메뉴 건너뛰기




Volumn 28, Issue 1, 2011, Pages 601-614

Population genetic analysis of the uncoupling proteins supports a role for UCP3 in human cold resistance

Author keywords

climate; evolution; natural selection; nonshivering thermogenesis; obesity

Indexed keywords

UNCOUPLING PROTEIN 3;

EID: 78650502334     PISSN: 07374038     EISSN: 15371719     Source Type: Journal    
DOI: 10.1093/molbev/msq228     Document Type: Article
Times cited : (53)

References (99)
  • 2
    • 77049164783 scopus 로고
    • Protection afforded by sickle-cell trait against subtertian malarial infection
    • Allison AC. 1954. Protection afforded by sickle-cell trait against subtertian malarial infection. Br Med J. 1:290-294.
    • (1954) Br Med J , vol.1 , pp. 290-294
    • Allison, A.C.1
  • 3
    • 0032189845 scopus 로고    scopus 로고
    • Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes
    • Argyropoulos G, Brown AM, Willi SM, Zhu J, He Y, Reitman M, Gevao SM, Spruill I, Garvey WT. 1998. Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes. J Clin Invest. 102:1345-1351.
    • (1998) J Clin Invest , vol.102 , pp. 1345-1351
    • Argyropoulos, G.1    Brown, A.M.2    Willi, S.M.3    Zhu, J.4    He, Y.5    Reitman, M.6    Gevao, S.M.7    Spruill, I.8    Garvey, W.T.9
  • 4
    • 0035195527 scopus 로고    scopus 로고
    • Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice
    • Bezaire V, Hofmann W, Kramer JK, Kozak LP, Harper ME. 2001. Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice. Am J Physiol Endocrinol Metab. 281:E975-E982.
    • (2001) Am J Physiol Endocrinol Metab , vol.281
    • Bezaire, V.1    Hofmann, W.2    Kramer, J.K.3    Kozak, L.P.4    Harper, M.E.5
  • 5
    • 33751545322 scopus 로고    scopus 로고
    • Automating resequencing-based detection of insertion-deletion polymorphisms
    • Bhangale TR, Stephens M, Nickerson DA. 2006. Automating resequencing-based detection of insertion-deletion polymorphisms. Nat Genet. 38:1457-1462.
    • (2006) Nat Genet , vol.38 , pp. 1457-1462
    • Bhangale, T.R.1    Stephens, M.2    Nickerson, D.A.3
  • 7
    • 0033382027 scopus 로고    scopus 로고
    • Endogenous mutations in human uncoupling protein 3 alter its functional properties
    • Brown AM, Dolan JW, Willi SM, Garvey WT, Argyropoulos G. 1999. Endogenous mutations in human uncoupling protein 3 alter its functional properties. FEBS Lett. 464:189-193.
    • (1999) FEBS Lett , vol.464 , pp. 189-193
    • Brown, A.M.1    Dolan, J.W.2    Willi, S.M.3    Garvey, W.T.4    Argyropoulos, G.5
  • 8
    • 0032742372 scopus 로고    scopus 로고
    • UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged
    • Cadenas S, Buckingham JA, Samec S, Seydoux J, Din N, Dulloo AG, Brand MD. 1999. UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged. FEBS Lett. 462:257-260.
    • (1999) FEBS Lett , vol.462 , pp. 257-260
    • Cadenas, S.1    Buckingham, J.A.2    Samec, S.3    Seydoux, J.4    Din, N.5    Dulloo, A.G.6    Brand, M.D.7
  • 9
    • 0037066430 scopus 로고    scopus 로고
    • A human genome diversity cell line panel
    • 41 co-authors
    • Cann HM, de Toma C, Cazes L, et al. (41 co-authors). 2002. A human genome diversity cell line panel. Science 296:261-262.
    • (2002) Science , vol.296 , pp. 261-262
    • Cann, H.M.1    De Toma, C.2    Cazes, L.3
  • 10
    • 0347989317 scopus 로고    scopus 로고
    • Brown adipose tissue: Function and physiological significance
    • Cannon B, Nedergaard J. 2004. Brown adipose tissue: function and physiological significance. Physiol Rev. 84:277-359.
    • (2004) Physiol Rev , vol.84 , pp. 277-359
    • Cannon, B.1    Nedergaard, J.2
  • 11
    • 34447130778 scopus 로고    scopus 로고
    • Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance
    • 16 co-authors
    • Choi CS, Fillmore JJ, Kim JK, et al. (16 co-authors). 2007. Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance. J Clin Invest. 117:1995-2003.
    • (2007) J Clin Invest , vol.117 , pp. 1995-2003
    • Choi, C.S.1    Fillmore, J.J.2    Kim, J.K.3
  • 12
    • 0032884928 scopus 로고    scopus 로고
    • Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis
    • 26 co-authors
    • Chung WK, Luke A, Cooper RS, et al. (26 co-authors). 1999. Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis. Diabetes 48:1890-1895.
