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Volumn 30, Issue 7, 2008, Pages 1228-1250

Maraviroc: A CCR5-receptor antagonist for the treatment of HIV-1 infection

Author keywords

CCR5 receptor antagonist; entry inhibitor; HIV 1 infection; maraviroc

Indexed keywords

APLAVIROC; ATAZANAVIR; CHEMOKINE RECEPTOR CCR5 ANTAGONIST; DARUNAVIR; EFAVIRENZ; ETRAVIRINE; KETOCONAZOLE; LAMIVUDINE PLUS ZIDOVUDINE; LOPINAVIR PLUS RITONAVIR; MARAVIROC; NEVIRAPINE; PLACEBO; RALTEGRAVIR; RIFAMPICIN; RITONAVIR; SAQUINAVIR; VICRIVIROC;

EID: 48549106475     PISSN: 01492918     EISSN: 1879114X     Source Type: Journal    
DOI: 10.1016/S0149-2918(08)80048-3     Document Type: Article
Times cited : (136)

References (63)
  • 1
    • 48549093414 scopus 로고    scopus 로고
    • 2007 AIDS epidemic update [UNAIDS Web site].
    • 2007 AIDS epidemic update [UNAIDS Web site].
  • 2
    • 48549097268 scopus 로고    scopus 로고
    • Accessed
    • (February 10, 2008). http://www.unaids.org/en/KnowledgeCentre/HIVData/EpiUpdate/EpiUpdArchive/2007default.asp Accessed
    • (2008)
  • 3
    • 0037367636 scopus 로고    scopus 로고
    • New antiretroviral drugs
    • Gulick R.M. New antiretroviral drugs. Clin Microbiol Infect 9 (2003) 186-193
    • (2003) Clin Microbiol Infect , vol.9 , pp. 186-193
    • Gulick, R.M.1
  • 4
    • 33749021387 scopus 로고    scopus 로고
    • Emergence of drug resistance is associated with an increased risk of death among patients first starting HAART
    • Hogg R.S., Bangsberg D.R., Lima V.D., et al. Emergence of drug resistance is associated with an increased risk of death among patients first starting HAART. PLoS Med. 3 (2006) e356
    • (2006) PLoS Med. , vol.3
    • Hogg, R.S.1    Bangsberg, D.R.2    Lima, V.D.3
  • 5
    • 9444228307 scopus 로고    scopus 로고
    • Time to virological failure of 3 classes of antiretrovirals after initiation of highly active antiretroviral therapy: Results from the EuroSIDA Study Group
    • for the Euro-SIDA Study Group
    • Mocroft A., Ledergerber B., Viard J.P., et al., for the Euro-SIDA Study Group. Time to virological failure of 3 classes of antiretrovirals after initiation of highly active antiretroviral therapy: Results from the EuroSIDA Study Group. J Infect Dis 190 (2004) 1947-1956
    • (2004) J Infect Dis , vol.190 , pp. 1947-1956
    • Mocroft, A.1    Ledergerber, B.2    Viard, J.P.3
  • 6
    • 0035313589 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 entry inhibitors PRO 542 and T-20 are potently synergistic in blocking virus-cell and cell-cell fusion
    • Nagashima K.A., Thompson D.A., Rosenfield S.I., et al. Human immunodeficiency virus type 1 entry inhibitors PRO 542 and T-20 are potently synergistic in blocking virus-cell and cell-cell fusion. J Infect Dis 183 (2001) 1121-1125
    • (2001) J Infect Dis , vol.183 , pp. 1121-1125
    • Nagashima, K.A.1    Thompson, D.A.2    Rosenfield, S.I.3
  • 7
    • 0042376485 scopus 로고    scopus 로고
    • A new classification for HIV-1
    • for the HIV Network for Prevention Trials Vaccine Preparedness Protocol Team
    • Berger E.A., Doms R.W., Fenyö E.M., et al., for the HIV Network for Prevention Trials Vaccine Preparedness Protocol Team. A new classification for HIV-1. Nature 319 (1998) 240
    • (1998) Nature , vol.319 , pp. 240
    • Berger, E.A.1    Doms, R.W.2    Fenyö, E.M.3
  • 8
    • 16044373004 scopus 로고    scopus 로고
    • Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene
    • Samson M., Libert F., Doranz B.J., et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382 (1996) 722-725
