Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay

Journal of Biological Chemistry

Volumn 280, Issue 48, 2005, Pages 39709-39715

  Stokes, Neil R ^a   Sievers, Jörg ^a   Barker, Stephanie ^a   Bennett, James M ^a   Brown, David R ^a   Collins, Ian ^a   Errington, Veronica M ^a   Foulger, David ^a   Hall, Michelle ^a   Halsey, Rowena ^a   Johnson, Hazel ^a   Rose, Valerie ^a   Thomaides, Helena B ^a   Haydon, David J ^a   Czaplewski, Lloyd G ^a   Errington, Jeff ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; ASSAYS; BACTERIA; BIOCHEMICAL ENGINEERING; CYTOLOGY; GENETIC ENGINEERING; PROTEINS;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SCREENING ASSAY; BACTERIAL CYTOKINESIS; PATHOGEN; PRE-EXISTING RESISTANCE;

CELLS;

3 METHOXYBENZAMIDE; ANTIBIOTIC AGENT; BACITRACIN; BACTERIAL PROTEIN; CARBENICILLIN; CEFALEXIN; DIMETHYL SULFOXIDE; ERYTHROMYCIN; FOSFOMYCIN; FTSZ PROTEIN; FTSZ PROTEIN INHIBITOR; KANAMYCIN; MONENSIN; OFLOXACIN; PC 170942; PC 175515; PC 175565; PC 175568; PC 58538; SPECTINOMYCIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ANIMAL CELL; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM IDENTIFICATION; CELL DIVISION; CONTROLLED STUDY; CYTOKINESIS; DRUG POTENCY; DRUG SCREENING; MOLECULAR CLONING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN TARGETING;

ANTI-INFECTIVE AGENTS; BACILLUS SUBTILIS; BACTERIAL PROTEINS; BETA-ALANINE; CELL DIVISION; CLONING, MOLECULAR; CYTOKINESIS; CYTOSKELETAL PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE, BACTERIAL; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; GTP PHOSPHOHYDROLASES; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MUTATION; PHENOTYPE; PHENYL ETHERS; TEMPERATURE; TIME FACTORS;

ANIMALIA; BACTERIA (MICROORGANISMS);

EID: 28844488672     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M506741200     Document Type: Article

References (23)

1. Ohashi, Y., Chijiiwa, Y., Suzuki, K., Takahashi, K., Nanamiya, H., Sato, T., Hosoya, Y., Ochi, K., and Kawamura, F. (1999) J. Bacteriol. 181, 1348-1351
2. Jennings, L. D., Foreman, K. W., Rush, T. S., III, Tsao, D. H. H., Mosyak, L., Kincaid, S. L., Sukhdeo, M. N., Sutherland, A. G., Ding, W., Kenny, C. H., Sabus, C. L., Liu, H., Dushin, E. G., Moghazeh, S. L., Labthavikul, P., Petersen, P. J., Tuckman, M., and Ruzin, A. V. (2004) Bioorg. Med. Chem. 12, 5115-5131
3. Sutherland, A. G., Alvarez, J., Ding, W., Foreman, K. W., Kenny, D. H., Labthavikul, P., Mosyak, L., Petersen, P. J., Rush, T. S., III, Ruzin, A., Tsao, D. H. H., and Wheless, K. L. (2003) Org. Biomol. Chem. 1, 4138-4140
4. Margalit, D. N., Romberg, L., Mets, R. B., Hebert, A. M., Mitchison, T. J., Kirschner, M. W., and RayChaudhuri, D. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 11821-11826
5. Wang, J., Galgoci, A., Kodali, S., Herath, K. B., Jayasriya, H., Dorso, K., Vicente, F., González, A., Cully, D., Bramhill, D., and Singh, S. (2003) J. Biol. Chem. 278, 44424-44428
6. White, E. L., Suline, W. J., Ross, L. J., Seitz, L. E., and Reynolds, R. C. (2002) J. Antimicrob. Chemother. 50, 111-114
7. Reynolds, R. C., Srivastava, S., Ross, L. J., Suling, W. J., and White, E. L. (2004) Bioorg. Med. Chem. Lett. 14, 3161-3164
8. Anagnostopoulos, C., and Spizizen, J. (1961) J. Bacteriol. 81, 741-746
9. Jenkinson, H. F. (1983) J. Gen. Microbiol 129, 1945-1958
10. Kunst, F., and Rapoport, G. (1995) J. Bacteriol 177, 2403-2407
11. Karamata, D., and Gross, J. D. (1970) Mol. Gen. Genet. 108, 277-287
12. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
13. Haeusser, D. P., Schwartz, R. L., Smith, A. M., Oates, M. E., and Levin, P. A. (2004) Mol. Microbiol. 52, 801-814
14. Arends, S. J., and Weiss, D. S. (2004) J. Bacteriol. 186, 880-884
15. Errington, J. (2001) Curr. Opin. Microbiol. 4, 660-666
16. Errington, J., Daniel, R. A., and Scheffers, D. J. (2003) Microbiol. Mol. Biol. Rev. 67, 52-65
17. Errington, J., and Mandelstam, J. (1986) J. Gen. Microbiol. 132, 2967-2976
18. Zhang, J.-H., Chung, T. D. Y., and Oldenburg, K. R. (1999) J. Biomol. Screen. 4, 67-73
19. Eberhardt, C., Kuerschner, L., and Weiss, D. S. (2003) J. Bacteriol. 185, 3726-3734
20. Löwe, J., and Amos, L. A. (1998) Nature 391, 203-206
21. Pinho, M. G., and Errington, J. (2003) Mol. Microbiol. 50, 871-881
22. Addinall, S. G., Cao, C., and Lutkenhaus, J. (1997) J. Bacteriol. 179, 4277-4284
23. Reynolds, P. E. (1989) Eur. J. Clin. Microbiol. Infect. Dis. 8, 943-950