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Volumn 33, Issue 8, 1997, Pages 1314-1322

The status of p53 in the metastatic progression of colorectal cancer

Author keywords

Colorectal cancer metastase; Immunohistochemistry; Loss of heterozygosity; mRNA expression; p53 mutations; PCR

Indexed keywords

MESSENGER RNA; PROTEIN P53;

EID: 17144473545     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-8049(97)00118-4     Document Type: Article
Times cited : (31)

References (56)
  • 2
    • 0025876591 scopus 로고
    • The p53 tumour suppressor gene
    • Levine AJ, Momand J, Finlay CA. The p53 tumour suppressor gene. Nature 1991, 351, 453-456.
    • (1991) Nature , vol.351 , pp. 453-456
    • Levine, A.J.1    Momand, J.2    Finlay, C.A.3
  • 3
    • 0025633582 scopus 로고
    • Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas and other neoplasms
    • Malkin D, Li FP, Strong LC, et al. Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas and other neoplasms. Science 1990, 250, 1233-1238.
    • (1990) Science , vol.250 , pp. 1233-1238
    • Malkin, D.1    Li, F.P.2    Strong, L.C.3
  • 4
    • 0025648762 scopus 로고
    • Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome
    • Srivastava S, Zou ZQ, Pirollo K, Blattner W, Chang EH. Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome. Nature 1990, 348, 747-749.
    • (1990) Nature , vol.348 , pp. 747-749
    • Srivastava, S.1    Zou, Z.Q.2    Pirollo, K.3    Blattner, W.4    Chang, E.H.5
  • 5
    • 0026530299 scopus 로고
    • Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms
    • Malkin D, Jolly KW, Barbier N, et al. Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms. N Engl J med 1992, 326, 1309-1315.
    • (1992) N Engl J Med , vol.326 , pp. 1309-1315
    • Malkin, D.1    Jolly, K.W.2    Barbier, N.3
  • 6
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: Clues to cancer etiology and molecular pathogenesis
    • Greenblatt MS, Bennett WP, Hollstein M, Harris CC. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res 1994, 54, 4855-4878.
    • (1994) Cancer Res , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 7
    • 0025375355 scopus 로고
    • Structural aspects of the p53 protein in relation to gene evolution
    • Soussi T, Caron-de-Fromentel C, May P. Structural aspects of the p53 protein in relation to gene evolution. Oncogene 1990, 5, 945-952.
    • (1990) Oncogene , vol.5 , pp. 945-952
    • Soussi, T.1    Caron-De-Fromentel, C.2    May, P.3
  • 8
    • 0028986128 scopus 로고
    • p53 gene mutations inside and outside of exons 5-8: The patterns differ in breast and other cancers
    • Hartmann A, Blaszyk H, McGovern RM, et al. p53 gene mutations inside and outside of exons 5-8: the patterns differ in breast and other cancers. Oncogene 1995, 10, 681-688.
    • (1995) Oncogene , vol.10 , pp. 681-688
    • Hartmann, A.1    Blaszyk, H.2    McGovern, R.M.3
  • 9
    • 0025731379 scopus 로고
    • Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation
    • Milner J, Medcalf EA. Cotranslation of activated mutant p53 with wild type drives the wild-type p53 protein into the mutant conformation. Cell 1991, 65, 765-774.
    • (1991) Cell , vol.65 , pp. 765-774
    • Milner, J.1    Medcalf, E.A.2
  • 10
    • 0029315510 scopus 로고
    • Tumor suppressors, kinases and clamps: How p53 regulates the cell cycle in response to DNA damage
    • Cox LS, Lane DP. Tumor suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage. Bioessays 1995, 17, 501-508.
    • (1995) Bioessays , vol.17 , pp. 501-508
    • Cox, L.S.1    Lane, D.P.2
  • 12
    • 0025180506 scopus 로고
    • p53 is associated with p34cdc2 in transformed cells
    • Milner J, Cook A, Mason J. p53 is associated with p34cdc2 in transformed cells. Embo J 1990, 9, 2885-2889.
    • (1990) Embo J , vol.9 , pp. 2885-2889
    • Milner, J.1    Cook, A.2    Mason, J.3
  • 14
    • 0026496885 scopus 로고
    • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
    • Kastan MB, Zhan Q, el-Deiry WS, et al. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 1992, 71, 587-597.
