Synthesis and vasodilatory activity of new N-acylhydrazone derivatives, designed as LASSBio-294 analogues

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 10, 2005, Pages 3431-3437

  Silva, Alexandre G ^a   Zapata Sudo, Gisele ^a   Kummerle, Arthur E ^a   Fraga, Carlos A M ^a   Barreiro, Eliezer J ^a   Sudo, Roberto T ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Aorta; N Acylhydrazone; Safrole; Vasodilation

Indexed keywords

HYDRAZONE DERIVATIVE; LASSBIO 294; LASSBIO 785; LASSBIO 786; LASSBIO 788; LASSBIO 791; N ALLYL (2 THIENYLIDENE) 3,4 METHYLENEDIOXYBENZOYLHYDRAZINE; N BENZYL (2 THIENYLIDENE) 3,4 METHYLENEDIOXYBENZOYLHYDRAZINE; N METHYL (2 THIENYLIDENE) 3,4 METHYLENEDIOXYBENZOYLHYDRAZINE; N' (2 THIOPHEN 2 YLMETHYL) 3,4 METHYLENEDIOXYBENZOYLHYDRAZINE; PHENYLEPHRINE; UNCLASSIFIED DRUG; VASODILATOR AGENT;

ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; INOTROPISM; MALE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VASODILATATION;

RATTUS NORVEGICUS;

EID: 17444420766     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.03.003     Document Type: Article

References (14)

1. G.S. Stokes J. Clin. Hypertens. 6 2004 192
2. E.J. Barreiro, C.A.M. Fraga, A.L.P. Miranda, and C.R. Rodrigues Quim. Nova 25 2002 129
3. P.C. Lima, K.C.M. Silva, P.H.O. Leda, A.L.P. Miranda, C.A.M. Fraga, and E.J. Barreiro Eur. J. Med. Chem. 35 2000 187
4. E.J. Barreiro Quim. Nova 25 2002 1172
5. R.T. Sudo, G. Zapata-Sudo, and E.J. Barreiro Brit. J. Pharmacol. 134 2001 603
6. C.L.M. Silva, F. Noel, and E.J. Barreiro Brit. J. Pharmacol. 135 2002 293
7. V.D. Piaz, M.P. Giovannoni, and C. Castellana J. Med. Chem. 40 1997 1417
8. Purchased from Aldrich, Milwaukee, USA
9. K. Thangaraj, and L.R. Morgan Synth. Commun. 24 1994 2063
10. R. Calabretta, C. Gallina, and C. Giordano Synthesis 1991 536
11. J.M. Figueiredo, C.A. Câmara, E.G. Amarante, A.L.P. Miranda, F.M. Santos, C.R. Rodrigues, C.A.M. Fraga, and E.J. Barreiro Bioorg. Med. Chem. 8 2000 2243
12. A.C. Cunha, J.L.M. Tributino, A.L.P. Miranda, C.A.M. Fraga, and E.J. Barreiro II Farmaco 57 2002 999
13. A.C. Cunha, J.M. Figueiredo, J.L.M. Tributino, A.L.P. Miranda, H.C. Castro, R.B. Zingali, C.A.M. Fraga, M.C.B.V. Souza, V.F. Ferreira, and E.J. Barreiro Bioorg. Med. Chem. 11 2003 2051
14. G.A. Silva, L.M.M. Costa, F.C.F. Brito, A.L.P. Miranda, E.J. Barreiro, and C.A.M. Fraga Bioorg. Med. Chem. 12 2004 3149