Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model

Bioscience, Biotechnology and Biochemistry

Volumn 74, Issue 11, 2010, Pages 2299-2306

  Urata, Nakaba M ^a,b   Urakami, Kazuma M ^a,c   Zawa, Yusuke O ^a   Inoshita, Noriaki K ^d   Rie, Kazuhiro I ^c   Shirasawa, Takuji ^e   Shimizu, Takahiko ^a,b  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d Immuno Biological Laboratories Co Ltd   (Japan)

^e JUNTENDO UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; Amyloid ; Mouse model; Silymarin

Indexed keywords

ALZHEIMER'S DISEASE; AMYLOID PRECURSOR PROTEINS; BEHAVIORAL CHANGES; COGNITIVE IMPAIRMENT; FIBRIL FORMATION; IN-VITRO; IN-VIVO; LIVER DISEASE; MEDICINAL HERB; MOUSE MODELS; NEUROTOXICITY; PC12 CELLS; SENILE PLAQUES; SILYMARIN; TRANSGENIC MICE;

BEHAVIORAL RESEARCH; DISEASES; GLYCOPROTEINS; OLIGOMERS;

PLANTS (BOTANY);

PROTECTIVE AGENT; SILYMARIN;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL; ARTICLE; CELL STRAIN; DISEASE MODEL; MENTAL DISEASE; MOUSE; RAT; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ANIMALS; DISEASE MODELS, ANIMAL; MENTAL DISORDERS; MICE; MICE, TRANSGENIC; PC12 CELLS; PLAQUE, AMYLOID; PROTECTIVE AGENTS; RATS; SILYMARIN;

MUS; MUS MUSCULUS; SILYBUM MARIANUM;

EID: 78649763592     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.100524     Document Type: Article

References (61)

