메뉴 건너뛰기




Volumn 11, Issue 2, 2009, Pages 125-131

The chemokine receptors CXCR4 and CXCR3 in cancer

Author keywords

[No Author keywords available]

Indexed keywords

AMD 4365; AMG 487; ANTINEOPLASTIC AGENT; CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; CTCE 9908; CXCL11 CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; PLERIXAFOR; TN 14003; UNCLASSIFIED DRUG;

EID: 60349085081     PISSN: 15233790     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11912-009-0019-1     Document Type: Review
Times cited : (100)

References (39)
  • 2
    • 0035282432 scopus 로고    scopus 로고
    • Involvement of chemokine receptors in breast cancer metastasis
    • Muller A, Homey B, Soto H, et al.: Involvement of chemokine receptors in breast cancer metastasis. Nature 2001, 410:50-56.
    • (2001) Nature , vol.410 , pp. 50-56
    • Muller, A.1    Homey, B.2    Soto, H.3
  • 3
    • 9244234390 scopus 로고    scopus 로고
    • CXCR4 regulates growth of both primary and metastatic breast cancer
    • Smith MCP, Luker KE, Gargow JR, et al.: CXCR4 regulates growth of both primary and metastatic breast cancer. Cancer Res 2004, 64:8604-8612.
    • (2004) Cancer Res , vol.64 , pp. 8604-8612
    • Smith, M.C.P.1    Luker, K.E.2    Gargow, J.R.3
  • 4
    • 2342591450 scopus 로고    scopus 로고
    • The significance of the cancer cell expression of the chemokine receptor CXCR4
    • Balkwill F: The significance of the cancer cell expression of the chemokine receptor CXCR4. Semin Cancer Biol 2004, 14:171-179.
    • (2004) Semin Cancer Biol , vol.14 , pp. 171-179
    • Balkwill, F.1
  • 5
    • 0037108923 scopus 로고    scopus 로고
    • Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer
    • Scotten CJ, Wilson JL, Scott K, et al.: Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res 2002, 62:5930-5938.
    • (2002) Cancer Res , vol.62 , pp. 5930-5938
    • Scotten, C.J.1    Wilson, J.L.2    Scott, K.3
  • 6
    • 0142102523 scopus 로고    scopus 로고
    • T140 analogs as CXCR4 antagonists identified as antimetastatic agents in the treatment of breast cancer
    • Tamamura H, Hori A, Kanzaki N, et al.: T140 analogs as CXCR4 antagonists identified as antimetastatic agents in the treatment of breast cancer. FEBS Lett 2003, 550:79-83.
    • (2003) FEBS Lett , vol.550 , pp. 79-83
    • Tamamura, H.1    Hori, A.2    Kanzaki, N.3
  • 7
    • 0036606772 scopus 로고    scopus 로고
    • CXCR4 neutralization a novel therapeutic approach for non-Hodgkin's lymphoma
    • Bertolini F, Dell'Agnola C, Mancuso P, et al.: CXCR4 neutralization a novel therapeutic approach for non-Hodgkin's lymphoma. Cancer Res 2002, 62:3106-3112.
    • (2002) Cancer Res , vol.62 , pp. 3106-3112
    • Bertolini, F.1    Dell'Agnola, C.2    Mancuso, P.3
  • 8
    • 0037115647 scopus 로고    scopus 로고
    • Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells
    • Murakami T, Maki W, Cardones AR, et al.: Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells. Cancer Res 2002, 62:7328-7334.
    • (2002) Cancer Res , vol.62 , pp. 7328-7334
    • Murakami, T.1    Maki, W.2    Cardones, A.R.3
  • 9
    • 44349100383 scopus 로고    scopus 로고
    • Organ selectivity in metastasis: Regulation by chemokines and their receptors
    • Ben-Baruch A: Organ selectiRity in metastasis: regulation by chemokines and their receptors. Clin Exp Metastasis 2008, 25:345-356.