    • (1999) Diabetes , vol.48 , pp. 1890-1895
    • Chung, W.K.1    Luke, A.2    Cooper, R.S.3
  • 13
    • 0029843407 scopus 로고    scopus 로고
    • Additive effect of A/G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity
    • Clement K, Ruiz J, Cassard-Doulcier AM, Bouillaud F, Ricquier D, Basdevant A, Guy-Grand B, Froguel P. 1996. Additive effect of A/G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity. Int J Obes Relat Metab Disord. 20:1062-1066.
    • (1996) Int J Obes Relat Metab Disord , vol.20 , pp. 1062-1066
    • Clement, K.1    Ruiz, J.2    Cassard-Doulcier, A.M.3    Bouillaud, F.4    Ricquier, D.5    Basdevant, A.6    Guy-Grand, B.7    Froguel, P.8
  • 14
  • 16
    • 77956491134 scopus 로고    scopus 로고
    • Using environmental correlations to identify loci underlying local adaptation
    • Coop G, Witonsky D, Di Rienzo A, Pritchard JK. 2010. Using environmental correlations to identify loci underlying local adaptation. Genetics. 185:1411-1423.
    • (2010) Genetics , vol.185 , pp. 1411-1423
    • Coop, G.1    Witonsky, D.2    Di Rienzo, A.3    Pritchard, J.K.4
  • 17
    • 64349105205 scopus 로고    scopus 로고
    • Identification and importance of brown adipose tissue in adult humans
    • 12 co-authors
    • Cypess AM, Lehman S, Williams G, et al. (12 co-authors). 2009. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 360:1509-1517.
    • (2009) N Engl J Med , vol.360 , pp. 1509-1517
    • Cypess, A.M.1    Lehman, S.2    Williams, G.3
  • 20
    • 0031957513 scopus 로고    scopus 로고
    • Uncoupling protein-1 mRNA expression in obese human subjects: The role of sequence variations at the uncoupling protein-1 gene locus
    • Esterbauer H, Oberkofler H, Liu YM, Breban D, Hell E, Krempler F, Patsch W. 1998. Uncoupling protein-1 mRNA expression in obese human subjects: the role of sequence variations at the uncoupling protein-1 gene locus. J Lipid Res. 39:834-844.
    • (1998) J Lipid Res , vol.39 , pp. 834-844
    • Esterbauer, H.1    Oberkofler, H.2    Liu, Y.M.3    Breban, D.4    Hell, E.5    Krempler, F.6    Patsch, W.7
  • 21
    • 0034972150 scopus 로고    scopus 로고
    • A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans
    • 12 co-authors
    • Esterbauer H, Schneitler C, Oberkofler H, et al. (12 co-authors). 2001. A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nat Genet. 28:178-183.
    • (2001) Nat Genet , vol.28 , pp. 178-183
    • Esterbauer, H.1    Schneitler, C.2    Oberkofler, H.3
  • 22
    • 0031019249 scopus 로고    scopus 로고
    • Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
    • 11 co-authors
    • Fleury C, Neverova M, Collins S, et al. (11 co-authors). 1997. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet. 15:269-272.
    • (1997) Nat Genet , vol.15 , pp. 269-272
    • Fleury, C.1    Neverova, M.2    Collins, S.3
  • 23
    • 0030637363 scopus 로고    scopus 로고
    • Resting energy expenditure in obese African American and Caucasian women
    • Foster GD, Wadden TA, Vogt RA. 1997. Resting energy expenditure in obese African American and Caucasian women. Obes Res. 5:1-8.
    • (1997) Obes Res , vol.5 , pp. 1-8
    • Foster, G.D.1    Wadden, T.A.2    Vogt, R.A.3
  • 24
    • 0030869755 scopus 로고    scopus 로고
    • Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin
    • Gong DW, He Y, Karas M, Reitman M. 1997. Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. J Biol Chem. 272:24129-24132.
    • (1997) J Biol Chem , vol.272 , pp. 24129-24132
    • Gong, D.W.1    He, Y.2    Karas, M.3    Reitman, M.4
  • 25
    • 0032973459 scopus 로고    scopus 로고
    • Assessment of uncoupling activity of the human uncoupling protein 3 short form and three mutants of the uncoupling protein gene using a yeast heterologous expression system
    • Hagen T, Zhang CY, Slieker LJ, Chung WK, Leibel RL, Lowell BB. 1999. Assessment of uncoupling activity of the human uncoupling protein 3 short form and three mutants of the uncoupling protein gene using a yeast heterologous expression system. FEBS Lett. 454:201-206.
