M, Kakuda TN, et al. An open, randomized, two-period, crossover study in two cohorts to investigate the effect of steady-state TMC125 (etravirine) and the combination of TMC125/darunavir/ritonavir on the steady-state pharmacokinetics of oral maraviroc in healthy subjects. Presented at: 11th European AIDS Conference; October 24-27, 2007; Madrid, Spain. Abstract P4.33/02.
-
-
-
-
48
-
-
48549087729
-
-
Muirhead G, Pozniak A, Gazzard B, et al. A novel probe drug interaction study to investigate the effect of selected ARV combinations on the pharmacokinetics of a single oral dose of maraviroc (UK-427,857) in HIV +ve subjects. Presented at: 12th Conference on Retroviruses Infections; February 22-25, 2005; Boston, Mass. Abstract 663.
-
Muirhead G, Pozniak A, Gazzard B, et al. A novel probe drug interaction study to investigate the effect of selected ARV combinations on the pharmacokinetics of a single oral dose of maraviroc (UK-427,857) in HIV +ve subjects. Presented at: 12th Conference on Retroviruses Infections; February 22-25, 2005; Boston, Mass. Abstract 663.
-
-
-
-
49
-
-
40549090550
-
Effect of maraviroc on the pharmaco-kinetics of midazolam, lamivudine/ zidovudine, and ethinyloestradiol/ levonorgestrel in healthy volunteers
-
Abel S., Russell D., Whitlock L.A., et al. Effect of maraviroc on the pharmaco-kinetics of midazolam, lamivudine/ zidovudine, and ethinyloestradiol/ levonorgestrel in healthy volunteers. Br J Clin Pharmacol 65 Suppl 1 (2008) 19-26
-
(2008)
Br J Clin Pharmacol
, vol.65
, Issue.SUPPL. 1
, pp. 19-26
-
-
Abel, S.1
Russell, D.2
Whitlock, L.A.3
-
50
-
-
40549124307
-
The effects of cotrimoxazole or tenofovir co-administration on the pharmacokinetics of maraviroc in healthy volunteers
-
Abel S., Russell D., Whitlock L.A., et al. The effects of cotrimoxazole or tenofovir co-administration on the pharmacokinetics of maraviroc in healthy volunteers. BrJ Clin Pharmacol 65 Suppl 1 (2008) 47-53
-
(2008)
BrJ Clin Pharmacol
, vol.65
, Issue.SUPPL. 1
, pp. 47-53
-
-
Abel, S.1
Russell, D.2
Whitlock, L.A.3
-
51
-
-
48549099490
-
-
Thomson Medical Economics, Montvale, NJ
-
2008 Drug Topics Red Book (2008), Thomson Medical Economics, Montvale, NJ
-
(2008)
2008 Drug Topics Red Book
-
-
-
52
-
-
48549103992
-
-
Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents.
-
Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents.
-
-
-
-
53
-
-
48549084559
-
-
February 10, Accessed
-
(2008). http://aidsinfo.nih.gov/contentfiles/AdultanclAdolescentGL.pdf February 10, Accessed
-
(2008)
-
-
-
54
-
-
48549096761
-
-
FAQs-physician questions [Trofile co-receptor tropism assay Web site]..
-
FAQs-physician questions [Trofile co-receptor tropism assay Web site]..
-
-
-
-
55
-
-
48549106179
-
-
February 10, Accessed
-
(2008). http://www.trofileassay.com/FAQs_Physician-Questions February 10, Accessed
-
(2008)
-
-
-
56
-
-
48549099491
-
-
Kuehne FC, Chancellor J, Mollon P, Powderly W. Modelling the costeffectiveness of maraviroc for anti retroviral treatment-experienced individuals. Presented at: 11th European AIDS Conference; October 24-27, 2007; Madrid, Spain. Abstract P10.4/02.
-
Kuehne FC, Chancellor J, Mollon P, Powderly W. Modelling the costeffectiveness of maraviroc for anti retroviral treatment-experienced individuals. Presented at: 11th European AIDS Conference; October 24-27, 2007; Madrid, Spain. Abstract P10.4/02.
-
-
-
-
57
-
-
33646443202
-
Emergence of CXCR4-using human immunodeficiencyvirus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir
-
Westby M., Lewis M., Whitcomb J., et al. Emergence of CXCR4-using human immunodeficiencyvirus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir. J Virol 80 (2006) 4909-4920
-
(2006)
J Virol
, vol.80
, pp. 4909-4920
-
-
Westby, M.1
Lewis, M.2
Whitcomb, J.3
-
58
-
-
28544434492
-
CCR5 antagonists: Host-targeted antivirals for the treatment of HIV infec tion
-
Westby M., and van der Ryst E. CCR5 antagonists: Host-targeted antivirals for the treatment of HIV infec tion. Antivir Chem Chemother 16 (2005) 339-354
-
(2005)
Antivir Chem Chemother
, vol.16
, pp. 339-354
-
-
Westby, M.1
van der Ryst, E.2
-
59
-
-
35548984868
-
CCR5 antagonists in the treatment of treatment-experi enced patients infected with CCR5 tropic HIV-1
-
Lorenzen T., Stoehr A., Walther I., and Plettenberg A. CCR5 antagonists in the treatment of treatment-experi enced patients infected with CCR5 tropic HIV-1. Eur J Med Res 12 (2007) 419-425
-
(2007)
Eur J Med Res
, vol.12
, pp. 419-425
-
-
Lorenzen, T.1
Stoehr, A.2
Walther, I.3
Plettenberg, A.4
-
60
-
-
48549094517
-
-
van der Ryst E, Westby M. Changes in HIV-1 co-receptor tropism for patients participating in the maravi roc MOTIVATE 1 and 2 clinical trials. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 1720, 2007; Chicago, III. Abstract H715.
-
van der Ryst E, Westby M. Changes in HIV-1 co-receptor tropism for patients participating in the maravi roc MOTIVATE 1 and 2 clinical trials. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 1720, 2007; Chicago, III. Abstract H715.
-
-
-
-
61
-
-
48549083623
-
-
Reeves JD, Han D, Liu Y, et al. Enhancements to the Trofile HIV coreceptor tropism assay enable im proved detection of CXCR4-using subpopulations and earlier detection of CXCR4-using viruses in sequential patient samples. Presented at: 11th European AIDS Conference/ EACS; October 24-27, 2007; Madrid, Spain. Abstract P1.2/03.
-
Reeves JD, Han D, Liu Y, et al. Enhancements to the Trofile HIV coreceptor tropism assay enable im proved detection of CXCR4-using subpopulations and earlier detection of CXCR4-using viruses in sequential patient samples. Presented at: 11th European AIDS Conference/ EACS; October 24-27, 2007; Madrid, Spain. Abstract P1.2/03.
-
-
-
-
62
-
-
34147112358
-
Identifying safety concerns from genetic data: Lesions from the development of CCR5 inhibitors
-
Telenti A., and Egger M. Identifying safety concerns from genetic data: Lesions from the development of CCR5 inhibitors. AntivirTher 12 (2007) 147-148
-
(2007)
AntivirTher
, vol.12
, pp. 147-148
-
-
Telenti, A.1
Egger, M.2
-
63
-
-
35548963749
-
Treatment with CCR5 antagonists: Which patient may have a benefit?
-
Mueller M.C., and Bogner J.R. Treatment with CCR5 antagonists: Which patient may have a benefit?. Eur J Med Res 12 (2007) 441-452
-
(2007)
Eur J Med Res
, vol.12
, pp. 441-452
-
-
Mueller, M.C.1
Bogner, J.R.2
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