Pharmacokinetic analysis of in vivo disposition of succinylated proteins targeted to liver nonparenchymal cells via scavenger receptors: Importance of molecular size and negative charge density for in vivo recognition by receptors

Journal of Pharmacology and Experimental Therapeutics

Volumn 301, Issue 2, 2002, Pages 467-477

  Yamasaki, Yasuomi ^a   Sumimoto, Kazuya ^a   Nishikawa, Makiya ^a   Yamashita, Fumiyoshi ^a   Yamaoka, Kiyoshi ^a   Hashida, Mitsuru ^a   Takakura, Yoshinobu ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; BOVINE SERUM ALBUMIN; DRUG CARRIER; IMMUNOGLOBULIN G; INDIUM 111; POLYCYTIDYLIC ACID; POLYINOSINIC ACID; PROTEIN SUCCINATE; RECOMBINANT PROTEIN; SCAVENGER RECEPTOR; SUCCINIC ANHYDRIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG LIVER LEVEL; DRUG RECEPTOR BINDING; DRUG TISSUE LEVEL; DRUG UPTAKE; DRUG URINE LEVEL; IN VIVO STUDY; ISOTOPE LABELING; KIDNEY; LIVER CELL; MACROMOLECULE; MALE; MICHAELIS CONSTANT; MOLECULAR RECOGNITION; MOLECULAR SIZE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; RECEPTOR AFFINITY;

ANIMALS; AREA UNDER CURVE; BINDING, COMPETITIVE; COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; INDIUM; INFUSIONS, INTRAVENOUS; KIDNEY; LIVER; MALE; MEMBRANE PROTEINS; METABOLIC CLEARANCE RATE; MICE; MICROSCOPY, CONFOCAL; POLY C; POLY I; RECEPTORS, IMMUNOLOGIC; RECEPTORS, LIPOPROTEIN; RECEPTORS, SCAVENGER; SCAVENGER RECEPTORS, CLASS B; SERUM ALBUMIN;

EID: 0036226357     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.301.2.467     Document Type: Article

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