    • (1999) FEBS Lett , vol.454 , pp. 201-206
    • Hagen, T.1    Zhang, C.Y.2    Slieker, L.J.3    Chung, W.K.4    Leibel, R.L.5    Lowell, B.B.6
  • 26
    • 0002448869 scopus 로고
    • Disease and evolution
    • Haldane JBS. 1949. Disease and evolution. Ric Sci Suppl A. 19:68-76.
    • (1949) Ric Sci Suppl A , vol.19 , pp. 68-76
    • Jbs, H.1
  • 27
    • 0035074953 scopus 로고    scopus 로고
    • Uncoupling protein 3 genetic variants in human obesity: The c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population
    • Halsall DJ, Luan J, Saker P, Huxtable S, Farooqi IS, Keogh J, Wareham NJ, O'Rahilly S. 2001. Uncoupling protein 3 genetic variants in human obesity: the c-55t promoter polymorphism is negatively correlated with body mass index in a UK Caucasian population. Int J Obes Relat Metab Disord. 25:472-477.
    • (2001) Int J Obes Relat Metab Disord , vol.25 , pp. 472-477
    • Halsall, D.J.1    Luan, J.2    Saker, P.3    Huxtable, S.4    Farooqi, I.S.5    Keogh, J.6    Wareham, N.J.7    O'Rahilly, S.8
  • 28
    • 38749103590 scopus 로고    scopus 로고
    • The common -55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipopro-tein cholesterol levels in the general Japanese population
    • Hamada T, Kotani K, Fujiwara S, Sano Y, Domichi M, Tsuzaki K, Sakane N. 2008. The common -55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipopro-tein cholesterol levels in the general Japanese population. Metabolism 57:410-415.
    • (2008) Metabolism , vol.57 , pp. 410-415
    • Hamada, T.1    Kotani, K.2    Fujiwara, S.3    Sano, Y.4    Domichi, M.5    Tsuzaki, K.6    Sakane, N.7
  • 29
    • 77952405169 scopus 로고    scopus 로고
    • Human adaptations to diet, subsistence, and ecoregion are due to subtle shifts in allele frequency
    • 11 co-authors
    • Hancock AM, Witonsky DB, Ehler E, et al. (11 co-authors). 2010. Human adaptations to diet, subsistence, and ecoregion are due to subtle shifts in allele frequency. Proc Natl Acad Sci USA. 107(Suppl 2):8924-8930.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.SUPPL. 2 , pp. 8924-8930
    • Hancock, A.M.1    Witonsky, D.B.2    Ehler, E.3
  • 31
    • 0036182511 scopus 로고    scopus 로고
    • Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria
    • Harper JA, Stuart JA, Jekabsons MB, Roussel D, Brindle KM, Dickinson K, Jones RB, Brand MD. 2002. Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria. Biochem J. 361:49-56.
    • (2002) Biochem J , vol.361 , pp. 49-56
    • Harper, J.A.1    Stuart, J.A.2    Jekabsons, M.B.3    Roussel, D.4    Brindle, K.M.5    Dickinson, K.6    Jones, R.B.7    Brand, M.D.8
  • 33
    • 18844439645 scopus 로고    scopus 로고
    • Soft sweeps: Molecular population genetics of adaptation from standing genetic variation
    • Hermisson J, Pennings PS. 2005. Soft sweeps: molecular population genetics of adaptation from standing genetic variation. Genetics 169:2335-2352.
    • (2005) Genetics , vol.169 , pp. 2335-2352
    • Hermisson, J.1    Pennings, P.S.2
  • 35
    • 0035133171 scopus 로고    scopus 로고
    • Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: An hypothesis
    • Himms-Hagen J, Harper ME. 2001. Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis. Exp Biol Med (May-wood). 226:78-84.
    • (2001) Exp Biol Med (May-wood) , vol.226 , pp. 78-84
    • Himms-Hagen, J.1    Harper, M.E.2
  • 36
    • 0035692320 scopus 로고    scopus 로고
    • Two-locus sampling distributions and their application
    • Hudson RR. 2001. Two-locus sampling distributions and their application. Genetics 159:1805-1817.
    • (2001) Genetics , vol.159 , pp. 1805-1817
    • Hudson, R.R.1
  • 37
    • 0036184745 scopus 로고    scopus 로고
    • Generating samples under a Wright-Fisher neutral model of genetic variation
    • Hudson RR. 2002. Generating samples under a Wright-Fisher neutral model of genetic variation. Bioinformatics 18:337-338.
    • (2002) Bioinformatics , vol.18 , pp. 337-338
    • Hudson, R.R.1
  • 38
    • 0028215929 scopus 로고
    • Evidence for positive selection in the superoxide dismutase (Sod) region of Drosophila melanogaster
    • Hudson RR, Bailey K, Skarecky D, Kwiatowski J, Ayala FJ. 1994. Evidence for positive selection in the superoxide dismutase (Sod) region of Drosophila melanogaster. Genetics 136: 1329-1340.
