Pathogenicity determinants and allergens

The Aspergilli: Genomics, Medical Aspects, Biotechnology, and Research Methods

Volumn , Issue , 2007, Pages 377-400

  Krappmann, Sven ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 78649962171     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9781420008517     Document Type: Chapter

References (227)

1. Hawksworth, D.L., The magnitude of fungal diversity: the 1.5 million species estimate revisited, Mycol. Res., 105, 1422, 2001.
2. McClelland, E.E., Bernhardt, P., and Casadevall, A., Coping with multiple virulence factors: which is most important?, PLoS Pathog., 1, e40, 2005.
3. Brakhage, A.A., Systemic fungal infections caused by Aspergillus species: epidemiology, infection process and virulence determinants, Curr. Drug. Targets, 6, 875, 2005.
4. Clemons, K.V. and Stevens, D.A., The contribution of animal models of aspergillosis to understanding pathogenesis, therapy and virulence, Med. Mycol., 43 Suppl 1, S101, 2005.
5. Latge, J.P., Aspergillus fumigatus and aspergillosis, Clin. Microbiol. Rev., 12, 310, 1999.
6. Latge, J.P., The pathobiology of Aspergillus fumigatus, Trends Microbiol., 9, 382, 2001.
7. Rementeria, A., Lopez-Molina, N., Ludwig, A. et al., Genes and molecules involved in Aspergillus fumigatus virulence, Rev. Iberoam. Micol., 22, 1, 2005.
8. Tomee, J.F. and Kauffman, H.F., Putative virulence factors of Aspergillus fumigatus, Clin. Exp. Allergy, 30, 476, 2000.
9. Kauffman, C.A., Fungal infections, Proc. Am. Thorac. Soc., 3, 35, 2006.
10. Oren, I. and Goldstein, N., Invasive pulmonary aspergillosis, Curr. Opin. Pulm. Med., 8, 195, 2002.
11. McNeil, M.M., Nash, S.L., Hajjeh, R.A. et al., Trends in mortality due to invasive mycotic diseases in the United States, 1980-1997, Clin. Infect. Dis., 33, 641, 2001.
12. Kontoyiannis, D.P. and Bodey, G.P., Invasive aspergillosis in 2002: an update, Eur. J. Clin. Microbiol. Infect. Dis., 21, 161, 2002.
13. Lin, S.J., Schranz, J., and Teutsch, S.M., Aspergillosis case-fatality rate: systematic review of the literature, Clin. Infect. Dis., 32, 358, 2001.
14. Rosenberg, E. and Ben-Haim, Y., Microbial diseases of corals and global warming, Environ. Microbiol., 4, 318, 2002.
15. Tell, L.A., Aspergillosis in mammals and birds: impact on veterinary medicine, Med. Mycol., 43 Suppl 1, S71, 2005.
16. Rüchel, R. and Reichard, U., Pathogenesis and clinical presentation of aspergillosis, Contrib. Microbiol., 2, 21, 1999.
17. Moss, R.B., Pathophysiology and immunology of allergic bronchopulmonary aspergillosis, Med. Mycol., 43 Suppl 1, S203, 2005.
18. Hope, W.W., Walsh, T.J., and Denning, D.W., The invasive and saprophytic syndromes due to Aspergillus spp., Med. Mycol., 43 Suppl 1, S207, 2005.
19. Casadevall, A. and Pirofski, L.A., Host-pathogen interactions: redefining the basic concepts of virulence and pathogenicity, Infect. Immun., 67, 3703, 1999.
20. Casadevall, A. and Pirofski, L.A., The damage-response framework of microbial pathogenesis, Nat. Rev. Microbiol., 1, 17, 2003.
21. Schaffner, A., Douglas, H., and Braude, A., Selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus. Observations on these two lines of defense in vivo and in vitro with human and mouse phagocytes, J. Clin. Invest., 69, 617, 1982.
22. Schneemann, M. and Schaffner, A., Host defense mechanism in Aspergillus fumigatus infections, Contrib. Microbiol., 2, 57, 1999.
23. Ibrahim-Granet, O., Philippe, B., Boleti, H. et al., Phagocytosis and intracellular fate of Aspergillus fumigatus conidia in alveolar macrophages, Infect. Immun., 71, 891, 2003.
24. Levitz, S.M. and Diamond, R.D., Mechanisms of resistance of Aspergillus fumigatus conidia to killing by neutrophils in vitro, J. Infect. Dis., 152, 33, 1985.
25. Levitz, S.M. and Farrell, T.P., Human neutrophil degranulation stimulated by Aspergillus fumigatus, J. Leukoc. Biol., 47, 170, 1990.
26. Fridkin, S.K. and Jarvis, W.R., Epidemiology of nosocomial fungal infections, Clin. Microbiol. Rev., 9, 499, 1996.
27. Hayes-Lattin, B. and Maziarz, R.T., Update in the epidemiology, prophylaxis, and treatment of fungal infections in patients with hematologic disorders, Leuk. Lymphoma, 45, 669, 2004.
28. Wald, A., Leisenring, W., van Burik, J.A. et al., Epidemiology of Aspergillus infections in a large cohort of patients undergoing bone marrow transplantation, J. Infect. Dis., 175, 1459, 1997.
29. Garlanda, C., Hirsch, E., Bozza, S. et al., Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response, Nature, 420, 182, 2002.
30. Gersuk, G.M., Underhill, D.M., Zhu, L. et al., Dectin-1 and TLRs permit macrophages to distinguish between different Aspergillus fumigatus cellular states, J. Immunol., 176, 3717, 2006.
31. Meier, A., Kirschning, C.J., Nikolaus, T. et al., Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages, Cell. Microbiol., 5, 561, 2003.
32. Steele, C., Rapaka, R.R., Metz, A. et al., The β-glucan receptor dectin-1 recognizes specific morphologies of Aspergillus fumigatus, PLoS Pathog., 1, e42, 2005.
