메뉴 건너뛰기




Volumn 991, Issue , 2003, Pages 111-119

Mitochondrial mechanisms of neural cell death and neuroprotective interventions in Parkinson's disease

Author keywords

Apoptosis; Bax; Calcium; Cytochrome c; Excitotoxicity

Indexed keywords

CASPASE; CINCHOCAINE; CYTOCHROME C; FREE RADICAL; NEUROTOXIN; PROPRANOLOL; PROTEIN BAX; PROTEINASE; REACTIVE OXYGEN METABOLITE; ROTENONE; SUPEROXIDE;

EID: 0038389668     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2003.tb07469.x     Document Type: Conference Paper
Times cited : (232)

References (36)
  • 1
    • 0024848034 scopus 로고
    • Abnormalities of the electron transport chain in idiopathic Parkinson's disease
    • PARKER, W.D.J., S.J. BOYSON & J.K. PARKS. 1989. Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann. Neurol. 26: 719-723.
    • (1989) Ann. Neurol. , vol.26 , pp. 719-723
    • Parker, W.D.J.1    Boyson, S.J.2    Parks, J.K.3
  • 2
    • 0030612117 scopus 로고    scopus 로고
    • Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects
    • SHULTS, C.W., R.H. HAAS, D. PASSOV & M.F. BEAL. 1997. Coenzyme Q10 levels correlate with the activities of complexes I and II/III in mitochondria from parkinsonian and nonparkinsonian subjects. Ann. Neurol. 42: 261-264.
    • (1997) Ann. Neurol. , vol.42 , pp. 261-264
    • Shults, C.W.1    Haas, R.H.2    Passov, D.3    Beal, M.F.4
  • 3
    • 0029908226 scopus 로고    scopus 로고
    • Origin and functional consequences of the complex I defect in Parkinson's disease
    • SWERDLOW, R.H., J.K. PARKS, S.W. MILLER, et al. 1996. Origin and functional consequences of the complex I defect in Parkinson's disease. Ann. Neurol. 40: 663-671.
    • (1996) Ann. Neurol. , vol.40 , pp. 663-671
    • Swerdlow, R.H.1    Parks, J.K.2    Miller, S.W.3
  • 4
    • 0030923869 scopus 로고    scopus 로고
    • Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease
    • SHEEHAN, J.P., R.H. SWERDLOW, S.W. MILLER, et al. 1997. Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease. J. Neurosci. 17: 4612-4622.
    • (1997) J. Neurosci. , vol.17 , pp. 4612-4622
    • Sheehan, J.P.1    Swerdlow, R.H.2    Miller, S.W.3
  • 5
    • 0034102780 scopus 로고    scopus 로고
    • Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines
    • TRIMMER, P.A., R.H. SWERDLOW, J.K. PARKS, et al. 2000. Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines. Exp. Neurol. 162: 37-50.
    • (2000) Exp. Neurol. , vol.162 , pp. 37-50
    • Trimmer, P.A.1    Swerdlow, R.H.2    Parks, J.K.3
  • 6
    • 0033681149 scopus 로고    scopus 로고
    • Chronic systemic pesticide exposure reproduces features of Parkinson's disease
    • BETARBET, R., T.B. SHERER, G. MACKENZIE, et al. 2000. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 3: 1301-1306.
    • (2000) Nat. Neurosci. , vol.3 , pp. 1301-1306
    • Betarbet, R.1    Sherer, T.B.2    MacKenzie, G.3
  • 7
    • 0033782296 scopus 로고    scopus 로고
    • Mitochondrial participation in ischemic and traumatic neural cell death
    • FISKUM, G. 2000. Mitochondrial participation in ischemic and traumatic neural cell death. J. Neurotrauma 17: 843-855.
    • (2000) J. Neurotrauma , vol.17 , pp. 843-855
    • Fiskum, G.1
  • 8
    • 0036584982 scopus 로고    scopus 로고
    • Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans
    • QIU, J., M.J. WHALEN, P. LOWENSTEIN, et al. 2002. Upregulation of the Fas receptor death-inducing signaling complex after traumatic brain injury in mice and humans. J. Neurosci. 22: 3504-3511.
    • (2002) J. Neurosci. , vol.22 , pp. 3504-3511
    • Qiu, J.1    Whalen, M.J.2    Lowenstein, P.3
  • 11
    • 0036829946 scopus 로고    scopus 로고
    • Neuroprotective and neurorestorative strategies for Parkinson's disease
    • DAWSON, T.M. & V.L. DAWSON. 2002. Neuroprotective and neurorestorative strategies for Parkinson's disease. Nat. Neurosci. 5 Suppl.: 1058-1061.
    • (2002) Nat. Neurosci. , vol.5 , Issue.SUPPL. , pp. 1058-1061
    • Dawson, T.M.1    Dawson, V.L.2
  • 12