    • (1996) Nature , vol.382 , pp. 722-725
    • Samson, M.1    Libert, F.2    Doranz, B.J.3
  • 9
    • 15844388931 scopus 로고    scopus 로고
    • Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection
    • Liu R., Paxton W.A., Choe S., et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86 (1996) 367-377
    • (1996) Cell , vol.86 , pp. 367-377
    • Liu, R.1    Paxton, W.A.2    Choe, S.3
  • 10
    • 0035881173 scopus 로고    scopus 로고
    • Homozygous and heterozygous CCR5-Delta32 genotypes are associated with resistance to HIV infection
    • Marmor M., Sheppard H.W., Donnell D., et al. Homozygous and heterozygous CCR5-Delta32 genotypes are associated with resistance to HIV infection. J Acquir Immune Defic Syndr 27 (2001) 472-481
    • (2001) J Acquir Immune Defic Syndr , vol.27 , pp. 472-481
    • Marmor, M.1    Sheppard, H.W.2    Donnell, D.3
  • 11
    • 0007643930 scopus 로고    scopus 로고
    • Association between CCR5 genotype and the clinical course of HIV-11 infection
    • de Roda Husman A.M., Koot M., Cornelissen M., et al. Association between CCR5 genotype and the clinical course of HIV-11 infection. Ann Intern Med 127 (1997) 882-890
    • (1997) Ann Intern Med , vol.127 , pp. 882-890
    • de Roda Husman, A.M.1    Koot, M.2    Cornelissen, M.3
  • 12
    • 34147102357 scopus 로고    scopus 로고
    • Assessing theoretical risk and benefit suggested by genetic association studies of CCR5: Experience in a drug development programme for maraviroc
    • Wheeler J., McHale M., Jackson V., and Penny M. Assessing theoretical risk and benefit suggested by genetic association studies of CCR5: Experience in a drug development programme for maraviroc. Antivir Ther 12 (2007) 233-245
    • (2007) Antivir Ther , vol.12 , pp. 233-245
    • Wheeler, J.1    McHale, M.2    Jackson, V.3    Penny, M.4
  • 13
  • 14
    • 0141814730 scopus 로고    scopus 로고
    • The entry of entry inhibitors: A fusion of science and medicine
    • Moore J.P., and Doms R.W. The entry of entry inhibitors: A fusion of science and medicine. Proc Natl Acad Sci U S A 100 (2003) 10598-10602
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10598-10602
    • Moore, J.P.1    Doms, R.W.2
  • 15
    • 0037059049 scopus 로고    scopus 로고
    • Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics
    • Reeves J.D., Gallo S.A., Ahmad N., et al. Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics. Proc Natl Acad Sci U S A 99 (2002) 16249-16254
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 16249-16254
    • Reeves, J.D.1    Gallo, S.A.2    Ahmad, N.3
  • 16
    • 0037320947 scopus 로고    scopus 로고
    • HIV-1 cell entry and advances in viral entry inhibitor therapy
    • Cooley L.A., and Lewin S.R. HIV-1 cell entry and advances in viral entry inhibitor therapy. J Clin Virol 26 (2003) 1121-1132
    • (2003) J Clin Virol , vol.26 , pp. 1121-1132
    • Cooley, L.A.1    Lewin, S.R.2
  • 17
    • 0035145352 scopus 로고    scopus 로고
    • The potential for HIV fusion inhibition
    • Cammack N. The potential for HIV fusion inhibition. Curr Opin Infect Dis 14 (2001) 13-16
    • (2001) Curr Opin Infect Dis , vol.14 , pp. 13-16
    • Cammack, N.1
  • 18
    • 0034312298 scopus 로고    scopus 로고
    • The plasma membrane as a combat zone in the HIV battlefield
    • Doms R.W., and Trono D. The plasma membrane as a combat zone in the HIV battlefield. Genes Dev 14 (2000) 2677-2688
    • (2000) Genes Dev , vol.14 , pp. 2677-2688
    • Doms, R.W.1    Trono, D.2
  • 19
    • 27644510382 scopus 로고    scopus 로고