33. Moss, R.B., Allergic bronchopulmonary aspergillosis, Clin. Rev. Allergy Immunol., 23, 87, 2002.
34. Knutsen, A.P., Genetic and respiratory tract risk factors for aspergillosis: ABPA and asthma with fungal sensitization, Med. Mycol., 44 Suppl 1, S77, 2006.
35. Klich, M., Identification of clinically relevant aspergilli, Med. Mycol., 44 Suppl 1, 227, 2006.
36. Al-Doory, Y. and Wagner, G.E., Apergillosis, Thomas, Springfield, 1985.
37. Schmitt, H.J., Blevins, A., Sobeck, K. et al., Aspergillus species from hospital air and from patients, Mycoses, 33, 539, 1990.
38. Chazalet, V., Debeaupuis, J.P., Sarfati, J. et al., Molecular typing of environmental and patient isolates of Aspergillus fumigatus from various hospital settings, J. Clin. Microbiol., 36, 1494, 1998.
39. Debeaupuis, J.P., Sarfati, J., Chazalet, V. et al., Genetic diversity among clinical and environmental isolates of Aspergillus fumigatus, Infect. Immun., 65, 3080, 1997.
40. Walsh, T.J. and Groll, A.H., Overview: non-fumigatus species of Aspergillus: perspectives on emerging pathogens in immunocompromised hosts, Curr. Opin. Investig. Drugs, 2, 1366, 2001.
41. Klich, M.A., Biogeography of Aspergillus species in soil and litter, Mycologia, 94, 21, 2002.
42. Segal, B.H., DeCarlo, E.S., Kwon-Chung, K.J. et al., Aspergillus nidulans infection in chronic granulomatous disease, Medicine, 77, 345, 1998.
43. Verweij, P.E., van den Bergh, M.F., Rath, P.M. et al., Invasive aspergillosis caused by Aspergillus ustus: case report and review, J. Clin. Microbiol., 37, 1606, 1999.
44. Bignell, E., Negrete-Urtasun, S., Calcagno, A.M. et al., The Aspergillus pH-responsive transcription factor PacC regulates virulence, Mol. Microbiol., 55, 1072, 2005.
45. Armstrong, D., History of opportunistic infection in the immunocompromised host, Clin. Infect. Dis., 17 Suppl 2, S318, 1993.
46. Casadevall, A. and Pirofski, L.A., Host-pathogen interactions: basic concepts of microbial commensalism, colonization, infection, and disease, Infect. Immun., 68, 6511, 2000.
47. Paisley, D., Robson, G.D., and Denning, D.W., Correlation between in vitro growth rate and in vivo virulence in Aspergillus fumigatus, Med. Mycol., 43, 397, 2005.
48. Tekaia, F. and Latge, J.P., Aspergillus fumigatus: saprophyte or pathogen?, Curr. Opin. Microbiol., 8, 385, 2005.
49. Beffa, T., Staib, F., Lott Fischer, J. et al., Mycological control and surveillance of biological waste and compost, Med. Mycol., 36 Suppl 1, 137, 1998.
50. Ryckeboer, J., Mergaert, J., Coosemans, J. et al., Microbiological aspects of biowaste during composting in a monitored compost bin, J. Appl. Microbiol., 94, 127, 2003.
51. Nierman, W.C., Pain, A., Anderson, M.J. et al., Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus, Nature, 438, 1151, 2005.
52. Chang, Y.C., Tsai, H.F., Karos, M. et al., THTA, a thermotolerance gene of Aspergillus fumigatus, Fungal Genet. Biol., 41, 888, 2004.
53. Bhabhra, R. and Askew, D.S., Thermotolerance and virulence of Aspergillus fumigatus: role of the fungal nucleolus, Med. Mycol., 43 Suppl 1, S87, 2005.
54. Bhabhra, R., Miley, M.D., Mylonakis, E. et al., Disruption of the Aspergillus fumigatus gene encoding nucleolar protein CgrA impairs thermotolerant growth and reduces virulence, Infect. Immun., 72, 4731, 2004.
55. Bouchara, J.P., Sanchez, M., Esnault, K. et al., Interactions between Aspergillus fumigatus and host matrix proteins, Contrib. Microbiol., 2, 167, 1999.
56. Gil, M.L., Penalver, M.C., Lopez-Ribot, J.L. et al., Binding of extracellular matrix proteins to Aspergillus fumigatus conidia, Infect. Immun., 64, 5239, 1996.
57. Bouchara, J.P., Bouali, A., Tronchin, G. et al., Binding of fibrinogen to the pathogenic Aspergillus species, J. Med. Vet. Mycol., 26, 327, 1988.
58. Tronchin, G., Esnault, K., Renier, G. et al., Expression and identification of a laminin-binding protein in Aspergillus fumigatus conidia, Infect. Immun., 65, 9, 1997.
59. Penalver, M.C., O’Connor, J.E., Martinez, J.P. et al., Binding of human fibronectin to Aspergillus fumigatus conidia, Infect. Immun., 64, 1146, 1996.
60. Tronchin, G., Esnault, K., Sanchez, M. et al., Purification and partial characterization of a 32-kilodalton sialic acid-specific lectin from Aspergillus fumigatus, Infect. Immun., 70, 6891, 2002.
61. Paris, S., Debeaupuis, J.P., Crameri, R. et al., Conidial hydrophobins of Aspergillus fumigatus, Appl. Environ. Microbiol., 69, 1581, 2003.
62. Thau, N., Monod, M., Crestani, B. et al., rodletless mutants of Aspergillus fumigatus, Infect. Immun., 62, 4380, 1994.
63. Jahn, B., Boukhallouk, F., Lotz, J. et al., Interaction of human phagocytes with pigmentless Aspergillus conidia, Infect. Immun., 68, 3736, 2000.
