Metabolism of sanguinarine in human and in rat: Characterization of oxidative metabolites produced by human CYP1A1 and CYP1A2 and rat liver microsomes using liquid chromatography-tandem mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 52, Issue 3, 2010, Pages 391-397

  Deroussent, Alain ^a   Ré, Micheline ^a   Hoellinger, Henri ^b   Cresteil, Thierry ^b  

^a INSTITUT GUSTAVE ROUSSY   (France)

^b CNRS   (France)

Author keywords

Human CYP1A; LC MS MS; Metabolism; Rat liver microsome; Sanguinarine

Indexed keywords

5,6 DIHYDROSANQUINARINE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; DRUG METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SANGUINARINE; UNCLASSIFIED DRUG;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DRUG DETOXIFICATION; DRUG METABOLISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; TANDEM MASS SPECTROMETRY;

ANIMALS; BENZOPHENANTHRIDINES; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; HUMANS; ISOENZYMES; ISOQUINOLINES; MALE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 77649186569     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2009.09.014     Document Type: Article

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