    • (1992) Cell , vol.71 , pp. 587-597
    • Kastan, M.B.1    Zhan, Q.2    El-Deiry, W.S.3
  • 15
    • 0026801062 scopus 로고
    • Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
    • Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 1992, 70, 923-935.
    • (1992) Cell , vol.70 , pp. 923-935
    • Livingstone, L.R.1    White, A.2    Sprouse, J.3    Livanos, E.4    Jacks, T.5    Tlsty, T.D.6
  • 16
    • 0026801977 scopus 로고
    • Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
    • Yin Y, Tainsky MA, Bischoff FZ, Strong LC, Wahl GM. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 1992, 70, 937-948.
    • (1992) Cell , vol.70 , pp. 937-948
    • Yin, Y.1    Tainsky, M.A.2    Bischoff, F.Z.3    Strong, L.C.4    Wahl, G.M.5
  • 17
    • 0027109075 scopus 로고
    • Cancer. p53, guardian of the genome
    • Lane DP. Cancer. p53, guardian of the genome. Nature 1992, 358, 15-16.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 19
    • 0026053582 scopus 로고
    • Mutant p53 proteins bind DNA abnormally in vitro
    • Kern SE, Kinzler KW, Baker SJ, et al. Mutant p53 proteins bind DNA abnormally in vitro. Oncogene 1991, 6, 131-136.
    • (1991) Oncogene , vol.6 , pp. 131-136
    • Kern, S.E.1    Kinzler, K.W.2    Baker, S.J.3
  • 20
    • 0026535237 scopus 로고
    • p53: A transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer
    • Unger T, Nau MM, Segal S, Minna JD. p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer. Embol J 1992, 11, 1383-1390.
    • (1992) Embol J , vol.11 , pp. 1383-1390
    • Unger, T.1    Nau, M.M.2    Segal, S.3    Minna, J.D.4
  • 21
    • 0025634118 scopus 로고
    • p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis
    • Baker SJ, Preisinger AC, Jessup JM, et al. p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 1990, 50, 7717-7722.
    • (1990) Cancer Res , vol.50 , pp. 7717-7722
    • Baker, S.J.1    Preisinger, A.C.2    Jessup, J.M.3
  • 22
    • 0028088897 scopus 로고
    • Association of p53 mutations with short survival in colorectal cancer
    • Hamelin R, Laurent-Puig P, Olschwang S, et al. Association of p53 mutations with short survival in colorectal cancer. Gastroenterology 1994, 106, 42-48.
    • (1994) Gastroenterology , vol.106 , pp. 42-48
    • Hamelin, R.1    Laurent-Puig, P.2    Olschwang, S.3
  • 24
    • 0028879677 scopus 로고
    • p53 point mutation and survival in colorectal cancer patients
    • Goh HS, Yao J, Smith DR. p53 point mutation and survival in colorectal cancer patients. Cancer Res 1995, 55, 5217-5221.
    • (1995) Cancer Res , vol.55 , pp. 5217-5221
    • Goh, H.S.1    Yao, J.2    Smith, D.R.3
  • 25
    • 0030035991 scopus 로고    scopus 로고
    • Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas
    • Smith DR, Ji CY, Goh HS. Prognostic significance of p53 overexpression and mutation in colorectal adenocarcinomas. Br J Cancer 1996, 74, 216-223.
    • (1996) Br J Cancer , vol.74 , pp. 216-223
    • Smith, D.R.1    Ji, C.Y.2    Goh, H.S.3
  • 26
    • 0028171960 scopus 로고
    • p53 nuclear overexpression: An independent predictor of survival in lymph node-positive colorectal cancer patients
    • Zeng ZS, Sarkis AS, Zhang ZF, et al. p53 nuclear overexpression: an independent predictor of survival in lymph node-positive colorectal cancer patients. J Clin Oncol 1994, 12, 2043-2050.
    • (1994) J Clin Oncol , vol.12 , pp. 2043-2050
    • Zeng, Z.S.1    Sarkis, A.S.2    Zhang, Z.F.3
  • 28
    • 0029023358 scopus 로고
    • Evaluation of p53 protein expression as a marker for long-term prognosis in colorectal carcinoma
    • Mulder JW, Baas IO, Polak MM, Goodman SM, Offerhaus GJ. Evaluation of p53 protein expression as a marker for long-term prognosis in colorectal carcinoma. Br J Cancer 1995, 71, 1257-1262.