64. Bok, J.W., Balajee, S.A., Marr, K.A. et al., LaeA, a regulator of morphogenetic fungal virulence factors, Eukaryot. Cell, 4, 1574, 2005.
65. Bok, J.W. and Keller, N.P., LaeA, a regulator of secondary metabolism in Aspergillus spp., Eukaryot. Cell, 3, 527, 2004.
66. Bernard, M. and Latge, J.P., Aspergillus fumigatus cell wall: composition and biosynthesis, Med. Mycol., 39 Suppl 1, 9, 2001.
67. Beauvais, A., Bruneau, J.M., Mol, P.C. et al., Glucan synthase complex of Aspergillus fumigatus, J. Bacteriol., 183, 2273, 2001.
68. Firon, A., Beauvais, A., Latge, J.P. et al., Characterization of essential genes by parasexual genetics in the human fungal pathogen Aspergillus fumigatus: impact of genomic rearrangements associated with electroporation of DNA, Genetics, 161, 1077, 2002.
69. Beauvais, A., Maubon, D., Park, S. et al., Two α(1-3) glucan synthases with different functions in Aspergillus fumigatus, Appl. Environ. Microbiol., 71, 1531, 2005.
70. Latge, J.P., Mouyna, I., Tekaia, F. et al., Specific molecular features in the organization and biosynthesis of the cell wall of Aspergillus fumigatus, Med. Mycol., 43 Suppl 1, S15, 2005.
71. Mellado, E., Aufauvre-Brown, A., Specht, C.A. et al., A multigene family related to chitin synthase genes of yeast in the opportunistic pathogen Aspergillus fumigatus, Mol. Gen. Genet., 246, 353, 1995.
72. Roncero, C., The genetic complexity of chitin synthesis in fungi, Curr. Genet., 41, 367, 2002.
73. −) of Aspergillus fumigatus, Fungal Genet. Biol., 38, 98, 2003.
74. Mellado, E., Specht, C.A., Robbins, P.W. et al., Cloning and characterization of chsD, a chitin synthaselike gene of Aspergillus fumigatus, FEMS Microbiol. Lett., 143, 69, 1996.
75. Mellado, E., Aufauvre-Brown, A., Gow, N.A. et al., The Aspergillus fumigatus chsC and chsG genes encode class III chitin synthases with different functions, Mol. Microbiol., 20, 667, 1996.
76. Aufauvre-Brown, A., Mellado, E., Gow, N.A. et al., Aspergillus fumigatus chsE: a gene related to CHS3 of Saccharomyces cerevisiae and important for hyphal growth and conidiophore development but not pathogenicity, Fungal Genet. Biol., 21, 141, 1997.
77. Chabane, S., Sarfati, J., Ibrahim-Granet, O. et al., Glycosylphosphatidylinositol-anchored Ecm33p influences conidial cell wall biosynthesis in Aspergillus fumigatus, Appl. Environ. Microbiol., 72, 3259, 2006.
78. Romano, J., Nimrod, G., Ben-Tal, N. et al., Disruption of the Aspergillus fumigatus ECM33 homologue results in rapid conidial germination, antifungal resistance and hypervirulence, Microbiology, 152, 1919, 2006.
79. Bignell, E., Rogers, T., and Haynes, K., Host recognition by fungal pathogens, in Pathogenic Fungi-Host interactions and emerging strategies for control, San-Blas, G. and Calderone, A. (eds), Caister Academic Press, Norfolk, 2004.
80. Wek, R.C., Jiang, H.Y., and Anthony, T.G., Coping with stress: eIF2 kinases and translational control, Biochem. Soc. Trans., 34, 7, 2006.
81. Krappmann, S., Bignell, E.M., Reichard, U. et al., The Aspergillus fumigatus transcriptional activator CpcA contributes significantly to the virulence of this fungal pathogen, Mol. Microbiol., 52, 785, 2004.
82. Sasse, C., Bignell, E.M., Hasenberg, M. et al., Basal expression of the Aspergillus fumigatus transcriptional activator CpcA is sufficient to support pulmonary aspergillosis, unpublished.
83. Catlett, N.L., Yoder, O.C., and Turgeon, B.G., Whole-genome analysis of two-component signal transduction genes in fungal pathogens, Eukaryot. Cell, 2, 1151, 2003.
84. Du, C., Sarfati, J., Latge, J.P. et al., The role of the sakA (Hog1) and tcsB (sln1) genes in the oxidant adaptation of Aspergillus fumigatus, Med. Mycol., 44, 211, 2006.
85. Pott, G.B., Miller, T.K., Bartlett, J.A. et al., The isolation of FOS-1, a gene encoding a putative twocomponent histidine kinase from Aspergillus fumigatus, Fungal Genet. Biol., 31, 55, 2000.
86. Clemons, K.V., Miller, T.K., Selitrennikoff, C.P. et al., fos-1, a putative histidine kinase as a virulence factor for systemic aspergillosis, Med. Mycol., 40, 259, 2002.
87. Chant, J. and Stowers, L., GTPase cascades choreographing cellular behavior: movement, morphogenesis, and more, Cell, 81, 1, 1995.
88. Fortwendel, J.R., Panepinto, J.C., Seitz, A.E. et al., Aspergillus fumigatus rasA and rasB regulate the timing and morphology of asexual development, Fungal Genet. Biol., 41, 129, 2004.
89. Fortwendel, J.R., Zhao, W., Bhabhra, R. et al., A fungus-specific ras homolog contributes to the hyphal growth and virulence of Aspergillus fumigatus, Eukaryot. Cell, 4, 1982, 2005.
90. May, G.S., Xue, T., Kontoyiannis, D.P. et al., Mitogen activated protein kinases of Aspergillus fumigatus, Med. Mycol., 43 Suppl 1, S83, 2005.
91. Xue, T., Nguyen, C.K., Romans, A. et al., A mitogen-activated protein kinase that senses nitrogen regulates conidial germination and growth in Aspergillus fumigatus, Eukaryot. Cell, 3, 557, 2004.