    • (2008) Clin Exp Metastasis , vol.25 , pp. 345-356
    • Ben-Baruch, A.1
  • 10
    • 33751256842 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: Implications for angiogenesis and glioma cell invasion
    • Zagzag D, Lukyanov Y, Lan L, et al.: Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: Implications for angiogenesis and glioma cell invasion. Lab Invest 2006, 86:1221-1232.
    • (2006) Lab Invest , vol.86 , pp. 1221-1232
    • Zagzag, D.1    Lukyanov, Y.2    Lan, L.3
  • 11
    • 34748871683 scopus 로고    scopus 로고
    • Androgen receptor negatively influences the expression of chemokine receptors (CXCR4, CCR1) and ligand-mediated migration in prostate cancer DU-145
    • Akashi T, Koizumi K, Nagakawa O, et al.: Androgen receptor negatively influences the expression of chemokine receptors (CXCR4, CCR1) and ligand-mediated migration in prostate cancer DU-145. Oncol Rep 2006, 16:831-836.
    • (2006) Oncol Rep , vol.16 , pp. 831-836
    • Akashi, T.1    Koizumi, K.2    Nagakawa, O.3
  • 12
    • 68949099424 scopus 로고    scopus 로고
    • Post-transcriptional regulation of chemokine receptor CXCR4 by estrogen in HER overexpressing, estrogen receptor-positive breast cancer cells
    • Sep 19 [Epub ahead of print]
    • Sengupta S, Schiff R, Katzenellenbogen BS: Post-transcriptional regulation of chemokine receptor CXCR4 by estrogen in HER overexpressing, estrogen receptor-positive breast cancer cells. Breast Cancer Res Treat 2008 Sep 19 [Epub ahead of print].
    • (2008) Breast Cancer Res Treat
    • Sengupta, S.1    Schiff, R.2    Katzenellenbogen, B.S.3
  • 13
    • 33646261865 scopus 로고    scopus 로고
    • Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer
    • Holland JD, Kochetkova M, Akekawatchai C, et al.: Differential functional activation of chemokine receptor CXCR4 is mediated by G proteins in breast cancer. Cancer Res 2006, 66:4117-4124.
    • (2006) Cancer Res , vol.66 , pp. 4117-4124
    • Holland, J.D.1    Kochetkova, M.2    Akekawatchai, C.3
  • 14
    • 41849096039 scopus 로고    scopus 로고
    • Endothelial cells and normal breast epithelial cells enhance invasion of breast carcinoma cells by CXCR4-dependent up-regulation of urokinase-type plasminogen activator receptor (uPAR, CD87) expression
    • Serrati S, Margheri F, Fibbi G, et al.: Endothelial cells and normal breast epithelial cells enhance invasion of breast carcinoma cells by CXCR4-dependent up-regulation of urokinase-type plasminogen activator receptor (uPAR, CD87) expression. J Pathol 2008, 214:545-554.
    • (2008) J Pathol , vol.214 , pp. 545-554
    • Serrati, S.1    Margheri, F.2    Fibbi, G.3
  • 15
    • 28844458917 scopus 로고    scopus 로고
    • Transactivation of CXCR4 by the insulin-like growth factor-1 receptor (IGF-1R) in human MDA-MB-231 breast cancer epithelial cells
    • Akekawtchai C, Holland JD, Kochetkova M, et al.: Transactivation of CXCR4 by the insulin-like growth factor-1 receptor (IGF-1R) in human MDA-MB-231 breast cancer epithelial cells. J Biol Chem 2005, 280:39701-39708.
    • (2005) J Biol Chem , vol.280 , pp. 39701-39708
    • Akekawtchai, C.1    Holland, J.D.2    Kochetkova, M.3
  • 16
    • 40949136474 scopus 로고    scopus 로고
    • CXC12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone
    • Chinni SR, Yamamoto H, Dong Z, et al.: CXC12/CXCR4 transactivates HER2 in lipid rafts of prostate cancer cells and promotes growth of metastatic deposits in bone. Mol Cancer Res 2008, 6:446-457.
