메뉴 건너뛰기




Volumn 102, Issue 8, 2010, Pages 898-908

Pathobiology of colorectal cancer hepatic metastases with an emphasis on prognostic factors

Author keywords

angiogenesis; cadherins; epithelial mesenchymal transformation EMT; integrins; miRNA

Indexed keywords

ANGIOGENESIS; CANCER MORTALITY; CELL INTERACTION; CELL MIGRATION; COLORECTAL CANCER; HUMAN; LIVER METASTASIS; PRIORITY JOURNAL; PROGNOSIS; REVIEW;

EID: 78650648695     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21817     Document Type: Review
Times cited : (38)

References (133)
  • 4
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, et al.: Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139: 871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3
  • 5
    • 0242720727 scopus 로고    scopus 로고
    • Expression profiling of epithelial plasticity in tumor progression
    • Jechlinger M, Grunert S, Tamir IH, et al.: Expression profiling of epithelial plasticity in tumor progression. Oncogene 2003; 22: 7155-7169.
    • (2003) Oncogene , vol.22 , pp. 7155-7169
    • Jechlinger, M.1    Grunert, S.2    Tamir, I.H.3
  • 6
    • 33748116186 scopus 로고    scopus 로고
    • A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer
    • Spaderna S, Schmalhofer O, Hlubek F, et al.: A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer. Gastroenterology 2006; 131: 830-840.
    • (2006) Gastroenterology , vol.131 , pp. 830-840
    • Spaderna, S.1    Schmalhofer, O.2    Hlubek, F.3
  • 7
    • 21044453012 scopus 로고    scopus 로고
    • Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer
    • Schimanski CC, Schmitz G, Kashyap A, et al.: Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer. Oncogene 2005; 24: 3100-3109.
    • (2005) Oncogene , vol.24 , pp. 3100-3109
    • Schimanski, C.C.1    Schmitz, G.2    Kashyap, A.3
  • 8
    • 39049160267 scopus 로고    scopus 로고
    • The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer
    • Spaderna S, Schmalhofer O, Wahlbuhl M, et al.: The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer Res 2008; 68: 537-544.
    • (2008) Cancer Res , vol.68 , pp. 537-544
    • Spaderna, S.1    Schmalhofer, O.2    Wahlbuhl, M.3
  • 9
    • 33745086313 scopus 로고    scopus 로고
    • Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients
    • Shioiri M, Shida T, Koda K, et al.: Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients. Br J Cancer 2006; 94: 1816-1822.
    • (2006) Br J Cancer , vol.94 , pp. 1816-1822
    • Shioiri, M.1    Shida, T.2    Koda, K.3
  • 10
    • 0035892362 scopus 로고    scopus 로고
    • Laminin-5 in the progression of carcinomas
    • Lohi J,: Laminin-5 in the progression of carcinomas. Int J Cancer J Int Cancer 2001; 94: 763-767.
    • (2001) Int J Cancer J Int Cancer , vol.94 , pp. 763-767
    • Lohi, J.1
  • 12
    • 0034568845 scopus 로고    scopus 로고
    • Tumor cell budding and laminin-5 expression in colorectal carcinoma can be modulated by the tissue micro-environment
    • Sordat I, Rousselle P, Chaubert P, et al.: Tumor cell budding and laminin-5 expression in colorectal carcinoma can be modulated by the tissue micro-environment. Int J Cancer J Int Cancer 2000; 88: 708-717.
    • (2000) Int J Cancer J Int Cancer , vol.88 , pp. 708-717
    • Sordat, I.1    Rousselle, P.2    Chaubert, P.3
  • 13
    • 33644912882 scopus 로고    scopus 로고
    • Laminin-5 (laminin-332): Unique biological activity and role in tumor growth and invasion
    • Miyazaki K,: Laminin-5 (laminin-332): Unique biological activity and role in tumor growth and invasion. Cancer Sci 2006; 97: 91-98.
    • (2006) Cancer Sci , vol.97 , pp. 91-98
    • Miyazaki, K.1
  • 14
    • 77951947152 scopus 로고    scopus 로고
    • The engagement of selectins and their ligands in colorectal cancer liver metastases
    • Paschos KA, Canovas D, Bird NC,: The engagement of selectins and their ligands in colorectal cancer liver metastases. J Cell Mol Med 2010; 14: 165-174.
    • (2010) J Cell Mol Med , vol.14 , pp. 165-174
    • Paschos, K.A.1    Canovas, D.2    Bird, N.C.3
  • 15
    • 60849107267 scopus 로고    scopus 로고
    • The role of cell adhesion molecules in the progression of colorectal cancer and the development of liver metastasis
    • Paschos KA, Canovas D, Bird NC,: The role of cell adhesion molecules in the progression of colorectal cancer and the development of liver metastasis. Cell Signal 2009; 21: 665-674.
    • (2009) Cell Signal , vol.21 , pp. 665-674
    • Paschos, K.A.1    Canovas, D.2    Bird, N.C.3
  • 16
    • 23144442645 scopus 로고    scopus 로고
    • Regulation of cadherin-mediated adhesion in morphogenesis
    • Gumbiner BM,: Regulation of cadherin-mediated adhesion in morphogenesis. Nat Rev Mol Cell Biol 2005; 6: 622-634.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 622-634
    • Gumbiner, B.M.1
  • 17
    • 0028923175 scopus 로고
    • Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome
    • Dorudi S, Hanby AM, Poulsom R, et al.: Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome. Br J Cancer 1995; 71: 614-616.
    • (1995) Br J Cancer , vol.71 , pp. 614-616
    • Dorudi, S.1    Hanby, A.M.2    Poulsom, R.3
  • 18
    • 25444447939 scopus 로고    scopus 로고
    • Expression of E-cadherin, beta-catenin, and CD-44v6 cell adhesion molecules in primary tumors and metastases of colorectal adenocarcinoma
    • Delektorskaya VV, Perevoshchikov AG, Golovkov DA, et al.: Expression of E-cadherin, beta-catenin, and CD-44v6 cell adhesion molecules in primary tumors and metastases of colorectal adenocarcinoma. Bull Exp Biol Med 2005; 139: 706-710.
    • (2005) Bull Exp Biol Med , vol.139 , pp. 706-710
    • Delektorskaya, V.V.1    Perevoshchikov, A.G.2    Golovkov, D.A.3
  • 19
    • 33750438082 scopus 로고    scopus 로고
    • Prognostic significance of beta-catenin in colorectal cancer with liver metastasis
    • Han SA, Chun H, Park CM, et al.: Prognostic significance of beta-catenin in colorectal cancer with liver metastasis. Clin Oncol (R Coll Radiol) 2006; 18: 761-767.
    • (2006) Clin Oncol (R Coll Radiol) , vol.18 , pp. 761-767
    • Han, S.A.1    Chun, H.2    Park, C.M.3
  • 20
    • 45949094481 scopus 로고    scopus 로고
    • Nuclear beta-catenin expression at the invasive front and in the vessels predicts liver metastasis in colorectal carcinoma
    • Suzuki H, Masuda N, Shimura T, et al.: Nuclear beta-catenin expression at the invasive front and in the vessels predicts liver metastasis in colorectal carcinoma. Anticancer Res 2008; 28: 1821-1830.
    • (2008) Anticancer Res , vol.28 , pp. 1821-1830
    • Suzuki, H.1    Masuda, N.2    Shimura, T.3
  • 21
    • 38849201199 scopus 로고    scopus 로고
    • Expression of the cell-cell adhesion molecule beta-catenin in colorectal carcinomas and their metastases
    • Buhmeida A, Elzagheid A, Algars A, et al.: Expression of the cell-cell adhesion molecule beta-catenin in colorectal carcinomas and their metastases. Acta Pathol Microbiol Immunol Scand 2008; 116: 1-9.
