Characterization of nicotinamidases: Steady state kinetic parameters, classwide inhibition by nicotinaldehydes, and catalytic mechanism

Biochemistry

Volumn 49, Issue 49, 2010, Pages 10421-10439

  French, Jarrod B ^a   Cen, Yana ^b   Vrablik, Tracy L ^c   Xu, Ping ^b   Allen, Eleanor ^b   Hanna Rose, Wendy ^c   Sauve, Anthony A ^b  

^a Department of Obstetrics Gynecology   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARCHAEA; BORRELIA BURGDORFERI; CAENORHABDITIS ELEGANS; CARBONYL CARBON; CATALYTIC MECHANISMS; CATALYTIC RESIDUE; CATALYTIC TRANSITION METALS; CEREVISIAE; DROSOPHILA MELANOGASTER; EFFICIENT CATALYSTS; ELEGANS; EUBACTERIA; KINETIC ANALYSIS; KINETIC ASSAY; LIFE SPAN; LYME DISEASE; METABOLIC ENZYMES; NANOMOLAR RANGE; NICOTINIC ACID; OXYANION HOLE; PATHOGENIC MICROBES; PLASMODIUM FALCIPARUM; SACCHAROMYCES CEREVISIAE; STEADY STATE; STEADY-STATE KINETICS; STREPTOCOCCUS PNEUMONIAE; STRUCTURAL WORKS; THIOESTERS;

ALDEHYDES; AMIDES; CATALYSTS; ENZYME INHIBITION; ION EXCHANGE; KINETIC PARAMETERS; MAMMALS; METABOLISM; METAL IONS; MICROORGANISMS; OXYGEN; PULMONARY DISEASES; TRANSITION METAL COMPOUNDS; TRANSITION METALS; YEAST;

ENZYMES;

4 METHOXY 3 PYRIDINECARBOXALDEHYDE; 5 METHOXY 3 PYRIDINECARBOXALDEHYDE; 5 METHYL 3 PYRIDINECARBOXALDEHYDE; 6 FLUORO 3 PYRIDINECARBOXALDEHYDE; ALDEHYDE; NICOTINALDEHYDE; NICOTINAMIDASE; NICOTINAMIDE; NICOTINIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BORRELIA BURGDORFERI; CAENORHABDITIS ELEGANS; CATALYSIS; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; ENZYME SPECIFICITY; GENE MUTATION; MOLECULAR CLONING; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; STEADY STATE; STREPTOCOCCUS PNEUMONIAE;

ALDEHYDES; AMINO ACID SEQUENCE; ANIMALS; BORRELIA BURGDORFERI; CAENORHABDITIS ELEGANS; CATALYSIS; DROSOPHILA MELANOGASTER; HUMANS; MOLECULAR SEQUENCE DATA; NICOTINAMIDASE; PLASMODIUM FALCIPARUM; SACCHAROMYCES CEREVISIAE;

BACTERIA (MICROORGANISMS); BORRELIA BURGDORFERI; CAENORHABDITIS ELEGANS; CORYNEBACTERINEAE; DROSOPHILA MELANOGASTER; INVERTEBRATA; MAMMALIA; PLASMODIUM FALCIPARUM; PROTOZOA; SACCHAROMYCES CEREVISIAE; STREPTOCOCCUS PNEUMONIAE;

EID: 78650115180     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1012518     Document Type: Article

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