    • Maraviroc (UUK-427,857), a potent, orally bioavailable,and selective small-molecule inhibitor of chemokine receptor CCR5 with broadspectrum anti-human immunode-ficiency virus type 1 activity
    • Dorr P., Westby M., Dobbs S., et al. Maraviroc (UUK-427,857), a potent, orally bioavailable,and selective small-molecule inhibitor of chemokine receptor CCR5 with broadspectrum anti-human immunode-ficiency virus type 1 activity. Antimi-crob Agents Chemother 49 (2005) 4721-4732
    • (2005) Antimi-crob Agents Chemother , vol.49 , pp. 4721-4732
    • Dorr, P.1    Westby, M.2    Dobbs, S.3
  • 20
    • 34547642109 scopus 로고    scopus 로고
    • Maraviroc, a chemokine CCR5 receptor antagonist for the treatment of HIV infection and AIDS
    • Meanwell N.A., and Kadow J.F. Maraviroc, a chemokine CCR5 receptor antagonist for the treatment of HIV infection and AIDS. Curr Opin Investig Drugs 8 (2007) 669-681
    • (2007) Curr Opin Investig Drugs , vol.8 , pp. 669-681
    • Meanwell, N.A.1    Kadow, J.F.2
  • 21
    • 30744447460 scopus 로고    scopus 로고
    • Efficacy of shortterm monotherapy with maraviroc, a new CCR5 ntagonist, n patients infected with HIV-1
    • Fätkenheuer G., Pozniak A.L., Johnson M.A., et al. Efficacy of shortterm monotherapy with maraviroc, a new CCR5 ntagonist, n patients infected with HIV-1. Nat Med 11 (2005) 1170-1172
    • (2005) Nat Med , vol.11 , pp. 1170-1172
    • Fätkenheuer, G.1    Pozniak, A.L.2    Johnson, M.A.3
  • 22
    • 34249711352 scopus 로고    scopus 로고
    • Access denied? The status of coreceptor inhibition to counter HIV entry
    • Biswas P., Tambussi G., and Lazzarin A. Access denied? The status of coreceptor inhibition to counter HIV entry. Expert Opin Pharmacother 8 (2007) 923-933
    • (2007) Expert Opin Pharmacother , vol.8 , pp. 923-933
    • Biswas, P.1    Tambussi, G.2    Lazzarin, A.3
  • 23
    • 40549135975 scopus 로고    scopus 로고
    • Assessment of the pharmaco-kinetics, safety and tolerability of maraviroc, a novel CCR5 antagonist, in healthy volunteers
    • Abel S., van der Ryst E., Rosario M.C., et al. Assessment of the pharmaco-kinetics, safety and tolerability of maraviroc, a novel CCR5 antagonist, in healthy volunteers. Br J Clin Pharmacol 65 1 (2008) 5-18
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.1 , pp. 5-18
    • Abel, S.1    van der Ryst, E.2    Rosario, M.C.3
  • 24
    • 48549095315 scopus 로고    scopus 로고
    • Dumond JB, Patterson KB, Pecha A, et al. Maraviroc pharmacokinetics in blood plasma, genital tract fluid and tissue in healthy female volunteers. Presented at: 15th Conference on Retroviruses and Opportunistic Infections; Febreary 3-6, 2008; Boston, Mass. Abstract 135LB.
    • Dumond JB, Patterson KB, Pecha A, et al. Maraviroc pharmacokinetics in blood plasma, genital tract fluid and tissue in healthy female volunteers. Presented at: 15th Conference on Retroviruses and Opportunistic Infections; Febreary 3-6, 2008; Boston, Mass. Abstract 135LB.
  • 25
    • 48549098418 scopus 로고    scopus 로고
    • Lalezari J, Goodrich J, DeJesus E, et al, for the MOTIVATE 1 Study Team. Efficacy and safety of maraviroc in antiretroviral-experienced patients infected with CCR5-tropic HIV-1: 48-Weeks results of MOTIVATE-1 Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 17-20, 2007; Chicago, Ill. Abstract 104bLB.
    • Lalezari J, Goodrich J, DeJesus E, et al, for the MOTIVATE 1 Study Team. Efficacy and safety of maraviroc in antiretroviral-experienced patients infected with CCR5-tropic HIV-1: 48-Weeks results of MOTIVATE-1 Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 17-20, 2007; Chicago, Ill. Abstract 104bLB.
