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Volumn 187, Issue 2, 1998, Pages 79-89

Identification of a polyketide synthase gene (pksP) of Aspergillus fumigatus involved in conidial pigment biosynthesis and virulence

Author keywords

Aspergillus fumigatus; Conidia; Pigment; Polyketide synthase; Virulence

Indexed keywords

REACTIVE OXYGEN METABOLITE; SYNTHETASE;

EID: 0031730240     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004300050077     Document Type: Article
Times cited : (239)

References (54)
  • 2
    • 0021889549 scopus 로고
    • General method for cloning Neurospora crassa nuclear genes by complementation of mutants
    • Akins RA, Lambowitz AM (1985) General method for cloning Neurospora crassa nuclear genes by complementation of mutants. Mol Cell Biol 5: 2272-2278
    • (1985) Mol Cell Biol , vol.5 , pp. 2272-2278
    • Akins, R.A.1    Lambowitz, A.M.2
  • 3
    • 0031164766 scopus 로고    scopus 로고
    • Autonomous plasmid replication in Aspergillus nidulans: AMA1 and MATE elements
    • Aleksenko A, Clutterbuck AJ (1997) Autonomous plasmid replication in Aspergillus nidulans: AMA1 and MATE elements. Fungal Genet Biol 21: 373-387
    • (1997) Fungal Genet Biol , vol.21 , pp. 373-387
    • Aleksenko, A.1    Clutterbuck, A.J.2
  • 4
    • 0017834531 scopus 로고
    • Oxygen-dependent microbial killing by phagocytes (first of two parts)
    • Babior BM (1978) Oxygen-dependent microbial killing by phagocytes (first of two parts). N Engl J Med 298: 659-668
    • (1978) N Engl J Med , vol.298 , pp. 659-668
    • Babior, B.M.1
  • 5
    • 0020586876 scopus 로고
    • Transformation of Aspergillus nidulans by the orotidine-5′-phosphate decarboxylase gene of Neurospora crassa
    • Ballance DJ, Buxton FP, Turner G (1983) Transformation of Aspergillus nidulans by the orotidine-5′-phosphate decarboxylase gene of Neurospora crassa. Biochem Biophys Res Commun 112: 284-289
    • (1983) Biochem Biophys Res Commun , vol.112 , pp. 284-289
    • Ballance, D.J.1    Buxton, F.P.2    Turner, G.3
  • 6
    • 0000772612 scopus 로고
    • Biosynthesis and functions of fungal melanins
    • Bell AA, Wheeler MH (1986) Biosynthesis and functions of fungal melanins. Annu Rev Phytopathol 24: 411-451
    • (1986) Annu Rev Phytopathol , vol.24 , pp. 411-451
    • Bell, A.A.1    Wheeler, M.H.2
  • 8
    • 0028021306 scopus 로고
    • Bidirectional gene transfer between Aspergillus fumigatus and Aspergillus nidulans
    • Borgia PT, Dodge CL, Eagleton LE, Adams TH (1994) Bidirectional gene transfer between Aspergillus fumigatus and Aspergillus nidulans. FEMS Microbiol Lett 122: 227-232
    • (1994) FEMS Microbiol Lett , vol.122 , pp. 227-232
    • Borgia, P.T.1    Dodge, C.L.2    Eagleton, L.E.3    Adams, T.H.4
  • 11
    • 0030873053 scopus 로고    scopus 로고
    • Genetic diversity among clinical and environmental isolates of Aspergillus fumigatus
    • Debeaupuis J-P, Sarfati J, Chazalet V, Latgé J-P (1997) Genetic diversity among clinical and environmental isolates of Aspergillus fumigatus. Infect Immun 65: 3080-3085
    • (1997) Infect Immun , vol.65 , pp. 3080-3085
    • Debeaupuis, J.-P.1    Sarfati, J.2    Chazalet, V.3    Latgé, J.-P.4
  • 13
    • 0028141419 scopus 로고
    • Invasive aspergillosis in immunocompromised patients
    • Denning DW (1994) Invasive aspergillosis in immunocompromised patients. Curr Opin Infect Dis 7: 456-462
    • (1994) Curr Opin Infect Dis , vol.7 , pp. 456-462
    • Denning, D.W.1
  • 14
    • 84907132717 scopus 로고
    • Pathogenicity and virulence of wild-type and melanin-deficient Wangiella dermatitidis