    • (2008) Acta Pathol Microbiol Immunol Scand , vol.116 , pp. 1-9
    • Buhmeida, A.1    Elzagheid, A.2    Algars, A.3
  • 22
    • 61449495071 scopus 로고    scopus 로고
    • Serum response factor enhances liver metastasis of colorectal carcinoma via alteration of the E-cadherin/beta-catenin complex
    • Choi HN, Kim KR, Lee JH, et al.: Serum response factor enhances liver metastasis of colorectal carcinoma via alteration of the E-cadherin/beta-catenin complex. Oncol Rep 2009; 21: 57-63.
    • (2009) Oncol Rep , vol.21 , pp. 57-63
    • Choi, H.N.1    Kim, K.R.2    Lee, J.H.3
  • 24
    • 39749184140 scopus 로고    scopus 로고
    • Integrins: A method of early intervention in the treatment of colorectal liver metastases
    • Robertson JH, Iga AM, Sales KM, et al.: Integrins: A method of early intervention in the treatment of colorectal liver metastases. Curr Pharm Des 2008; 14: 296-305.
    • (2008) Curr Pharm des , vol.14 , pp. 296-305
    • Robertson, J.H.1    Iga, A.M.2    Sales, K.M.3
  • 25
    • 0025979573 scopus 로고
    • Expression of VLA-alpha 2, VLA-alpha 6, and VLA-beta 1 chains in normal mucosa and adenomas of the colon, and in colon carcinomas and their liver metastases
    • Koretz K, Schlag P, Boumsell L, et al.: Expression of VLA-alpha 2, VLA-alpha 6, and VLA-beta 1 chains in normal mucosa and adenomas of the colon, and in colon carcinomas and their liver metastases. Am J Pathol 1991; 138: 741-750.
    • (1991) Am J Pathol , vol.138 , pp. 741-750
    • Koretz, K.1    Schlag, P.2    Boumsell, L.3
  • 26
    • 0031017019 scopus 로고    scopus 로고
    • Role of alpha 5 beta 1 integrin in determining malignant properties of colon carcinoma cells
    • Gong J, Wang D, Sun L, et al.: Role of alpha 5 beta 1 integrin in determining malignant properties of colon carcinoma cells. Cell Growth Differ Mol Biol J Am Assoc Cancer Res 1997; 8: 83-90.
    • (1997) Cell Growth Differ Mol Biol J Am Assoc Cancer Res , vol.8 , pp. 83-90
    • Gong, J.1    Wang, D.2    Sun, L.3
  • 27
    • 39549097542 scopus 로고    scopus 로고
    • Blocking alpha2 integrins on rat CC531s colon carcinoma cells prevents operation-induced augmentation of liver metastases outgrowth
    • Van Der Bij G, Oosterling S, Bögels M, et al.: Blocking alpha2 integrins on rat CC531s colon carcinoma cells prevents operation-induced augmentation of liver metastases outgrowth. Hepatology 2008; 47: 532-543.
    • (2008) Hepatology , vol.47 , pp. 532-543
    • Van Der Bij, G.1    Oosterling, S.2    Bögels, M.3
  • 28
    • 0032793097 scopus 로고    scopus 로고
    • Laminin mediates tethering and spreading of colon cancer cells in physiological shear flow
    • Kitayama J, Nagawa H, Tsuno N, et al.: Laminin mediates tethering and spreading of colon cancer cells in physiological shear flow. Br J Cancer 1999; 80: 1927-1934.
    • (1999) Br J Cancer , vol.80 , pp. 1927-1934
    • Kitayama, J.1    Nagawa, H.2    Tsuno, N.3
  • 29
    • 14944348752 scopus 로고    scopus 로고
    • Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma
    • Bates RC, Bellovin DI, Brown C, et al.: Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest 2005; 115: 339-347.
    • (2005) J Clin Invest , vol.115 , pp. 339-347
    • Bates, R.C.1    Bellovin, D.I.2    Brown, C.3
  • 30
    • 49749092745 scopus 로고    scopus 로고
    • Suppression of integrin alphaupsilonbeta6 by RNA interference in colon cancer cells inhibits extracellular matrix degradation through the MAPK pathway
    • Wang J, Zhang Z, Xu K, et al.: Suppression of integrin alphaupsilonbeta6 by RNA interference in colon cancer cells inhibits extracellular matrix degradation through the MAPK pathway. Int J Cancer J Int Cancer 2008; 123: 1311-1317.
    • (2008) Int J Cancer J Int Cancer , vol.123 , pp. 1311-1317
    • Wang, J.1    Zhang, Z.2    Xu, K.3
  • 31
    • 58149187467 scopus 로고    scopus 로고
    • The desmoplastic reaction surrounding hepatic colorectal adenocarcinoma metastases aids tumor growth and survival via alphav integrin ligation
    • Conti JA, Kendall TJ, Bateman A, et al.: The desmoplastic reaction surrounding hepatic colorectal adenocarcinoma metastases aids tumor growth and survival via alphav integrin ligation. Clin Cancer Res Off J Am Assoc Cancer Res 2008; 14: 6405-6413.
    • (2008) Clin Cancer Res off J Am Assoc Cancer Res , vol.14 , pp. 6405-6413
    • Conti, J.A.1    Kendall, T.J.2    Bateman, A.3
  • 32
    • 70349754433 scopus 로고    scopus 로고
    • Integrin α2 mediates selective metastasis to the liver
    • Yoshimura K, Meckel K, Laird L, et al.: Integrin α2 mediates selective metastasis to the liver. Cancer Res 2009; 69: 7320-7328.
    • (2009) Cancer Res , vol.69 , pp. 7320-7328
    • Yoshimura, K.1    Meckel, K.2    Laird, L.3
  • 33
    • 0028108393 scopus 로고
    • Structural motifs for recognition and adhesion in members of the immunoglobulin superfamily
    • Holness CL, Simmons DL,: Structural motifs for recognition and adhesion in members of the immunoglobulin superfamily. J Cell Sci 1994; 107: 2065-2070.
    • (1994) J Cell Sci , vol.107 , pp. 2065-2070
    • Holness, C.L.1    Simmons, D.L.2
  • 35
    • 0033057177 scopus 로고    scopus 로고
    • The carcinoembryonic antigen (CEA) family: Structures, suggested functions and expression in normal and malignant tissues
    • Hammarstrom S,: The carcinoembryonic antigen (CEA) family: Structures, suggested functions and expression in normal and malignant tissues. Semin Cancer Biol 1999; 9: 67-81.
    • (1999) Semin Cancer Biol , vol.9 , pp. 67-81
    • Hammarstrom, S.1
  • 36
    • 0036118491 scopus 로고    scopus 로고
    • Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation
    • Ilantzis C, DeMarte L, Screaton RA, et al.: Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. Neoplasia (New York, NY) 2002; 4: 151-163.
    • (2002) Neoplasia (New York, NY) , vol.4 , pp. 151-163
    • Ilantzis, C.1    Demarte, L.2    Screaton, R.A.3
  • 37
    • 34250353411 scopus 로고    scopus 로고
    • Carcinoembryonic antigen inhibits anoikis in colorectal carcinoma cells by interfering with TRAIL-R2 (DR5) signaling
    • Samara RN, Laguinge LM, Jessup JM,: Carcinoembryonic antigen inhibits anoikis in colorectal carcinoma cells by interfering with TRAIL-R2 (DR5) signaling. Cancer Res 2007; 67: 4774-4782.