  • 26
    • 48549095627 scopus 로고    scopus 로고
    • Fatkenheuer G, Konourina I, Nelson M, et al, for the MOTIVATE 2 Study Team. Efficacy and safety of maraviroc (MVC) plus optimized background therapy (OBT)in viraemic, antiretroviral treatment-experienced patients infected with CCR5-ttropic (R5)HIV-1 in Europe, Australia and North America (MMOTIVATE 2): 48-Week results. Presented at: 11th European Conference; October 24-27, 2007; Madrid, Spain. Abstract PS3/5.
    • Fatkenheuer G, Konourina I, Nelson M, et al, for the MOTIVATE 2 Study Team. Efficacy and safety of maraviroc (MVC) plus optimized background therapy (OBT)in viraemic, antiretroviral treatment-experienced patients infected with CCR5-ttropic (R5)HIV-1 in Europe, Australia and North America (MMOTIVATE 2): 48-Week results. Presented at: 11th European Conference; October 24-27, 2007; Madrid, Spain. Abstract PS3/5.
  • 27
    • 15344350690 scopus 로고    scopus 로고
    • Species differences in the disposition of the CCR5 antagonist, UK-4427,857, a new potential treatment for HIV
    • Walker D.K., Abel S., Comby P., et al. Species differences in the disposition of the CCR5 antagonist, UK-4427,857, a new potential treatment for HIV. Drug Metab Dispos 33 (2005) 587-595
    • (2005) Drug Metab Dispos , vol.33 , pp. 587-595
    • Walker, D.K.1    Abel, S.2    Comby, P.3
  • 28
    • 48549101175 scopus 로고    scopus 로고
    • Maraviroc tablets NDA 22-128 [briefing document] [US Food and Drug Administration Web site].
    • Maraviroc tablets NDA 22-128 [briefing document] [US Food and Drug Administration Web site].
  • 29
    • 48549089549 scopus 로고    scopus 로고
    • February 10, Accessed
    • (2008). http://wwww.fda.gov/ohrms/dockets/ac/007/briefing/2007-4283b1-01-Pfizer.pdf February 10, Accessed
    • (2008)
  • 30
    • 48549087976 scopus 로고    scopus 로고
    • Hoepelman IM, Ayoub A, Heera J, et al. The incidence of severe liver enzyme abnormalities and hepatic adverse events in the maraviroc clinical development programme. Presented at: 11th European AIDS Conference; 24-27, 2007; Madrid, Spain. Abstract LBP7.99/1.
    • Hoepelman IM, Ayoub A, Heera J, et al. The incidence of severe liver enzyme abnormalities and hepatic adverse events in the maraviroc clinical development programme. Presented at: 11th European AIDS Conference; 24-27, 2007; Madrid, Spain. Abstract LBP7.99/1.
  • 31
    • 33847237614 scopus 로고    scopus 로고
    • Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bbound receptor for entry
    • Westby M., Smith-Burchnell C., Mori J., et al. Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bbound receptor for entry. J Virol 81 (2007) 2359-2371
    • (2007) J Virol , vol.81 , pp. 2359-2371
    • Westby, M.1    Smith-Burchnell, C.2    Mori, J.3
  • 32
    • 48549090574 scopus 로고    scopus 로고
    • Naeger LK. Resistance and tropism-maraviroc.
    • Naeger LK. Resistance and tropism-maraviroc.
  • 33
    • 48549097658 scopus 로고    scopus 로고
    • Accessed
    • (July 10, 2008). http://www.scribd.com/doc/1118185/US-Food-and-Drug-Administration-20074283s10204FDA-Naeger Accessed
    • (2008)
  • 34
    • 48549095176 scopus 로고    scopus 로고
    • McFadyen L, Jacqmin P, Wade JR, et al. Maraviroc (MVC) exposure-efficacy relationship in treatment-experienced HIV-1-infected patients. Presented at: 11th European Conference; October 24-27, 2007; Madrid, Spain. Abstract P4.1/06.
    • McFadyen L, Jacqmin P, Wade JR, et al. Maraviroc (MVC) exposure-efficacy relationship in treatment-experienced HIV-1-infected patients. Presented at: 11th European Conference; October 24-27, 2007; Madrid, Spain. Abstract P4.1/06.
