CYP1A2-mediated biotransformation of cardioactive 2-thienylidene-3,4- methylenedioxybenzoylhydrazine (LASSBio-294) by rat liver microsomes and human recombinant CYP enzymes

European Journal of Medicinal Chemistry

Volumn 46, Issue 1, 2011, Pages 349-355

  Fraga, Aline Guerra M ^a   Da Silva, Leandro Louback ^a   Fraga, Carlos Alberto Manssour ^a   Barreiro, Eliezer J ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

1,3 Benzodioxole; Cardioactive drug candidate (LASSBio 294); Docking; Human isozymes; LC MS analysis; Liver microsome metabolism; N Acylhydrazone (NAH)

Indexed keywords

2 THIENYLIDENE 3,4 DIHYDROXYBENZOYLHYDRAZINE; 2 THIENYLIDENE 3,4 METHYLENEDIOXYBENZOYLHYDRAZINE; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; DRUG METABOLITE; FURAFYLLINE; HYDRAZINE DERIVATIVE; KETOCONAZOLE; LASSBIO 294; QUINIDINE; RECOMBINANT ENZYME; SULFAPHENAZOLE; UNCLASSIFIED DRUG;

ARTICLE; BIOTRANSFORMATION; DRUG CLEARANCE; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MICROSOME METABOLISM; MALE; MOLECULAR DOCKING; NONHUMAN; OXIDATION; RAT;

ANIMALS; BIOTRANSFORMATION; CATALYTIC DOMAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 CYP1A2; HEART; HUMANS; HYDRAZONES; MALE; MASS SPECTROMETRY; MICROSOMES, LIVER; MODELS, MOLECULAR; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; THIOPHENES;

EID: 78650509950     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.11.024     Document Type: Article

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