92. Brakhage, A.A. and Liebmann, B., Aspergillus fumigatus conidial pigment and cAMP signal transduction:significance for virulence, Med. Mycol., 43 Suppl 1, S75, 2005.
93. Oliver, B.G., Panepinto, J.C., Askew, D.S. et al., cAMP alteration of growth rate of Aspergillus fumigatus and Aspergillus niger is carbon-source dependent, Microbiology, 148, 2627, 2002.
94. Rhodes, J.C., Oliver, B.G., Askew, D.S. et al., Identification of genes of Aspergillus fumigatus upregulated during growth on endothelial cells, Med. Mycol., 39, 253, 2001.
95. Oliver, B.G., Panepinto, J.C., Fortwendel, J.R. et al., Cloning and expression of pkaC and pkaR, the genes encoding the cAMP-dependent protein kinase of Aspergillus fumigatus, Mycopathologia, 154, 85, 2002.
96. Liebmann, B., Gattung, S., Jahn, B. et al., cAMP signaling in Aspergillus fumigatus is involved in the regulation of the virulence gene pksP and in defense against killing by macrophages, Mol. Genet. Genomics, 269, 420, 2003.
97. Liebmann, B., Muller, M., Braun, A. et al., The cyclic AMP-dependent protein kinase a network regulates development and virulence in Aspergillus fumigatus, Infect. Immun., 72, 5193, 2004.
98. Zhao, W., Panepinto, J.C., Fortwendel, J.R. et al., Deletion of the regulatory subunit of protein kinase A in Aspergillus fumigatus alters morphology, sensitivity to oxidative damage, and virulence, Infect. Immun., 74, 4865, 2006.
99. Borges-Walmsley, M.I. and Walmsley, A.R., cAMP signalling in pathogenic fungi: control of dimorphic switching and pathogenicity, Trends Microbiol., 8, 133, 2000.
100. Lee, N., D’Souza, C.A., and Kronstad, J.W., Of smuts, blasts, mildews, and blights: cAMP signaling in phytopathogenic fungi, Annu. Rev. Phytopathol., 41, 399, 2003.
101. Penalva, M.A. and Arst, H.N., Jr., Recent advances in the characterization of ambient pH regulation of gene expression in filamentous fungi and yeasts, Annu. Rev. Microbiol., 58, 425, 2004.
102. Kraus, P.R. and Heitman, J., Coping with stress: calmodulin and calcineurin in model and pathogenic fungi, Biochem. Biophys. Res. Commun., 311, 1151, 2003.
103. da Silva Ferreira, M.E., Kress, M.R., Savoldi, M. et al., The akuB(KU80) mutant deficient for nonhomologous end joining is a powerful tool for analyzing pathogenicity in Aspergillus fumigatus, Eukaryot. Cell, 5, 207, 2006.
104. Steinbach, W.J., Cramer, R.A., Jr., Perfect, B.Z. et al., Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus, Eukaryot. Cell, 5, 1091, 2006.
105. Purnell, D.M., The effects of specific auxotrophic mutations on the virulence of Aspergillus nidulans for mice, Mycopathol. Mycol. Appl., 50, 195, 1973.
106. Brown, J.S., Aufauvre-Brown, A., Brown, J. et al., Signature-tagged and directed mutagenesis identify PABA synthetase as essential for Aspergillus fumigatus pathogenicity, Mol. Microbiol., 36, 1371, 2000.
107. d’Enfert, C., Diaquin, M., Delit, A. et al., Attenuated virulence of uridine-uracil auxotrophs of Aspergillus fumigatus, Infect. Immun., 64, 4401, 1996.
108. Liebmann, B., Mühleisen, T.W., Müller, M. et al., Deletion of the Aspergillus fumigatus lysine biosynthesis gene lysF encoding homoaconitase leads to attenuated virulence in a low-dose mouse infection model of invasive aspergillosis, Arch. Microbiol., 181, 378, 2004.
109. Maerker, C., Rohde, M., Brakhage, A.A. et al., Methylcitrate synthase from Aspergillus fumigatus. Propionyl-CoA affects polyketide synthesis, growth and morphology of conidia, FEBS J., 272, 3615, 2005.
110. Ebel, F., Schwienbacher, M., Beyer, J. et al., Analysis of the regulation, expression, and localisation of the isocitrate lyase from Aspergillus fumigatus, a potential target for antifungal drug development, Fungal Genet. Biol., 43, 476, 2006.
111. Hondmann, D.H. and Visser, J., Carbon metabolism, Prog. Ind. Microbiol., 29, 61, 1994.
112. Romano, A.H., Sugar transport systems of baker’s yeast and filamentous fungi, in Carbohydrate Metabolism in Cultured Cells, Morgan, E. J. (ed.), Plenum Press Co., New York, 1986, pp. 225.
113. Ruijter, G.J. and Visser, J., Carbon repression in Aspergilli, FEMS Microbiol. Lett., 151, 103, 1997.
114. Rhodes, J.C., Aspergillus fumigatus: growth and virulence, Med. Mycol., 44, Suppl 1, S77, 2006.
115. Krappmann, S. and Braus, G.H., Nitrogen metabolism of Aspergillus and its role in pathogenicity, Med. Mycol., 43 Suppl 1, S31, 2005.
116. Hensel, M., Arst, H.N., Jr., Aufauvre-Brown, A. et al., The role of the Aspergillus fumigatus areA gene in invasive pulmonary aspergillosis, Mol. Gen. Genet., 258, 553, 1998.
117. Panepinto, J.C., Oliver, B.G., Amlung, T.W. et al., Expression of the Aspergillus fumigatus rheb homologue, rhbA, is induced by nitrogen starvation, Fungal Genet. Biol., 36, 207, 2002.