    • (1994) Genetics , vol.136 , pp. 1329-1340
    • Hudson, R.R.1    Bailey, K.2    Skarecky, D.3    Kwiatowski, J.4    Ayala, F.J.5
  • 39
    • 0026512283 scopus 로고
    • A statistical test for detecting geographic subdivision
    • Hudson RR, Boos DD, Kaplan NL. 1992. A statistical test for detecting geographic subdivision. Mol Biol Evol. 9:138-151.
    • (1992) Mol Biol Evol , vol.9 , pp. 138-151
    • Hudson, R.R.1    Boos, D.D.2    Kaplan, N.L.3
  • 40
    • 39749197456 scopus 로고    scopus 로고
    • Genotype, haplotype and copy-number variation in worldwide human populations
    • 24 co-authors
    • Jakobsson M, Scholz SW, Scheet P, et al. (24 co-authors). 2008. Genotype, haplotype and copy-number variation in worldwide human populations. Nature 451:998-1003.
    • (2008) Nature , vol.451 , pp. 998-1003
    • Jakobsson, M.1    Scholz, S.W.2    Scheet, P.3
  • 41
    • 69449089547 scopus 로고    scopus 로고
    • The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes
    • Jia JJ, Zhang X, Ge CR, Jois M. 2009. The polymorphisms of UCP2 and UCP3 genes associated with fat metabolism, obesity and diabetes. Obes Rev. 10:519-526.
    • (2009) Obes Rev , vol.10 , pp. 519-526
    • Jia, J.J.1    Zhang, X.2    Ge, C.R.3    Jois, M.4
  • 42
    • 0030377430 scopus 로고    scopus 로고
    • Differences in resting energy expenditure in prepubertal black children and white children
    • Kaplan AS, Zemel BS, Stallings VA. 1996. Differences in resting energy expenditure in prepubertal black children and white children. J Pediatr. 129:643-647.
    • (1996) J Pediatr , vol.129 , pp. 643-647
    • Kaplan, A.S.1    Zemel, B.S.2    Stallings, V.A.3
  • 44
    • 0042092646 scopus 로고    scopus 로고
    • The NCEP-NCAR 50-year reanalysis: Monthly means CD-ROM and documentation
    • 13 co-authors
    • Kistler R, Kalnay E, Collins W, et al. (13 co-authors). 2001. The NCEP-NCAR 50-year reanalysis: monthly means CD-ROM and documentation. Bull Am Meteor Soc. 82:247-267.
    • (2001) Bull Am Meteor Soc , vol.82 , pp. 247-267
    • Kistler, R.1    Kalnay, E.2    Collins, W.3
  • 46
    • 0037039366 scopus 로고    scopus 로고
    • A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2
    • Krauss S, Zhang CY, Lowell BB. 2002. A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc Natl Acad Sci USA. 99:118-122.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 118-122
    • Krauss, S.1    Zhang, C.Y.2    Lowell, B.B.3
  • 50
    • 0029363115 scopus 로고
    • Measurement of physical activity among black and white obese women
    • Kushner RF, Racette SB, Neil K, Schoeller DA. 1995. Measurement of physical activity among black and white obese women. Obes Res. 3(Suppl 2):261s-265s.
    • (1995) Obes Res , vol.3 , Issue.SUPPL. 2
    • Kushner, R.F.1    Racette, S.B.2    Neil, K.3    Schoeller, D.A.4
  • 52
    • 0033040742 scopus 로고    scopus 로고
    • Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle
    • Lanni A, Beneduce L, Lombardi A, Moreno M, Boss O, Muzzin P, Giacobino JP, Goglia F. 1999. Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle. FEBS Lett. 444:250-254.
    • (1999) FEBS Lett , vol.444 , pp. 250-254
    • Lanni, A.1    Beneduce, L.2    Lombardi, A.3    Moreno, M.4    Boss, O.5    Muzzin, P.6    Giacobino, J.P.7    Goglia, F.8
  • 53
    • 0036092736 scopus 로고    scopus 로고
    • Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE study
    • 12 co-authors
    • Lanouette CM, Chagnon YC, Rice T, et al. (12 co-authors). 2002. Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE study. J Appl Physiol. 92:1111-1118.
    • (2002) J Appl Physiol , vol.92 , pp. 1111-1118
    • Lanouette, C.M.1    Chagnon, Y.C.2    Rice, T.3
  • 56
    • 0033787068 scopus 로고    scopus 로고
    • Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
    • Li B, Nolte LA, Ju JS, Han DH, Coleman T, Holloszy JO, Semenkovich CF. 2000. Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice. Nat Med. 6:1115-1120.