    • (1995) Br J Cancer , vol.71 , pp. 1257-1262
    • Mulder, J.W.1    Baas, I.O.2    Polak, M.M.3    Goodman, S.M.4    Offerhaus, G.J.5
  • 29
    • 0027946507 scopus 로고
    • Expression and mutational analysis of Nm23-H1 in liver metastases of colorectal cancer
    • Heide, I, Thiede C, Poppe K, de Kant E, Huhn D, Rochlitz C. Expression and mutational analysis of Nm23-H1 in liver metastases of colorectal cancer. Br J Cancer 1994, 70, 1267-1271.
    • (1994) Br J Cancer , vol.70 , pp. 1267-1271
    • Heide, I.1    Thiede, C.2    Poppe, K.3    De Kant, E.4    Huhn, D.5    Rochlitz, C.6
  • 30
    • 0024604481 scopus 로고
    • Amplification of a highly polymorphic VNTR segment by the polymerase chain reaction
    • Horn GT, Richards B, Klinger KW. Amplification of a highly polymorphic VNTR segment by the polymerase chain reaction. Nucleic Acids Res 1989, 17, 2140.
    • (1989) Nucleic Acids Res , vol.17 , pp. 2140
    • Horn, G.T.1    Richards, B.2    Klinger, K.W.3
  • 31
    • 0022483186 scopus 로고
    • Isolation of human-p53-specific monoclonal antibodies and their use in the studies of human p53 expression
    • Banks L, Matlashewski G, Crawford L. Isolation of human-p53-specific monoclonal antibodies and their use in the studies of human p53 expression. Eur J Biochem 1986, 159, 529-534.
    • (1986) Eur J Biochem , vol.159 , pp. 529-534
    • Banks, L.1    Matlashewski, G.2    Crawford, L.3
  • 32
    • 0021331061 scopus 로고
    • Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes)
    • Cordell JL, Falini B, Erber WN, et al. Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes). J Histochem Cytochem 1984, 32, 219-229.
    • (1984) J Histochem Cytochem , vol.32 , pp. 219-229
    • Cordell, J.L.1    Falini, B.2    Erber, W.N.3
  • 33
    • 0024338294 scopus 로고
    • Detection of amplified oncogenes by differential polymerase chain reaction
    • Frye RA, Benz CC, Liu E. Detection of amplified oncogenes by differential polymerase chain reaction. Oncogene 1989, 4, 1153-1157.
    • (1989) Oncogene , vol.4 , pp. 1153-1157
    • Frye, R.A.1    Benz, C.C.2    Liu, E.3
  • 34
    • 0025305575 scopus 로고
    • Polymerase chain reaction based assay to detect allelic loss in human DNA: Loss of β-interferon gene in chronic myelogenous leukemia
    • Neubauer A, Neubauer N, Liu E. Polymerase chain reaction based assay to detect allelic loss in human DNA: loss of β-interferon gene in chronic myelogenous leukemia. Nucleic Acids Res 1990, 18, 993-998.
    • (1990) Nucleic Acids Res , vol.18 , pp. 993-998
    • Neubauer, A.1    Neubauer, N.2    Liu, E.3
  • 35
    • 0023709002 scopus 로고
    • A variation in the structure of the protein-coding region of the human p53 gene
    • Buchman VL, Chumakov PM, Ninkina NN, Samarina OP, Georgiev GP. A variation in the structure of the protein-coding region of the human p53 gene. Gene 1988, 70, 245-252.
    • (1988) Gene , vol.70 , pp. 245-252
    • Buchman, V.L.1    Chumakov, P.M.2    Ninkina, N.N.3    Samarina, O.P.4    Georgiev, G.P.5
  • 36
    • 0023638001 scopus 로고
    • The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit
    • Gussow D, Rein R, Ginjaar I, et al. The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit. J Immunol 1987, 139, 3132-3138.
    • (1987) J Immunol , vol.139 , pp. 3132-3138
    • Gussow, D.1    Rein, R.2    Ginjaar, I.3
  • 37
    • 0026010027 scopus 로고
    • Axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase
    • O'Bryan JP, Frye RA, Cogswell PC, et al. axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase. Mol Cell Biol 1991, 11, 5016-5031.