    • (2007) Cancer Res , vol.67 , pp. 4774-4782
    • Samara, R.N.1    Laguinge, L.M.2    Jessup, J.M.3
  • 38
    • 34247522572 scopus 로고    scopus 로고
    • A co-clustering model involving alpha5beta1 integrin for the biological effects of GPI-anchored human carcinoembryonic antigen (CEA)
    • Camacho-Leal P, Zhai AB, Stanners CP,: A co-clustering model involving alpha5beta1 integrin for the biological effects of GPI-anchored human carcinoembryonic antigen (CEA). J Cell Physiol 2007; 211: 791-802.
    • (2007) J Cell Physiol , vol.211 , pp. 791-802
    • Camacho-Leal, P.1    Zhai, A.B.2    Stanners, C.P.3
  • 39
    • 0020322699 scopus 로고
    • A new Kupffer cell receptor mediating plasma clearance of carcinoembryonic antigen by the rat
    • Toth CA, Thomas P, Broitman SA, et al.: A new Kupffer cell receptor mediating plasma clearance of carcinoembryonic antigen by the rat. Biochem J 1982; 204: 377-381.
    • (1982) Biochem J , vol.204 , pp. 377-381
    • Toth, C.A.1    Thomas, P.2    Broitman, S.A.3
  • 40
    • 0035866769 scopus 로고    scopus 로고
    • Role of carcinoembryonic antigen in the progression of colon cancer cells that express carbohydrate antigen
    • Minami S, Furui J, Kanematsu T,: Role of carcinoembryonic antigen in the progression of colon cancer cells that express carbohydrate antigen. Cancer Res 2001; 61: 2732-2735.
    • (2001) Cancer Res , vol.61 , pp. 2732-2735
    • Minami, S.1    Furui, J.2    Kanematsu, T.3
  • 41
    • 34249811532 scopus 로고    scopus 로고
    • Carcinoembryonic antigen-stimulated THP-1 macrophages activate endothelial cells and increase cell-cell adhesion of colorectal cancer cells
    • Aarons CB, Bajenova O, Andrews C, et al.: Carcinoembryonic antigen-stimulated THP-1 macrophages activate endothelial cells and increase cell-cell adhesion of colorectal cancer cells. Clin Exp Metastasis 2007; 24: 201-209.
    • (2007) Clin Exp Metastasis , vol.24 , pp. 201-209
    • Aarons, C.B.1    Bajenova, O.2    Andrews, C.3
  • 42
    • 63849339429 scopus 로고    scopus 로고
    • The high affinity selectin glycan ligand C2-O-sLex and mRNA transcripts of the core 2 beta-1,6-N-acetylglucosaminyltransferase (C2GnT1) gene are highly expressed in human colorectal adenocarcinomas
    • St Hill CA, Farooqui M, Mitcheltree G, et al.: The high affinity selectin glycan ligand C2-O-sLex and mRNA transcripts of the core 2 beta-1,6-N- acetylglucosaminyltransferase (C2GnT1) gene are highly expressed in human colorectal adenocarcinomas. BMC Cancer 2009; 9: 79.
    • (2009) BMC Cancer , vol.9 , pp. 79
    • St Hill, C.A.1    Farooqui, M.2    Mitcheltree, G.3
  • 43
    • 0035877986 scopus 로고    scopus 로고
    • Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase-deficient mice
    • Sperandio M, Thatte A, Foy D, et al.: Severe impairment of leukocyte rolling in venules of core 2 glucosaminyltransferase-deficient mice. Blood 2001; 97: 3812-3819.
    • (2001) Blood , vol.97 , pp. 3812-3819
    • Sperandio, M.1    Thatte, A.2    Foy, D.3
  • 44
    • 0027499085 scopus 로고
    • Expression of CD44R1 adhesion molecule in colon carcinomas and metastases
    • Tanabe KK, Ellis LM, Saya H,: Expression of CD44R1 adhesion molecule in colon carcinomas and metastases. Lancet 1993; 341: 725.
    • (1993) Lancet , vol.341 , pp. 725
    • Tanabe, K.K.1    Ellis, L.M.2    Saya, H.3
  • 45
    • 34250792850 scopus 로고    scopus 로고
    • A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression
    • Kuhn S, Koch M, Nabel T, et al.: A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression. Mol Cancer Res 2007; 5: 553-567.
    • (2007) Mol Cancer Res , vol.5 , pp. 553-567
    • Kuhn, S.1    Koch, M.2    Nabel, T.3
  • 46
    • 0030980675 scopus 로고    scopus 로고
    • Expression of CD44 splice variants in colorectal cancer
    • Wong LS, Cantrill JE, Morris AG, et al.: Expression of CD44 splice variants in colorectal cancer. Br J Surg 1997; 84: 363-367.
    • (1997) Br J Surg , vol.84 , pp. 363-367
    • Wong, L.S.1    Cantrill, J.E.2    Morris, A.G.3
  • 47
    • 0031776902 scopus 로고    scopus 로고
    • CD44V6 expression in human colorectal carcinoma
    • Coppola D, Hyacinthe M, Fu L, et al.: CD44V6 expression in human colorectal carcinoma. Hum Pathol 1998; 29: 627-635.
    • (1998) Hum Pathol , vol.29 , pp. 627-635
    • Coppola, D.1    Hyacinthe, M.2    Fu, L.3
  • 48
    • 0037693895 scopus 로고    scopus 로고
    • Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry
    • Visse R, Nagase H,: Matrix metalloproteinases and tissue inhibitors of metalloproteinases: Structure, function, and biochemistry. Circ Res 2003; 92: 827-839.
    • (2003) Circ Res , vol.92 , pp. 827-839
    • Visse, R.1    Nagase, H.2
  • 49
    • 1242292412 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases (MMPs) in colorectal cancer
    • Zucker S, Vacirca J,: Role of matrix metalloproteinases (MMPs) in colorectal cancer. Cancer Metastasis Rev 2004; 23: 101-117.
    • (2004) Cancer Metastasis Rev , vol.23 , pp. 101-117
    • Zucker, S.1    Vacirca, J.2
  • 50
    • 23344454275 scopus 로고    scopus 로고
    • Quantitative estimation of matrix metalloproteinases 2 and 7 (MMP-2, MMP-7) and tissue inhibitors of matrix metalloproteinases 1 and 2 (TIMP-1, TIMP-2) in colorectal carcinoma tissue samples
    • Pesta M, Holubec L, Topolcan O, et al.: Quantitative estimation of matrix metalloproteinases 2 and 7 (MMP-2, MMP-7) and tissue inhibitors of matrix metalloproteinases 1 and 2 (TIMP-1, TIMP-2) in colorectal carcinoma tissue samples. Anticancer Res 2005; 25: 3387-3391.
    • (2005) Anticancer Res , vol.25 , pp. 3387-3391
    • Pesta, M.1    Holubec, L.2    Topolcan, O.3
  • 51
    • 34547141354 scopus 로고    scopus 로고
    • Clinical, biological, and molecular aspects of metastasis in colorectal cancer
    • Stein U, Schlag PM,: Clinical, biological, and molecular aspects of metastasis in colorectal cancer. Recent Results Cancer Res 2007; 176: 61-80.
    • (2007) Recent Results Cancer Res , vol.176 , pp. 61-80
    • Stein, U.1    Schlag, P.M.2
  • 52
    • 28844498773 scopus 로고    scopus 로고
    • Molecular mechanisms of hepatic metastasis in colorectal cancer
    • Rudmik LR, Magliocco AM,: Molecular mechanisms of hepatic metastasis in colorectal cancer. J Surg Oncol 2005; 92: 347-359.