    • (2000) Nat Med , vol.6 , pp. 1115-1120
    • Li, B.1    Nolte, L.A.2    Ju, J.S.3    Han, D.H.4    Coleman, T.5    Holloszy, J.O.6    Semenkovich, C.F.7
  • 57
    • 39749181521 scopus 로고    scopus 로고
    • Worldwide human relationships inferred from genome-wide patterns of variation
    • 11 co-authors
    • Li JZ, Absher DM, Tang H, et al. (11 co-authors). 2008. Worldwide human relationships inferred from genome-wide patterns of variation. Science 319:1100-1104.
    • (2008) Science , vol.319 , pp. 1100-1104
    • Li, J.Z.1    Absher, D.M.2    Tang, H.3
  • 58
    • 33746493901 scopus 로고    scopus 로고
    • A geographically explicit genetic model of worldwide human-settlement history
    • Liu H, Prugnolle F, Manica A, Balloux F. 2006. A geographically explicit genetic model of worldwide human-settlement history. Am J Hum Genet. 79:230-237.
    • (2006) Am J Hum Genet , vol.79 , pp. 230-237
    • Liu, H.1    Prugnolle, F.2    Manica, A.3    Balloux, F.4
  • 59
    • 25144493070 scopus 로고    scopus 로고
    • Linkage and association analyses of the UCP3 gene with obesity phenotypes in Caucasian families
    • Liu YJ, Liu PY, Long J, Lu Y, Elze L, Recker RR, Deng HW. 2005. Linkage and association analyses of the UCP3 gene with obesity phenotypes in Caucasian families. Physiol Genomics. 22: 197-203.
    • (2005) Physiol Genomics , vol.22 , pp. 197-203
    • Liu, Y.J.1    Liu, P.Y.2    Long, J.3    Lu, Y.4    Elze, L.5    Recker, R.R.6    Deng, H.W.7
  • 60
    • 0344320742 scopus 로고
    • Aspects of the population dynamics of the abnormal hemoglobin and glucose-6-phosphate dehydrogenase deficiency genes
    • Livingstone FB. 1964. Aspects of the population dynamics of the abnormal hemoglobin and glucose-6-phosphate dehydrogenase deficiency genes. Am J Hum Genet. 16:435-450.
    • (1964) Am J Hum Genet , vol.16 , pp. 435-450
    • Livingstone, F.B.1
  • 61
    • 0037499856 scopus 로고    scopus 로고
    • Effects of uncoupling protein 1 and beta3-adrenergic receptor gene polymorphisms on body size and serum lipid concentrations in Japanese women
    • Matsushita H, Kurabayashi T, Tomita M, Kato N, Tanaka K. 2003. Effects of uncoupling protein 1 and beta3-adrenergic receptor gene polymorphisms on body size and serum lipid concentrations in Japanese women. Maturitas 45:39-45.
    • (2003) Maturitas , vol.45 , pp. 39-45
    • Matsushita, H.1    Kurabayashi, T.2    Tomita, M.3    Kato, N.4    Tanaka, K.5
  • 62
    • 0030357637 scopus 로고    scopus 로고
    • Determinants of resting energy expenditure in young black girls and young white girls
    • Morrison JA, Alfaro MP, Khoury P, Thornton BB, Daniels SR. 1996. Determinants of resting energy expenditure in young black girls and young white girls. J Pediatr. 129:637-642.
    • (1996) J Pediatr , vol.129 , pp. 637-642
    • Morrison, J.A.1    Alfaro, M.P.2    Khoury, P.3    Thornton, B.B.4    Daniels, S.R.5
  • 63
    • 0346101854 scopus 로고    scopus 로고
    • The -3826 A/G variant of the uncoupling protein-1 gene diminishes postprandial thermogenesis after a high fat meal in healthy boys
    • Nagai N, Sakane N, Ueno LM, Hamada T, Moritani T. 2003. The -3826 A/G variant of the uncoupling protein-1 gene diminishes postprandial thermogenesis after a high fat meal in healthy boys. J Clin Endocrinol Metab. 88:5661-5667.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5661-5667
    • Nagai, N.1    Sakane, N.2    Ueno, L.M.3    Hamada, T.4    Moritani, T.5
  • 64
    • 43149088949 scopus 로고    scopus 로고
    • Brown adipose tissue specific lack of uncoupling protein 3 is associated with impaired cold tolerance and reduced transcript levels of metabolic genes
    • Nau K, Fromme T, Meyer CW, von Praun C, Heldmaier G, Klingenspor M. 2008. Brown adipose tissue specific lack of uncoupling protein 3 is associated with impaired cold tolerance and reduced transcript levels of metabolic genes. J Comp Physiol B. 178:269-277.
