Electric charge influence of dextran derivatives on their tumor accumulation after intravenous injection

Drug Delivery: Journal of Delivery and Targeting of Therapeutic Agents

Volumn 4, Issue 3, 1997, Pages 213-221

  Tabata, Yasuhiko ^a   Kawai, Toshiyuki ^a   Murakami, Yoshiyuki ^a   Ikada, Yoshito ^a,b  

^a KYOTO UNIVERSITY   (Japan)

^b Res Ctr for Biomedical Engineering   (Japan)

Author keywords

Body distribution; Dextran; Electric charge; Molecular weight; Tumor accumulation

Indexed keywords

DEXTRAN; DEXTRAN DERIVATIVE;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG TARGETING; ELECTRICITY; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; TUMOR;

EID: 0030881215     PISSN: 10717544     EISSN: None     Source Type: Journal    
DOI: 10.3109/10717549709051895     Document Type: Article

References (29)

1. Beauchamp, C. O., Gonias, S. L., Menapace, D. P., and Pizzo, S. V. 1983. A new procedure for the synthesis of polyethylene glycol-protein addvats; effects on function, receptor recognition, and clearance of superoxide dimulase, lactoferrin, and α2-macroglobulin. Ann. Biochem. 131:25-33.
2. 125I-labeled human growth hormone of high specific radioactivity. Biochem. J. 89:114-123.
3. Hirano, T., Ohashi, S., Morimoto, S., Tsuda, K., Kobayahi, T., and Tsukagoshi, S. 1986. Synthesis of antitumor-active conjugates of Adriamycin or daunomycin with copolymer of divinyl ether and maleic anhydride. Macromol. Chem. 187:2815-2824.
4. Janiak, M., Budzynski, W., Gnatowski, B., Radzilcowski, C., Szmigielski, S., Jeljaszewicz, J., and Pulverer, G. 1984. Stimulatory effect of Propionibacterium granulosum KP-45, glucan and pyran copolymer on the activity of natural killer (NK) cells in murine lungs. Immunobiology 167:328-337.
5. Kagawa, K., and Tomizawa, S. 1980. Exocytotic excretion of dextran sulfates from liver to bile. Jpn. J. Pharmacol. 30:101-108.
6. Kaplan, A. M., Kuus, K., and Ottenbrite, R. M. 1985. Macrophage activation and antitumor activity of cyclohexyl-1,3-dioxepin and 4-methyl-2-pentonyl maleic anhydride copolymers. Proc. Ann. NY Acad. Sci. 446:169-184.
7. Kato, Y., Saito, M., Fukushima, H., Takeda, Y., and Hara, T. 1984. Antitumor activity of 1-beta-D-arabinofuranosylcytosine conjugated with polyglutamic acid and its derivative. Cancer Res. 44:25-30.
8. Kishida, A., Iwata, H., Tamada, Y., and Ikada, Y. 1991. Cell behavior on polymer surfaces grafted with non-ionic and ionic monomers. Biomaterials 12:786-792.
9. Maeda, H., and Matsumura, Y. 1989. Tumoritropic and lymphotropic principles of macromolecular drugs. Crit. Rev. Ther. Drug Carrier Syst. 6:193-210.
10. Matsumoto, K., Hirayama, C., and Motozato, Y. 1981. Preparation of bead-shaped cellulosic ion exchangers. Chem. Soc. Jpn. 12:1890-1898.
11. Murakami, Y., Tabata, Y., and Ikada, Y. 1997. Tumor accumulation of poly(ethylene glycol) with different molecular weights after intraavenous injection. Drug Deliv. 4:23-31.
12. Ottenbrite, R. M. 1985. Antitumor activity of polycarboxylic acid polymers. J. Macromol. Sci.-Chem. A22:819-832.
13. Peska, J., Stamberg, J., and Hradil, J. 1986. Chemical transformations of polymers. XIX. Ion exchange derivatives of bead cellulose. Angew Makrom. Chem. 53:73-80.
14. Przybylski, M., Zaharko, D. S., M. A., Adamson, R. H., Schyltz, R. M., and Ringsdorf, H. 1978. DIVEMA-methotrexate: Immune-adjuvant role of polymeric carriers linked to anti-tumor agents. Cancer Treat. Rep. 62:1837-1843.
15. Regelson, W. 1986. Advances in intraperitoneal (intracavitary) administration of synthetic polymers for immunotherapy and chemotherapy. J. Bioactive Compat. Polym. 1:84-107.
16. Roos, C. F., Matsumoto, S., Takakura, Y., Hashida, M., and Sezaki, H. 1984. Physicochemical and antitumor characteristics of some polyamino acid prodrugs of mitomycin C. Int. J. Pharm. 22:75-87.
17. Rosowsky, A., Forsch, R. A., Galivan, J., Susten, S. S., and Freisheim, J. H. 1985. Region specific gamma-conjugation of methotrexate to poly (L-lysine). Chemical and biological studies. Mol. Pharmacol. 27:141-147.
18. Sato, K., Itakura, K., Nishida, K., Takakura, Y., Hashida, M., and Sezaki, H. 1989. Disposition of a polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate, in the perfused rat liver. J. Pharm. Sci. 78:11-16.
19. Seymour, L. W. 1992. Passive tumor targeting of soluble macromolecules and drug conjugates. Crit. Rev. Ther. Drug Carrier Syst. 9:135-187.
20. Singh, M., Ferdous, A. J., Branham, M., and Betageri, G. V. 1996. Trends in drug targeting for cancer treatment. Drug Deliv. 3:289-304.
21. Takakura, Y., Takagi, A., Hashida, M., and Sezaki, H. 1987. Disposition and tumor localization of mitomycin C-dextran conjugates in mice. Pharm. Res. 4:293-300.
22. Takakura, Y., Atumi, R., Hashida, M., and Sezaki, H. 1987. Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate with anionic charge. II. Disposition and pharmacokinetics following intravenous and intramuacular administration. Int. J. Pharm. 37:145-154.
23. Takakura, Y., Fujita, T., Hashida, M., and Sezaki, H. 1990. Disposition characteristics of macromolecules in tumor-bearing mice. Pharm. Res. 7:339-346.
24. Watanabe, K., Saiki, I., Uraki, Y., Tokura, S., and Azuma, I. 1990. 6-O-Carboxymethyl-chitin (CM-chitin) as a drug carrier. Chem. Pharm. Bull. Tokyo 38:506-509.
25. Yamaoka, K., Tanigawara, Y., Nakagawa, T., and Uno, T. 1981. A pharmacokinetic analysis program (MULTI) for microcomputer. J. Pharmacobiodyn. 4:879-885.
26. Yamaoka, T., Tabata, Y., and Ikada, Y. 1993. Body distribution profile of polysaccharides after intravenous administration. Drug Deliv. 1:75-82.
27. Yamaoka, T., Tabata, Y., and Ikada, Y. 1994. Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice. J. Pharm. Sci. 83:601-606.
28. Yamaoka, Y., Kuroda, M., Tabata, Y., and Ikada, Y. 1995. Body distribution of dextran derivatives with electric charges after intravenous administration. Int. J. Pharm. 113:149-157.
29. Zunino, F., Savi, G., Dasdia, T., and Gambetta, R. 1982. Anti-tumor activity of daunorubicin linked to poly-L-aspartic acid. Int. J. Cancer 30:465-470.