    • (2008) Mol Cancer Res , vol.6 , pp. 446-457
    • Chinni, S.R.1    Yamamoto, H.2    Dong, Z.3
  • 17
    • 3042616145 scopus 로고    scopus 로고
    • Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4
    • Liang Z, Wu T, Lou H, et al.: Inhibition of breast cancer metastasis by selective synthetic polypeptide against CXCR4. Cancer Res 2004, 64:4302-4308.
    • (2004) Cancer Res , vol.64 , pp. 4302-4308
    • Liang, Z.1    Wu, T.2    Lou, H.3
  • 18
    • 34547634399 scopus 로고    scopus 로고
    • CXC chemokine receptor-4-antagonist blocks both growth of primary tumor and metastasis of head and neck cancer in xenograft mouse models
    • Yoon Y, Liang Z, Zhang X, et al.: CXC chemokine receptor-4-antagonist blocks both growth of primary tumor and metastasis of head and neck cancer in xenograft mouse models. Cancer Res 2007, 15:7518-7524.
    • (2007) Cancer Res , vol.15 , pp. 7518-7524
    • Yoon, Y.1    Liang, Z.2    Zhang, X.3
  • 19
    • 0344823964 scopus 로고    scopus 로고
    • A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors
    • Rubin JB, Kung AL, Klein RS, et al.: A small-molecule antagonist of CXCR4 inhibits intracranial growth of primary brain tumors. Proc Natl Acad Sci U S A 2003, 100:13513-13518.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 13513-13518
    • Rubin, J.B.1    Kung, A.L.2    Klein, R.S.3
  • 20
    • 33846670549 scopus 로고    scopus 로고
    • Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo
    • Yang L, Jackson E, Woerner BM, et al.: Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res 2007, 67:651-658.
    • (2007) Cancer Res , vol.67 , pp. 651-658
    • Yang, L.1    Jackson, E.2    Woerner, B.M.3
  • 21
    • 42449111736 scopus 로고    scopus 로고
    • Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases
    • Kim SY, Lee CH, Midura BV, et al.: Inhibition of the CXCR4/CXCL12 chemokine pathway reduces the development of murine pulmonary metastases. Clin Exp Metastasis 2008, 25:201-211.
    • (2008) Clin Exp Metastasis , vol.25 , pp. 201-211
    • Kim, S.Y.1    Lee, C.H.2    Midura, B.V.3
  • 22
    • 12444260282 scopus 로고    scopus 로고
    • An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig and I-TAC, and acts as functional receptor for platelet factor 4
    • Lasagni L, Francalanci M, Annunziato F, et al.: An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig and I-TAC, and acts as functional receptor for platelet factor 4. J Exp Med 2003, 197:1537-1549.
    • (2003) J Exp Med , vol.197 , pp. 1537-1549
    • Lasagni, L.1    Francalanci, M.2    Annunziato, F.3
  • 23
    • 8444241446 scopus 로고    scopus 로고
    • Identification and partial characterization of a variant of human CXR3 generated by posttranscriptional exon skipping
    • Ehlert JE, Addison CA, Burdick MD, et al.: Identification and partial characterization of a variant of human CXR3 generated by posttranscriptional exon skipping. J Immunol 2004, 173:6234-6240.
    • (2004) J Immunol , vol.173 , pp. 6234-6240
    • Ehlert, J.E.1    Addison, C.A.2    Burdick, M.D.3
  • 24
    • 34250817446 scopus 로고    scopus 로고
    • CXCR3 chemokine receptor immunoreactivity in primary cutaneous malignant melanoma: Correlation with clinicopathologic prognostic factors
    • Monteagudo C, Martin JM, Jorda E, Llombart-Bosch A: CXCR3 chemokine receptor immunoreactivity in primary cutaneous malignant melanoma: correlation with clinicopathologic prognostic factors. J Clin Pathol 2007, 60:596-599.