    • (2005) J Surg Oncol , vol.92 , pp. 347-359
    • Rudmik, L.R.1    Magliocco, A.M.2
  • 53
    • 34648829207 scopus 로고    scopus 로고
    • Prognostic significance of expression of matrix metalloproteinase in colorectal adenocarcinomas and their metastases
    • Delektorskaya VV, Perevoshchikov AG, Golovkov DA, et al.: Prognostic significance of expression of matrix metalloproteinase in colorectal adenocarcinomas and their metastases. Bull Exp Biol Med 2007; 143: 455-458.
    • (2007) Bull Exp Biol Med , vol.143 , pp. 455-458
    • Delektorskaya, V.V.1    Perevoshchikov, A.G.2    Golovkov, D.A.3
  • 54
    • 67650140630 scopus 로고    scopus 로고
    • Key enzymes of the extracellular matrix in colorectal cancer
    • Golovkov DA,: Key enzymes of the extracellular matrix in colorectal cancer. Bull Exp Biol Med 2009; 147: 353-356.
    • (2009) Bull Exp Biol Med , vol.147 , pp. 353-356
    • Golovkov, D.A.1
  • 55
    • 61449230902 scopus 로고    scopus 로고
    • Differences in the gene expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in primary colorectal tumors and their synchronous liver metastases
    • Gentner B, Wein A, Croner RS, et al.: Differences in the gene expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in primary colorectal tumors and their synchronous liver metastases. Anticancer Res 2009; 29: 67-74.
    • (2009) Anticancer Res , vol.29 , pp. 67-74
    • Gentner, B.1    Wein, A.2    Croner, R.S.3
  • 56
    • 41149085227 scopus 로고    scopus 로고
    • Prognostic values of matrix metalloproteinase family expression in human colorectal carcinoma
    • Asano T, Tada M, Cheng S, et al.: Prognostic values of matrix metalloproteinase family expression in human colorectal carcinoma. J Surg Res 2008; 146: 32-42.
    • (2008) J Surg Res , vol.146 , pp. 32-42
    • Asano, T.1    Tada, M.2    Cheng, S.3
  • 57
    • 40649121508 scopus 로고    scopus 로고
    • Evolving role of uPA/uPAR system in human cancers
    • Dass K, Ahmad A, Azmi AS, et al.: Evolving role of uPA/uPAR system in human cancers. Cancer Treat Rev 2008; 34: 122-136.
    • (2008) Cancer Treat Rev , vol.34 , pp. 122-136
    • Dass, K.1    Ahmad, A.2    Azmi, A.S.3
  • 58
    • 0033583761 scopus 로고    scopus 로고
    • Plasma urokinase receptor levels in patients with colorectal cancer: Relationship to prognosis
    • Stephens RW, Nielsen HJ, Christensen IJ, et al.: Plasma urokinase receptor levels in patients with colorectal cancer: Relationship to prognosis. J Natl Cancer Inst 1999; 91: 869-874.
    • (1999) J Natl Cancer Inst , vol.91 , pp. 869-874
    • Stephens, R.W.1    Nielsen, H.J.2    Christensen, I.J.3
  • 59
    • 0032515761 scopus 로고    scopus 로고
    • Association between plasma concentrations of plasminogen activator inhibitor-1 and survival in patients with colorectal cancer
    • Nielsen HJ, Pappot H, Christensen IJ, et al.: Association between plasma concentrations of plasminogen activator inhibitor-1 and survival in patients with colorectal cancer. Br Med J (Clin Res Ed) 1998; 316: 829-830.
    • (1998) Br Med J (Clin Res Ed) , vol.316 , pp. 829-830
    • Nielsen, H.J.1    Pappot, H.2    Christensen, I.J.3
  • 60
    • 0029144854 scopus 로고
    • Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas
    • Pyke C, Salo S, Ralfkiaer E, et al.: Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas. Cancer Res 1995; 55: 4132-4139.
    • (1995) Cancer Res , vol.55 , pp. 4132-4139
    • Pyke, C.1    Salo, S.2    Ralfkiaer, E.3
  • 61
    • 0034782184 scopus 로고    scopus 로고
    • Liver metastases from colorectal adenocarcinomas grow in three patterns with different angiogenesis and desmoplasia
    • Vermeulen PB, Colpaert C, Salgado R, et al.: Liver metastases from colorectal adenocarcinomas grow in three patterns with different angiogenesis and desmoplasia. J Pathol 2001; 195: 336-342.
    • (2001) J Pathol , vol.195 , pp. 336-342
    • Vermeulen, P.B.1    Colpaert, C.2    Salgado, R.3
  • 62
    • 62449284577 scopus 로고    scopus 로고
    • Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases
    • Illemann M, Bird N, Majeed A, et al.: Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases. Int J Cancer 2009; 124: 1860-1870.
    • (2009) Int J Cancer , vol.124 , pp. 1860-1870
    • Illemann, M.1    Bird, N.2    Majeed, A.3
  • 63
    • 0033810052 scopus 로고    scopus 로고
    • Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma. Evidence for its role in colonic tumorigenesis
    • Friedmann Y, Vlodavsky I, Aingorn H, et al.: Expression of heparanase in normal, dysplastic, and neoplastic human colonic mucosa and stroma. Evidence for its role in colonic tumorigenesis. Am J Pathol 2000; 157: 1167-1175.
    • (2000) Am J Pathol , vol.157 , pp. 1167-1175
    • Friedmann, Y.1    Vlodavsky, I.2    Aingorn, H.3
  • 64
    • 0028946604 scopus 로고
    • Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer
    • Di Renzo MF, Olivero M, Giacomini A, et al.: Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer. Clin Cancer Res Off J Am Assoc Cancer Res 1995; 1: 147-154.
    • (1995) Clin Cancer Res off J Am Assoc Cancer Res , vol.1 , pp. 147-154
    • Di Renzo, M.F.1    Olivero, M.2    Giacomini, A.3
  • 65
    • 0038604793 scopus 로고    scopus 로고
    • Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated beta-catenin
    • Herynk MH, Tsan R, Radinsky R, et al.: Activation of c-Met in colorectal carcinoma cells leads to constitutive association of tyrosine-phosphorylated beta-catenin. Clin Exp Metastasis 2003; 20: 291-300.
    • (2003) Clin Exp Metastasis , vol.20 , pp. 291-300
    • Herynk, M.H.1    Tsan, R.2    Radinsky, R.3
  • 66
    • 58149352266 scopus 로고    scopus 로고
    • MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis
    • Stein U, Walther W, Arlt F, et al.: MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Nat Med 2009; 15: 59-67.
    • (2009) Nat Med , vol.15 , pp. 59-67
    • Stein, U.1    Walther, W.2    Arlt, F.3
  • 67
    • 77949329326 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors: New insights into cancer-related inflammation
    • Lazennec G, Richmond A,: Chemokines and chemokine receptors: New insights into cancer-related inflammation. Trends Mol Med 2010; 16: 133-144.
    • (2010) Trends Mol Med , vol.16 , pp. 133-144
    • Lazennec, G.1    Richmond, A.2
  • 68
    • 77953288700 scopus 로고    scopus 로고
    • Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival
    • Doll D, Keller L, Maak M, et al.: Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival. Int J Colorectal Dis 2010; 25: 573-581.
