Development and evaluation of a novel method for preclinical measurement of tissue vascular volume

Molecular Pharmaceutics

Volumn 7, Issue 5, 2010, Pages 1848-1857

  Boswell, C Andrew ^a   Ferl, Gregory Z ^a   Mundo, Eduardo E ^a   Schweiger, Michelle G ^a   Marik, Jan ^a   Reich, Michael P ^a   Theil, Frank Peter ^a   Fielder, Paul J ^a   Khawli, Leslie A ^a  

^a GENENTECH INC   (United States)

Author keywords

physiologically based pharmacokinetic modeling; red blood cell labeling; TechneScan PYP; Vascular volume

Indexed keywords

IMMUNOGLOBULIN G; IODINE 125; IODOBENZOATE TRASTUZUMAB I 125; IODOBENZOIC ACID DERIVATIVE; PERTECHNETIC ACID TC 99M; PYROPHOSPHATE TECHNETIUM TC 99M; STANNOUS PYROPHOSPHATE; TRASTUZUMAB; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLADDER; BLOOD TRANSFUSION; BLOOD VOLUME; BOLUS INJECTION; CELL LABELING; CONTROLLED STUDY; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG UPTAKE; ERYTHROCYTE; FEMALE; IN VIVO STUDY; ISOTOPE LABELING; KIDNEY; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SIMULATION; SINGLE DRUG DOSE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; TISSUE; TISSUE VASCULAR VOLUME;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; BLOOD VESSELS; BLOOD VOLUME; CHEMISTRY, PHARMACEUTICAL; DRUG DISCOVERY; ERYTHROCYTES; FEMALE; MICE; MICE, NUDE; MODELS, BIOLOGICAL; PHARMACOKINETICS; POSITRON-EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY; RADIOPHARMACEUTICALS; TECHNETIUM TC 99M PYROPHOSPHATE; TISSUE DISTRIBUTION;

EID: 77957732044     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp100183k     Document Type: Article

References (54)