    • Dixon DM, Polak A, Szaniszlo PJ (1987) Pathogenicity and virulence of wild-type and melanin-deficient Wangiella dermatitidis. J Med Vet Mycol 25: 97-106
    • (1987) J Med Vet Mycol , vol.25 , pp. 97-106
    • Dixon, D.M.1    Polak, A.2    Szaniszlo, P.J.3
  • 16
    • 0028802415 scopus 로고
    • Characterization of the polyketide synthase gene (pksL1) required for aflatoxin biosynthesis in Aspergillus parasiticus
    • Feng GH, Leonard TJ (1995) Characterization of the polyketide synthase gene (pksL1) required for aflatoxin biosynthesis in Aspergillus parasiticus. J Bacteriol 177: 6246-6254
    • (1995) J Bacteriol , vol.177 , pp. 6246-6254
    • Feng, G.H.1    Leonard, T.J.2
  • 17
    • 0027742655 scopus 로고
    • Co-transformation with autonomously-replicating helper plasmids facilitates gene cloning from an Aspergillus nidulans gene library
    • Gems DH, Clutterbuck AJ (1993) Co-transformation with autonomously-replicating helper plasmids facilitates gene cloning from an Aspergillus nidulans gene library. Curr Genet 24: 520-524
    • (1993) Curr Genet , vol.24 , pp. 520-524
    • Gems, D.H.1    Clutterbuck, A.J.2
  • 18
    • 0002949582 scopus 로고
    • The structure and organisation of nuclear genes of filamentous fungi
    • Kinghorn JR (ed). IRL Press, Oxford
    • Gurr SJ, Unkles SE, Kinghorn JR (1987) The structure and organisation of nuclear genes of filamentous fungi. In: Kinghorn JR (ed) Gene structure in eukuryotic microbes. IRL Press, Oxford, pp 93-139
    • (1987) Gene Structure in Eukuryotic Microbes , pp. 93-139
    • Gurr, S.J.1    Unkles, S.E.2    Kinghorn, J.R.3
  • 19
    • 0027284157 scopus 로고
    • Complement binding to Aspergillus conidia correlates with pathogenicity
    • Henwick S, Hetherington SV, Patrie CC (1993) Complement binding to Aspergillus conidia correlates with pathogenicity. J Lab Clin Med 122: 27-35
    • (1993) J Lab Clin Med , vol.122 , pp. 27-35
    • Henwick, S.1    Hetherington, S.V.2    Patrie, C.C.3
  • 21
    • 0028811381 scopus 로고
    • Polyketide synthase gene manipulation: A structure-function approach in engineering novel antibiotics
    • Hutchinson CR, Fujii I (1995) Polyketide synthase gene manipulation: a structure-function approach in engineering novel antibiotics. Annu Rev Microbiol 49: 201-238
    • (1995) Annu Rev Microbiol , vol.49 , pp. 201-238
    • Hutchinson, C.R.1    Fujii, I.2
  • 22
    • 0027384213 scopus 로고
    • Antioxidant function of fungal melanin
    • Jacobson ES, Tinnell SB (1993) Antioxidant function of fungal melanin. J Bacteriol 175: 7102-7104
    • (1993) J Bacteriol , vol.175 , pp. 7102-7104
    • Jacobson, E.S.1    Tinnell, S.B.2
  • 23
    • 0028786391 scopus 로고
    • Antioxidant function of melanin in black fungi
    • Jacobson ES, Hove E, Emery HS (1995) Antioxidant function of melanin in black fungi. Infect Immun 63: 4944-4945
    • (1995) Infect Immun , vol.63 , pp. 4944-4945
    • Jacobson, E.S.1    Hove, E.2    Emery, H.S.3
  • 24
    • 0030729225 scopus 로고    scopus 로고
    • Isolation and characterisation of an Aspergillus fumigatus mutant strain with pigmentless conidia and reduced virulence
    • Jahn B, Koch A, Schmidt A, Wanner G, Gehringer H, Bhakdi S, Brakhage AA (1997) Isolation and characterisation of an Aspergillus fumigatus mutant strain with pigmentless conidia and reduced virulence. Infect Immun 65: 5110-5117
    • (1997) Infect Immun , vol.65 , pp. 5110-5117
    • Jahn, B.1    Koch, A.2    Schmidt, A.3    Wanner, G.4    Gehringer, H.5    Bhakdi, S.6    Brakhage, A.A.7
  • 25
    • 0024428511 scopus 로고
    • Activation of C3 and binding to Aspergillus fumigatus conidia and hyphae
    • Kozel TR, Wilson MA, Farrell TP, Levitz SM (1989) Activation of C3 and binding to Aspergillus fumigatus conidia and hyphae. Infect Immun 57: 3412-3417
