The role of heparan sulfate in the glomerular basement membrane

Kidney International

Volumn 73, Issue 3, 2008, Pages 247-248

  Morita, H ^a   Yoshimura, A ^a   Kimata, K ^b  

^a SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

^b AICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSAMINOGLYCAN; HEPARAN SULFATE;

DEACYLATION; EPIMERIZATION; GENE; GENE EXPRESSION; GENE MUTATION; GLOMERULUS BASEMENT MEMBRANE; GLOMERULUS FILTRATION; HUMAN; KIDNEY DISEASE; LAMB2 GENE; NEPHROTIC SYNDROME; NONHUMAN; NOTE; PODOCYTE; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEINURIA; SULFATION;

EID: 38149079892     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5002659     Document Type: Note

References (10)

1. Farquhar MG, Wissig SL, Palade GE. Glomerular permeability. I. Ferritin transfer across the normal glomerular capillary wall. 1961. J Am Soc Nephrol 1999; 10: 2645-2662.
2. Comper WD, Glasgow EF. Charge selectivity in kidney ultrafiltration. Kidney Int 1995; 47: 1242-1251.
3. Kestillä M, Lenkkeri U, Männikkö M et al. Positionally cloned gene for a novel glomerular protein - nephrin - is mutated in congenital nephrotic syndrome. Mol Cell 1998; 1: 575-582.
4. Zenker M, Aigner T, Wendler O et al. Human laminin beta-2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities. Hum Mol Genet 2004; 13: 2625-2632.
5. -/- mice, implicating the glomerular basement membrane as an albumin barrier. J Clin Invest 2006; 116: 2272-2279.
6. van den Hoven MJ, Wijnhoven TJ, Li J-P et al. Decrease of anionic sites in the glomerular basement membrane by heparanase does not lead to a clear renal phenotype. Kidney Int 2008; 73: 278-287.
7. Okada Y, Yamada S, Toyoshima M et al. Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. J Biol Chem 2002; 277: 42488-42495.
8. Wijnhoven TJ, Lensen JF, Wismans RG et al. In vivo degradation of heparan sulfates in the glomerular basement membrane does not result in proteinuria. J Am Soc Nephrol 2007; 18: 823-832.
9. van den Hoven MJ, Rops AL, Vlodavsky I et al. Heparanase in glomerular diseases. Kidney Int 2007; 72: 543-548.
10. van den Hoven MJ, Rops AL, Bakker MA et al. Increased expression of heparanase in overt diabetic nephropathy. Kidney Int 2006; 70: 2100-2108.