    • (2010) Int J Colorectal Dis , vol.25 , pp. 573-581
    • Doll, D.1    Keller, L.2    Maak, M.3
  • 69
    • 34848813857 scopus 로고    scopus 로고
    • Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer
    • Rubie C, Frick VO, Pfeil S, et al.: Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer. World J Gastroenterol 2007; 13: 4996-5002.
    • (2007) World J Gastroenterol , vol.13 , pp. 4996-5002
    • Rubie, C.1    Frick, V.O.2    Pfeil, S.3
  • 70
    • 60349085081 scopus 로고    scopus 로고
    • The chemokine receptors CXCR4 and CXCR3 in cancer
    • Fulton AM,: The chemokine receptors CXCR4 and CXCR3 in cancer. Curr Oncol Rep 2009; 11: 125-131.
    • (2009) Curr Oncol Rep , vol.11 , pp. 125-131
    • Fulton, A.M.1
  • 71
    • 0038079014 scopus 로고    scopus 로고
    • The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases
    • Zeelenberg IS, Ruuls-Van Stalle L, Roos E,: The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. Cancer Res 2003; 63: 3833-3839.
    • (2003) Cancer Res , vol.63 , pp. 3833-3839
    • Zeelenberg, I.S.1    Ruuls-Van Stalle, L.2    Roos, E.3
  • 72
    • 18444401114 scopus 로고    scopus 로고
    • Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival
    • Kim J, Takeuchi H, Lam ST, et al.: Chemokine receptor CXCR4 expression in colorectal cancer patients increases the risk for recurrence and for poor survival. J Clin Oncol Off J Am Soc Clin Oncol 2005; 23: 2744-2753.
    • (2005) J Clin Oncol off J Am Soc Clin Oncol , vol.23 , pp. 2744-2753
    • Kim, J.1    Takeuchi, H.2    Lam, S.T.3
  • 73
    • 20144389538 scopus 로고    scopus 로고
    • Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer
    • Schimanski CC, Schwald S, Simiantonaki N, et al.: Effect of chemokine receptors CXCR4 and CCR7 on the metastatic behavior of human colorectal cancer. Clin Cancer Res Off J Am Assoc Cancer Res 2005; 11: 1743-1750.
    • (2005) Clin Cancer Res off J Am Assoc Cancer Res , vol.11 , pp. 1743-1750
    • Schimanski, C.C.1    Schwald, S.2    Simiantonaki, N.3
  • 74
    • 68949200810 scopus 로고    scopus 로고
    • Hepatic stellate cells promote liver metastasis of colon cancer cells by the action of SDF-1/CXCR4 axis
    • Matsusue R, Kubo H, Hisamori S, et al.: Hepatic stellate cells promote liver metastasis of colon cancer cells by the action of SDF-1/CXCR4 axis. Ann Surg Oncol 2009; 16: 2645-2653.
    • (2009) Ann Surg Oncol , vol.16 , pp. 2645-2653
    • Matsusue, R.1    Kubo, H.2    Hisamori, S.3
  • 75
    • 69949092197 scopus 로고    scopus 로고
    • Tumor cell-microenvironment interaction models coupled with clinical validation reveal CCL2 and SNCG as two predictors of colorectal cancer hepatic metastasis
    • Hu H, Sun L, Guo C, et al.: Tumor cell-microenvironment interaction models coupled with clinical validation reveal CCL2 and SNCG as two predictors of colorectal cancer hepatic metastasis. Clin Cancer Res Off J Am Assoc Cancer Res 2009; 15: 5485-5493.
    • (2009) Clin Cancer Res off J Am Assoc Cancer Res , vol.15 , pp. 5485-5493
    • Hu, H.1    Sun, L.2    Guo, C.3
  • 76
    • 33646350054 scopus 로고    scopus 로고
    • Chemokine receptor CCR6 expression level and liver metastases in colorectal cancer
    • Ghadjar P, Coupland SE, Na IK, et al.: Chemokine receptor CCR6 expression level and liver metastases in colorectal cancer. J Clin Oncol Off J Am Soc Clin Oncol 2006; 24: 1910-1916.
    • (2006) J Clin Oncol off J Am Soc Clin Oncol , vol.24 , pp. 1910-1916
    • Ghadjar, P.1    Coupland, S.E.2    Na, I.K.3
  • 77
    • 43049131055 scopus 로고    scopus 로고
    • PRL PTPs: Mediators and markers of cancer progression
    • Bessette DC, Qiu D, Pallen CJ,: PRL PTPs: Mediators and markers of cancer progression. Cancer Metastasis Rev 2008; 27: 231-252.
    • (2008) Cancer Metastasis Rev , vol.27 , pp. 231-252
    • Bessette, D.C.1    Qiu, D.2    Pallen, C.J.3
  • 78
    • 0035834386 scopus 로고    scopus 로고
    • A phosphatase associated with metastasis of colorectal cancer
    • Saha S, Bardelli A, Buckhaults P, et al.: A phosphatase associated with metastasis of colorectal cancer. Science (New York, NY) 2001; 294: 1343-1346.
    • (2001) Science (New York, NY) , vol.294 , pp. 1343-1346
    • Saha, S.1    Bardelli, A.2    Buckhaults, P.3
  • 79
    • 8444228839 scopus 로고    scopus 로고
    • High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: A predictive molecular marker of metachronous liver and lung metastases
    • Kato H, Semba S, Miskad UA, et al.: High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer: A predictive molecular marker of metachronous liver and lung metastases. Clin Cancer Res Off J Am Assoc Cancer Res 2004; 10: 7318-7328.
    • (2004) Clin Cancer Res off J Am Assoc Cancer Res , vol.10 , pp. 7318-7328
    • Kato, H.1    Semba, S.2    Miskad, U.A.3
  • 80
    • 60349088869 scopus 로고    scopus 로고
    • Prognostic value of PRL-3 overexpression in early stages of colonic cancer
    • Xing X, Peng L, Qu L, et al.: Prognostic value of PRL-3 overexpression in early stages of colonic cancer. Histopathology 2009; 54: 309-318.
    • (2009) Histopathology , vol.54 , pp. 309-318
    • Xing, X.1    Peng, L.2    Qu, L.3
  • 81
    • 70349939382 scopus 로고    scopus 로고
    • Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer
    • Siena S, Sartore-Bianchi A, Di Nicolantonio F, et al.: Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer. J Natl Cancer Instit 2009; 101: 1308-1324.
    • (2009) J Natl Cancer Instit , vol.101 , pp. 1308-1324
    • Siena, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3
  • 82
    • 68149175266 scopus 로고    scopus 로고
    • Multiplexed cell signaling analysis of metastatic and nonmetastatic colorectal cancer reveals COX2-EGFR signaling activation as a potential prognostic pathway biomarker
    • Pierobon M, Calvert V, Belluco C, et al.: Multiplexed cell signaling analysis of metastatic and nonmetastatic colorectal cancer reveals COX2-EGFR signaling activation as a potential prognostic pathway biomarker. Clin Colorectal Cancer 2009; 8: 110-117.
    • (2009) Clin Colorectal Cancer , vol.8 , pp. 110-117
    • Pierobon, M.1    Calvert, V.2    Belluco, C.3
  • 83
    • 42249101554 scopus 로고    scopus 로고
    • Amphiregulin is a promising prognostic marker for liver metastases of colorectal cancer
    • Yamada M, Ichikawa Y, Yamagishi S, et al.: Amphiregulin is a promising prognostic marker for liver metastases of colorectal cancer. Clin Cancer Res Off J Am Assoc Cancer Res 2008; 14: 2351-2356.
