Structure-based prediction and biosynthesis of the major mammalian metabolite of the cardioactive prototype LASSBio-294

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 12, 2010, Pages 3734-3736

  Carneiro, Emmanuel O ^a   Andrade, Carolina H ^a   Braga, Rodolpho C ^a   Tôrres, Andréa C B ^a   Alves, Rosângela O ^a   Lião, Luciano M ^b   Fraga, Carlos A M ^b   Barreiro, Eliezer J ^b   Oliveira, Valéria De ^a  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Biosynthesis; Cytochrome P450; Drug metabolism; LASSBio 294; Structure based

Indexed keywords

3,4 METHYLENEDIOXYBENZOYL 2 THIENYLHYDRAZONE; DRUG METABOLITE; HYDRAZONE DERIVATIVE; INOTROPIC AGENT; LASSBIO 294; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; INOTROPISM; NONHUMAN; VASODILATATION;

ANIMALS; BEAUVERIA; CARDIOTONIC AGENTS; DOGS; HYDRAZONES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; THIOPHENES; VASODILATION;

MAMMALIA;

EID: 77954214021     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.04.073     Document Type: Article

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