1. Boswell, C. A.; Deng, R.; Lin, K.; Putnam, W. S.; Lei, C.; Theil, F. P.; Joshi, A.; Fielder, P. J.; Khawli, L. A. In vitro-in vivo correlations of pharmacokinetics, pharmacodynamics and metabolism for antibody therapeutics. In Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes; Mrsny, R. J., Daugherty, A., Eds.; Informa HealthCare: New York, 2009; pp 15 - 52.
2. Brown, R. P.; Delp, M. D.; Lindstedt, S. L.; Rhomberg, L. R.; Beliles, R. P. Physiological parameter values for physiologically based pharmacokinetic models Toxicol. Ind. Health 1997, 13 (4) 407-484
3. Davies, B.; Morris, T. Physiological parameters in laboratory animals and humans Pharm. Res. 1993, 10 (7) 1093-1095
4. Baxter, L. T.; Zhu, H.; Mackensen, D. G.; Jain, R. K. Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice Cancer Res. 1994, 54 (6) 1517-1528
5. Baxter, L. T.; Zhu, H.; Mackensen, D. G.; Butler, W. F.; Jain, R. K. Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model Cancer Res. 1995, 55 (20) 4611-4622
6. Urva, S. R.; Yang, V. C.; Balthasar, J. P. Physiologically based pharmacokinetic model for T84.66: a monoclonal anti-CEA antibody J. Pharm. Sci. 2010, 99 (3) 1582-1600
7. Poulin, P.; Theil, F. P. Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution J. Pharm. Sci. 2002, 91 (1) 129-156
8. Mordenti, J. Man versus beast: pharmacokinetic scaling in mammals J. Pharm. Sci. 1986, 75 (11) 1028-1040
9. Bjorkman, S.; Wada, D. R.; Stanski, D. R.; Ebling, W. F. Comparative physiological pharmacokinetics of fentanyl and alfentanil in rats and humans based on parametric single-tissue models J. Pharmacokinet. Biopharm. 1994, 22 (5) 381-410
10. Ferl, G. Z.; Wu, A. M.; DiStefano, J. J., 3rd. A predictive model of therapeutic monoclonal antibody dynamics and regulation by the neonatal Fc receptor (FcRn) Ann. Biomed. Eng. 2005, 33 (11) 1640-1652
11. Montet, X.; Figueiredo, J. L.; Alencar, H.; Ntziachristos, V.; Mahmood, U.; Weissleder, R. Tomographic fluorescence imaging of tumor vascular volume in mice Radiology 2007, 242 (3) 751-758
12. O'Connor, J. P.; Carano, R. A.; Clamp, A. R.; Ross, J.; Ho, C. C.; Jackson, A.; Parker, G. J.; Rose, C. J.; Peale, F. V.; Friesenhahn, M.; Mitchell, C. L.; Watson, Y.; Roberts, C.; Hope, L.; Cheung, S.; Reslan, H. B.; Go, M. A.; Pacheco, G. J.; Wu, X.; Cao, T. C.; Ross, S.; Buonaccorsi, G. A.; Davies, K.; Hasan, J.; Thornton, P.; del Puerto, O.; Ferrara, N.; van Bruggen, N.; Jayson, G. C. Quantifying antivascular effects of monoclonal antibodies to vascular endothelial growth factor: insights from imaging Clin. Cancer Res. 2009, 15 (21) 6674-6682
13. Weissleder, R.; Cheng, H. C.; Marecos, E.; Kwong, K.; Bogdanov, A., Jr. Non-invasive in vivo mapping of tumour vascular and interstitial volume fractions Eur. J. Cancer 1998, 34 (9) 1448-1454
14. Kim, Y. R.; Rebro, K. J.; Schmainda, K. M. Water exchange and inflow affect the accuracy of T1-GRE blood volume measurements: implications for the evaluation of tumor angiogenesis Magn. Reson. Med. 2002, 47 (6) 1110-1120
15. Bhujwalla, Z. M.; Artemov, D.; Natarajan, K.; Ackerstaff, E.; Solaiyappan, M. Vascular differences detected by MRI for metastatic versus nonmetastatic breast and prostate cancer xenografts Neoplasia 2001, 3 (2) 143-153
16. Henderson, E.; Sykes, J.; Drost, D.; Weinmann, H. J.; Rutt, B. K.; Lee, T. Y. Simultaneous MRI measurement of blood flow, blood volume, and capillary permeability in mammary tumors using two different contrast agents Magn. Reson. Imaging 2000, 12 (6) 991-1003
17. Ter-Pogossian, M. M.; Phelps, M. E.; Grubb, R. L., Jr.; Gado, M. Measure of regional cerebral blood volume in vivo by means of excited fluorescent x-radiation, and factors affecting this parameter Eur. Neurol. 1971, 6 (1) 218-223
