Hyporesponsiveness of donor cells to lipopolysaccharide stimulation reduces the severity of experimental idiopathic pneumonia syndrome: Potential role for a gut-lung axis of inflammation

Journal of Immunology

Volumn 165, Issue 11, 2000, Pages 6612-6619

  Cooke, K R ^a   Hill, G R ^a   Gerbitz, A ^a   Kobzik, L ^a   Martin, T R ^a   Crawford, J M ^a   Brewer, J P ^a   Ferrara, J L M ^a  

^a UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; ENDOTOXIN; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ALLOGENIC BONE MARROW TRANSPLANTATION; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HISTOPATHOLOGY; INTESTINE INJURY; LUNG INJURY; LUNG LAVAGE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL;

EID: 0034548082     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.11.6612     Document Type: Article

References (67)

1. Idiopathic pneumonia syndrome after bone marrow transplantation
2. Clinical course of idiopathic pneumonia after bone marrow transplantation
3. Acute graft versus host disease and the risks for idiopathic pneumonia after marrow transplantation for severe aplastic anemia
4. Idiopathic pneumonia syndrome: Changing spectrum of lung injury after marrow transplantation
5. An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation. I. The roles of minor H antigens and endotoxin
6. An acute pulmonary syndrome possibly representing acute graft-versus-host disease involving the lung interstitium
7. Host reactive donor T cells are associated with lung injury after experimental allogeneic bone marrow transplantation
8. The effect of donor T lymphocytes and total-body irradiation on hematopoietic engraftment and pulmonary toxicity following experimental allogeneic bone marrow transplantation
9. Pneumopathies of the graft-versus-host reaction: Alveolitis associated with an increased level of tumor necrosis factor mRNA and chronic interstitial pneumonitis
10. Lung injury induced by alloreactive Th1 cells is characterized by host-derived mononuclear cell inflammation and activation of alveolar macrophages
11. Idiopathic pneumonia syndrome in mice after allogeneic bone marrow transplantation
12. The critical early proinflammatory events associated with idiopathic pneumonia syndrome in irradiated murine allogeneic recipients are due to donor T cell infusion and potentiated by cyclophosphamide
13. Activated alveolar macrophage-derived nitric oxide predicts the development of lung damage after marrow transplantation in mice
14. High levels of peroxynitrite are generated in the lungs of irradiated mice given cyclophosphamide and allogeneic T cells: A potential mechanism of injury after marrow transplantation
15. 1-hybrid mice with acute graft-versus-host reactions
16. TNFα neutralization reduces lung injury after experimental allogeneic bone marrow transplantation
17. Increased serum levels of tumor necrosis factor α precede major complications of bone marrow transplantation
18. Idiopathic pneumonia after bone marrow transplantation: Cytokine activation and lipopolysaccharide amplification in the bronchoalveolar compartment
19. Lipopolysaccharide nonresponder cells: The C3H/HeJ defect
20. Mice genetically hyporesponsive to lipopolysaccharide (LPS) exhibit a defect in endocytic uptake of LPS and ceramide
21. Defective LPS signaling in C3H/HeJ and C57BL/20ScCr mice: Mutations in Tlr4 gene
22. Tumor necrosis factor-α production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft versus host disease
23. Endotoxin protein: A B cell mitogen and polyclonal activator of C3H/Hej lymphocytes
24. Mast cell activation enhances airway responsiveness to methacholine in the mouse
25. Total body irradiation effects on acute graft versus host disease: The role of gastrointestinal damage and inflammatory cytokines
26. Diagnosis of graft-versus-host disease in mice transplanted across minor histocompatibility barriers
27. Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation
28. Soluble tumor necrosis factor (TNF) receptors are effective therapeutic agents in lethal endotoxemia and function simultaneously as both TNF carriers and TNF antagonists
29. Pharmacokinetic parameters and biodistribution of soluble cytokine receptors
30. CD28 engraftment and proinflammatory cytokines contribute to T cell expansion and long-term survival in vivo
31. + T cells
32. Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-versus-host disease
33. The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: Rationale for the use of cytokine shields in allogeneic bone marrow transplantation
34. The locus of tumor necrosis factor-α action in lung inflammation
35. Inflammatory reactions induced by pretransplant conditioning - An alternative target for modulation of acute GVHD and complications following allogeneic bone marrow transplantation
36. TNF-α levels are increased during bone marrow transplant conditioning in patients who develop acute GVHD
37. Modulation of acute graft-versus-host disease after allogeneic bone marrow transplantation by tumor necrosis factor α (TNF-α) release in the course of pretransplant conditioning: Role of conditioning regimens and prophylactic application of a monoclonal antibody neutralizing human TNF-α (MAK 195F)
38. Differential effects of anti-Fas ligand and anti-tumor necrosis factor α antibodies on acute graft-versus-host disease pathologies
39. Expression of a tumor necrosis factor-α transgene in murine lung causes lymphocytic and fibrosing alveolitis: A mouse model of progressive pulmonary fibrosis
40. Compartmentalization of intraalveolar and systemic lipopolysaccharide-induced tumor necrosis factor and the pulmonary inflammatory response
41. Relationship between soluble CD14, lipopolysaccharide binding protein, and the alveolar inflammatory response in patients with acute respiratory distress syndrome
42. Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor α during graft-versus-host disease
43. Inflammatory cytokines in idiopathic pneumonia syndrome after bone marrow transplantation
44. Cytokine-induced sequential migration of neutrophils through endothelium and epithelium
45. TNF-α released by comigrating monocytes promotes transendothelial migration of activated lymphocytes
46. Lung injuries associated with graft-versus-host reactions
47. Requirement of CD4-positive T cells for cellular recruitment to the lungs of mice in response to a particulate intratracheal antigen
48. Pulmonary dendritic cells: Sentinels of lung associated lymphoid tissues
49. Pentoxifylline prevents tumor necrosis factor-induced lung injury
50. Tumor necrosis factor a regulates in vivo intrapulmonary expression of ICAM-1
51. Modulation of endothelial cell adhesion molecule expression in a situation of chronic inflammatory stimulation
52. TNF α regulation of FAS ligand expression on the vascular endothelium modulates leukocyte extravasation
53. The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice
54. Cytotoxic T cells deficient in both functional Fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease
55. Progressive accumulation of bacterial lipopolysaccharide in vivo during murine acute graft-versus-host disease
56. The gut mucosal barrier in bone marrow transplantation
57. Effect of IgM-enriched intravenous immunoglobulin (Pentaglobulin) on endotoxaemia and anti-endotoxin antibodies in bone marrow transplantation
58. Tumor necrosis factor-α regulates in vivo nitric oxide synthesis and induces liver injury during endotoxemia
59. Tumor necrosis factor α mediates lethal activity of killed gram-negative and gram-positive bacteria in D-galactosamine treated mice
60. Cellular and molecular biology of the inflamed liver
61. Liver-lung interactions during E. coli endotoxemia
62. The fate of intravenously injected endotoxin in normal rats and in rats with liver failure
63. Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine treated mice
64. Temporal relationship between the major complications of bone marrow transplantation for leukemia
65. Indispensable role for TNFα and IFNγ at the effector phase of liver injury mediated by Th1 cells specific to hepatitis B virus surface antigen
66. IL-11 separates graft-versus-leukemia effects from graft-versus-host disease after bone marrow transplantation
67. Keratinocyte growth factor (KGF) separates graft versus leukemia effects from graft-versus-host disease