  • 35
    • 48549105653 scopus 로고    scopus 로고
    • Saag M, Ive P, Heera J, et al. A multicenter, randomized, double-bblind, comparative trial of a novel CCR5 antagonist, maraviroc, versus efavirenz, both in combination with combivir (zidovudine [ZDV]/lamivudine [3TC]), for the treatment of antiretroviral naive subjects infected with R5 HIV-1: Week 48 results of the MERIT study. Presented at: 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; July 22-25, 2007; Sydney, Australia. Abstract WESS104.
    • Saag M, Ive P, Heera J, et al. A multicenter, randomized, double-bblind, comparative trial of a novel CCR5 antagonist, maraviroc, versus efavirenz, both in combination with combivir (zidovudine [ZDV]/lamivudine [3TC]), for the treatment of antiretroviral naive subjects infected with R5 HIV-1: Week 48 results of the MERIT study. Presented at: 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; July 22-25, 2007; Sydney, Australia. Abstract WESS104.
  • 36
    • 48549098419 scopus 로고    scopus 로고
    • van der Ryst E, Cooper D, Konourina I, et al. Efficacy of maraviroc in combination with at least one other potent new antiretroviral drug: 24-Week combined analysis of the MOTIVATE 1 and 2 studies. Presented at: 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; July 22-25, 2007; Sydney, Australia. Abstract WEPEB115LB.
    • van der Ryst E, Cooper D, Konourina I, et al. Efficacy of maraviroc in combination with at least one other potent new antiretroviral drug: 24-Week combined analysis of the MOTIVATE 1 and 2 studies. Presented at: 4th International AIDS Society Conference on HIV Pathogenesis, Treatment and Prevention; July 22-25, 2007; Sydney, Australia. Abstract WEPEB115LB.
  • 37
    • 48549092111 scopus 로고    scopus 로고
    • Gulick RM, van der Ryst E, Lampiris H, et al. Efficacy and safety of once-daily (QD) compared with twicedaily (BID) maraviroc plus optimized background therapy (OBT) in treatment-experienced patients infected with CCR5-tropic HIV-1: 24-Week combined analysis of the MOTIVATE 1 and 2 studies. Presented at: 4th International AIDS Society Conference on HIV Pathogenesis, Prevention; July 22-25, 2007; Sydney, Australia. Abstract WEPEB116LB.
    • Gulick RM, van der Ryst E, Lampiris H, et al. Efficacy and safety of once-daily (QD) compared with twicedaily (BID) maraviroc plus optimized background therapy (OBT) in treatment-experienced patients infected with CCR5-tropic HIV-1: 24-Week combined analysis of the MOTIVATE 1 and 2 studies. Presented at: 4th International AIDS Society Conference on HIV Pathogenesis, Prevention; July 22-25, 2007; Sydney, Australia. Abstract WEPEB116LB.
  • 38
    • 48549090416 scopus 로고    scopus 로고
    • Hardy D, Reynes J, Konourina I, et al. Efficacy and safety of maraviroc plus optimized background therapy in treatment-experienced patients infected with CCR5-ttropic HIV-1: 48-Week combined analysis of the MOTIVATE studies. Presented at: 15th Conference on Retroviruses Infections; February 3-6, 2008; Boston, Mass. Abstract 792.
    • Hardy D, Reynes J, Konourina I, et al. Efficacy and safety of maraviroc plus optimized background therapy in treatment-experienced patients infected with CCR5-ttropic HIV-1: 48-Week combined analysis of the MOTIVATE studies. Presented at: 15th Conference on Retroviruses Infections; February 3-6, 2008; Boston, Mass. Abstract 792.
  • 39
    • 48549097803 scopus 로고    scopus 로고
    • Mayer H, van der Ryst E, Saag M, et al. Safety and efficacy of maraviroc, a novel CCR5 antagonist, when used in combination with optimized background therapy for the treatment of antiretroviral-experienced subjects infected with dual/mixed-tropic HIV-1: 24-Week results of a Phase 2b exploratory trial. Presented at: 16th International AIDS Conference; August 13-18, 2006; Toronto, Canada. Abstract TH HLB 0215.
