Verification of the intermolecular parallel β-sheet in E22K-Aβ42 aggregates by solid-state NMR using rotational resonance: Implications for the supramolecular arrangement of the toxic conformer of Aβ42

Bioscience, Biotechnology and Biochemistry

Volumn 72, Issue 8, 2008, Pages 2170-2175

  Masuda, Yuichi ^a   Nakanishi, Azusa ^a   Ohashi, Ryutaro ^a   Takegoshi, Kiyonori ^a   Shimizu, Takahiko ^b,c   Shirasawa, Takuji ^b,d   Irie, Kazuhiro ^a  

^a KYOTO UNIVERSITY   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^d JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

A 42; Alzheimer's disease; Intermolecular parallel sheet; Italian mutation; Solid state NMR

Indexed keywords

AGGLOMERATION; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TOXIC MATERIALS;

ALZHEIMER'S DISEASE; ITALIAN MUTATION; ROTATIONAL RESONANCE; SOLID-STATE NMR; SUPRAMOLECULAR ARRANGEMENTS;

AGGREGATES;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); GLUTAMIC ACID; LYSINE; PEPTIDE FRAGMENT;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE; PROTEIN SECONDARY STRUCTURE; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

AMYLOID BETA-PROTEIN; GLUTAMIC ACID; LYSINE; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY;

EID: 50649115134     PISSN: 09168451     EISSN: 13476947     Source Type: Journal    
DOI: 10.1271/bbb.80250     Document Type: Article

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