Evolution of MRSA during hospital transmission and intercontinental spread

Science

Volumn 327, Issue 5964, 2010, Pages 469-474

  Harris, Simon R ^a   Feil, Edward J ^b   Holden, Matthew T G ^a   Quail, Michael A ^a   Nickerson, Emma K ^c,d   Chantratita, Narisara ^c   Gardete, Susana ^e,f   Tavares, Ana ^e   Day, Nick ^c,g   Lindsay, Jodi A ^h   Edgeworth, Jonathan D ^i,j   De Lencastre, Hermínia ^e,f   Parkhill, Julian ^a   Peacock, Sharon J ^c,d   Bentley, Stephen D ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b University of Bath   (United Kingdom)

^c MAHIDOL UNIVERSITY   (Thailand)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^f ROCKEFELLER UNIVERSITY   (United States)

^g UNIVERSITY OF OXFORD   (United Kingdom)

^h ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

ⁱ GUY S HOSPITAL   (United Kingdom)

^j GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

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Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; FUSIDIC ACID; GENOMIC DNA; PSEUDOMONIC ACID; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; TRIMETHOPRIM;

EPIDEMIOLOGY; GENOMICS; HOSPITAL SECTOR; INFECTIOUS DISEASE; MICROBIAL ECOLOGY; PATHOTYPE;

ARTICLE; BACTERIAL INFECTION; BACTERIAL TRANSMISSION; ECOLOGY; EVOLUTION; GENE MAPPING; GENE SEQUENCE; GENOMICS; GEOGRAPHY; HOSPITAL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; ASIA; BACTERIAL GENOME; BACTERIUM IDENTIFICATION; CLASSIFICATION; CROSS INFECTION; DISEASE TRANSMISSION; DNA SEQUENCE; EUROPE; GENETICS; HUMAN; ISOLATION AND PURIFICATION; METHODOLOGY; MICROBIOLOGY; MOLECULAR EPIDEMIOLOGY; MOLECULAR EVOLUTION; MOLECULAR GENETICS; PHYLOGENY; SOUTH AMERICA; STAPHYLOCOCCUS INFECTION; STATISTICAL MODEL; TIME; UNITED STATES;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

ASIA; BACTERIAL TYPING TECHNIQUES; CROSS INFECTION; EUROPE; EVOLUTION, MOLECULAR; GENOME, BACTERIAL; GENOMICS; HUMANS; LIKELIHOOD FUNCTIONS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MOLECULAR EPIDEMIOLOGY; MOLECULAR SEQUENCE DATA; PHYLOGENY; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA; SOUTH AMERICA; STAPHYLOCOCCAL INFECTIONS; TIME FACTORS; UNITED STATES;

EID: 75649084906     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1182395     Document Type: Article

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28. The Sanger Institute is core funded by the Wellcome Trust. We thank C. Milheiriço and J. D. Cockfield for preparation of genomic DNA and G. Dougan and the Sanger Institute Sequencing and Informatics groups for general support. S.G. and A.T. were supported by grants SFRH/BPD/25403/2005 and SFRH/BD/44220/2008, respectively, from Fundação para a Ciência e Tecnologia, Portugal. E.K.N., N.C., N.D., and S.J.P. were funded by the Wellcome Trust. Funding for the sequencing of the TW20 genome was provided by Guy's and St. Thomas' Charity. J.D.E. receives funding from the Department of Health via the National Institute for Health Research's comprehensive Biomedical Research Centre award to Guy's and St. Thomas' National Health Service Foundation Trust in partnership with King's College London. The Illumina Genome Analyzer reads are deposited in the Short Read Archive (National Center for Biotechnology Information) under the accession no. ERA000102. The annotated chromosome of TW20 has been submitted to European Molecular Biology Laboratory with the accession number FN433596.