    • Mayer H, van der Ryst E, Saag M, et al. Safety and efficacy of maraviroc, a novel CCR5 antagonist, when used in combination with optimized background therapy for the treatment of antiretroviral-experienced subjects infected with dual/mixed-tropic HIV-1: 24-Week results of a Phase 2b exploratory trial. Presented at: 16th International AIDS Conference; August 13-18, 2006; Toronto, Canada. Abstract TH HLB 0215.
  • 40
    • 48549100276 scopus 로고    scopus 로고
    • Goodrich JM, Saag M, van der Ryst E, et al. 48-Week safety and efficacy of maraviroc, a novel CCR5 antagonist, in combination with optimized background therapy (OBT) for the treatment of antiretroviral-experienced patients infected with dual/mixed-tropic HIV-1. Presented at: 45th Annual Meeting of Infectious Diseases Society of America; October 4-7, 2007; Diego, Calif. Abstract LB-22.
    • Goodrich JM, Saag M, van der Ryst E, et al. 48-Week safety and efficacy of maraviroc, a novel CCR5 antagonist, in combination with optimized background therapy (OBT) for the treatment of antiretroviral-experienced patients infected with dual/mixed-tropic HIV-1. Presented at: 45th Annual Meeting of Infectious Diseases Society of America; October 4-7, 2007; Diego, Calif. Abstract LB-22.
  • 41
    • 48549103726 scopus 로고    scopus 로고
    • McHale M, Abel S, Russell D, et al. Overview of Phase 1 and 2a safety and efficacy data of maraviroc (UK-427,857). Presented at: 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment; July 24-27, 2005; Rio de Janeiro, Brazil. Abstract TuOa 0204.
    • McHale M, Abel S, Russell D, et al. Overview of Phase 1 and 2a safety and efficacy data of maraviroc (UK-427,857). Presented at: 3rd International AIDS Society Conference on HIV Pathogenesis and Treatment; July 24-27, 2005; Rio de Janeiro, Brazil. Abstract TuOa 0204.
  • 42
    • 40549135640 scopus 로고    scopus 로고
    • Effect of single doses of maraviroc on the QT/QTc interval in healthy subjects
    • Davis J.D., Hackman F., Layton G., et al. Effect of single doses of maraviroc on the QT/QTc interval in healthy subjects. Br J Clin Pharmacol 65 Suppl 1 (2008) 68-75
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.SUPPL. 1 , pp. 68-75
    • Davis, J.D.1    Hackman, F.2    Layton, G.3
  • 44
    • 40549127134 scopus 로고    scopus 로고
    • Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers
    • Abel S., Russell D., Taylor-Worth R.J., et al. Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. Br J Clin Pharmacol 65 Suppl 1 (2008) 27-37
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.SUPPL. 1 , pp. 27-37
    • Abel, S.1    Russell, D.2    Taylor-Worth, R.J.3
  • 45
    • 48549088706 scopus 로고    scopus 로고
    • Abel S, Ridgway C, Hamlin J, et al. An open, randomized, 2-way cross-over study to investigate the effect of darunavir/ritonavir on the pharmacokinetics of maraviroc in healthy subjects. Presented at: 16th International HIV Drug Resistance Workshop; July 12-16, 2007; Barbados, West Indies. Abstract 55.
    • Abel S, Ridgway C, Hamlin J, et al. An open, randomized, 2-way cross-over study to investigate the effect of darunavir/ritonavir on the pharmacokinetics of maraviroc in healthy subjects. Presented at: 16th International HIV Drug Resistance Workshop; July 12-16, 2007; Barbados, West Indies. Abstract 55.
  • 46
    • 40549086936 scopus 로고    scopus 로고
    • Effects of CYP3A4 inducers with and without CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers
    • Abel S., Jenkins T.M., Whitlock L.A., et al. Effects of CYP3A4 inducers with and without CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. Br J Clin Pharmacol 65 Suppl 1 (2008) 38-46
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.SUPPL. 1 , pp. 38-46
    • Abel, S.1    Jenkins, T.M.2    Whitlock, L.A.3
  • 47
    • 48549088227 scopus 로고    scopus 로고
    • Davis J, Scholler-GGyyre M, Kakuda TN, et al. An open, randomized, two-period, crossover study in two cohorts to investigate the effect of steady-state TMC125 (etravirine) and the combination of TMC125/darunavir/ritonavir on the steady-state pharmacokinetics of oral maraviroc in healthy subjects. Presented at: 11th European AIDS Conference; October 24-27, 2007; Madrid, Spain. Abstract P4.33/02.