    • (1989) Infect Immun , vol.57 , pp. 3412-3417
    • Kozel, T.R.1    Wilson, M.A.2    Farrell, T.P.3    Levitz, S.M.4
  • 26
    • 0003150971 scopus 로고
    • Melanin biosynthesis: Prerequisite for successful invasion of the plant host by appressoria of Colletotrichum and Pyricularia
    • Cole GT, Hoch HC (eds). Plenum Press, New York
    • Kubo Y, Furusawa I (1991) Melanin biosynthesis: prerequisite for successful invasion of the plant host by appressoria of Colletotrichum and Pyricularia. In: Cole GT, Hoch HC (eds) The fungal spore and disease initiation in plants and animals. Plenum Press, New York, pp 205-217
    • (1991) The Fungal Spore and Disease Initiation in Plants and Animals , pp. 205-217
    • Kubo, Y.1    Furusawa, I.2
  • 27
    • 0022635758 scopus 로고
    • Encapsulation and melanin formation as indicators of virulence in Cryptococcus neoformans
    • Kwon-Chung KJ, Rhodes JC (1986) Encapsulation and melanin formation as indicators of virulence in Cryptococcus neoformans. Infect Immun 51: 218-223
    • (1986) Infect Immun , vol.51 , pp. 218-223
    • Kwon-Chung, K.J.1    Rhodes, J.C.2
  • 28
    • 0020316973 scopus 로고
    • Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice
    • Kwon-Chung KJ, Polacheck I, Popkin TJ (1982) Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice. J Bacteriol 150: 1414-1421
    • (1982) J Bacteriol , vol.150 , pp. 1414-1421
    • Kwon-Chung, K.J.1    Polacheck, I.2    Popkin, T.J.3
  • 29
    • 0025010497 scopus 로고
    • Isolation and molecular characterisation of the Aspergillus nidulans wA gene
    • Mayorga ME, Timberlake WE (1990) Isolation and molecular characterisation of the Aspergillus nidulans wA gene. Genetics 126: 73-79
    • (1990) Genetics , vol.126 , pp. 73-79
    • Mayorga, M.E.1    Timberlake, W.E.2
  • 30
    • 0026723218 scopus 로고
    • The developmentally regulated Aspergillus nidulans wa gene encodes a polypeptide homologous to polyketide and fatty acid synthases
    • Mayorga ME, Timberlake WE (1992) The developmentally regulated Aspergillus nidulans wA gene encodes a polypeptide homologous to polyketide and fatty acid synthases. Mol Gen Genet 235: 205-212
    • (1992) Mol Gen Genet , vol.235 , pp. 205-212
    • Mayorga, M.E.1    Timberlake, W.E.2
  • 32
    • 0017082126 scopus 로고
    • Sources and incidence of airborne Aspergillus fumigatus (Fres.)
    • Mullins J, Harvey R, Seaton A (1976) Sources and incidence of airborne Aspergillus fumigatus (Fres.). Clin Allergy 6: 209-217
    • (1976) Clin Allergy , vol.6 , pp. 209-217
    • Mullins, J.1    Harvey, R.2    Seaton, A.3
  • 33
    • 0023772260 scopus 로고
    • Fungal infections of the immunocompromised host: Clinical and laboratory aspects
    • Musial CE, Cockerill FR, Roberts GD (1988) Fungal infections of the immunocompromised host: clinical and laboratory aspects. Clin Microbiol Rev 1: 349-364
    • (1988) Clin Microbiol Rev , vol.1 , pp. 349-364
    • Musial, C.E.1    Cockerill, F.R.2    Roberts, G.D.3
  • 34
    • 0028358576 scopus 로고
    • A versatile shuttle cosmid vector for the efficient construction of genomic libraries and for the cloning of fungal genes
    • Osiewacz HD (1994) A versatile shuttle cosmid vector for the efficient construction of genomic libraries and for the cloning of fungal genes. Curr Genet 26: 87-90
    • (1994) Curr Genet , vol.26 , pp. 87-90
    • Osiewacz, H.D.1
  • 35
    • 0023512725 scopus 로고
    • Transformation of Aspergillus based on the hygromycin B resistance marker from Escherichia coli