118. Panepinto, J.C., Oliver, B.G., Fortwendel, J.R. et al., Deletion of the Aspergillus fumigatus gene encoding the Ras-related protein RhbA reduces virulence in a model of Invasive pulmonary aspergillosis, Infect. Immun., 71, 2819, 2003.
119. Natarajan, K., Meyer, M.R., Jackson, B.M. et al., Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast, Mol. Cell. Biol., 21, 4347, 2001.
120. Hinnebusch, A.G. and Natarajan, K., Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress, Eukaryot. Cell, 1, 22, 2002.
121. Yang, W., Kim, W.S., Fang, A. et al., Carbon and nitrogen source nutrition of fumagillin biosynthesis by Aspergillus fumigatus, Curr. Microbiol., 46, 275, 2003.
122. Nordstrom, U.M., Bark degradation by Aspergillus fumigatus. Growth studies, Can. J. Microbiol., 20, 283, 1974.
123. Santos, R., Firmino, A.A., de Sa, C.M. et al., Keratinolytic activity of Aspergillus fumigatus Fresenius, Curr. Microbiol., 33, 364, 1996.
124. Monod, M., Fatih, A., Jaton-Ogay, K. et al., The secreted proteases of pathogenic species of Aspergillus and their possible role in virulence., Can. J. Bot., 73, S1081, 1995.
125. Monod, M., Jaton-Ogay, K., and Reichard, U., Aspergillus fumigatus-secreted proteases as antigenic molecules and virulence factors, Contrib. Microbiol., 2, 182, 1999.
126. Frosco, M., Chase, T., Jr., and Macmillan, J.D., Purification and properties of the elastase from Aspergillus fumigatus, Infect. Immun., 60, 728, 1992.
127. Kolattukudy, P.E., Lee, J.D., Rogers, L.M. et al., Evidence for possible involvement of an elastolytic serine protease in aspergillosis, Infect. Immun., 61, 2357, 1993.
128. Larcher, G., Bouchara, J.P., Annaix, V. et al., Purification and characterization of a fibrinogenolytic serine proteinase from Aspergillus fumigatus culture filtrate, FEBS Lett., 308, 65, 1992.
129. Monod, M., Togni, G., Rahalison, L. et al., Isolation and characterisation of an extracellular alkaline protease of Aspergillus fumigatus, J. Med. Microbiol., 35, 23, 1991.
130. Reichard, U., Buttner, S., Eiffert, H. et al., Purification and characterisation of an extracellular serine proteinase from Aspergillus fumigatus and its detection in tissue, J. Med. Microbiol., 33, 243, 1990.
131. Monod, M., Paris, S., Sanglard, D. et al., Isolation and characterization of a secreted metalloprotease of Aspergillus fumigatus, Infect. Immun., 61, 4099, 1993.
132. Reichard, U., Eiffert, H., and Rüchel, R., Purification and characterization of an extracellular aspartic proteinase from Aspergillus fumigatus, J. Med. Vet. Mycol., 32, 427, 1994.
133. Jaton-Ogay, K., Suter, M., Crameri, R. et al., Nucleotide sequence of a genomic and a cDNA clone encoding an extracellular alkaline protease of Aspergillus fumigatus, FEMS Microbiol. Lett., 71, 163, 1992.
134. Monod, M., Paris, S., Sarfati, J. et al., Virulence of alkaline protease-deficient mutants of Aspergillus fumigatus, FEMS Microbiol. Lett., 106, 39, 1993.
135. Tang, C.M., Cohen, J., and Holden, D.W., An Aspergillus fumigatus alkaline protease mutant constructed by gene disruption is deficient in extracellular elastase activity, Mol. Microbiol., 6, 1663, 1992.
136. Jaton-Ogay, K., Paris, S., Huerre, M. et al., Cloning and disruption of the gene encoding an extracellular metalloprotease of Aspergillus fumigatus, Mol. Microbiol., 14, 917, 1994.
137. Sirakova, T.D., Markaryan, A., and Kolattukudy, P.E., Molecular cloning and sequencing of the cDNA and gene for a novel elastinolytic metalloproteinase from Aspergillus fumigatus and its expression in Escherichia coli, Infect. Immun., 62, 4208, 1994.
138. Monod, M., Capoccia, S., Lechenne, B. et al., Secreted proteases from pathogenic fungi, Int. J. Med. Microbiol., 292, 405, 2002.
139. Reichard, U., Cole, G.T., Hill, T.W. et al., Molecular characterization and influence on fungal development of ALP2, a novel serine proteinase from Aspergillus fumigatus, Int. J. Med. Microbiol., 290, 549, 2000.
140. Ibrahim-Granet, O. and d’Enfert, C., The Aspergillus fumigatus mepB gene encodes an 82 kDa intracellular metalloproteinase structurally related to mammalian thimet oligopeptidases, Microbiology, 143, 2247, 1997.
141. Ramesh, M.V., Sirakova, T.D., and Kolattukudy, P.E., Cloning and characterization of the cDNAs and genes (mep20) encoding homologous metalloproteinases from Aspergillus flavus and A. fumigatus, Gene, 165, 121, 1995.
142. Reichard, U., Cole, G.T., Rüchel, R. et al., Molecular cloning and targeted deletion of PEP2 which encodes a novel aspartic proteinase from Aspergillus fumigatus, Int. J. Med. Microbiol., 290, 85, 2000.
143. Beauvais, A., Monod, M., Debeaupuis, J.P. et al., Biochemical and antigenic characterization of a new dipeptidyl-peptidase isolated from Aspergillus fumigatus, J. Biol. Chem., 272, 6238, 1997.
144. Beauvais, A., Monod, M., Wyniger, J. et al., Dipeptidyl-peptidase IV secreted by Aspergillus fumigatus, a fungus pathogenic to humans, Infect. Immun., 65, 3042, 1997.