    • Davis J, Scholler-GGyyre M, Kakuda TN, et al. An open, randomized, two-period, crossover study in two cohorts to investigate the effect of steady-state TMC125 (etravirine) and the combination of TMC125/darunavir/ritonavir on the steady-state pharmacokinetics of oral maraviroc in healthy subjects. Presented at: 11th European AIDS Conference; October 24-27, 2007; Madrid, Spain. Abstract P4.33/02.
  • 48
    • 48549087729 scopus 로고    scopus 로고
    • Muirhead G, Pozniak A, Gazzard B, et al. A novel probe drug interaction study to investigate the effect of selected ARV combinations on the pharmacokinetics of a single oral dose of maraviroc (UK-427,857) in HIV +ve subjects. Presented at: 12th Conference on Retroviruses Infections; February 22-25, 2005; Boston, Mass. Abstract 663.
    • Muirhead G, Pozniak A, Gazzard B, et al. A novel probe drug interaction study to investigate the effect of selected ARV combinations on the pharmacokinetics of a single oral dose of maraviroc (UK-427,857) in HIV +ve subjects. Presented at: 12th Conference on Retroviruses Infections; February 22-25, 2005; Boston, Mass. Abstract 663.
  • 49
    • 40549090550 scopus 로고    scopus 로고
    • Effect of maraviroc on the pharmaco-kinetics of midazolam, lamivudine/ zidovudine, and ethinyloestradiol/ levonorgestrel in healthy volunteers
    • Abel S., Russell D., Whitlock L.A., et al. Effect of maraviroc on the pharmaco-kinetics of midazolam, lamivudine/ zidovudine, and ethinyloestradiol/ levonorgestrel in healthy volunteers. Br J Clin Pharmacol 65 Suppl 1 (2008) 19-26
    • (2008) Br J Clin Pharmacol , vol.65 , Issue.SUPPL. 1 , pp. 19-26
    • Abel, S.1    Russell, D.2    Whitlock, L.A.3
  • 50
    • 40549124307 scopus 로고    scopus 로고
    • The effects of cotrimoxazole or tenofovir co-administration on the pharmacokinetics of maraviroc in healthy volunteers
    • Abel S., Russell D., Whitlock L.A., et al. The effects of cotrimoxazole or tenofovir co-administration on the pharmacokinetics of maraviroc in healthy volunteers. BrJ Clin Pharmacol 65 Suppl 1 (2008) 47-53
    • (2008) BrJ Clin Pharmacol , vol.65 , Issue.SUPPL. 1 , pp. 47-53
    • Abel, S.1    Russell, D.2    Whitlock, L.A.3
  • 51
    • 48549099490 scopus 로고    scopus 로고
    • Thomson Medical Economics, Montvale, NJ
    • 2008 Drug Topics Red Book (2008), Thomson Medical Economics, Montvale, NJ
    • (2008) 2008 Drug Topics Red Book
  • 52
    • 48549103992 scopus 로고    scopus 로고
    • Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents.
    • Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents.
  • 53
    • 48549084559 scopus 로고    scopus 로고
    • February 10, Accessed
    • (2008). http://aidsinfo.nih.gov/contentfiles/AdultanclAdolescentGL.pdf February 10, Accessed
    • (2008)
  • 54
    • 48549096761 scopus 로고    scopus 로고
    • FAQs-physician questions [Trofile co-receptor tropism assay Web site]..
    • FAQs-physician questions [Trofile co-receptor tropism assay Web site]..
  • 55
    • 48549106179 scopus 로고    scopus 로고
    • February 10, Accessed
    • (2008). http://www.trofileassay.com/FAQs_Physician-Questions February 10, Accessed
    • (2008)
  • 56
    • 48549099491 scopus 로고    scopus 로고
    • Kuehne FC, Chancellor J, Mollon P, Powderly W. Modelling the costeffectiveness of maraviroc for anti retroviral treatment-experienced individuals. Presented at: 11th European AIDS Conference; October 24-27, 2007; Madrid, Spain. Abstract P10.4/02.