    • Punt PJ, Oliver RP, Dingemanse MA, Powels PH, van den Hondel CAMJJ (1987) Transformation of Aspergillus based on the hygromycin B resistance marker from Escherichia coli. Gene 56: 117-124
    • (1987) Gene , vol.56 , pp. 117-124
    • Punt, P.J.1    Oliver, R.P.2    Dingemanse, M.A.3    Powels, P.H.4    Van Den Hondel, C.A.M.J.J.5
  • 39
    • 0028866847 scopus 로고
    • Structural analysis of PKS1, a polyketide synthase gene involved in melanin biosynthesis in Colletotrichum lagenarium
    • Takano Y, Kubo Y, Shimizu K, Mise K, Okuno T, Furusawa I (1995) Structural analysis of PKS1, a polyketide synthase gene involved in melanin biosynthesis in Colletotrichum lagenarium. Mol Gen Genet 249: 162-167
    • (1995) Mol Gen Genet , vol.249 , pp. 162-167
    • Takano, Y.1    Kubo, Y.2    Shimizu, K.3    Mise, K.4    Okuno, T.5    Furusawa, I.6
  • 40
    • 0026660149 scopus 로고
    • An Aspergillus fumigatus alkaline protease mutant constructed by gene disruption is deficient in extracellular elastase activity
    • Tang CM, Cohen J, Holden DW (1992) An Aspergillus fumigatus alkaline protease mutant constructed by gene disruption is deficient in extracellular elastase activity. Mol Microbiol 6: 1663-1671
    • (1992) Mol Microbiol , vol.6 , pp. 1663-1671
    • Tang, C.M.1    Cohen, J.2    Holden, D.W.3
  • 41
    • 0025053058 scopus 로고
    • Insertional inactivation and cloning of the wA gene of Aspergillus nidulans
    • Tilburn J, Roussel F, Scazzocchio C (1990) Insertional inactivation and cloning of the wA gene of Aspergillus nidulans. Genetics 126: 81-90
    • (1990) Genetics , vol.126 , pp. 81-90
    • Tilburn, J.1    Roussel, F.2    Scazzocchio, C.3
  • 42
    • 0030844004 scopus 로고    scopus 로고
    • Aspergillus fumigatus arp1 modulates conidial pigmentation and complement deposition
    • Tsai H-F, Washburn RG, Chang YC, Kwon-Chung KJ (1997) Aspergillus fumigatus arp1 modulates conidial pigmentation and complement deposition. Mol Microbiol 26: 175-183
    • (1997) Mol Microbiol , vol.26 , pp. 175-183
    • Tsai, H.-F.1    Washburn, R.G.2    Chang, Y.C.3    Kwon-Chung, K.J.4
  • 43
    • 0031801247 scopus 로고    scopus 로고
    • The developmentally regulated alb1 gene of Aspergillus fumigatus: Its role in modulation of conidial morphology and virulence
    • Tsai H-F, Yun CC, Washburn RG, Wheeler MH, Kwon-Chung KJ (1998) The developmentally regulated alb1 gene of Aspergillus fumigatus: its role in modulation of conidial morphology and virulence. J Bacteriol 180: 3031-3038
    • (1998) J Bacteriol , vol.180 , pp. 3031-3038
    • Tsai, H.-F.1    Yun, C.C.2    Washburn, R.G.3    Wheeler, M.H.4    Kwon-Chung, K.J.5
  • 44
    • 0024353993 scopus 로고
    • Nosocomial aspergillosis: Environmental microbiology, hospital epidemiology, diagnosis and treatment
    • Walsh TJ, Dixon DM (1989) Nosocomial aspergillosis: environmental microbiology, hospital epidemiology, diagnosis and treatment. Eur J Epidemiol 5: 131-142
    • (1989) Eur J Epidemiol , vol.5 , pp. 131-142
    • Walsh, T.J.1    Dixon, D.M.2
  • 45
    • 0028356443 scopus 로고
    • Susceptibility of melanized and nonmelanized Cryptococcus neoformans to nitrogen- and oxygen-derived oxidants
    • Wang Y, Casadevall A (1994) Susceptibility of melanized and nonmelanized Cryptococcus neoformans to nitrogen- and oxygen-derived oxidants. Infect Immun 62: 3004-3007
    • (1994) Infect Immun , vol.62 , pp. 3004-3007
    • Wang, Y.1    Casadevall, A.2
  • 46
    • 0029131284 scopus 로고
    • Cryptococcus neoformans melanin and virulence: Mechanism of action
    • Wang Y, Aisen P, Casadevall A (1995) Cryptococcus neoformans melanin and virulence: mechanism of action. Infect Immun 63: 3131-3136
    • (1995) Infect Immun , vol.63 , pp. 3131-3136
