A novel synthetic compound PHID (8-Phenyl-6a, 7, 8, 9, 9a, 10-hexahydro-6H-isoindolo [5, 6-g] quinoxaline-7, 9-dione) protects SH-SY5Y cells against MPP+-induced cytotoxicity through inhibition of reactive oxygen species generation and JNK signaling

European Journal of Pharmacology

Volumn 650, Issue 1, 2011, Pages 48-57

  Kim, In Su ^a   Koppula, Sushruta ^a   Kim, Byung Wook ^a   Song, Min Dong ^a   Jung, Ju Yeon ^a   Lee, Gwang ^b   Lee, Hee Soon ^c   Choi, Dong Kug ^a  

^a Konkuk University   (South Korea)

^b Ajou University   (South Korea)

^c Chungbuk National University   (South Korea)

Author keywords

Apoptosis; Cytotoxicity; MPP+; Parkinson's disease; PHID; Reactive oxygen species

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; 8 PHENYL 6A,7,8,9,9A,10 HEXAHYDRO 6H ISOINDOLO[5,6 G]QUINOXALINE 7,9 DIONE; CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; QUINOXALINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DEGENERATIVE DISEASE; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; MOUSE; NEUROBLASTOMA CELL; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

1-METHYL-4-PHENYLPYRIDINIUM; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; ISOINDOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINOXALINES; REACTIVE OXYGEN SPECIES;

EID: 78649722931     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.09.063     Document Type: Article

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