1. Glenner GG and Wong CW, Biochem. Biophys. Res. Commun., 120, 885-890 (1984).
2. Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, and Beyreuther K, Proc. Natl. Acad. Sci. USA, 82, 4245-4249 (1985).
3. Haass C and Selkoe DJ, Nat. Rev. Mol. Cell Biol., 8, 101-112 (2007).
4. Murakami K, Masuda Y, Shirasawa T, Shimizu T, and Irie K, Geriatr. Gerontol. Int., 10, S169-S179 (2010).
5. Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, and Selkoe DJ, Nature, 416, 535-539 (2002).
6. Roychaudhuri R, Yang M, Hoshi MM, and Teplow DB, J. Biol. Chem., 284, 4749-4753 (2009).
7. Pietta PG, J. Nat. Prod., 63, 1035-1042 (2000).
8. Morillas-Ruiz JM, Villegas Garcia JA, Lopez FJ, Vidal-Guevara ML, and Zafrilla P, Clin. Nutr., 25, 444-453 (2006).
9. Duthie GG, Gardner PT, and Kyle JA, Proc. Nutr. Soc., 62, 599-603 (2003).
10. Porat Y, Abramowitz A, and Gazit E, Chem. Biol. Drug Des., 67, 27-37 (2006).
11. Ono K, Hamaguchi T, Naiki H, and Yamada M, Biochim. Biophys. Acta, 1762, 575-586 (2006).
12. Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, and Cole GM, J. Biol. Chem., 280, 5892-5901 (2005).
13. Baum L, Lam CW, Cheung SK, Kwok T, Lui V, Tsoh J, Lam L, Leung V, Hui E, Ng C, Woo J, Chiu HF, Goggins WB, Zee BC, Cheng KF, Fong CY, Wong A, Mok H, Chow MS, Ho PC, Ip SP, Ho CS, Yu XW, Lai CY, Chan MH, Szeto S, Chan IH, and Mok V, J. Clin. Psychopharmacol., 28, 110-113 (2008).
14. Lee JI, Narayan M, and Barrett JS, J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 845, 95-103 (2007).
15. Saller R, Melzer J, Reichling J, Brignoli R, and Meier R, Forsch. Komplementmed., 14, 70-80 (2007).
16. Morazzoni P, Montalbetti A, Malandrino S, and Pifferi G, Eur. J. Drug Metab. Pharmacokinet., 18, 289-297 (1993).
17. Valenzuela A, Barria T, Guerra R, and Garrido A, Biochem. Biophys. Res. Commun., 126, 712-718 (1985).
18. Mucke L, Masliah E, Yu GQ, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, and McConlogue L, J. Neurosci., 20, 4050-4058 (2000).
19. Murakami K, Irie K, Morimoto A, Ohigashi H, Shindo M, Nagao M, Shimizu T, and Shirasawa T, Biochem. Biophys. Res. Commun., 294, 5-10 (2002).
20. Naiki H and Gejyo F, Methods Enzymol., 309, 305-318 (1999).
21. Murakami K, Irie K, Morimoto A, Ohigashi H, Shindo M, Nagao M, Shimizu T, and Shirasawa T, J. Biol. Chem., 278, 46179-46187 (2003).
22. Masuda Y, Nakanishi A, Ohashi R, Takegoshi K, Shimizu T, Shirasawa T, and Irie K, Biosci. Biotechnol. Biochem., 72, 2170-2175 (2008).
23. Shearman MS, Ragan CI, and Iversen LL, Proc. Natl. Acad. Sci. USA, 91, 1470-1474 (1994).
24. Sanchez-Mejia RO, Newman JW, Toh S, Yu GQ, Zhou Y, Halabisky B, Cisse M, Scearce-Levie K, Cheng IH, Gan L, Palop JJ, Bonventre JV, and Mucke L, Nat. Neurosci., 11, 1311-1318 (2008).
25. Meilandt WJ, Yu GQ, Chin J, Roberson ED, Palop JJ, Wu T, Scearce-Levie K, and Mucke L, J. Neurosci., 28, 5007-5017 (2008).
26. Satoh Y, Endo S, Ikeda T, Yamada K, Ito M, Kuroki M, Hiramoto T, Imamura O, Kobayashi Y, Watanabe Y, Itohara S, and Takishima K, J. Neurosci., 27, 10765-10776 (2007).
27. Hudson SA, Ecroyd H, Kee TW, and Carver JA, FEBS J., 276, 5960-5972 (2009).
28. Forloni G, Curr. Opin. Neurol., 9, 492-500 (1996).
29. Kowall NW, Neurobiol. Aging, 15, 257-258 (1994).
30. Morimoto A, Irie K, Murakami K, Masuda Y, Ohigashi H, Nagao M, Fukuda H, Shimizu T, and Shirasawa T, J. Biol. Chem., 279, 52781-52788 (2004).
