A Colorectal Cancer Expression Profile That Includes Transforming Growth Factor β Inhibitor BAMBI Predicts Metastatic Potential

Gastroenterology

Volumn 137, Issue 1, 2009, Pages 165-175

  Fritzmann, Johannes ^a,b   Morkel, Markus ^a   Besser, Daniel ^a   Budczies, Jan ^c   Kosel, Frauke ^a   Brembeck, Felix H ^a   Stein, Ulrike ^a,b   Fichtner, Iduna ^a   Schlag, Peter M ^a,b   Birchmeier, Walter ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b Department for Surgery and Surgical Oncology ^*  (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BCL9 2 PROTEIN; BETA CATENIN; BMP AND ACTIVIN MEMBRANE BOUND INHIBITOR; MEMBRANE PROTEIN; PROTEIN; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; CELL INVASION; CELL MIGRATION; CELL MOTILITY; COLORECTAL CANCER; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC MARKER; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER METASTASIS; LYMPH NODE METASTASIS; METASTASIS; METASTASIS POTENTIAL; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SURVIVAL TIME;

EID: 67649234580     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2009.03.041     Document Type: Article

References (43)

1. Jemal A., Siegel R., Ward E., et al. Cancer statistics, 2008. CA Cancer J Clin 58 (2008) 71-96
2. de la Chapelle A. Genetic predisposition to colorectal cancer. Nat Rev Cancer 4 (2004) 769-780
3. Kinzler K.W., and Vogelstein B. Lessons from hereditary colorectal cancer. Cell 87 (1996) 159-170
4. Bienz M., and Clevers H. Linking colorectal cancer to Wnt signaling. Cell 103 (2000) 311-320
5. Gavert N., Sheffer M., Raveh S., et al. Expression of L1-CAM and ADAM10 in human colon cancer cells induces metastasis. Cancer Res 67 (2007) 7703-7712
6. Saha S., Bardelli A., Buckhaults P., et al. A phosphatase associated with metastasis of colorectal cancer. Science 294 (2001) 1343-1346
7. Stein U., Arlt F., Walther W., et al. The metastasis-associated gene S100A4 is a novel target of β-catenin/T-cell factor signaling in colon cancer. Gastroenterology 131 (2006) 1486-1500
8. Cardoso J., Boer J., Morreau H., et al. Expression and genomic profiling of colorectal cancer. Biochim Biophys Acta 1775 (2007) 103-137
9. Massague J. Sorting out breast-cancer gene signatures. N Engl J Med 356 (2007) 294-297
10. van de Vijver M.J., He Y.D., van't Veer L.J., et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 347 (2002) 1999-2009
11. Bierie B., and Moses H.L. TGF-β and cancer. Cytokine Growth Factor Rev 17 (2006) 29-40
12. Massague J. TGFβ in cancer. Cell 134 (2008) 215-230
13. Polakis P. Wnt signaling and cancer. Genes Dev 14 (2000) 1837-1851
14. Fodde R., Smits R., and Clevers H. APC, signal transduction and genetic instability in colorectal cancer. Nat Rev Cancer 1 (2001) 55-67
15. Inomata M., Ochiai A., Akimoto S., et al. Alteration of β-catenin expression in colonic epithelial cells of familial adenomatous polyposis patients. Cancer Res 56 (1996) 2213-2217
16. Brembeck F.H., Schwarz-Romond T., Bakkers J., et al. Essential role of BCL9-2 in the switch between β-catenin's adhesive and transcriptional functions. Genes Dev 18 (2004) 2225-2230
17. Grady W.M., and Markowitz S.D. Genetic and epigenetic alterations in colon cancer. Annu Rev Genomics Hum Genet 3 (2002) 101-128
18. Takayama T., Miyanishi K., Hayashi T., et al. Colorectal cancer: genetics of development and metastasis. J Gastroenterol 41 (2006) 185-192
19. Munoz N.M., Upton M., Rojas A., et al. Transforming growth factor β receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res 66 (2006) 9837-9844
20. Kang Y. Pro-metastasis function of TGFβ mediated by the Smad pathway. J Cell Biochem 98 (2006) 1380-1390
21. Itoh S., and ten Dijke P. Negative regulation of TGF-β receptor/Smad signal transduction. Curr Opin Cell Biol 19 (2007) 176-184