18. Laking, G. R.; Price, P. M. Positron emission tomographic imaging of angiogenesis and vascular function Br. J. Radiol. 2003, 76 Spec No 1 (1) S50-59
19. O'Connor, J. P.; Jackson, A.; Parker, G. J.; Jayson, G. C. DCE-MRI biomarkers in the clinical evaluation of antiangiogenic and vascular disrupting agents Br. J. Cancer 2007, 96 (2) 189-195
20. 99mTc: a new approach to blood pool visualization J. Nucl. Med. 1977, 18 (3) 305-308
21. 99mTc labeled, heat treated red blood cells Radiology 1980, 136 (2) 501-3
22. 99mTc-labeled red blood cells J. Nucl. Med. 1976, 17 (02) 126-32
23. Srivastava, S. C.; Chervu, L. R. Radionuclide-labeled red blood cells: current status and future prospects Semin. Nucl. Med. 1984, 14 (2) 68-82
24. Tofts, P. S. Modeling tracer kinetics in dynamic Gd-DTPA MR imaging J. Magn. Reson. Imaging 1997, 7 (1) 91-101
25. Blumenthal, R. D.; Osorio, L.; Ochakovskaya, R.; Ying, Z.; Goldenberg, D. M. Regulation of tumour drug delivery by blood flow chronobiology Eur. J. Cancer 2000, 36 (14) 1876-1884
26. Gullino, P. M.; Grantham, F. H. The vascular space of growing tumors Cancer Res. 1964, 24, 1727-1732
27. Sands, H.; Shah, S. A.; Gallagher, B. M. Vascular volume and permeability of human and murine tumors grown in athymic mice Cancer Lett 1985, 27 (1) 15-21
28. Shockley, T. R.; Lin, K.; Sung, C.; Nagy, J. A.; Tompkins, R. G.; Dedrick, R. L.; Dvorak, H. F.; Yarmush, M. L. A quantitative analysis of tumor specific monoclonal antibody uptake by human melanoma xenografts: effects of antibody immunological properties and tumor antigen expression levels Cancer Res. 1992, 52 (2) 357-366
29. Sung, C.; Youle, R. J.; Dedrick, R. L. Pharmacokinetic analysis of immunotoxin uptake in solid tumors: role of plasma kinetics, capillary permeability, and binding Cancer Res. 1990, 50 (22) 7382-7392
30. van Schaijk, F. G.; Oosterwijk, E.; Molkenboer-Kuenen, J. D.; Soede, A. C.; McBride, B. J.; Goldenberg, D. M.; Oyen, W. J.; Corstens, F. H.; Boerman, O. C. Pretargeting with bispecific anti-renal cell carcinoma x anti-DTPA(In) antibody in 3 RCC models J. Nucl. Med. 2005, 46 (3) 495-501
31. Lockman, P. R.; McAfee, G.; Geldenhuys, W. J.; Van der Schyf, C. J.; Abbruscato, T. J.; Allen, D. D. Brain uptake kinetics of nicotine and cotinine after chronic nicotine exposure J Pharmacol. Exp. Ther. 2005, 314 (2) 636-642
32. Park, S.; Sinko, P. J. P-glycoprotein and multidrug resistance-associated proteins limit the brain uptake of saquinavir in mice J. Pharmacol. Exp. Ther. 2005, 312 (3) 1249-1256
33. O'Connor, S. W.; Bale, W. F. Accessibility of circulating immunoglobulin G to the extravascular compartment of solid rat tumors Cancer Res. 1984, 44 (9) 3719-3723
34. Ferrier, M. C.; Sarin, H.; Fung, S. H.; Schatlo, B.; Pluta, R. M.; Gupta, S. N.; Choyke, P. L.; Oldfield, E. H.; Thomasson, D.; Butman, J. A. Validation of dynamic contrast-enhanced magnetic resonance imaging-derived vascular permeability measurements using quantitative autoradiography in the RG2 rat brain tumor model Neoplasia 2007, 9 (7) 546-555
35. Boswell, C. A.; Bumbaca, D.; Pastuskovas, C. V.; Mundo, E. E.; Shen, B. Q.; Carano, R. A. D.; Marik, J.; Williams, S. P.; Theil, F. P.; Fielder, P. J.; van Bruggen, N.; Khawli, L. A. Molecular imaging in cancer drug development. In Molecular imaging probes for cancer research, 1 st ed.; Chen, X., Ed. World Scientific: Hackensack, NJ, 2010; in press.
36. Vanhove, C.; Lahoutte, T.; Defrise, M.; Bossuyt, A.; Franken, P. R. Reproducibility of left ventricular volume and ejection fraction measurements in rat using pinhole gated SPECT Eur. J. Nucl. Med. Mol. Imaging 2005, 32 (2) 211-220
