High-resolution crystal structures of streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes

Biochemistry

Volumn 49, Issue 40, 2010, Pages 8803-8812

  French, Jarrod B ^a   Cen, Yana ^b   Sauve, Anthony A ^b   Ealick, Steven E ^a  

^a Department of Obstetrics Gynecology   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIOCHEMICAL ANALYSIS; CATALYTIC MECHANISMS; HIGH RESOLUTION CRYSTAL STRUCTURE; MULTICELLULAR EUKARYOTES; NEGATIVE CHARGE; NICOTINIC ACID; OXYANION HOLE; REACTION INTERMEDIATE; SALVAGE ENZYMES; STREPTOCOCCUS PNEUMONIAE; STRUCTURAL EVIDENCE; SUBSTRATE BINDING; THIOESTERS; WATER MOLECULE;

ACIDS; ALDEHYDES; AMIDES; CATALYSTS; CRYSTAL STRUCTURE; ENZYMES; LIGANDS; MAMMALS; METAL IONS; MOLECULES; QUANTUM CHEMISTRY; REACTION INTERMEDIATES; SUBSTRATES;

ENZYME INHIBITION;

ALDEHYDE DERIVATIVE; ANION; METAL ION; NICOTINAMIDASE; NICOTINAMIDE; THIOESTER; WATER;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIAE;

ALDEHYDES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; METALS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NIACIN; NIACINAMIDE; NICOTINAMIDASE; PROTEIN CONFORMATION; STREPTOCOCCUS PNEUMONIAE;

EUKARYOTA; MAMMALIA; PROKARYOTA; STREPTOCOCCUS PNEUMONIAE;

EID: 77957657121     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi1012436     Document Type: Article

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