145. Shen, D.K., Noodeh, A.D., Kazemi, A. et al., Characterisation and expression of phospholipases B from the opportunistic fungus Aspergillus fumigatus, FEMS Microbiol. Lett., 239, 87, 2004.
146. Reichard, U., Monod, M., Odds, F. et al., Virulence of an aspergillopepsin-deficient mutant of Aspergillus fumigatus and evidence for another aspartic proteinase linked to the fungal cell wall, J. Med. Vet. Mycol., 35, 189, 1997.
147. Tang, C.M., Cohen, J., Krausz, T. et al., The alkaline protease of Aspergillus fumigatus is not a virulence determinant in two murine models of invasive pulmonary aspergillosis, Infect. Immun., 61, 1650, 1993.
148. Keller, N.P., Turner, G., and Bennett, J.W., Fungal secondary metabolism-from biochemistry to genomics, Nat. Rev. Microbiol., 3, 937, 2005.
149. Coyle, C.M. and Panaccione, D.G., An ergot alkaloid biosynthesis gene and clustered hypothetical genes from Aspergillus fumigatus, Appl. Environ. Microbiol., 71, 3112, 2005.
150. Bennett, J.W. and Klich, M., Mycotoxins, Clin. Microbiol. Rev., 16, 497, 2003.
151. Mitchell, C.G., Slight, J., and Donaldson, K., Diffusible component from the spore surface of the fungus Aspergillus fumigatus which inhibits the macrophage oxidative burst is distinct from gliotoxin and other hyphal toxins, Thorax, 52, 796, 1997.
152. Kamei, K., Watanabe, A., Nishimura, K. et al., Cytotoxicity of Aspergillus fumigatus culture filtrate against macrophages, Nippon Ishinkin Gakkai Zasshi, 43, 37, 2002.
153. Kamei, K. and Watanabe, A., Aspergillus mycotoxins and their effect on the host, Med. Mycol., 43 Suppl 1, S95, 2005.
154. Tsunawaki, S., Yoshida, L.S., Nishida, S. et al., Fungal metabolite gliotoxin inhibits assembly of the human respiratory burst NADPH oxidase, Infect. Immun., 72, 3373, 2004.
155. Watanabe, A., Kamei, K., Sekine, T. et al., Immunosuppressive substances in Aspergillus fumigatus culture filtrate, J. Infect. Chemother., 9, 114, 2003.
156. Wichmann, G., Herbarth, O., and Lehmann, I., The mycotoxins citrinin, gliotoxin, and patulin affect interferon-gamma rather than interleukin-4 production in human blood cells, Environ. Toxicol., 17, 211, 2002.
157. Yamada, A., Kataoka, T., and Nagai, K., The fungal metabolite gliotoxin: immunosuppressive activity on CTL-mediated cytotoxicity, Immunol. Lett., 71, 27, 2000.
158. Nieminen, S.M., Maki-Paakkanen, J., Hirvonen, M.R. et al., Genotoxicity of gliotoxin, a secondary metabolite of Aspergillus fumigatus, in a battery of short-term test systems, Mutat. Res., 520, 161, 2002.
159. Suen, Y.K., Fung, K.P., Lee, C.Y. et al., Gliotoxin induces apoptosis in cultured macrophages via production of reactive oxygen species and cytochrome c release without mitochondrial depolarization, Free. Radic. Res., 35, 1, 2001.
160. Cramer, R.A., Jr., Gamcsik, M.P., Brooking, R.M. et al., Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production, Eukaryot. Cell, 5, 972, 2006.
161. Schindler, D.G. and Davies, J.E., Specific cleavage of ribosomal RNA caused by alpha sarcin, Nucleic Acids Res., 4, 1097, 1977.
162. Lamy, B., Davies, J., and Schindler, D., The Aspergillus ribonucleolytic toxins (ribotoxins), Targeted Diagn. Ther., 7, 237, 1992.
163. Lamy, B., Moutaouakil, M., Latge, J.P. et al., Secretion of a potential virulence factor, a fungal ribonucleotoxin, during human aspergillosis infections, Mol. Microbiol., 5, 1811, 1991.
164. Kao, R., Martinez-Ruiz, A., Martinez del Pozo, A. et al., Mitogillin and related fungal ribotoxins, Methods Enzymol., 341, 324, 2001.
165. Smith, J.M., Davies, J.E., and Holden, D.W., Construction and pathogenicity of Aspergillus fumigatus mutants that do not produce the ribotoxin restrictocin, Mol. Microbiol., 9, 1071, 1993.
166. Smith, J.M., Tang, C.M., Van Noorden, S. et al., Virulence of Aspergillus fumigatus double mutants lacking restriction and an alkaline protease in a low-dose model of invasive pulmonary aspergillosis, Infect. Immun., 62, 5247, 1994.
167. Chauhan, N., Latge, J.P., and Calderone, R., Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus, Nat. Rev. Microbiol., 4, 435, 2006.
168. Calera, J.A., Paris, S., Monod, M. et al., Cloning and disruption of the antigenic catalase gene of Aspergillus fumigatus, Infect. Immun., 65, 4718, 1997.
169. Paris, S., Wysong, D., Debeaupuis, J.P. et al., Catalases of Aspergillus fumigatus, Infect. Immun., 71, 3551, 2003.
170. Fluckiger, S., Mittl, P.R., Scapozza, L. et al., Comparison of the crystal structures of the human manganese superoxide dismutase and the homologous Aspergillus fumigatus allergen at 2-Å resolution, J. Immunol., 168, 1267, 2002.
171. Holdom, M.D., Hay, R.J., and Hamilton, A.J., The Cu, Zn superoxide dismutases of Aspergillus flavus, Aspergillus niger, Aspergillus nidulans, and Aspergillus terreus: purification and biochemical comparison with the Aspergillus fumigatus Cu, Zn superoxide dismutase, Infect. Immun., 64, 3326, 1996.
