Metabolite Isolation and Identification

Encyclopedia of Analytical Science: Second Edition

Volumn , Issue , 2004, Pages 305-311

  Nnane, I P ^a   Tao, X ^a  

^a TEMPLE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; METABOLISM;

BIOANALYSIS; DRUG CANDIDATES; DRUG DISCOVERY; DRUG METABOLISMS; IN-VITRO; ISOLATION AND IDENTIFICATION; METABOLIC PATHWAYS; NEW CHEMICAL ENTITIES; REGULATORY REQUIREMENTS; VITRO AND IN VIVO;

METABOLITES;

EID: 78650514031     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B0-12-369397-7/00109-6     Document Type: Chapter

References (11)

1. Clarke N.J., Rindgen D., Korfmacher W.A., Cox K.A. Systematic LC/MS metabolite identification in drug discovery. Analytical Chemistry 2001, 73(15):430A-439A.
2. Donato M.T., Castell J.V. Strategies and molecular probes to investigate the role of cytochrome P450 in drug metabolism: Focus on in vitro studies. Clinical Pharmacokinetics 2003, 42(2):153-178.
3. Ekins S. In silico approaches to predicting drug metabolism, toxicology and beyond. Biochemical Society Transactions 2003, 31(Pt 3):611-614.
4. Ekins S., Ring B.J., Grace J., McRobie-Belle D.J., Wrighton S.A. Present and future in vitro approaches for drug metabolism. Journal of Pharmacological Toxicological Methods 2000, 44(1):313-324.
5. Gunaratna C. Biotrap sample extraction column: A new approach for on-line sample preparation in drug metabolism studies. Current Separations 1998, 17(3):83-86.
6. Guttendorf R.J. The emerging role of A.D.M.E. in optimizing drug discovery and design http://www.netsci.org/Science/Special/feature06.html.
7. Kostiainen R., Kotiaho T., Kuuranne T., Auriola S. Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies. Journal of Mass Spectrometry 2003, 38(4):357-372.
8. Nnane I.P., Damani L.A., Hutt A.J. Drug metabolism studies: Metabolite isolation and identification. Encyclopedia of Analytical Science 1995, vol. 2:944-951. Academic Press, London.
9. Papac D.I., Shahrokh Z. Mass spectrometry innovations in drug discovery and development. Pharmaceutical Research 2001, 18(2):131-145.
10. Smith D.A. Design of drugs through a consideration of drug metabolism and pharmacokinetics. European Journal of Drug Metabolism and Pharmacokinetics 1994, 3:193-199.
11. Watt A.P., Mortishire-Smith R.J., Gerhard U., Thomas S.R. Metabolite identification in drug discovery. Current Opinion in Drug Discovery & Development 2003, 6(1):57-65.