    • (2008) J Comp Physiol B , vol.178 , pp. 269-277
    • Nau, K.1    Fromme, T.2    Meyer, C.W.3    Von Praun, C.4    Heldmaier, G.5    Klingenspor, M.6
  • 65
    • 77951439152 scopus 로고    scopus 로고
    • Trait-associated SNPs are more likely to be eQTLs: Annotation to enhance discovery from GWAS
    • Nicolae DL, Gamazon E, Zhang W, Duan S, Dolan ME, Cox NJ. 2010. Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet. 6:e1000888
    • (2010) PLoS Genet , vol.6
    • Nicolae, D.L.1    Gamazon, E.2    Zhang, W.3    Duan, S.4    Dolan, M.E.5    Cox, N.J.6
  • 67
    • 70350069921 scopus 로고    scopus 로고
    • Spatial patterns of variation due to natural selection in humans
    • Novembre J, Di Rienzo A. 2009. Spatial patterns of variation due to natural selection in humans. Nat Rev Genet. 10:745-755.
    • (2009) Nat Rev Genet , vol.10 , pp. 745-755
    • Novembre, J.1    Di Rienzo, A.2
  • 68
    • 0035109378 scopus 로고    scopus 로고
    • Haldane's sieve and adaptation from the standing genetic variation
    • Orr HA, Betancourt AJ. 2001. Haldane's sieve and adaptation from the standing genetic variation. Genetics 157:875-884.
    • (2001) Genetics , vol.157 , pp. 875-884
    • Orr, H.A.1    Betancourt, A.J.2
  • 69
    • 0031800882 scopus 로고    scopus 로고
    • Development of infrared imaging to measure thermogenesis in cell culture: Thermogenic effects of uncoupling protein-2, troglitazone, and beta-adrenoceptor agonists
    • Paulik MA, Buckholz RG, Lancaster ME, Dallas WS, Hull-Ryde EA, Weiel JE, Lenhard JM. 1998. Development of infrared imaging to measure thermogenesis in cell culture: thermogenic effects of uncoupling protein-2, troglitazone, and beta-adrenoceptor agonists. Pharm Res. 15:944-949.
    • (1998) Pharm Res , vol.15 , pp. 944-949
    • Paulik, M.A.1    Buckholz, R.G.2    Lancaster, M.E.3    Dallas, W.S.4    Hull-Ryde, E.A.5    Weiel, J.E.6    Lenhard, J.M.7
  • 70
    • 33646592536 scopus 로고    scopus 로고
    • Soft sweeps II-molecular population genetics of adaptation from recurrent mutation or migration
    • Pennings PS, Hermisson J. 2006a. Soft sweeps II-molecular population genetics of adaptation from recurrent mutation or migration. Mol Biol Evol. 23:1076-1084.
    • (2006) Mol Biol Evol , vol.23 , pp. 1076-1084
    • Pennings, P.S.1    Hermisson, J.2
  • 71
    • 33845971545 scopus 로고    scopus 로고
    • Soft sweeps III: The signature of positive selection from recurrent mutation
    • Pennings PS, Hermisson J. 2006b. Soft sweeps III: the signature of positive selection from recurrent mutation. PLoS Genet. 2:e186.
    • (2006) PLoS Genet , vol.2
    • Pennings, P.S.1    Hermisson, J.2
  • 72
    • 0036021391 scopus 로고    scopus 로고
    • Inferences about human demography based on multilocus analyses of noncoding sequences
    • Pluzhnikov A, Di Rienzo A, Hudson RR. 2002. Inferences about human demography based on multilocus analyses of noncoding sequences. Genetics 161:1209-1218.
    • (2002) Genetics , vol.161 , pp. 1209-1218
    • Pluzhnikov, A.1    Di Rienzo, A.2    Hudson, R.R.3
  • 73
    • 76749097550 scopus 로고    scopus 로고
    • The genetics of human adaptation: Hard sweeps, soft sweeps, and polygenic adaptation
    • Pritchard JK, Pickrell JK, Coop G. 2010. The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation. Curr Biol. 20:R208-R215.
    • (2010) Curr Biol , vol.20
    • Pritchard, J.K.1    Pickrell, J.K.2    Coop, G.3
  • 74
    • 28644440530 scopus 로고    scopus 로고
    • The signature of positive selection on standing genetic variation
    • Przeworski M, Coop G, Wall JD. 2005. The signature of positive selection on standing genetic variation. Evolution 59: 2312-2323.
    • (2005) Evolution , vol.59 , pp. 2312-2323
    • Przeworski, M.1    Coop, G.2    Wall, J.D.3
  • 75
    • 27644509150 scopus 로고    scopus 로고
    • Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa
    • Ramachandran S, Deshpande O, Roseman CC, Rosenberg NA, Feldman MW, Cavalli-Sforza LL. 2005. Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa. Proc Natl Acad Sci USA. 102:15942-15947.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15942-15947
    • Ramachandran, S.1    Deshpande, O.2    Roseman, C.C.3    Rosenberg, N.A.4    Feldman, M.W.5    Cavalli-Sforza, L.L.6
  • 78
  • 79
    • 33749575795 scopus 로고    scopus 로고
    • Standardized subsets of the HGDP-CEPH human genome diversity cell line panel, accounting for atypical and duplicated samples and pairs of close relatives
    • Rosenberg NA. 2006. Standardized subsets of the HGDP-CEPH human genome diversity cell line panel, accounting for atypical and duplicated samples and pairs of close relatives. Ann Hum Genet. 70:841-847.