172. Holdom, M.D., Lechenne, B., Hay, R.J. et al., Production and characterization of recombinant Aspergillus fumigatus Cu, Zn superoxide dismutase and its recognition by immune human sera, J. Clin. Microbiol., 38, 558, 2000.
173. Burns, C., Geraghty, R., Neville, C. et al., Identification, cloning, and functional expression of three glutathione transferase genes from Aspergillus fumigatus, Fungal Genet. Biol., 42, 319, 2005.
174. Reeves, E.P., Reiber, K., Neville, C. et al., A nonribosomal peptide synthetase (Pes1) confers protection against oxidative stress in Aspergillus fumigatus, FEBS J., 273, 3038, 2006.
175. Amitani, R., Taylor, G., Elezis, E.N. et al., Purification and characterization of factors produced by Aspergillus fumigatus which affect human ciliated respiratory epithelium, Infect. Immun., 63, 3266, 1995.
176. Tomee, J.F., Wierenga, A.T., Hiemstra, P.S. et al., Proteases from Aspergillus fumigatus induce release of proinflammatory cytokines and cell detachment in airway epithelial cell lines, J. Infect. Dis., 176, 300, 1997.
177. Robertson, M.D., Seaton, A., Milne, L.J. et al., Resistance of spores of Aspergillus fumigatus to ingestion by phagocytic cells, Thorax, 42, 466, 1987.
178. Robertson, M.D., Seaton, A., Milne, L.J. et al., Suppression of host defences by Aspergillus fumigatus, Thorax, 42, 19, 1987.
179. Robertson, M.D., Seaton, A., Raeburn, J.A. et al., Inhibition of phagocyte migration and spreading by spore diffusates of Aspergillus fumigatus, J. Med. Vet. Mycol., 25, 389, 1987.
180. Nicholson, W.J., Slight, J., and Donaldson, K., Inhibition of the transcription factors NF-kappa B and AP-1 underlies loss of cytokine gene expression in rat alveolar macrophages treated with a diffusible product from the spores of Aspergillus fumigatus, Am. J. Respir. Cell. Mol. Biol., 15, 88, 1996.
181. Bertout, S., Badoc, C., Mallie, M. et al., Spore diffusate isolated from some strains of Aspergillus fumigatus inhibits phagocytosis by murine alveolar macrophages, FEMS Immunol. Med. Microbiol., 33, 101, 2002.
182. Henwick, S., Hetherington, S.V., and Patrick, C.C., Complement binding to Aspergillus conidia correlates with pathogenicity, J. Lab. Clin. Med., 122, 27, 1993.
183. Washburn, R.G., DeHart, D.J., Agwu, D.E. et al., Aspergillus fumigatus complement inhibitor: production, characterization, and purification by hydrophobic interaction and thin-layer chromatography, Infect. Immun., 58, 3508, 1990.
184. Washburn, R.G., Hammer, C.H., and Bennett, J.E., Inhibition of complement by culture supernatants of Aspergillus fumigatus, J. Infect. Dis., 154, 944, 1986.
185. Funk, C.D., Prostaglandins and leukotrienes: advances in eicosanoid biology, Science, 294, 1871, 2001.
186. Noverr, M.C., Phare, S.M., Toews, G.B. et al., Pathogenic yeasts Cryptococcus neoformans and Candida albicans produce immunomodulatory prostaglandins, Infect. Immun., 69, 2957, 2001.
187. Tsitsigiannis, D.I., Bok, J.W., Andes, D. et al., Aspergillus cyclooxygenase-like enzymes are associated with prostaglandin production and virulence, Infect. Immun., 73, 4548, 2005.
188. Bell, A.A. and Wheeler, M.H., Biosynthesis and functions of fungal melanins., Annu. Rev. Phytopathol., 24, 411, 1986.
189. Brakhage, A.A., Langfelder, K., Wanner, G. et al., Pigment biosynthesis and virulence, Contrib. Microbiol., 2, 205, 1999.
190. Jahn, B., Koch, A., Schmidt, A. et al., Isolation and characterization of a pigmentless-conidium mutant of Aspergillus fumigatus with altered conidial surface and reduced virulence, Infect. Immun., 65, 5110, 1997.
191. Jahn, B., Langfelder, K., Schneider, U. et al., PKSP-dependent reduction of phagolysosome fusion and intracellular kill of Aspergillus fumigatus conidia by human monocyte-derived macrophages, Cell. Microbiol., 4, 793, 2002.
192. Langfelder, K., Jahn, B., Gehringer, H. et al., Identification of a polyketide synthase gene (pksP) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence, Med. Microbiol. Immunol. (Berl.), 187, 79, 1998.
193. Tsai, H.F., Chang, Y.C., Washburn, R.G. et al., The developmentally regulated alb1 gene of Aspergillus fumigatus: its role in modulation of conidial morphology and virulence, J. Bacteriol., 180, 3031, 1998.
194. Haas, H., Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage, Appl. Microbiol. Biotechnol., 62, 316, 2003.
195. 5-monooxygenase (sidA) and a nonribosomal peptide synthetase (sidC), Mol. Microbiol., 49, 359, 2003.
196. Oberegger, H., Zadra, I., Schoeser, M. et al., Identification of members of the Aspergillus nidulans SREA regulon: genes involved in siderophore biosynthesis and utilization, Biochem. Soc. Trans., 30, 781, 2002.
197. Schrettl, M., Bignell, E., Kragl, C. et al., Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence, J. Exp. Med., 200, 1213, 2004.
198. Keller, N., Bok, J.W., Chung, D. et al., LaeA, a global regulator of Aspergillus toxins, Med. Mycol., 2006.
199. Cornillet, A., Camus, C., Nimubona, S. et al., Comparison of epidemiological, clinical, and biological features of invasive aspergillosis in neutropenic and nonneutropenic patients: a 6-year survey, Clin. Infect. Dis., 43, 577, 2006.