    • (2008) Clin Cancer Res off J Am Assoc Cancer Res , vol.14 , pp. 2351-2356
    • Yamada, M.1    Ichikawa, Y.2    Yamagishi, S.3
  • 84
    • 77953666101 scopus 로고    scopus 로고
    • The VEGF family in cancer and antibody-based strategies for their inhibition
    • [Epub ahead of print].
    • Sullivan LA, Brekken RA,: The VEGF family in cancer and antibody-based strategies for their inhibition. mAbs 2010; 2: 165-175. [Epub ahead of print].
    • (2010) MAbs , vol.2 , pp. 165-175
    • Sullivan, L.A.1    Brekken, R.A.2
  • 85
    • 0031866661 scopus 로고    scopus 로고
    • Vascular endothelial growth factor expression is reduced in liver metastasis from colorectal cancer and correlates with urokinase-type plasminogen activator
    • Berney CR, Yang JL, Fisher RJ, et al.: Vascular endothelial growth factor expression is reduced in liver metastasis from colorectal cancer and correlates with urokinase-type plasminogen activator. Anticancer Res 1998; 18: 973-977.
    • (1998) Anticancer Res , vol.18 , pp. 973-977
    • Berney, C.R.1    Yang, J.L.2    Fisher, R.J.3
  • 86
    • 0034164580 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor and thrombospondin-1 in colorectal carcinoma
    • Maeda K, Nishiguchi Y, Yashiro M, et al.: Expression of vascular endothelial growth factor and thrombospondin-1 in colorectal carcinoma. Int J Mol Med 2000; 5: 373-378.
    • (2000) Int J Mol Med , vol.5 , pp. 373-378
    • Maeda, K.1    Nishiguchi, Y.2    Yashiro, M.3
  • 87
    • 31544433148 scopus 로고    scopus 로고
    • Vascular endothelial growth factor messenger RNA expression level is preserved in liver metastases compared with corresponding primary colorectal cancer
    • Kuramochi H, Hayashi K, Uchida K, et al.: Vascular endothelial growth factor messenger RNA expression level is preserved in liver metastases compared with corresponding primary colorectal cancer. Clin Cancer Res Off J Am Assoc Cancer Res 2006; 12: 29-33.
    • (2006) Clin Cancer Res off J Am Assoc Cancer Res , vol.12 , pp. 29-33
    • Kuramochi, H.1    Hayashi, K.2    Uchida, K.3
  • 88
    • 67650753834 scopus 로고    scopus 로고
    • The role of the angiopoietins in vascular morphogenesis
    • Thomas M, Augustin H,: The role of the angiopoietins in vascular morphogenesis. Angiogenesis 2009; 12: 125-137.
    • (2009) Angiogenesis , vol.12 , pp. 125-137
    • Thomas, M.1    Augustin, H.2
  • 89
    • 0035447959 scopus 로고    scopus 로고
    • Differential expression of angiopoietin-1 and angiopoietin-2 in colon carcinoma. A possible mechanism for the initiation of angiogenesis
    • Ahmad SA, Liu W, Jung YD, et al.: Differential expression of angiopoietin-1 and angiopoietin-2 in colon carcinoma. A possible mechanism for the initiation of angiogenesis. Cancer 2001; 92: 1138-1143.
    • (2001) Cancer , vol.92 , pp. 1138-1143
    • Ahmad, S.A.1    Liu, W.2    Jung, Y.D.3
  • 90
    • 33845188987 scopus 로고    scopus 로고
    • Expression and prognostic significance of angiopoietin in colorectal carcinoma
    • Chung YC, Hou YC, Chang CN, et al.: Expression and prognostic significance of angiopoietin in colorectal carcinoma. J Surg Oncol 2006; 94: 631-638.
    • (2006) J Surg Oncol , vol.94 , pp. 631-638
    • Chung, Y.C.1    Hou, Y.C.2    Chang, C.N.3
  • 92
    • 25144508039 scopus 로고    scopus 로고
    • Expression of thrombospondin-1 in resected colorectal liver metastases predicts poor prognosis
    • Sutton CD, O'Byrne K, Goddard JC, et al.: Expression of thrombospondin-1 in resected colorectal liver metastases predicts poor prognosis. Clin Cancer Res Off J Am Assoc Cancer Res 2005; 11: 6567-6573.
    • (2005) Clin Cancer Res off J Am Assoc Cancer Res , vol.11 , pp. 6567-6573
    • Sutton, C.D.1    O'Byrne, K.2    Goddard, J.C.3
  • 93
    • 0035403794 scopus 로고    scopus 로고
    • Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer
    • Maeda K, Nishiguchi Y, Kang SM, et al.: Expression of thrombospondin-1 inversely correlated with tumor vascularity and hematogenous metastasis in colon cancer. Oncol Rep 2001; 8: 763-766.
    • (2001) Oncol Rep , vol.8 , pp. 763-766
    • Maeda, K.1    Nishiguchi, Y.2    Kang, S.M.3
  • 94
    • 0032894743 scopus 로고    scopus 로고
    • Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer
    • Tokunaga T, Nakamura M, Oshika Y, et al.: Thrombospondin 2 expression is correlated with inhibition of angiogenesis and metastasis of colon cancer. Br J Cancer 1999; 79: 354-359.
    • (1999) Br J Cancer , vol.79 , pp. 354-359
    • Tokunaga, T.1    Nakamura, M.2    Oshika, Y.3
  • 95
    • 32444442819 scopus 로고    scopus 로고
    • Angiogenesis and p53 at the invading tumor edge: Prognostic markers for colorectal cancer beyond stage
    • Georgiou L, Minopoulos G, Lirantzopoulos N, et al.: Angiogenesis and p53 at the invading tumor edge: Prognostic markers for colorectal cancer beyond stage. J Surg Res 2006; 131: 118-123.
    • (2006) J Surg Res , vol.131 , pp. 118-123
    • Georgiou, L.1    Minopoulos, G.2    Lirantzopoulos, N.3
  • 96
    • 67650995763 scopus 로고    scopus 로고
    • Clinical significance of microvessel count in patients with metastatic liver cancer originating from colorectal carcinoma
    • Nanashima A, Shibata K, Nakayama T, et al.: Clinical significance of microvessel count in patients with metastatic liver cancer originating from colorectal carcinoma. Ann Surg Oncol 2009; 16: 2130-2137.
    • (2009) Ann Surg Oncol , vol.16 , pp. 2130-2137
    • Nanashima, A.1    Shibata, K.2    Nakayama, T.3
  • 97
    • 67949094077 scopus 로고    scopus 로고
    • COX-2, VEGF and tumour angiogenesis
    • Toomey D, Murphy J, Conlon K,: COX-2, VEGF and tumour angiogenesis. Surgeon 2009; 7: 174-180.
    • (2009) Surgeon , vol.7 , pp. 174-180
    • Toomey, D.1    Murphy, J.2    Conlon, K.3
  • 98
    • 76849095665 scopus 로고    scopus 로고
    • The role of COX-2 in intestinal inflammation and colorectal cancer
    • Wang D, Dubois RN,: The role of COX-2 in intestinal inflammation and colorectal cancer. Oncogene 2009; 29: 781-788.
    • (2009) Oncogene , vol.29 , pp. 781-788
    • Wang, D.1    Dubois, R.N.2
  • 99
    • 11144224065 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression: A significant prognostic indicator for patients with colorectal cancer
    • Soumaoro LT, Uetake H, Higuchi T, et al.: Cyclooxygenase-2 expression: A significant prognostic indicator for patients with colorectal cancer. Clin Cancer Res Off J Am Assoc Cancer Res 2004; 10: 8465-8471.
