CC Chemokine Receptor 2 Expression in Donor Cells Serves an Essential Role in Graft-versus-Host-Disease

Journal of Immunology

Volumn 171, Issue 9, 2003, Pages 4875-4885

  Rao, Arun R ^a,b   Quinones, Marlon P ^a,b   Garavito, Edgar ^a,b   Kalkonde, Yogeshwar ^a,b   Jimenez, Fabio ^a,b   Gibbons, Caroline ^a,b   Perez, Jennifer ^a,b   Melby, Peter ^a,b   Kuziel, William ^d   Reddick, Robert L ^b   Ahuja, Sunil K ^a,b,c   Ahuja, Seema S ^a,b  

^a SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

^c Vet Admin Ctr for Res on AIDS   (United States)

^d UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CHEMOKINE; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR2; GAMMA INTERFERON;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE MARROW APLASIA; CELL COMPARTMENTALIZATION; CELL FRACTIONATION; CELL INFILTRATION; CHRONIC DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE MODEL; DOSE RESPONSE; GRAFT VERSUS HOST REACTION; HISTOPATHOLOGY; MOLECULAR MODEL; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SPLEEN CELL; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; WILD TYPE;

EID: 10744233412     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.171.9.4875     Document Type: Article

References (58)

1. Flowers, M. E., E. Kansu, and K. M. Sullivan. 1999. Pathophysiology and treatment of graft-versus-host disease. Hematol. Oncol. Clin. North Am. 13:1091.
2. Cavazzana-Calvo, M., I. Andre-Schmutz, S. Hacein-Bey-Abina, D. Bensoussan, F. Le Deist, and A. Fischer. 2002. Improving immune reconstitution while preventing graft-versus-host disease in allogeneic stem cell transplantation. Semin. Hematol. 39:32.
3. Murphy, W. J., and B. R. Blazar. 1999. New strategies for preventing graft-versus-host disease. Curr. Opin. Immunol. 11:509.
4. Koh, C. Y., L. A. Welniak, and W. J. Murphy. 2000. Adoptive cellular immunotherapy: NK cells and bone marrow transplantation. Histol. Histopathol. 15:1201.
5. Tanaka, J., M. Imamura, M. Kasai, M. Asaka, and B. Torok-Storb. 1999. The role of accessory cells in allogeneic peripheral blood stem cell transplantation. Int. J. Hematol. 69:70.
6. Aranha, F. J., A. C. Vigorito, C. A. De Sousa, G. B. Oliveira, R. Zulli, and I. Lorand-Metze. 2002. The influence of the graft monocytes in the outcome of allogeneic bone marrow transplantation. Haematologica 87:219.
7. + cells derived from granulocyte colony-stimulating factor-mobilized peripheral blood mononuclear cells. Blood 89:1629.
8. + cells in anti-class II GVHD. J. Immunol. 144:2946.
9. Sprent, J., M. Hurd, M. Schaefer, and W. Heath. 1995. Split tolerance in spleen chimeras. J. Immunol. 154:1198.
10. Luster, A. D. 1998. Chemokines-chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338:436.
11. Luther, S. A., and J. G. Cyster. 2001. Chemokines as regulators of T cell differentiation. Nat. Immunol. 2:102.
12. Baggiolini, M. 2001. Chemokines in pathology and medicine. J. Intern. Med. 250:91.
13. Serody, J. S., D. N. Cook, S. L. Kirby, E. Reap, T. C. Shea, and J. A. Frelinger. 1999. Murine T lymphocytes incapable of producing macrophage inhibitory protein-1 are impaired in causing graft-versus-host disease across a class I but not class II major histocompatibility complex barrier. Blood 93:43.
14. + T cells to the liver, lung, and spleen during graft-versus-host disease. Blood 96:2973.
15. + T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease. J. Clin. Invest. 104:49.
16. Caux, C., S. Ait-Yahia, K. Chemin, O. de Bouteiller, M. C. Dieu-Nosjean, B. Homey, C. Massacrier, B. Vanbervliet, A. Zlotnik, and A. Vicari. 2000. Dendritic cell biology and regulation of dendritic cell trafficking by chemokines. Springer Semin. Immunopathol. 22:345.
17. Sato, N., S. K. Ahuja, M. Quinones, V. Kostecki, R. L. Reddick, P. C. Melby, W. A. Kuziel, and S. S. Ahuja. 2000. CC chemokine receptor (CCR)2 is required for Langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells: absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokines, β cell outgrowth, and sustained neutrophilic inflammation. J. Exp. Med. 192:205.