    • (1991) Mol Cell Biol , vol.11 , pp. 5016-5031
    • O'Bryan, J.P.1    Frye, R.A.2    Cogswell, P.C.3
  • 38
    • 0025145277 scopus 로고
    • 5-methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes
    • Rideout WM, Coetzee GA, Olumi AF, Jones PA. 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Science 1990, 249, 1288-1290.
    • (1990) Science , vol.249 , pp. 1288-1290
    • Rideout, W.M.1    Coetzee, G.A.2    Olumi, A.F.3    Jones, P.A.4
  • 39
    • 0029027343 scopus 로고
    • Complete and tissue-independent methylation of CpG sites in the p53 gene: Implications for mutations in human cancers
    • Tornaletti S, Pfeifer GP. Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers. Oncogene 1995, 10, 1493-1499.
    • (1995) Oncogene , vol.10 , pp. 1493-1499
    • Tornaletti, S.1    Pfeifer, G.P.2
  • 40
    • 0025618980 scopus 로고
    • Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: A comparison of the 'hot spot' mutant phenotypes
    • Hinds PW, Finlay CA, Quartin RS, et al. Mutant p53 DNA clones from human colon carcinomas cooperate with ras in transforming primary rat cells: a comparison of the 'hot spot' mutant phenotypes. Cell Growth Differ 1990, 1, 571-580.
    • (1990) Cell Growth Differ , vol.1 , pp. 571-580
    • Hinds, P.W.1    Finlay, C.A.2    Quartin, R.S.3
  • 41
    • 0026609019 scopus 로고
    • Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation
    • Bodner SM, Minna JD, Jensen SM, et al. Expression of mutant p53 proteins in lung cancer correlates with the class of p53 gene mutation. Oncogene 1992, 7, 743-749.
    • (1992) Oncogene , vol.7 , pp. 743-749
    • Bodner, S.M.1    Minna, J.D.2    Jensen, S.M.3
  • 42
    • 0027999502 scopus 로고
    • Gene expression analysis by a competitive and differential PCR with antisense competitors
    • de-Kant E, Rochlitz CF, Herrmann R. Gene expression analysis by a competitive and differential PCR with antisense competitors. Biotechniques 1994, 17, 934-942.
    • (1994) Biotechniques , vol.17 , pp. 934-942
    • De-Kant, E.1    Rochlitz, C.F.2    Herrmann, R.3
  • 43
    • 0026051738 scopus 로고
    • Occurrence of Ki-ras and p53 mutations in primary colorectal tumors
    • Shaw P, Tardy S, Benito E, Obrador A, Costa J. Occurrence of Ki-ras and p53 mutations in primary colorectal tumors. Oncogene 1991, 6, 2121-2128.
    • (1991) Oncogene , vol.6 , pp. 2121-2128
    • Shaw, P.1    Tardy, S.2    Benito, E.3    Obrador, A.4    Costa, J.5
  • 44
    • 0028978774 scopus 로고
    • p53 gene mutations, p53 protein accumulation and compartmentalization in colorectal adenocarcinoma
    • Bosari S, Viale G, Roncalli M, et al. p53 gene mutations, p53 protein accumulation and compartmentalization in colorectal adenocarcinoma. Am J Pathol 1995, 147, 790-798.
    • (1995) Am J Pathol , vol.147 , pp. 790-798
    • Bosari, S.1    Viale, G.2    Roncalli, M.3
  • 46
    • 0026583497 scopus 로고
    • Alterations of the p53 gene are associated with the progression a human prostate carcinoma
    • Effert PJ, Neubauer A, Walther PJ, Liu ET. Alterations of the p53 gene are associated with the progression a human prostate carcinoma. J Urol 1992, 147, 789-793.
    • (1992) J Urol , vol.147 , pp. 789-793
    • Effert, P.J.1    Neubauer, A.2    Walther, P.J.3    Liu, E.T.4
  • 47
    • 0029125551 scopus 로고
    • Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression
    • Kastrinakis VW, Ramchurren N, Rieger KM, et al. Increased incidence of p53 mutations is associated with hepatic metastasis in colorectal neoplastic progression. Oncogens 1995, 11, 647-652.
