Kinetics and thermodynamics of dimer formation and dissociation for a recombinant humanized monoclonal antibody to vascular endothelial growth factor

Biochemistry

Volumn 38, Issue 42, 1999, Pages 13960-13967

  Moore, Jamie M R ^a,b   Patapoff, Thomas W ^a   Cromwell, Mary E M ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ENERGY; CARDIOVASCULAR SYSTEM; DISSOCIATION; GIBBS FREE ENERGY; GROWTH KINETICS; IONIC STRENGTH; PH EFFECTS; PROTEINS; REACTION KINETICS; SIZE EXCLUSION CHROMATOGRAPHY; THERMODYNAMIC PROPERTIES;

CANCER THERAPEUTIC; CONCENTRATION JUMP METHOD; DIMERIZATION; VASCULAR ENDOTHELIAL GROWTH FACTOR;

MONOCLONAL ANTIBODIES;

HUMAN MONOCLONAL ANTIBODY; RECOMBINANT ANTIBODY; VASCULOTROPIN;

ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; DIMERIZATION; DISSOCIATION; HUMAN; HYDROPHOBICITY; MOLECULAR INTERACTION; PRIORITY JOURNAL; THERMODYNAMICS;

ANIMALS; ANTIBODIES, MONOCLONAL; CALCIUM CHLORIDE; CHO CELLS; CHROMATOGRAPHY, GEL; CRICETINAE; DIMERIZATION; ENDOTHELIAL GROWTH FACTORS; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; LIGHT; LYMPHOKINES; MODELS, CHEMICAL; OSMOLAR CONCENTRATION; RECOMBINANT PROTEINS; SCATTERING, RADIATION; SODIUM CHLORIDE; TEMPERATURE; THERMODYNAMICS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0345426282     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9905516     Document Type: Article

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