    • (2006) Ann Hum Genet , vol.70 , pp. 841-847
    • Rosenberg, N.A.1
  • 80
    • 67650242165 scopus 로고    scopus 로고
    • High incidence of metabolically active brown adipose tissue in healthy adult humans: Effects of cold exposure and adiposity
    • 12 co-authors
    • Saito M, Okamatsu-Ogura Y, Matsushita M, et al. (12 co-authors). 2009. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes 58:1526-1531.
    • (2009) Diabetes , vol.58 , pp. 1526-1531
    • Saito, M.1    Okamatsu-Ogura, Y.2    Matsushita, M.3
  • 81
    • 27544497650 scopus 로고    scopus 로고
    • Calibrating a coalescent simulation of human genome sequence variation
    • DOI 10.1101/gr.3709305
    • Schaffner SF, Foo C, Gabriel S, Reich D, Daly MJ, Altshuler D. 2005. Calibrating a coalescent simulation of human genome sequence variation. Genome Res. 15:1576-1583. (Pubitemid 41545011)
    • (2005) Genome Research , vol.15 , Issue.11 , pp. 1576-1583
    • Schaffner, S.F.1    Foo, C.2    Gabriel, S.3    Reich, D.4    Daly, M.J.5    Altshuler, D.6
  • 82
    • 31644440526 scopus 로고    scopus 로고
    • Putative function and physiological relevance of the mitochondrial uncoupling pro-tein-3: Involvement in fatty acid metabolism?
    • Schrauwen P, Hoeks J, Hesselink MK. 2006. Putative function and physiological relevance of the mitochondrial uncoupling pro-tein-3: involvement in fatty acid metabolism? Prog Lipid Res. 45:17-41.
    • (2006) Prog Lipid Res , vol.45 , pp. 17-41
    • Schrauwen, P.1    Hoeks, J.2    Hesselink, M.K.3
  • 83
    • 0032933115 scopus 로고    scopus 로고
    • Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians
    • Schrauwen P, Xia J, Bogardus C, Pratley RE, Ravussin E. 1999a. Skeletal muscle uncoupling protein 3 expression is a determinant of energy expenditure in Pima Indians. Diabetes 48: 146-149.
    • (1999) Diabetes , vol.48 , pp. 146-149
    • Schrauwen, P.1    Xia, J.2    Bogardus, C.3    Pratley, R.E.4    Ravussin, E.5
  • 84
    • 0033406189 scopus 로고    scopus 로고
    • A novel polymorphism in the proximal UCP3 promoter region: Effect on skeletal muscle UCP3 mRNA expression and obesity in male non-diabetic Pima Indians
    • Schrauwen P, Xia J, Walder K, Snitker S, Ravussin E. 1999b. A novel polymorphism in the proximal UCP3 promoter region: effect on skeletal muscle UCP3 mRNA expression and obesity in male non-diabetic Pima Indians. Int J Obes Relat Metab Disord. 23:1242-1245.
    • (1999) Int J Obes Relat Metab Disord , vol.23 , pp. 1242-1245
    • Schrauwen, P.1    Xia, J.2    Walder, K.3    Snitker, S.4    Ravussin, E.5
  • 85
    • 0014832106 scopus 로고
    • Primary adult lactose intolerance and the milking habit: A problem in biologic and cultural interrelations. II. A culture historical hypothesis
    • Simoons FJ. 1970. Primary adult lactose intolerance and the milking habit: a problem in biologic and cultural interrelations. II. A culture historical hypothesis. Am J Dig Dis. 15: 695-710.
    • (1970) Am J Dig Dis , vol.15 , pp. 695-710
    • Simoons, F.J.1
  • 86
    • 38349178429 scopus 로고    scopus 로고
    • Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels
    • Slatter TL, Jones GT, Williams MJ, van Rij AM, McCormick SP. 2008. Novel rare mutations and promoter haplotypes in ABCA1 contribute to low-HDL-C levels. Clin Genet. 73:179-184.
    • (2008) Clin Genet , vol.73 , pp. 179-184
    • Slatter, T.L.1    Jones, G.T.2    Williams, M.J.3    Van Rij, A.M.4    McCormick, S.P.5
  • 88
    • 0035071957 scopus 로고    scopus 로고
    • A new statistical method for haplotype reconstruction from population data
    • Stephens M, Smith NJ, Donnelly P. 2001. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet. 68:978-989.