18. Sato, N., W. A. Kuziel, P. C. Melby, R. L. Reddick, V. Kostecki, W. Zhao, N. Maeda, S. K. Ahuja, and S. S. Ahuja. 1999. Defects in the generation of IFN-γ are overcome to control infection with Leishmania donovani in CC chemokine receptor (CCR) 5-, macrophage inflammatory protein-1α-, or CCR2-deficient mice. J. Immunol. 163:5519.
19. + T cell-mediated graft-versus-host disease. Transplantation 66:1220.
20. Blazar, B. R., P. A. Taylor, R. McElmurry, L. Tian, A. Panoskaltsis-Mortari, S. Lam, C. Lees, T. Waldschmidt, and D. A. Vallera. 1998. Engraftment of severe combined immune deficient mice receiving allogeneic bone marrow via In utero or postnatal transfer. Blood 92:3949.
21. Yoneyama, H., A. Harada, T. Imai, M. Baba, O. Yoshie, Y. Zhang, H. Higashi, M. Murai, H. Asakura, and K. Matsushima. 1998. Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice. J. Clin. Invest. 102:1933.
22. Quinones, M., S. K. Ahuja, P. C. Melby, L. Pate, R. L. Reddick, and S. S. Ahuja. 2000. Preformed membrane-associated stores of interleukin (IL)-12 are a previously unrecognized source of bioactive IL-12 that is mobilized within minutes of contact with an intracellular parasite. J. Exp. Med. 192:507.
23. Wells, A. D., H. Gudmundsdottir, and L. A. Turka. 1997. Following the fate of individual T cells throughout activation and clonal expansion: signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response. J. Clin. Invest. 100:3173.
24. + cells. J. Exp. Med. 180:307.
25. Wells, A. D., and L. A. Turka. 1998. Individual T cells hold unexpected clues to the nature of anergy and memory. Immunol. Res. 17:261.
26. Wells, A. D., X. C. Li, Y. Li, M. C. Walsh, X. X. Zheng, Z. Wu, G. Nunez, A. Tang, M. Sayegh, W. W. Hancock, et al. 1999. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat. Med. 5:1303.
27. Wells, A., H. Gudmundsdottir, M. Walsh, and L. A. Turka. 1999. Single-cell analysis of T-cell responses in vitro and in vivo: role of costimulatory signals. Transplant. Proc. 31:814.
28. Wells, A. D., X. C. Li, T. B. Strom, and L. A. Turka. 2001. The role of peripheral T-cell deletion in transplantation tolerance. Philos. Trans. R. Soc. London B 356:617.
29. Li, Y., X. C. Li, X. X. Zheng, A. D. Wells, L. A. Turka, and T. B. Strom. 1999. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat. Med. 5:1298.
30. Li, X. C., Y. Li, I. Dodge, A. D. Wells, X. X. Zheng, L. A. Turka, and T. B. Strom. 1999. Induction of allograft tolerance in the absence of Fas-mediated apoptosis. J. Immunol. 163:2500.
31. Suchin, E. J., P. B. Langmuir, E. Palmer, M. H. Sayegh, A. D. Wells, and L. A. Turka. 2001. Quantifying the frequency of alloreactive T cells in vivo: new answers to an old question. J. Immunol. 166:973.
32. Lund, P. K., A. B. Westvik, G. B. Joo, R. Ovstebo, K. B. Haug, and P. Kierulf. 2001. Flow cytometric evaluation of apoptosis, necrosis and recovery when culturing monocytes. J. Immunol. Methods 252:45.
33. Wasem, C., C. Frutschi, D. Arnold, C. Vallan, T. Lin, D. R. Green, C. Mueller, and T. Brunner. 2001. Accumulation and activation-induced release of preformed Fas (CD95) ligand during the pathogenesis of experimental graft-versus-host disease. J. Immunol. 167:2936.
34. Williamson, E., P. Garside, J. A. Bradley, and A. M. Mowat. 1996. IL-12 is a central mediator of acute graft-versus-host disease in mice. J. Immunol. 157:689.
35. Fowler, D. H., and R. E. Gress. 2000. Th2 and Tc2 cells in the regulation of GVHD, GVL, and graft rejection: considerations for the allogeneic transplantation therapy of leukemia and lymphoma. Leuk Lymphoma 38:221.
36. + T cells of Tc2 phenotype mediate a GVL effect and prevent marrow rejection. Vox Sang 74:331.
37. Fowler, D. H., K. Kurasawa, R. Smith, M. A. Eckhaus, and R. E. Gress. 1994. Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated mice. Blood 84:3540.
38. Blazar, B. R., P. A. Taylor, S. Smith, and D. A. Vallera. 1995. Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow grafts. Blood 85:842.