    • (2007) J Clin Pathol , vol.60 , pp. 596-599
    • Monteagudo, C.1    Martin, J.M.2    Jorda, E.3    Llombart-Bosch, A.4
  • 25
    • 34447524931 scopus 로고    scopus 로고
    • Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes
    • Kawada K, Hosogi H, Sonoshita M, et al.: Chemokine receptor CXCR3 promotes colon cancer metastasis to lymph nodes. Oncogene 2007, 26:4679-4688.
    • (2007) Oncogene , vol.26 , pp. 4679-4688
    • Kawada, K.1    Hosogi, H.2    Sonoshita, M.3
  • 26
    • 66449121642 scopus 로고    scopus 로고
    • CXCR3 expression is associated with poor survival in breast cancer and promotes metastasis in a murine model
    • in press
    • Ma X, Norsworthy K, Kundu N, et al.: CXCR3 expression is associated with poor survival in breast cancer and promotes metastasis in a murine model. Mol Cancer Ther, in press.
    • Mol Cancer Ther
    • Ma, X.1    Norsworthy, K.2    Kundu, N.3
  • 27
    • 0034651010 scopus 로고    scopus 로고
    • The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia
    • Jones D, Benjamin RJ, Shahsafaei A, Dorfman DM: The chemokine receptor CXCR3 is expressed in a subset of B-cell lymphomas and is a marker of B-cell chronic lymphocytic leukemia. Blood 2000, 95:627-632.
    • (2000) Blood , vol.95 , pp. 627-632
    • Jones, D.1    Benjamin, R.J.2    Shahsafaei, A.3    Dorfman, D.M.4
  • 28
    • 36749064570 scopus 로고    scopus 로고
    • The chemokine receptor CXCR3 is an independent prognostic factor in patients with localized clear cell renal cell carcinoma
    • Klatte T, Seligson DB, Leppert JT, et al.: The chemokine receptor CXCR3 is an independent prognostic factor in patients with localized clear cell renal cell carcinoma. J Urol 2008, 179:61-66.
    • (2008) J Urol , vol.179 , pp. 61-66
    • Klatte, T.1    Seligson, D.B.2    Leppert, J.T.3
  • 29
    • 2542612840 scopus 로고    scopus 로고
    • Pivotal role of CXCR3 in melanoma cell metastasis to lymph nodes
    • Kawada K, Sonoshita M, Sakashita H: Pivotal role of CXCR3 in melanoma cell metastasis to lymph nodes. Cancer Res 2004, 64:4010-4017.
    • (2004) Cancer Res , vol.64 , pp. 4010-4017
    • Kawada, K.1    Sonoshita, M.2    Sakashita, H.3
  • 30
    • 1842663068 scopus 로고    scopus 로고
    • The expression of the chemokine receptor CXCR3 and its ligand, CXCL10, in human breast adenocarcinoma cell lines
    • Goldberg-Bittman L, Neumark E, Sagi-Assif O, et al.: The expression of the chemokine receptor CXCR3 and its ligand, CXCL10, in human breast adenocarcinoma cell lines. Immunol Lett 2004, 92:171-178.
    • (2004) Immunol Lett , vol.92 , pp. 171-178
    • Goldberg-Bittman, L.1    Neumark, E.2    Sagi-Assif, O.3
  • 31
    • 11144352268 scopus 로고    scopus 로고
    • Cellular characteristics of neuroblastoma cells: Regulation by the ELR-CXC chemokine CXCL10 and expression of a CXCR3-like receptor
    • Goldberg-Bittman L, Sagi-Assif O, Meshel T, et al.: Cellular characteristics of neuroblastoma cells: Regulation by the ELR-CXC chemokine CXCL10 and expression of a CXCR3-like receptor. Cytokine 2005, 29:105-117.