    • (2004) Clin Cancer Res off J Am Assoc Cancer Res , vol.10 , pp. 8465-8471
    • Soumaoro, L.T.1    Uetake, H.2    Higuchi, T.3
  • 100
    • 67649446846 scopus 로고    scopus 로고
    • Messenger RNA expression of COX-2 and angiogenic factors in primary colorectal cancer and corresponding liver metastasis
    • Kobayashi H, Sugihara K, Uetake H, et al.: Messenger RNA expression of COX-2 and angiogenic factors in primary colorectal cancer and corresponding liver metastasis. Int J Oncol 2009; 34: 1147-1153.
    • (2009) Int J Oncol , vol.34 , pp. 1147-1153
    • Kobayashi, H.1    Sugihara, K.2    Uetake, H.3
  • 101
    • 35448968987 scopus 로고    scopus 로고
    • Correlations between cyclooxygenase-2 expression and angiogenic factors in primary tumors and liver metastases in colorectal cancer
    • Nakamoto RH, Uetake H, Iida S, et al.: Correlations between cyclooxygenase-2 expression and angiogenic factors in primary tumors and liver metastases in colorectal cancer. Jpn J Clin Oncol 2007; 37: 679-685.
    • (2007) Jpn J Clin Oncol , vol.37 , pp. 679-685
    • Nakamoto, R.H.1    Uetake, H.2    Iida, S.3
  • 102
    • 72449176846 scopus 로고    scopus 로고
    • Molecular origins of cancer: Molecular basis of colorectal cancer
    • Markowitz SD, Bertagnolli MM,: Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med 2009; 361: 2449-2460.
    • (2009) N Engl J Med , vol.361 , pp. 2449-2460
    • Markowitz, S.D.1    Bertagnolli, M.M.2
  • 103
    • 0029125551 scopus 로고
    • Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression
    • Kastrinakis W, Ramchurren N, Rieger K, et al.: Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression. Oncogene 1995; 11: 647-652.
    • (1995) Oncogene , vol.11 , pp. 647-652
    • Kastrinakis, W.1    Ramchurren, N.2    Rieger, K.3
  • 104
    • 17144473545 scopus 로고    scopus 로고
    • The status of p53 in the metastatic progression of colorectal cancer
    • Heide I, Thiede C, Sonntag T, et al.: The status of p53 in the metastatic progression of colorectal cancer. Eur J Cancer (Oxford, England: 1990) 1997; 33: 1314-1322.
    • (1997) Eur J Cancer (Oxford, England: 1990) , vol.33 , pp. 1314-1322
    • Heide, I.1    Thiede, C.2    Sonntag, T.3
  • 105
    • 0029130604 scopus 로고
    • P53 Mutations in matched primary and metastatic human tumors
    • Peller S, Halevy A, Slutzki S, et al.: p53 Mutations in matched primary and metastatic human tumors. Mol Carcinog 1995; 13: 166-172.
    • (1995) Mol Carcinog , vol.13 , pp. 166-172
    • Peller, S.1    Halevy, A.2    Slutzki, S.3
  • 106
    • 20344370492 scopus 로고    scopus 로고
    • P53 mutation analysis of colorectal liver metastases: Relation to actual survival, angiogenic status, and p53 overexpression
    • de Jong KP, Gouw AS, Peeters PM, et al.: P53 mutation analysis of colorectal liver metastases: Relation to actual survival, angiogenic status, and p53 overexpression. Clin Cancer Res Off J Am Assoc Cancer Res 2005; 11: 4067-4073.
    • (2005) Clin Cancer Res off J Am Assoc Cancer Res , vol.11 , pp. 4067-4073
    • De Jong, K.P.1    Gouw, A.S.2    Peeters, P.M.3
  • 107
    • 33749256649 scopus 로고    scopus 로고
    • Structural, functional and therapeutic biology of survivin
    • Sah NK, Khan Z, Khan GJ, et al.: Structural, functional and therapeutic biology of survivin. Cancer Lett 2006; 244: 164-171.
    • (2006) Cancer Lett , vol.244 , pp. 164-171
    • Sah, N.K.1    Khan, Z.2    Khan, G.J.3
  • 108
    • 61349092242 scopus 로고    scopus 로고
    • Expression of survivin and cortactin in colorectal adenocarcinoma: Association with clinicopathological parameters
    • Lee YY, Yu CP, Lin CK, et al.: Expression of survivin and cortactin in colorectal adenocarcinoma: Association with clinicopathological parameters. Dis Markers 2009; 26: 9-18.
    • (2009) Dis Markers , vol.26 , pp. 9-18
    • Lee, Y.Y.1    Yu, C.P.2    Lin, C.K.3
  • 109
    • 67649460732 scopus 로고    scopus 로고
    • Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer
    • Fang Y, Lu Z, Wang G, et al.: Elevated expressions of MMP7, TROP2, and survivin are associated with survival, disease recurrence, and liver metastasis of colon cancer. Int J Colorectal Dis 2009; 24: 875-884.
    • (2009) Int J Colorectal Dis , vol.24 , pp. 875-884
    • Fang, Y.1    Lu, Z.2    Wang, G.3
  • 110
    • 45849134073 scopus 로고    scopus 로고
    • Frizzled-7 as a potential therapeutic target in colorectal cancer
    • Ueno K, Hiura M, Suehiro Y, et al.: Frizzled-7 as a potential therapeutic target in colorectal cancer. Neoplasia (New York, NY) 2008; 10: 697-705.
    • (2008) Neoplasia (New York, NY) , vol.10 , pp. 697-705
    • Ueno, K.1    Hiura, M.2    Suehiro, Y.3
  • 111
    • 70349975727 scopus 로고    scopus 로고
    • Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells
    • Ueno K, Hazama S, Mitomori S, et al.: Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. Br J Cancer 2009; 101: 1374-1381.
    • (2009) Br J Cancer , vol.101 , pp. 1374-1381
    • Ueno, K.1    Hazama, S.2    Mitomori, S.3
  • 112
    • 67649238834 scopus 로고    scopus 로고
    • Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis
    • Carethers JM,: Intersection of transforming growth factor-beta and Wnt signaling pathways in colorectal cancer and metastasis. Gastroenterology 2009; 137: 33-36.
    • (2009) Gastroenterology , vol.137 , pp. 33-36
    • Carethers, J.M.1
  • 113
    • 74549166032 scopus 로고    scopus 로고
    • Chromosome 18q deletion as a novel molecular predictor for colorectal cancer with simultaneous hepatic metastasis
    • Tanaka T, Watanabe T, Kitayama J, et al.: Chromosome 18q deletion as a novel molecular predictor for colorectal cancer with simultaneous hepatic metastasis. Diagn Mol Pathol Am J Surg Pathol B 2009; 18: 219-225.
    • (2009) Diagn Mol Pathol Am J Surg Pathol B , vol.18 , pp. 219-225
    • Tanaka, T.1    Watanabe, T.2    Kitayama, J.3
  • 114
    • 0030593038 scopus 로고    scopus 로고
    • DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
    • Hahn SA, Schutte M, Hoque AT, et al.: DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science (New York, NY) 1996; 271: 350-353.
    • (1996) Science (New York, NY) , vol.271 , pp. 350-353
    • Hahn, S.A.1    Schutte, M.2    Hoque, A.T.3
  • 115
    • 33845269589 scopus 로고    scopus 로고
    • Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: A study matched for T- and N-classification
    • Tanaka T, Watanabe T, Kazama Y, et al.: Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: A study matched for T- and N-classification. Br J Cancer 2006; 95: 1562-1567.