    • (1995) Oncogens , vol.11 , pp. 647-652
    • Kastrinakis, V.W.1    Ramchurren, N.2    Rieger, K.M.3
  • 48
    • 0026660339 scopus 로고
    • Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens
    • Crook T, Vousden KH. Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens. Embo J 1992, 11, 3935-3940.
    • (1992) Embo J , vol.11 , pp. 3935-3940
    • Crook, T.1    Vousden, K.H.2
  • 49
    • 0029967254 scopus 로고    scopus 로고
    • Soft tissue sarcoma metastasis from clonal expansion of p53 mutated tumor cells
    • Pollock RE, Lang A, Luo J, El-Naggar AK, Yu D. Soft tissue sarcoma metastasis from clonal expansion of p53 mutated tumor cells. Oncogene 1996, 12, 2035-2039.
    • (1996) Oncogene , vol.12 , pp. 2035-2039
    • Pollock, R.E.1    Lang, A.2    Luo, J.3    El-Naggar, A.K.4    Yu, D.5
  • 50
    • 0025879530 scopus 로고
    • Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies
    • Bartek J, Bartkova J, Vojtesek B, et al. Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies. Oncogene 1991, 6, 1699-1703.
    • (1991) Oncogene , vol.6 , pp. 1699-1703
    • Bartek, J.1    Bartkova, J.2    Vojtesek, B.3
  • 51
    • 0026664077 scopus 로고
    • Expression of p53 and 17p allelic loss in colorectal carcnoma
    • Cunningham J, Lust JA, Schaid DJ, et al. Expression of p53 and 17p allelic loss in colorectal carcnoma. Cancer Res 1992, 52, 1974-1980.
    • (1992) Cancer Res , vol.52 , pp. 1974-1980
    • Cunningham, J.1    Lust, J.A.2    Schaid, D.J.3
  • 52
    • 0028903782 scopus 로고
    • Association of p53 gene and protein alterations with metastases in colorectal cancer
    • Bertorelle R, Esposito G, Del-Mistro A, et al. Association of p53 gene and protein alterations with metastases in colorectal cancer. Am J Surg Pathol 1995, 19, 463-471.
    • (1995) Am J Surg Pathol , vol.19 , pp. 463-471
    • Bertorelle, R.1    Esposito, G.2    Del-Mistro, A.3
  • 53
    • 0029610184 scopus 로고
    • Evidence for a mutual regulation of p53 and c-myc expression in human colorectal cancer metastases
    • Rochlitz CF, Heide I, Thiede C, Herrmann R, de Kant E. Evidence for a mutual regulation of p53 and c-myc expression in human colorectal cancer metastases. Ann Oncol 1995, 10, 981-986.
    • (1995) Ann Oncol , vol.10 , pp. 981-986
    • Rochlitz, C.F.1    Heide, I.2    Thiede, C.3    Herrmann, R.4    De Kant, E.5
  • 54
    • 0027302046 scopus 로고
    • Efficient screening of p53 mutations by denaturing gradient gel electrophoresis in colorectal tumors
    • Hamelin R, Jego N, Laurent-Puig P, Vidaud M, Thomas G. Efficient screening of p53 mutations by denaturing gradient gel electrophoresis in colorectal tumors. Oncogene 1993, 8, 2213-2220.
    • (1993) Oncogene , vol.8 , pp. 2213-2220
    • Hamelin, R.1    Jego, N.2    Laurent-Puig, P.3    Vidaud, M.4    Thomas, G.5
  • 55
    • 0026894465 scopus 로고
    • Mutations of p53 gene in human colorectal tumor in Japan: Molecular epidemiological aspects
    • Ishioka C, Suzuki T, Kanamaru R. Mutations of p53 gene in human colorectal tumor in Japan: molecular epidemiological aspects. Tohoku J Exp Med 1992, 167, 243-245.
    • (1992) Tohoku J Exp Med , vol.167 , pp. 243-245
    • Ishioka, C.1    Suzuki, T.2    Kanamaru, R.3
  • 56
    • 0026695813 scopus 로고
    • Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients
    • Kikuchi-Yanoshita R, Konishi M, Ito S, et al. Genetic changes of both p53 alleles associated with the conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis and non-familial adenomatous polyposis patients. Cancer Res 1992, 52, 3965-3971.
    • (1992) Cancer Res , vol.52 , pp. 3965-3971
    • Kikuchi-Yanoshita, R.1    Konishi, M.2    Ito, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.