    • Wang, Y.1    Aisen, P.2    Casadevall, A.3
  • 47
    • 0023191977 scopus 로고
    • Oxidative killing of Aspergillus fumigatus proceeds by parallel myeloperoxidase-dependent and -independent pathways
    • Washburn RG, Gallin JI, Bennett JE (1987) Oxidative killing of Aspergillus fumigatus proceeds by parallel myeloperoxidase-dependent and -independent pathways. Infect Immun 55: 2088-2092
    • (1987) Infect Immun , vol.55 , pp. 2088-2092
    • Washburn, R.G.1    Gallin, J.I.2    Bennett, J.E.3
  • 48
    • 0025779163 scopus 로고
    • Protein kinase-C-dependent and -independent activation of the NADPH oxidase of human neutrophils
    • Watson F, Robinson J, Edwards SW (1991) Protein kinase-C-dependent and -independent activation of the NADPH oxidase of human neutrophils. J Biol Chem 266: 7432-7439
    • (1991) J Biol Chem , vol.266 , pp. 7432-7439
    • Watson, F.1    Robinson, J.2    Edwards, S.W.3
  • 49
    • 0031861605 scopus 로고    scopus 로고
    • Development of a homologous transformation system for the human pathogenic fungus Aspergillus fumigatus based on the pyrG gene encoding orotidine monophosphate decarhoxylase
    • Weidner G, d'Enfert C, Koch A, Mol P, Brakhage AA (1998) Development of a homologous transformation system for the human pathogenic fungus Aspergillus fumigatus based on the pyrG gene encoding orotidine monophosphate decarhoxylase. Curr Genet 33: 378-385
    • (1998) Curr Genet , vol.33 , pp. 378-385
    • Weidner, G.1    D'Enfert, C.2    Koch, A.3    Mol, P.4    Brakhage, A.A.5
  • 50
    • 0023739789 scopus 로고
    • Melanins and their importance in pathogenic fungi
    • McGinnis MR (ed). Springer, New York
    • Wheeler MH, Bell AA (1988) Melanins and their importance in pathogenic fungi. In: McGinnis MR (ed) Current topics in medical mycology. Springer, New York, pp 338-387
    • (1988) Current Topics in Medical Mycology , pp. 338-387
    • Wheeler, M.H.1    Bell, A.A.2
  • 51
    • 0002446058 scopus 로고
    • The effects of tricyclazole, pyroquilon, phthalide, and related fungicides on the production of conidial wall pigments by Penicillium and Aspergillus species
    • Wheeler MH, Klich MA (1995) The effects of tricyclazole, pyroquilon, phthalide, and related fungicides on the production of conidial wall pigments by Penicillium and Aspergillus species. Pestic Biochem Physiol 52: 125-136
    • (1995) Pestic Biochem Physiol , vol.52 , pp. 125-136
    • Wheeler, M.H.1    Klich, M.A.2
  • 52
    • 85052235242 scopus 로고
    • Target sites of melanin biosynthesis inhibitors
    • Koller W (ed). CRC Press, London
    • Yamaguchi I, Kubo Y (1992) Target sites of melanin biosynthesis inhibitors. In: Koller W (ed) Target sites of fungicide action. CRC Press, London, pp 101-118
    • (1992) Target Sites of Fungicide Action , pp. 101-118
    • Yamaguchi, I.1    Kubo, Y.2
  • 53
    • 0029143685 scopus 로고
    • Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase
    • Yu J-H, Leonard TJ (1995) Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase. J Bacteriol 177: 4792-1800
    • (1995) J Bacteriol , vol.177 , pp. 4792-11800
    • Yu, J.-H.1    Leonard, T.J.2
  • 54
    • 0022642278 scopus 로고
    • Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Diagnostic features and outcome of treatment
    • Zuger A, Louie E, Holzman RS, Simberkoff MS, Rahal JJ (1986) Cryptococcal disease in patients with the acquired immunodeficiency syndrome. Diagnostic features and outcome of treatment. Ann Intern Med 104: 234-240
    • (1986) Ann Intern Med , vol.104 , pp. 234-240
    • Zuger, A.1    Louie, E.2    Holzman, R.S.3    Simberkoff, M.S.4    Rahal, J.J.5


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