    • (2006) Br J Cancer , vol.95 , pp. 1562-1567
    • Tanaka, T.1    Watanabe, T.2    Kazama, Y.3
  • 116
    • 55449088058 scopus 로고    scopus 로고
    • Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer
    • Togo N, Ohwada S, Sakurai S, et al.: Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. World J Gastroenterol 2008; 14: 4880-4888.
    • (2008) World J Gastroenterol , vol.14 , pp. 4880-4888
    • Togo, N.1    Ohwada, S.2    Sakurai, S.3
  • 117
    • 10744228797 scopus 로고    scopus 로고
    • Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells
    • Sekiya T, Adachi S, Kohu K, et al.: Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. J Biol Chem 2004; 279: 6840-6846.
    • (2004) J Biol Chem , vol.279 , pp. 6840-6846
    • Sekiya, T.1    Adachi, S.2    Kohu, K.3
  • 118
    • 67649234580 scopus 로고    scopus 로고
    • A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential
    • Fritzmann J, Morkel M, Besser D, et al.: A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential. Gastroenterology 2009; 137: 165-175.
    • (2009) Gastroenterology , vol.137 , pp. 165-175
    • Fritzmann, J.1    Morkel, M.2    Besser, D.3
  • 119
    • 23944526062 scopus 로고    scopus 로고
    • Activation of AKT kinases in cancer: Implications for therapeutic targeting
    • Bellacosa A, Kumar CC, Di Cristofano A, et al.: Activation of AKT kinases in cancer: Implications for therapeutic targeting. Adv Cancer Res 2005; 94: 29-86.
    • (2005) Adv Cancer Res , vol.94 , pp. 29-86
    • Bellacosa, A.1    Kumar, C.C.2    Di Cristofano, A.3
  • 120
    • 58149503692 scopus 로고    scopus 로고
    • Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis
    • Rychahou PG, Kang J, Gulhati P, et al.: Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis. Proc Natl Acad Sci USA 2008; 105: 20315-20320.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 20315-20320
    • Rychahou, P.G.1    Kang, J.2    Gulhati, P.3
  • 121
    • 77949435827 scopus 로고    scopus 로고
    • Molecular mechanisms to cetuximab and panitumumab in colorectal cancer
    • Bardelli A, Siena S,: Molecular mechanisms to cetuximab and panitumumab in colorectal cancer. J Clin Oncol 2010; 28: 1254-1261.
    • (2010) J Clin Oncol , vol.28 , pp. 1254-1261
    • Bardelli, A.1    Siena, S.2
  • 122
    • 77949528987 scopus 로고    scopus 로고
    • KRAS mutation in primary colorectal cancer tumors and related metastases: A potential role in predicition of lung metastasis
    • Cejas P, Lopez-Gomex M, Aguayo C, et al.: KRAS mutation in primary colorectal cancer tumors and related metastases: A potential role in predicition of lung metastasis. PLoS ONE 2009; 4: e1899.
    • (2009) PLoS ONE , vol.4
    • Cejas, P.1    Lopez-Gomex, M.2    Aguayo, C.3
  • 123
    • 77149163487 scopus 로고    scopus 로고
    • KRAS mutation correlates with accelerated metastatic progression in patients with colorectal liver metastases
    • Nash GM, Gimbel M, Shia J, et al.: KRAS mutation correlates with accelerated metastatic progression in patients with colorectal liver metastases. Ann Surg Oncol 2010; 17: 572-578.
    • (2010) Ann Surg Oncol , vol.17 , pp. 572-578
    • Nash, G.M.1    Gimbel, M.2    Shia, J.3
  • 124
    • 71049136170 scopus 로고    scopus 로고
    • MicroRNAs in colorectal cancer: Translation of molecular biology into clinical application
    • Slaby O, Svoboda M, Michalek J, et al.: MicroRNAs in colorectal cancer: Translation of molecular biology into clinical application. Mol Cancer 2009; 8: 102.
    • (2009) Mol Cancer , vol.8 , pp. 102
    • Slaby, O.1    Svoboda, M.2    Michalek, J.3
  • 125
    • 39049128249 scopus 로고    scopus 로고
    • Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer
    • Slaby O, Svoboda M, Fabian P, et al.: Altered expression of miR-21, miR-31, miR-143 and miR-145 is related to clinicopathologic features of colorectal cancer. Oncology 2007; 72: 397-402.
    • (2007) Oncology , vol.72 , pp. 397-402
    • Slaby, O.1    Svoboda, M.2    Fabian, P.3
  • 126
    • 38749089854 scopus 로고    scopus 로고
    • MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma
    • Schetter A, Leung S, Sohn J, et al.: MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma. JAMA 2008; 299: 425-436.
    • (2008) JAMA , vol.299 , pp. 425-436
    • Schetter, A.1    Leung, S.2    Sohn, J.3
  • 127
    • 35248889933 scopus 로고    scopus 로고
    • Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer
    • Mudduluru G, Medved F, Grobholz R, et al.: Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancer. Cancer 2007; 110: 1697-1707.
    • (2007) Cancer , vol.110 , pp. 1697-1707
    • Mudduluru, G.1    Medved, F.2    Grobholz, R.3
  • 128
    • 41749113108 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    • Asangani IA, Rasheed SA, Nikolova DA, et al.: MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008; 27: 2128-2136.
    • (2008) Oncogene , vol.27 , pp. 2128-2136
    • Asangani, I.A.1    Rasheed, S.A.2    Nikolova, D.A.3
  • 129
    • 85128713958 scopus 로고    scopus 로고
    • Prognostic values of microRNAs in colorectal cancer
    • Xi Y, Formentini A, Chien M, et al.: Prognostic values of microRNAs in colorectal cancer. Biomarker Insights 2006; 2: 113-121.
    • (2006) Biomarker Insights , vol.2 , pp. 113-121
    • Xi, Y.1    Formentini, A.2    Chien, M.3
  • 130
    • 67649425233 scopus 로고    scopus 로고
    • Over- and under-expressed microRNAs in human colorectal cancer
    • Motoyama K, Inoue H, Takatsuno Y, et al.: Over- and under-expressed microRNAs in human colorectal cancer. Int J Oncol 2009; 34: 1069-1075.
    • (2009) Int J Oncol , vol.34 , pp. 1069-1075
    • Motoyama, K.1    Inoue, H.2    Takatsuno, Y.3
  • 131
    • 61349141809 scopus 로고    scopus 로고
    • Clinicopathological significance of microRNA-31, -143 and -145 expression in colorectal cancer
    • Wang CJ, Zhou ZG, Wang L, et al.: Clinicopathological significance of microRNA-31, -143 and -145 expression in colorectal cancer. Dis Markers 2009; 26: 27-34.
    • (2009) Dis Markers , vol.26 , pp. 27-34
    • Wang, C.J.1    Zhou, Z.G.2    Wang, L.3
  • 132
    • 51049119231 scopus 로고    scopus 로고
    • Diagnostic and prognostic microRNAs in stage II colon cancer
    • Schepeler T, Reinert JT, Ostenfeld MS, et al.: Diagnostic and prognostic microRNAs in stage II colon cancer. Cancer Res 2008; 68: 6416-6424.
    • (2008) Cancer Res , vol.68 , pp. 6416-6424
    • Schepeler, T.1    Reinert, J.T.2    Ostenfeld, M.S.3
  • 133
    • 64049086575 scopus 로고    scopus 로고
    • MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells
    • Strillacci A, Griffoni C, Sansone P, et al.: MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells. Exp Cell Res 2009; 315: 1439-1447.
    • (2009) Exp Cell Res , vol.315 , pp. 1439-1447
    • Strillacci, A.1    Griffoni, C.2    Sansone, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.