22. Onichtchouk D., Chen Y.G., Dosch R., et al. Silencing of TGF-β signalling by the pseudoreceptor BAMBI. Nature 401 (1999) 480-485
23. Sekiya T., Adachi S., Kohu K., et al. Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-β signaling, as a target of the β-catenin pathway in colorectal tumor cells. J Biol Chem 279 (2004) 6840-6846
24. Togo N., Ohwada S., Sakurai S., et al. Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. World J Gastroenterol 14 (2008) 4880-4888
25. Hampf M., and Gossen M. A protocol for combined Photinus and Renilla luciferase quantification compatible with protein assays. Anal Biochem 356 (2006) 94-99
26. Klaus A., and Birchmeier W. Wnt signalling and its impact on development and cancer. Nat Rev Cancer 8 (2008) 387-398
27. Markowitz S., Wang J., Myeroff L., et al. Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science 268 (1995) 1336-1338
28. Schwarte-Waldhoff I., Klein S., Blass-Kampmann S., et al. DPC4/SMAD4 mediated tumor suppression of colon carcinoma cells is associated with reduced urokinase expression. Oncogene 18 (1999) 3152-3158
29. Dennler S., Itoh S., Vivien D., et al. Direct binding of Smad3 and Smad4 to critical TGF-β-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J 17 (1998) 3091-3100
30. Wang J., Sun L., Myeroff L., et al. Demonstration that mutation of the type II transforming growth factor β receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. J Biol Chem 270 (1995) 22044-22049
31. Brunschwig E.B., Wilson K., Mack D., et al. PMEPA1, a transforming growth factor-β-induced marker of terminal colonocyte differentiation whose expression is maintained in primary and metastatic colon cancer. Cancer Res 63 (2003) 1568-1575
32. Laping N.J., Grygielko E., Mathur A., et al. Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type I receptor kinase activity: SB-431542. Mol Pharmacol 62 (2002) 58-64
33. Hatzis P., van der Flier L.G., van Driel M.A., et al. Genome-wide pattern of TCF7L2/TCF4 chromatin occupancy in colorectal cancer cells. Mol Cell Biol 28 (2008) 2732-2744
34. Li M., Lin Y.M., Hasegawa S., et al. Genes associated with liver metastasis of colon cancer, identified by genome-wide cDNA microarray. Int J Oncol 24 (2004) 305-312
35. Shrout J., Yousefzadeh M., Dodd A., et al. β(2)microglobulin mRNA expression levels are prognostic for lymph node metastasis in colorectal cancer patients. Br J Cancer 98 (2008) 1999-2005
36. Moustakas A., Pardali K., Gaal A., et al. Mechanisms of TGF-β signaling in regulation of cell growth and differentiation. Immunol Lett 82 (2002) 85-91
37. Markowitz S.D., and Roberts A.B. Tumor suppressor activity of the TGF-β pathway in human cancers. Cytokine Growth Factor Rev 7 (1996) 93-102
38. Fodde R., and Brabletz T. Wnt/β-catenin signaling in cancer stemness and malignant behavior. Curr Opin Cell Biol 19 (2007) 150-158
39. Adachi S., Jigami T., Yasui T., et al. Role of a BCL9-related β-catenin-binding protein, B9L, in tumorigenesis induced by aberrant activation of Wnt signaling. Cancer Res 64 (2004) 8496-8501
40. Law C.H., Wright F.C., Rapanos T., et al. Impact of lymph node retrieval and pathological ultra-staging on the prognosis of stage II colon cancer. J Surg Oncol 84 (2003) 120-126
41. Weiss L., Grundmann E., Torhorst J., et al. Haematogenous metastatic patterns in colonic carcinoma: an analysis of 1541 necropsies. J Pathol 150 (1986) 195-203
42. Forrester E., Chytil A., Bierie B., et al. Effect of conditional knockout of the type II TGF-β receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen-induced tumor formation and metastasis. Cancer Res 65 (2005) 2296-2302
43. Tu W.H., Thomas T.Z., Masumori N., et al. The loss of TGF-β signaling promotes prostate cancer metastasis. Neoplasia 5 (2003) 267-277