37. Chin, B. B.; Metzler, S. D.; Lemaire, A.; Curcio, A.; Vemulapalli, S.; Greer, K. L.; Petry, N. A.; Turkington, T. G.; Coleman, R. E.; Rockman, H.; Jaszczak, R. J. Left ventricular functional assessment in mice: feasibility of high spatial and temporal resolution ECG-gated blood pool SPECT Radiology 2007, 245 (2) 440-448
38. Neumann, P.; Schicha, H.; Schurnbrand, P.; Bahre, M.; Emrich, D. Visualizing cardiac blood pool: comparison of three labeling methods Eur. J. Nucl. Med. 1983, 8 (11) 463-466
39. Patrick, S. T.; Glowniak, J. V.; Turner, F. E.; Robbins, M. S.; Wolfangel, R. G. Comparison of in vitro RBC labeling with the UltraTag RBC kit versus in vivo labeling J. Nucl. Med. 1991, 32 (2) 242-244
40. Callahan, R. J.; Froelich, J. W.; McKusick, K. A.; Leppo, J.; Strauss, H. W. A modified method for the in vivo labeling of red blood cells with Tc-99m: concise communication J. Nucl. Med. 1982, 23 (4) 315-318
41. Vaidyanathan, G.; Zalutsky, M. R. Preparation of N -succinimidyl 3-[I]iodobenzoate: an agent for the indirect radioiodination of proteins Nat. Protoc. 2006, 1 (2) 707-713
42. Wang, L. H.; Wang, Y. X.; Yin, D. Z.; Li, J. L. Radioiodination of aromatic organostannates J. Radioanal. Nucl. Chem. 2003, 258 (3) 685-688
43. Matloobi, M.; Rafii, H.; Beigi, D.; Khalaj, A.; Kamali-Dehghan, M. Synthesis of radioiodinated labeled peptides J Radioanal. Nucl. Chem. 2003, 257 (1) 71-73
44. 125I labeled N -succinimidyl p -iodobenzoate for use in radiolabeling antibodies Int. J. Rad. Appl. Instrum. B 1989, 16 (7) 727-733
45. LeBerthon, B.; Khawli, L. A.; Alauddin, M.; Miller, G. K.; Charak, B. S.; Mazumder, A.; Epstein, A. L. Enhanced tumor uptake of macromolecules induced by a novel vasoactive interleukin 2 immunoconjugate Cancer Res. 1991, 51 (10) 2694-2698
46. Khawli, L. A.; Miller, G. K.; Epstein, A. L. Effect of seven new vasoactive immunoconjugates on the enhancement of monoclonal antibody uptake in tumors Cancer 1994, 73 (3) 824-831
47. Sands, H.; Jones, P. L.; Shah, S. A.; Palme, D.; Vessella, R. L.; Gallagher, B. M. Correlation of vascular permeability and blood flow with monoclonal antibody uptake by human Clouser and renal cell xenografts Cancer Res. 1988, 48 (1) 188-193
48. Rehani, M. M.; Sharma, S. K. Site of Tc-99m binding to the red blood cell: concise communication J. Nucl. Med. 1980, 21 (7) 676-678
49. Mariani, G.; Pauwels, E. K.; AlSharif, A.; Marchi, S.; Boni, G.; Barreca, M.; Bellini, M.; Grosso, M.; de Bortoli, N.; Mumolo, G.; Costa, F.; Rubello, D.; Strauss, H. W. Radionuclide evaluation of the lower gastrointestinal tract J. Nucl. Med. 2008, 49 (5) 776-787
50. Seldin, D. W.; Simchon, S.; Jan, K. M.; Chien, S.; Alderson, P. O. Dependence of technetium-99m red blood cell labeling efficiency on red cell surface charge J. Nucl. Med. 1988, 29 (10) 1710-1713
51. Flores, J. E.; McFarland, L. M.; Vanderbilt, A.; Ogasawara, A. K.; Williams, S. P. The effects of anesthetic agent and carrier gas on blood glucose and tissue uptake in mice undergoing dynamic FDG-PET imaging: sevoflurane and isoflurane compared in air and in oxygen Mol. Imaging Biol. 2008, 10 (4) 192-200
52. Bailer, A. J. Testing for the equality of area under the curves when using destructive measurement techniques J. Pharmacokinet. Biopharm. 1988, 16 (3) 303-309
53. Thrall, J. H.; Freitas, J. E.; Swanson, D.; Rogers, W. L.; Clare, J. M.; Brown, M. L.; Pitt, B. Clinical comparison of cardiac blood pool visualization with technetium-99m red blood cells labeled in vivo and with technetium-99m human serum albumin J. Nucl. Med. 1978, 19 (7) 796-803
54. Boswell, C. A.; Lei, X. C.; Schweiger, M.; Reich, M.; Ferl, G. Z.; Theil, F.; Fielder, P. J.; Khawli, L. A. In vivo antibody uptake and physiological measurements in mouse lung and muscle: A compartmental physiologically-based pharmacokinetic (PBPK) modeling approach J. Labelled Compd. Radiopharm. 2009, 52, S102-S102