31. Murakami K, Hara H, Masuda Y, Ohigashi H, and Irie K, Chembiochem, 8, 2308-2314 (2007).
32. Murakami K, Irie K, Ohigashi H, Hara H, Nagao M, Shimizu T, and Shirasawa T, J. Am. Chem. Soc., 127, 15168-15174 (2005).
33. Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, and Selkoe DJ, Arch. Neurol., 66, 190-199 (2009).
34. Itagaki S, McGeer PL, Akiyama H, Zhu S, and Selkoe D, J. Neuroimmunol., 24, 173-182 (1989).
35. Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, and Cole GM, Am. J. Pathol., 152, 307-317 (1998).
36. Stalder M, Phinney A, Probst A, Sommer B, Staufenbiel M, and Jucker M, Am. J. Pathol., 154, 1673-1684 (1999).
37. Bornemann KD, Wiederhold KH, Pauli C, Ermini F, Stalder M, Schnell L, Sommer B, Jucker M, and Staufenbiel M, Am. J. Pathol., 158, 63-73 (2001).
38. Matsuoka Y, Picciano M, Malester B, La Francois J, Zehr C, Daeschner JM, Olschowka JA, Fonseca MI, O'Banion MK, Tenner AJ, Lemere CA, and Duff K, Am. J. Pathol., 158, 1345-1354 (2001).
39. Yao Y, Chinnici C, Tang H, Trojanowski JQ, Lee VM, and Pratico D, J. Neuroinflammation, 1, 21 (2004).
40. Steward O, Loesche J, and Horton WC, Brain Res. Bull., 2, 41-48 (1977).
41. Pellow S, Chopin P, File SE, and Briley M, J. Neurosci. Methods, 14, 149-167 (1985).
42. Assal F and van der Meulen M, Front. Neurol. Neurosci., 24, 54-65 (2009).
43. Millard CB and Broomfield CA, J. Neurochem., 64, 1909-1918 (1995).
44. Barner EL and Gray SL, Ann. Pharmacother., 32, 70-77 (1998).
45. Vaknin Y, Hadas R, Schafferman D, Murkhovsky L, and Bashan N, Int. J. Food Sci. Nutr., 59, 339-346 (2008).
46. Flora K, Hahn M, Rosen H, and Benner K, Am. J. Gastroenterol., 93, 139-143 (1998).
47. Gazak R, Walterova D, and Kren V, Curr. Med. Chem., 14, 315-338 (2007).
48. Kaur M and Agarwal R, Toxicol. Appl. Pharmacol., 224, 350-359 (2007).
49. Shalan MG, Mostafa MS, Hassouna MM, El-Nabi SE, and El-Refaie A, Toxicology, 206, 1-15 (2005).
50. Svobodova A, Zdarilova A, Maliskova J, Mikulkova H, Walterova D, and Vostalova J, J. Dermatol. Sci., 46, 21-30 (2007).
51. Wang J, Ho L, Zhao W, Ono K, Rosensweig C, Chen L, Humala N, Teplow DB, and Pasinetti GM, J. Neurosci., 28, 6388-6392 (2008).
52. Hamaguchi T, Ono K, Murase A, and Yamada M, Am. J. Pathol., 175, 2557-2565 (2009).
53. Starvaggi Cucuzza L, Motta M, Miretti S, Macchi E, Martignani E, Accornero P, and Baratta M, J. Anim. Physiol. Anim. Nutr. (Berl.), 94, 111-117 (2010).
54. Meeran SM and Katiyar SK, Front. Biosci., 13, 2191-2202 (2008).
55. Wang MJ, Lin WW, Chen HL, Chang YH, Ou HC, Kuo JS, Hong JS, and Jeng KC, Eur. J. Neurosci., 16, 2103-2112 (2002).
56. Espana J, Gimenez-Llort L, Valero J, Minano A, Rabano A, Rodriguez-Alvarez J, Laferla FM, and Saura CA, Biol. Psychiatry, 67, 513-521 (2010).
57. Lu P, Mamiya T, Lu LL, Mouri A, Zou L, Nagai T, Hiramatsu M, Ikejima T, and Nabeshima T, Br. J. Pharmacol., 157, 1270-1277 (2009).
58. Lu P, Mamiya T, Lu LL, Mouri A, Niwa M, Hiramatsu M, Zou LB, Nagai T, Ikejima T, and Nabeshima T, J. Pharmacol. Exp. Ther., 331, 319-326 (2009).
59. Martins IJ, Berger T, Sharman MJ, Verdile G, Fuller SJ, and Martins RN, J. Neurochem., 111, 1275-1308 (2009).
60. Helzner EP, Luchsinger JA, Scarmeas N, Cosentino S, Brickman AM, Glymour MM, and Stern Y, Arch. Neurol., 66, 343-348 (2009).
61. Huseini HF, Larijani B, Heshmat R, Fakhrzadeh H, Radjabipour B, Toliat T, and Raza M, Phytother. Res., 20, 1036-1039 (2006).+