In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets

Blood

Volumn 106, Issue 3, 2005, Pages 1113-1122

  Beilhack, Andreas ^a   Schulz, Stephan ^a   Baker, Jeanette ^a   Beilhack, Georg F ^a   Wieland, Courtney B ^a   Herman, Edward I ^a   Baker, Enosh M ^a   Cao, Yu An ^a   Contag, Christopher H ^a   Negrin, Robert S ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Center for Clinical Sciences Research Building   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN;

ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ALLOIMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOLUMINESCENCE; CONTROLLED STUDY; EFFECTOR CELL; GRAFT VERSUS HOST REACTION; IMMUNOCOMPETENT CELL; IN VITRO STUDY; IN VIVO STUDY; INTESTINE; LIVER; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC INFILTRATION; LYMPHOID ORGAN; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN; SPLEEN CELL; T LYMPHOCYTE SUBPOPULATION;

EID: 23044472871     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2005-02-0509     Document Type: Article

References (36)

1. Horrowitz M. Uses and growth of hematopoietic cell transplantation. In: Thomas ED, Blume KG, Forman SJ, Appelbaum FR, eds. Thomas' Hematopoietic Cell Transplantation. Maiden, MA: Blackwell; 2004:9-15.
2. Appelbaum FR. Haematopoietic cell transplantation as immunotherapy. Nature. 2001;411:385-389.
3. Shizuru JA. The experimental basis for hematopoietic cell transplantation for autoimmune diseases. In: Thomas ED, Blume KG, Forman SJ, Appelbaum FR, eds. Thomas' Hematopoietic Cell Transplantation. Maiden, MA: Blackwell; 2004: 324-343.
4. Sykes M, Sachs DH. Mixed chimerism. Philos Trans R Soc Lond B Biol Sci. 2001;356:707-726.
5. Ferrara JL, Deeg HJ, Division of Pediatric Oncology D-FCIBMA. Gratt-versus-host disease. N Engl J Med. 1991;324:667-674.
6. Hill GR, Ferrara JL. The primacy of the gastrointestinal tract as a target organ of acute gratt-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. Blood. 2000;95:2754-2759.
7. Edinger M, Cao YA, Verneris MR, Bachmann MH, Contag CH, Negrin RS. Revealing lymphoma growth and the efficacy of immune cell therapies using in vivo bioluminescence imaging. Blood. 2003;101:640-648.
8. Edinger M, Hoffmann P, Ermann J, et al. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med. 2003;9:1144-1150.
9. Cao YA, Wagers AJ, Beilhack A, et al. Shifting foci of hematopoiesis during reconstitution from single stem cells. Proc Natl Acad Sci USA. 2004; 101:221-226.
10. Anderson BE, McNiff J, Yan J, et al. Memory CD4+ T cells do not induce graft-versus-host disease. J Clin Invest. 2003;112:101-108.
11. Chen BJ, Cui X, Sempowski GD, Liu C, Chao NJ. Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease. Blood. 2004; 103:1534-1541.
12. + T cells are defective in mediating acute graft-versus-host disease but retain graft-versus-leukemia activity. Blood. 2004;103: 3970-3978.
13. Sale GE, Farr A, Hamilton BL. The murine fore-stomach: a sensitive site for graft-versus-host disease. Bone Marrow Transplant. 1991;7:263-267.
14. Gallatin WM, Weissman IL, Butcher EC. A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature. 1983;304:30-34.
15. Hamann A, Andrew DP, Jablonski-Westrich D, Holzmann B, Butcher EC. Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo. J Immunol. 1994;152:3282-3293.
16. Petrovic A, Alpdogan O, Willis LM, et al. LPAM (alpha 4 beta 7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease. Blood. 2004;103:1542-1547.
17. De Rosa SC, Roederer M. Eleven-color flow cytometry: a powerful tool for elucidation of the complex immune system. Clin Lab Med. 2001;21: 697-712.
18. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. 2 subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999;401:708-712.
19. Butcher EC, Picker LJ. Lymphocyte homing and homeostasis. Science. 1996;272:60-66.
20. Weninger W, Crowley MA, Manjunath N, von Andrian UH. Migratory properties of naive, effector, and memory CD8(+)T cells. J Exp Med. 2001; 194:953-966.
21. Ngo VN, Tang HL, Cyster JG. Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells. J Exp Med. 1998;188:181-191.
22. Lerner KG, Kao GF, Storb R, Buckner CD, Clift RA, Thomas ED. Histopathology of graft-vs.-host reaction (GvHR) in human recipients of marrow from HL-A-matched sibling donors. Transplant Proc. 1974;6:367-371.
23. Atkinson K. Bone-marrow and blood stem-cell transplantation. In: Berry CL, ed. Transplantation Pathology: A Guide for Practicing Pathologists. Current Topics in Pathology. Vol 92. New York, NY: Springer; 1999:107-136.
24. Heymer B, Bunjes D, Friedrich W. Clinical and Diagnostic Pathology of Graft-Versus-Host Disease (GvHD). New York, NY: Springer; 2002.
25. Murai M, Yoneyama H, Ezaki T, et al. Peyer patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. Nat Immunol. 2003;4:154-160.
26. Mora JR, Bono MR, Manjunath N, et al. Selective imprinting of gut-homing T cells by Peyer patch dendritic cells. Nature. 2003;424:88-93.
27. Johansson-Lindbom B, Svensson M, Wurbel MA, Malissen B, Marquez G, Agace W. Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant. J Exp Med. 2003;198: 963-969.
28. Stagg AJ, Kamm MA, Knight SC. Intestinal dendritic cells increase T cell expression of alpha4beta7 integrin. Eur J Immunol. 2002;32: 1445-1454.
29. Mora JR, Cheng G, Picarella D, Briskin M, Buchanan N, von Andrian UH. Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues. J Exp Med. 2005;201:303-316.
30. Panoskaltsis-Mortari A, Price A, Hermanson JR, et al. In vivo imaging of graft-versus-host-disease in mice. Blood. 2004;103:3590-3598.
31. Foster AE, Marangolo M, Sartor MM, et al. Human CD62L- memory T cells are less responsive to alloantigen stimulation than CD62L+ naive T cells: potential for adoptive immunotherapy and allodepletion. Blood. 2004;104:2403-2409.
32. Friedman JS, Alpdogan O, van den Brink MR, et al. Increasing T-cell age reduces effector activity but preserves proliferative capacity in a murine allogeneic major histocompatibility complex-mismatched bone marrow transplant model. Biol Blood Marrow Transplant. 2004;10:448-460.
33. Komgold R, Sprent J. Negative selection of T cells causing lethal graft-versus-host disease across minor histocompatibility barriers: role of the H-2 complex. J Exp Med. 1980;151:1114-1124.
34. Shlomchik WD, Couzens MS, Tang CB, et al. Prevention of graft versus host disease by inactivation of host antigen-presenting cells. Science. 1999;285:412-415.
35. Ermann J, Hoffmann P, Edinger M, et al. Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood. 2005;105:2220-2226.
36. Taylor PA, Panoskaltsis-Mortari A, Swedin JM, et al. L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood. 2004;104:3804-3812.