Ligand- and subunit-specific conformational changes in the ligand-binding domain and the TM2-TM3 linker of α1 β2 γ2 GABAA receptors

Journal of Biological Chemistry

Volumn 285, Issue 51, 2010, Pages 40373-40386

  Wang, Qian ^a   Pless, Stephan A ^a,b   Lynch, Joseph W ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION MECHANISMS; BOUND LIGANDS; CONFORMATIONAL CHANGE; CONFORMATIONAL MOBILITY; ENVIRONMENTALLY SENSITIVE; LIGAND BINDING DOMAIN; RECEPTOR-LIGAND BINDING; STRUCTURAL REARRANGEMENT; SUBUNIT INTERFACES; VOLTAGE CLAMP;

AMINO ACIDS; BIOCHEMISTRY; FLUOROMETERS; FLUOROPHORES; LIGANDS; MACHINERY;

BINDING SITES;

4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID RECEPTOR BETA2; 4 AMINOBUTYRIC ACID RECEPTOR GAMMA2; CYSTEINE; CYSTEINE LOOP RECEPTOR; DISULFIDE; LIGAND; RECEPTOR; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DIMERIZATION; FEMALE; FLUORESCENCE; FLUOROMETRY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; VOLTAGE CLAMP;

ANIMALS; DISULFIDES; FLUORESCENT DYES; GABA-A RECEPTOR AGONISTS; ION CHANNEL GATING; LIGANDS; PATCH-CLAMP TECHNIQUES; PROTEIN STRUCTURE, SECONDARY; PROTEIN SUBUNITS; RATS; RECEPTORS, GABA-A; XENOPUS LAEVIS;

EID: 78650039016     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.161513     Document Type: Article

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