    • Kuehne FC, Chancellor J, Mollon P, Powderly W. Modelling the costeffectiveness of maraviroc for anti retroviral treatment-experienced individuals. Presented at: 11th European AIDS Conference; October 24-27, 2007; Madrid, Spain. Abstract P10.4/02.
  • 57
    • 33646443202 scopus 로고    scopus 로고
    • Emergence of CXCR4-using human immunodeficiencyvirus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir
    • Westby M., Lewis M., Whitcomb J., et al. Emergence of CXCR4-using human immunodeficiencyvirus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir. J Virol 80 (2006) 4909-4920
    • (2006) J Virol , vol.80 , pp. 4909-4920
    • Westby, M.1    Lewis, M.2    Whitcomb, J.3
  • 58
    • 28544434492 scopus 로고    scopus 로고
    • CCR5 antagonists: Host-targeted antivirals for the treatment of HIV infec tion
    • Westby M., and van der Ryst E. CCR5 antagonists: Host-targeted antivirals for the treatment of HIV infec tion. Antivir Chem Chemother 16 (2005) 339-354
    • (2005) Antivir Chem Chemother , vol.16 , pp. 339-354
    • Westby, M.1    van der Ryst, E.2
  • 59
    • 35548984868 scopus 로고    scopus 로고
    • CCR5 antagonists in the treatment of treatment-experi enced patients infected with CCR5 tropic HIV-1
    • Lorenzen T., Stoehr A., Walther I., and Plettenberg A. CCR5 antagonists in the treatment of treatment-experi enced patients infected with CCR5 tropic HIV-1. Eur J Med Res 12 (2007) 419-425
    • (2007) Eur J Med Res , vol.12 , pp. 419-425
    • Lorenzen, T.1    Stoehr, A.2    Walther, I.3    Plettenberg, A.4
  • 60
    • 48549094517 scopus 로고    scopus 로고
    • van der Ryst E, Westby M. Changes in HIV-1 co-receptor tropism for patients participating in the maravi roc MOTIVATE 1 and 2 clinical trials. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 1720, 2007; Chicago, III. Abstract H715.
    • van der Ryst E, Westby M. Changes in HIV-1 co-receptor tropism for patients participating in the maravi roc MOTIVATE 1 and 2 clinical trials. Presented at: 47th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 1720, 2007; Chicago, III. Abstract H715.
  • 61
    • 48549083623 scopus 로고    scopus 로고
    • Reeves JD, Han D, Liu Y, et al. Enhancements to the Trofile HIV coreceptor tropism assay enable im proved detection of CXCR4-using subpopulations and earlier detection of CXCR4-using viruses in sequential patient samples. Presented at: 11th European AIDS Conference/ EACS; October 24-27, 2007; Madrid, Spain. Abstract P1.2/03.
    • Reeves JD, Han D, Liu Y, et al. Enhancements to the Trofile HIV coreceptor tropism assay enable im proved detection of CXCR4-using subpopulations and earlier detection of CXCR4-using viruses in sequential patient samples. Presented at: 11th European AIDS Conference/ EACS; October 24-27, 2007; Madrid, Spain. Abstract P1.2/03.
  • 62
    • 34147112358 scopus 로고    scopus 로고
    • Identifying safety concerns from genetic data: Lesions from the development of CCR5 inhibitors
    • Telenti A., and Egger M. Identifying safety concerns from genetic data: Lesions from the development of CCR5 inhibitors. AntivirTher 12 (2007) 147-148
    • (2007) AntivirTher , vol.12 , pp. 147-148
    • Telenti, A.1    Egger, M.2
  • 63
    • 35548963749 scopus 로고    scopus 로고
    • Treatment with CCR5 antagonists: Which patient may have a benefit?
    • Mueller M.C., and Bogner J.R. Treatment with CCR5 antagonists: Which patient may have a benefit?. Eur J Med Res 12 (2007) 441-452
    • (2007) Eur J Med Res , vol.12 , pp. 441-452
    • Mueller, M.C.1    Bogner, J.R.2


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