    • (2001) Am J Hum Genet , vol.68 , pp. 978-989
    • Stephens, M.1    Smith, N.J.2    Donnelly, P.3
  • 89
    • 0035947694 scopus 로고    scopus 로고
    • Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria
    • Stuart JA, Harper JA, Brindle KM, Jekabsons MB, Brand MD. 2001. Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria. J Biol Chem. 276: 18633-18639.
    • (2001) J Biol Chem , vol.276 , pp. 18633-18639
    • Stuart, J.A.1    Harper, J.A.2    Brindle, K.M.3    Jekabsons, M.B.4    Brand, M.D.5
  • 90
    • 11144358198 scopus 로고    scopus 로고
    • A gene atlas of the mouse and human protein-encoding transcrip-tomes
    • 13 co-authors
    • Su AI, Wiltshire T, Batalov S, et al. (13 co-authors). 2004. A gene atlas of the mouse and human protein-encoding transcrip-tomes. Proc Natl Acad Sci USA. 101:6062-6067.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 6062-6067
    • Su, A.I.1    Wiltshire, T.2    Batalov, S.3
  • 91
    • 0024313579 scopus 로고
    • Statistical method for testing the neutral mutation hypothesis by DNA polymorphism
    • Tajima F. 1989. Statistical method for testing the neutral mutation hypothesis by DNA polymorphism. Genetics 123:585-595.
    • (1989) Genetics , vol.123 , pp. 585-595
    • Tajima, F.1
  • 92
    • 33845900450 scopus 로고    scopus 로고
    • Convergent adaptation of human lactase persistence in Africa and Europe
    • 19 co-authors
    • Tishkoff SA, Reed FA, Ranciaro A, et al. (19 co-authors). 2007. Convergent adaptation of human lactase persistence in Africa and Europe. Nat Genet. 39:31-40.
    • (2007) Nat Genet , vol.39 , pp. 31-40
    • Tishkoff, S.A.1    Reed, F.A.2    Ranciaro, A.3
  • 93
    • 64349123664 scopus 로고    scopus 로고
    • Functional brown adipose tissue in healthy adults
    • 11 co-authors
    • Virtanen KA, Lidell ME, Orava J, et al. (11 co-authors). 2009. Functional brown adipose tissue in healthy adults. N Engl J Med. 360:1518-1525.
    • (2009) N Engl J Med , vol.360 , pp. 1518-1525
    • Virtanen, K.A.1    Lidell, M.E.2    Orava, J.3
  • 94
    • 29444451610 scopus 로고    scopus 로고
    • Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes
    • Voight BF, Adams AM, Frisse LA, Qian Y, Hudson RR, Di Rienzo A. 2005. Interrogating multiple aspects of variation in a full resequencing data set to infer human population size changes. Proc Natl Acad Sci USA. 102:18508-18513.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 18508-18513
    • Voight, B.F.1    Adams, A.M.2    Frisse, L.A.3    Qian, Y.4    Hudson, R.R.5    Di Rienzo, A.6
  • 95
    • 0016491430 scopus 로고
    • On the number of segregating sites in genetical models without recombination
    • Watterson GA. 1975. On the number of segregating sites in genetical models without recombination. Theor. Popul. Biol. 2:256-276.
    • (1975) Theor. Popul. Biol , vol.2 , pp. 256-276
    • Watterson, G.A.1
  • 96
    • 0032821623 scopus 로고    scopus 로고
    • Energy metabolism in African Americans: Potential risk factors for obesity
    • Weyer C, Snitker S, Bogardus C, Ravussin E. 1999. Energy metabolism in African Americans: potential risk factors for obesity. Am J Clin Nutr. 70:13-20.
    • (1999) Am J Clin Nutr , vol.70 , pp. 13-20
    • Weyer, C.1    Snitker, S.2    Bogardus, C.3    Ravussin, E.4
  • 97
    • 61349196250 scopus 로고    scopus 로고
    • Recent advances in adaptive thermogenesis: Potential implications for the treatment of obesity
    • Wijers SL, Saris WH, van Marken Lichtenbelt WD. 2009. Recent advances in adaptive thermogenesis: potential implications for the treatment of obesity. Obes Rev. 10:218-226.
    • (2009) Obes Rev , vol.10 , pp. 218-226
    • Wijers, S.L.1    Saris, W.H.2    Van Marken Lichtenbelt, W.D.3
  • 99
    • 0031179014 scopus 로고    scopus 로고
    • Resting metabolic rate in African-American and Caucasian girls
    • Yanovski SZ, Reynolds JC, Boyle AJ, Yanovski JA. 1997. Resting metabolic rate in African-American and Caucasian girls. Obes Res. 5:321-325.
    • (1997) Obes Res , vol.5 , pp. 321-325
    • Yanovski, S.Z.1    Reynolds, J.C.2    Boyle, A.J.3    Yanovski, J.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.