39. Murphy, W. J., L. A. Welniak, D. D. Taub, R. H. Wiltrout, P. A. Taylor, D. A. Vallera, M. Kopf, H. Young, D. L. Longo, and B. R. Blazar. 1998. Differential effects of the absence of interferon-γ and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice. J. Clin. Invest. 102:1742.
40. Nikolic, B., S. Lee, R. T. Bronson, M. J. Grusby, and M. Sykes. 2000. Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. J. Clin. Invest. 105:1289.
41. Tohda, S., T. Suzuki, K. Nagata, N. Nara, and N. Aoki. 1990. Successful treatment of a patient with posthepatitic severe aplastic anemia with bolus methylprednisolone. Jpn. J. Med. 29:191.
42. Selleri, C., J. P. Maciejewski, T. Sato, and N. S. Young. 1996. Interferon-γ constitutively expressed in the stromal microenvironment of human marrow cultures mediates potent hematopoietic inhibition. Blood 87:4149.
43. Yu, J. M., R. V. Emmons, Y. Hanazono, S. Sellers, N. S. Young, and C. E. Dunbar. 1999. Expression of interferon-γ by stromal cells inhibits murine long-term repopulating hematopoietic stem cell activity. Exp. Hematol. 27:895.
44. Miura, A., K. Endo, T. Sugawara, J. Kameoka, N. Watanabe, K. Meguro, O. Fukuhara, I. Sato, C. Suzuki, and K. Yoshinaga. 1991. T cell-mediated inhibition of erythropoiesis in aplastic anaemia: the possible role of IFN-γ and TNF-α. Br. J. Haematol. 78:442.
45. + T cell-mediated graft-versus-host disease: effects of conditioning. Biol. Blood Marrow Transplant. 6:604.
46. Morse, M. A., R. E. Coleman, G. Akabani, N. Niehaus, D. Coleman, and H. K. Lyerly. 1999. Migration of human dendritic cells after injection in patients with metastatic malignancies. Cancer Res. 59:56.
47. Blazar, B. R., F. P. Lindberg, E. Ingulli, A. Panoskaltsis-Mortari, P. A. Oldenborg, K. Iizuka, W. M. Yokoyama, and P. A. Taylor. 2001. CD47 (integrin-associated protein) engagement of dendritic cell and macrophage counterreceptors is required to prevent the clearance of donor lymphohematopoietic cells. J. Exp. Med. 194:541.
48. + immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J. Exp. Med. 193:1311.
49. Tamada, K., H. Tamura, D. Flies, Y. X. Fu, E. Celis, L. R. Pease, B. R. Blazar, and L. Chen. 2002. Blockade of LIGHT/LTβ and CD40 signaling induces allospecific T cell anergy, preventing graft-versus-host disease. J. Clin. Invest. 109:549.
50. Ruggeri, L., M. Capanni, E. Urbani, K. Perruccio, W. D. Shlomchik, A. Tosti, S. Posati, D. Rogaia, F. Frassoni, F. Aversa, et al. 2002. Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants. Science 295:2097.
51. Ruggeri, L., M. Capanni, M. Casucci, I. Volpi, A. Tosti, K. Perruccio, E. Urbani, R. S. Negrin, M. F. Martelli, and A. Velardi. 1999. Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. Blood 94:333.
52. Reed, J. C. 1996. Mechanisms of Bcl-2 family protein function and dysfunction in health and disease. Behring Inst. Mitt. 97:72.
53. Akari, H., S. Bour, S. Kao, A. Adachi, and K. Strebel. 2001. The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor κB-dependent expression of antiapoptotic factors. J. Exp. Med. 194:1299.
54. Ruckes, T., D. Saul, J. Van Snick, O. Hermine, and R. Grassmann. 2001. Autocrine antiapoptotic stimulation of cultured adult T-cell leukemia cells by overexpression of the chemokine I-309. Blood 98:1150.
55. Vlahakis, S. R., A. Villasis-Keever, T. Gomez, M. Vanegas, N. Vlahakis, and C. V. Paya. 2002. G protein-coupled chemokine receptors induce both survival and apoptotic signaling pathways. J. Immunol. 169:5546.
56. Reid, S., A. Ritchie, L. Boring, J. Gosling, S. Cooper, G. Hangoc, I. F. Charo, and H. E. Broxmeyer. 1999. Enhanced myeloid progenitor cell cycling and apoptosis in mice lacking the chemokine receptor, CCR2. Blood 93:1524.
57. Mackinnon, S. 1997. Donor leukocyte infusions. Baillieres Clin. Haematol. 10:357.
58. van Rhee, F., and H. J. Kolb. 1995. Donor leukocyte transfusions for leukemic relapse. Curr. Opin. Hematol. 2:423.