200. Pagano, L., Caira, M., Candoni, A. et al., The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study, Haematologica, 91, 1068, 2006.
201. Weichel, M., Flückiger, S., and Crameri, R., Molecular characterization of mould allergens involved in respiratory complications., Rec. Devel. Resp. Crit. Care Med., 2, 29, 2002.
202. Azuma, I., Kimura, H., Hirao, F. et al., Biochemical and immunological studies on Aspergillus. III. Chemical and immunological properties of glycopeptide obtained from Aspergillus fumigatus, Jpn. J. Microbiol., 15, 237, 1971.
203. Reiss, E. and Lehmann, P.F., Galactomannan antigenemia in invasive aspergillosis, Infect. Immun., 25, 357, 1979.
204. Crameri, R., Limacher, A., Weichel, M. et al., Structural aspects and clinical relevance of Aspergillus fumigatus antigens/allergens, Med. Mycol., 2006.
205. Ronning, C.M., Fedorova, N.D., Bowyer, P. et al., Genomics of Aspergillus fumigatus, Rev. Iberoam. Micol., 22, 223, 2005.
206. Crameri, R., Epidemiology and molecular basis of the involvement of Aspergillus fumigatus in allergic diseases, Contrib. Microbiol., 2, 44, 1999.
207. Moser, M., Crameri, R., Brust, E. et al., Diagnostic value of recombinant Aspergillus fumigatus allergen I/a for skin testing and serology, J. Allergy Clin. Immunol., 93, 1, 1994.
208. Moser, M., Crameri, R., Menz, G. et al., Cloning and expression of recombinant Aspergillus fumigatus allergen I/a (rAsp f I/a) with IgE binding and type I skin test activity, J. Immunol., 149, 454, 1992.
209. Arruda, L.K., Platts-Mills, T.A., Fox, J.W. et al., Aspergillus fumigatus allergen I, a major IgE-binding protein, is a member of the mitogillin family of cytotoxins, J. Exp. Med., 172, 1529, 1990.
210. Madan, T., Priyadarsiny, P., Vaid, M. et al., Use of a synthetic peptide epitope of Asp f 1, a major allergen or antigen of Aspergillus fumigatus, for improved immunodiagnosis of allergic bronchopulmonary aspergillosis, Clin. Diagn. Lab. Immunol., 11, 552, 2004.
211. Crameri, R., Recombinant Aspergillus fumigatus allergens: from the nucleotide sequences to clinical applications, Int. Arch. Allergy Immunol., 115, 99, 1998.
212. Crameri, R. and Blaser, K., Cloning Aspergillus fumigatus allergens by the pJuFo filamentous phage display system, Int. Arch. Allergy Immunol., 110, 41, 1996.
213. Mayer, C., Hemmann, S., Faith, A. et al., Cloning, production, characterization and IgE cross-reactivity of different manganese superoxide dismutases in individuals sensitized to Aspergillus fumigatus, Int. Arch. Allergy Immunol., 113, 213, 1997.
214. Kurup, V.P., Xia, J.Q., Shen, H.D. et al., Alkaline serine proteinase from Aspergillus fumigatus has synergistic effects on Asp-f-2-induced immune response in mice, Int. Arch. Allergy Immunol., 129, 129, 2002.
215. Crameri, R., Hemmann, S., Ismail, C. et al., Disease-specific recombinant allergens for the diagnosis of allergic bronchopulmonary aspergillosis, Int. Immunol., 10, 1211, 1998.
216. Hemmann, S., Nikolaizik, W.H., Schoni, M.H. et al., Differential IgE recognition of recombinant Aspergillus fumigatus allergens by cystic fibrosis patients with allergic bronchopulmonary aspergillosis or Aspergillus allergy, Eur. J. Immunol., 28, 1155, 1998.
217. Galagan, J.E., Calvo, S.E., Cuomo, C. et al., Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae, Nature, 438, 1105, 2005.
218. Nierman, W.C., May, G., Kim, H.S. et al., What the Aspergillus genomes have told us, Med. Mycol., 43 Suppl 1, S3, 2005.
219. Machida, M., Asai, K., Sano, M. et al., Genome sequencing and analysis of Aspergillus oryzae, Nature, 438, 1157, 2005.
220. Zhang, L., Wang, M., Li, R. et al., Expression of Aspergillus fumigatus virulence-related genes detected in vitro and in vivo with competitive RT-PCR, Mycopathologia, 160, 201, 2005.
221. Cortez, K.J., Lyman, C.A., Kottilil, S. et al., Functional genomics of innate host defense molecules in normal human monocytes in response to Aspergillus fumigatus, Infect. Immun., 74, 2353, 2006.
222. Ferreira, M.E., Malavazi, I., Savoldi, M. et al., Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole, Curr. Genet., 50, 32, 2006.
223. Carberry, S., Neville, C.M., Kavanagh, K.A. et al., Analysis of major intracellular proteins of Aspergillus fumigatus by MALDI mass spectrometry: identification and characterisation of an elongation factor 1B protein with glutathione transferase activity, Biochem. Biophys. Res. Commun., 341, 1096, 2006.
224. Kniemeyer, O., Lessing, F., Scheibner, O. et al., Optimisation of a 2-D gel electrophoresis protocol for the human-pathogenic fungus Aspergillus fumigatus, Curr. Genet., 49, 178, 2006.
225. Schwienbacher, M., Weig, M., Thies, S. et al., Analysis of the major proteins secreted by the human opportunistic pathogen Aspergillus fumigatus under in vitro conditions, Med. Mycol., 43, 623, 2005.
226. Brakhage, A.A. and Langfelder, K., Menacing mold: the molecular biology of Aspergillus fumigatus, Annu. Rev. Microbiol., 56, 433, 2002.
227. Krappmann, S., Tools to study molecular mechanisms of Aspergillus pathogenicity, Trends Microbiol., 14, 356, 2006.