Defining affinity with the GABA(A) receptor

Journal of Neuroscience

Volumn 18, Issue 21, 1998, Pages 8590-8604

  Jones, Mathew V ^a   Sahara, Yoshinori ^a,b   Dzubay, Jeffrey A ^a   Westbrook, Gary L ^a,c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Kinetics; Ligand gated channels; Molecular modeling; Selectivity; Synapse; Thermodynamic

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 4,5,6,7-TETRAHYDROISOXAZOLO(5,4-C)PYRIDIN-3-OL; BETA ALANINE; GABOXADOL; ISOXAZOLE DERIVATIVE; LIGAND; MUSCIMOL; PYRIDAZINE DERIVATIVE;

AGONIST; ANIMAL CELL; ARTICLE; DIFFUSION; HIPPOCAMPUS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; ANIMAL; CELL CULTURE; DRUG POTENTIATION; METABOLISM; NERVE CELL; PATCH CLAMP; PHYSIOLOGY;

ANIMALS; ANIMALS, NEWBORN; BETA-ALANINE; CELLS, CULTURED; GABA AGONISTS; GABA ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; HIPPOCAMPUS; ISOXAZOLES; LIGANDS; MUSCIMOL; NEURONS; PATCH-CLAMP TECHNIQUES; PYRIDAZINES; RATS; RECEPTORS, GABA-A;

EID: 0032194947     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-21-08590.1998     Document Type: Article

References (23)

1. Akk G, Auerbach A (1996) Inorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptors. Biophys J 70:2652-2658.
2. Akk G, Sine S, Auerbach A (1996) Binding sites contribute unequally to the gating of mouse nicotinic αD200N acetylcholine receptors. J Physiol (Lond) 496:185-196.
3. A receptor needs two homologous domains of the β-subunit for activation by GABA but not by pentobarbital. Nature 366:565-569.
4. Auerbach A (1993) A statistical analysis of acetylcholine receptor activation in Xenopus myocytes: stepwise versus concerted models of gating. J Physiol (Lond) 461:339-378.
5. Auger C, Marty A (1997) Heterogeneity of functional synaptic parameters among single release sites. Neuron 19:139-150.
6. Barbour B, Häusser M (1997) Intersynaptic diffusion of neurotransmitter. Trends Neurosci 20:377-384.
7. Benveniste M, Mayer ML (1991) Kinetic analysis of antagonist action at N-methyl-D-aspartic acid receptors. Biophys J 59:560-573.
8. Benveniste M, Clements J, Vyklicky Jr L, Mayer ML (1990a) A kinetic analysis of the modulation of N-methyl-D-aspartic acid receptors by glycine in mouse cultured hippocampal neurons. J Physiol (Lond) 428:333-357.
9. Benveniste M, Mienville J-M, Sernagor E, Mayer ML (1990b) Concentration-jump experiments with NMDA antagonists in mouse cultured hippocampal neurons. J Neurophysiol 63:1373-1384.
10. Busch C, Sakmann B (1990) Synaptic transmission in hippocampal neurons: numerical reconstruction of quantal IPSCs. Cold Spring Harb Symp Quant Biol 55:69-80.
11. A receptor in outside-out patches. Biophys J 66:1039-1050.
12. A receptor. Proc Natl Acad Sci USA 82:1832-1836.
13. Clements JD, Westbrook GL (1991) Activation kinetics reveal the number of glutamate and glycine binding sites on the N-methyl-D-aspartate receptor. Neuron 7:605-613.
14. Clements JD, Lester RA, Tong G, Jahr CE, Westbrook GL (1992) The time course of glutamate in the synaptic cleft. Science 258:1498-1501.
15. Clements JD, Feltz A, Sahara Y, Westbrook GL (1998) Activation kinetics of AMPA receptor channels reveal the number of functional agonist binding sites. J Neurosci 18:119-127.
16. Colquhoun D, Ogden DC (1988) Activation of ion channels in the frog end-plate by high concentrations of acetylcholine. J Physiol (Lond) 395:131-159.
17. Colquhoun D, Sakmann B (1985) Fast events in single-channel currents activated by acetylcholine and its analogues at the frog muscle end-plate. J Physiol (Lond) 369:501-557.
18. Colquhoun D, Large WA, Rang HP (1977) An analysis of the action of a false transmitter at the neuromuscular junction. J Physiol (Lond) 266:361-395.
19. Constanti A (1977a) A quantitative study of the γ-aminobutyric acid (GABA) dose/conductance relationship at the lobster inhibitory neuromuscular junction. Neuropharmacology 16:357-366.
20. Constanti A (1977b) Comparison of dose/conductance curves for GABA and some structurally related compounds at the lobster inhibitory neuromuscular junction. Neuropharmacology 16:367-374.
21. Dennis M, Giraudat J, Kotzyba-Hibert F, Goeldner M, Hirth C, Chang JY, Lazure C, Chretien M, Changeux JP (1988) Amino acids of the Torpedo marmorata acetylcholine receptor alpha subunit labeled by a photoaffinity ligand for the acetylcholine binding site. Biochemistry 27:2346-2357.
22. Diamond JS, Jahr CE (1997) Transporters buffer synaptically released glutamate on a submillisecond time scale. J Neurosci 17:4672-4687.
23. Dionne VE, Steinbach JH, Stevens CF (1978) An analysis of the dose-response relationship at voltage-clamped frog neuromuscular junctions. J Physiol (Lond) 281:421-444.