    • (2005) Cytokine , vol.29 , pp. 105-117
    • Goldberg-Bittman, L.1    Sagi-Assif, O.2    Meshel, T.3
  • 32
    • 33750305632 scopus 로고    scopus 로고
    • Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: Relevance for the development of human breast cancer
    • Datta D, Flaxenburg JA, Laxmanan S, et al.: Ras-induced modulation of CXCL10 and its receptor splice variant CXCR3-B in MDA-MB-435 and MCF-7 cells: Relevance for the development of human breast cancer. Cancer Res 2006, 66:9509-9518.
    • (2006) Cancer Res , vol.66 , pp. 9509-9518
    • Datta, D.1    Flaxenburg, J.A.2    Laxmanan, S.3
  • 33
    • 33747888160 scopus 로고    scopus 로고
    • Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer
    • Walser TC, Rifat S, Ma X, et al.: Antagonism of CXCR3 inhibits lung metastasis in a murine model of metastatic breast cancer. Cancer Res 2006, 66:7701-7707.
    • (2006) Cancer Res , vol.66 , pp. 7701-7707
    • Walser, T.C.1    Rifat, S.2    Ma, X.3
  • 34
    • 34248220334 scopus 로고    scopus 로고
    • CXCL10 promotes invasion-related properties in human colorectal carcinoma cells
    • Zipin-Roitman A, Meshel T, Sagi-Assif O, et al.: CXCL10 promotes invasion-related properties in human colorectal carcinoma cells. Cancer Res 2007, 67:3396-3405.
    • (2007) Cancer Res , vol.67 , pp. 3396-3405
    • Zipin-Roitman, A.1    Meshel, T.2    Sagi-Assif, O.3
  • 35
    • 0027169811 scopus 로고
    • IP-10, a C-X-C chemokine, elicits a potent thymus-dependent antitumor response in vivo
    • Luster AD, Leder P: IP-10, a C-X-C chemokine, elicits a potent thymus-dependent antitumor response in vivo. J Exp Med 1993, 178:1057-1065.
    • (1993) J Exp Med , vol.178 , pp. 1057-1065
    • Luster, A.D.1    Leder, P.2
  • 36
    • 12644261448 scopus 로고    scopus 로고
    • Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo
    • Sgadari C, Angiolillo AL, Cherney BW, et al.: Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo. Proc Natl Acad Sci U S A 1996, 93:13791-13796.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 13791-13796
    • Sgadari, C.1    Angiolillo, A.L.2    Cherney, B.W.3
  • 37
    • 0036569858 scopus 로고    scopus 로고
    • Immunotherapy with interleukin-10 depends on the CXC chemokines inducible protein-10 and monokine induced by IFN-gamma
    • Dorsey R, Kundu N, Yang Q, et al.: Immunotherapy with interleukin-10 depends on the CXC chemokines inducible protein-10 and monokine induced by IFN-gamma. Cancer Res 2002, 62:2606-2610.
    • (2002) Cancer Res , vol.62 , pp. 2606-2610
    • Dorsey, R.1    Kundu, N.2    Yang, Q.3
  • 38
    • 34247489551 scopus 로고    scopus 로고
    • Immune-mediated modulation of breast cancer growth and metastasis by the chemokine Mig (CXCL9) in a murine model
    • Walser TC, Ma X, Kundu N, et al.: Immune-mediated modulation of breast cancer growth and metastasis by the chemokine Mig (CXCL9) in a murine model. J Immunother 2007, 30:490-498.
    • (2007) J Immunother , vol.30 , pp. 490-498
    • Walser, T.C.1    Ma, X.2    Kundu, N.3
  • 39
    • 35748929086 scopus 로고    scopus 로고
    • Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients
    • Winter D, Moser J, Kriehuber E, et al.: Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients. J Immunol 2007, 179:4272-4282.
    • (2007) J Immunol , vol.179 , pp. 4272-4282
    • Winter, D.1    Moser, J.2    Kriehuber, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.