MPP+ induced apoptotic cell death in SH-SY5Y neuroblastoma cells: An electron microscope study

Journal of Neuroscience Research

Volumn 48, Issue 3, 1997, Pages 226-237

  Sheehan, Jason P ^a   Palmer, Patricia E ^a   Helm, Gregory A ^a   Tuttle, Jeremy B ^a,b  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

Author keywords

apoptosis; MPTP; neuroblastoma; Parkinson's disease; SH SY5Y

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ELECTRON MICROSCOPY; GOLGI COMPLEX; HUMAN; HUMAN CELL; MICROTUBULE; MITOCHONDRION; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; PARKINSON DISEASE; PRIORITY JOURNAL; SMOOTH ENDOPLASMIC RETICULUM;

1-METHYL-4-PHENYLPYRIDINIUM; APOPTOSIS; DOPAMINE AGENTS; HUMANS; MICROSCOPY, ELECTRON; NEUROBLASTOMA; STAINING AND LABELING; TUMOR CELLS, CULTURED;

EID: 0030964481     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19970501)48:3<226::AID-JNR5>3.0.CO;2-H     Document Type: Article

References (34)

1. Abe K, Aoki M, Kawagoe J, Yoshida T, Hattori A, Kogure K, Itoyama Y (1995): Ischemic delayed neuronal death: a mitochondrial hypothesis. Stroke 26:1478-1489.
2. Agid Y (1995): Aging, disease and nerve cell death. Bull Acad Natl Med 179:1193-1207.
3. Anglade P, Vyas S, Javoy-Agid F, Herrero MT, Michel PP, Marquez J, Mouatt-Prigent A, Ruberg M, Hirsch EC, Agid Y (1995): Apoptotic degeneration of nigral dopaminergic neurons in Parkinson's disease. Neurosci Abstr 21:489.3.
4. Ankarcrona M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P (1995): Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15:961-973.
5. Arends MJ, Wyllie AH (1991): Apoptosis: mechanisms and roles in pathology. Int Rev Pathol 32:223-253.
6. Arends MJ, Morris RG, Wyllie AH (1990): Apoptosis: the role of the endonuclease. Am J Pathol 136:593-608.
7. Beal MF (1995): Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 18:357-366.
8. Buja LM, Eigenbrodt ML, Eigenbrodt EH (1993): Apoptosis and necrosis: basic types and mechanisms of cell death. Arch Pathol Lab Med 117:1208-1214.
9. Bursch W, Kleine L, Tenniswood M (1990): Biochemistry of cell death by apoptosis. Biochem Cell Biol 68:1071-1074.
10. Busciglio J, Yankner BA (1995): Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 378:776-779.
11. Chu-Wang IW, Oppenheim RW (1978): Cell death of motorneurons in the chick embryo spinal chord. A light and electron microscopic study of naturally occurring and induced cell loss during development. J Comp Neurol 177:33-58.
12. Cotter TG, Lennon SV, Glynn JM, Green DR (1992): Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis. Cancer Res 52:997-1005.
13. DiMonte DA, Wu EY, Delanney LE, Irwin I, Langston JW (1992): Toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes. J Pharmacol Exp Ther 261:44-49.
14. Dipasquale B, Marini AM, Youle RJ (1991): Apoptosis and DNA degradation induced by 1-methyl-4-phenylpyridinium in neurons. Biochem Biophys Res Commun 181:1442-1448.
15. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992): Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501.
16. Gerlach M, Riederer P, Przuntek H, Youdim MB (1991): MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease. Eur J Pharmacol 208:273-286.
17. Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, Giaccia AJ (1996): Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 379:88-91.
18. Greenberg MS (1994): "Handbook of Neurosurgery." Ed 3. Lakeland, Florida: Greenberg Graphics, pp 74-78.
19. Greenlund LJS, Deckwerth TL, Johnson EM (1995): Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron 14:303-315.
20. Janson AM (1995): Apoptosis-like neuronal cell death in vivo in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease (PD). Neurosci Abstr 21:503.8.
21. Kerr JFR, Wyllie AH, Currie AR (1972): Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Br J Cancer 68:239-257.
22. Langston JW, Ballard PA, Tetrud JW, Irwin I (1983): Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219:979-980.
23. Ohyama H, Yamada T, Watanabe I (1981): Cell volume reduction associated with interphase death in rat thymocytes. Radiat Res 85:333-339.
24. Okazaki H, Scheithauer BW (1988): "Atlas of Neuropathology." New York: Gower Medical Publishing.
25. -) and nitric oxide simultaneously causes cyclosporin A-sensitive mitochondrial calcium efflux and depolarisation. Biochem Pharmacol 51:267-273.
26. Rajiv J, Wei Lee, Han E (1993): Neuronal death, cytoplasmic calcium and internucleosomal DNA fragmentation: evidence for DNA fragments being released from cells. Mol Brain Res 17:70-76.
27. Sloviter RS, Dean E, Neubort S (1993): Electron microscopic analysis of adrenalectomy-induced hippocampal granule cell degeneration in the rat: apoptosis in the adult central nervous system. J Comp Neurol 330:337-351.
28. Swerdlow RH, Parks JK, Miller SW, Tuttle JB, Trimmer PA, Sheehan JP, Bennett JP, Davis RE, Parker WD (1996): Origin and functional consequences of the complex I defect in Parkinson's disease. Ann Neurol 40:663-671.
29. Thomas LB, Gates DJ, Richfield EK, O'Brien TF, Schweitzer JB, Steindler DA (1995): DNA end labeling (TUNEL) in Huntington's disease and other neuropathological conditions. Exp Neurol 133:265-272.
30. Thompson HJ, Strange R, Schedin PJ (1992): Apoptosis in the genesis and prevention of cancer. Cancer Epidemiol Biomarkers Prev 1:597-602.
31. Walkinshaw G, Waters CM (1994): Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis. Neuroscience 63:975-987.
32. Waters CM, Moser W, Walkinshaw G, Mitchell IJ (1994): Death of neurons in the neonatal rodent and primate globus pallidus occurs by a mechanism of apoptosis. Neuroscience 63:881-894.
33. Watt JA, Pike CJ, Walencewicz-Wasserman AJ, Cotman CW (1994): Ultrastructural analysis of B-amyloid-induced apoptosis in cultured hippocampal neurons. Brain Res 661:147-156.
34. Wyllie AH, Kerr JFR, Currie AR (1980): Cell death: the significance of apoptosis. Int Rev Cytol 68:251-306.