    • 0036479054 scopus 로고    scopus 로고
    • Mitochondrial permeability transition in acute neurodegeneration
    • FRIBERG, H. & T. WIELOCH. 2002. Mitochondrial permeability transition in acute neurodegeneration. Biochimie 84: 241-250.
    • (2002) Biochimie , vol.84 , pp. 241-250
    • Friberg, H.1    Wieloch, T.2
  • 13
    • 0033774468 scopus 로고    scopus 로고
    • Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine nucleotides
    • KOWALTOWSKI, A.J., A.E. VERCESI & G. FISKUM. 2000. Bcl-2 prevents mitochondrial permeability transition and cytochrome c release via maintenance of reduced pyridine nucleotides. Cell Death. Differ. 7: 903-910.
    • (2000) Cell Death Differ. , vol.7 , pp. 903-910
    • Kowaltowski, A.J.1    Vercesi, A.E.2    Fiskum, G.3
  • 14
    • 0032569676 scopus 로고    scopus 로고
    • Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins
    • SEATON, T.A., J.M. COOPER & A.H. SCHAPIRA. 1998. Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins. Brain Res. 809: 12-17.
    • (1998) Brain Res. , vol.809 , pp. 12-17
    • Seaton, T.A.1    Cooper, J.M.2    Schapira, A.H.3
  • 15
    • 0032531886 scopus 로고    scopus 로고
    • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2
    • YANG, L., R.T. MATTHEWS, J.B. SCHULZ, et al. 1998. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride neurotoxicity is attenuated in mice overexpressing Bcl-2. J. Neurosci. 18: 8145-8152.
    • (1998) J. Neurosci. , vol.18 , pp. 8145-8152
    • Yang, L.1    Matthews, R.T.2    Schulz, J.B.3
  • 16
    • 0032831667 scopus 로고    scopus 로고
    • Calcium induced release of mitochondrial cytochrome c by different mechanisms selective for brain versus liver
    • ANDREYEV, A. & G. FISKUM. 1999. Calcium induced release of mitochondrial cytochrome c by different mechanisms selective for brain versus liver. Cell Death. Differ. 6: 825-832.
    • (1999) Cell Death Differ. , vol.6 , pp. 825-832
    • Andreyev, A.1    Fiskum, G.2
  • 17
    • 0037891050 scopus 로고    scopus 로고
    • Cyclosporin A-insensitive permeability transition in brain mitochondria: Inhibition by 2-aminoethoxydiphenyl borate
    • In press
    • CHINOPOULOS, C., A.A. STARKOV & G. FISKUM. 2003. Cyclosporin A-insensitive permeability transition in brain mitochondria: inhibition by 2-aminoethoxydiphenyl borate. J. Biol. Chem. In press.
    • (2003) J. Biol. Chem.
    • Chinopoulos, C.1    Starkov, A.A.2    Fiskum, G.3
  • 18
    • 0034523818 scopus 로고    scopus 로고
    • Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
    • KORSMEYER, S.J., M.C. WEI, M. SAITO, et al. 2000. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death Differ. 7: 1166-1173.
    • (2000) Cell Death Differ. , vol.7 , pp. 1166-1173
    • Korsmeyer, S.J.1    Wei, M.C.2    Saito, M.3
  • 19
    • 0036850312 scopus 로고    scopus 로고
    • Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane
    • KUWANA, T., M.R. MACKEY, G. PERKINS, et al. 2002. Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane. Cell 111: 331-342.
    • (2002) Cell , vol.111 , pp. 331-342
    • Kuwana, T.1    Mackey, M.R.2    Perkins, G.3
  • 20
    • 0035851110 scopus 로고    scopus 로고
    • Bh3 death domain peptide induces cell type-selective mitochondrial outer membrane permeability
    • POLSTER, B.M., K.W. KINNALLY & G. FISKUM. 2001. Bh3 death domain peptide induces cell type-selective mitochondrial outer membrane permeability. J. Biol. Chem. 276: 37887-37894.
    • (2001) J. Biol. Chem. , vol.276 , pp. 37887-37894
    • Polster, B.M.1    Kinnally, K.W.2    Fiskum, G.3
  • 21
    • 0035956874 scopus 로고    scopus 로고
    • Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
    • VILA, M., V. JACKSON-LEWIS, S. VUKOSAVIC, et al. 2001. Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease. Proc. Natl. Acad. Sci. USA 98: 2837-2842.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 2837-2842
    • Vila, M.1    Jackson-Lewis, V.2    Vukosavic, S.3
  • 22
    • 0242500310 scopus 로고    scopus 로고
    • Inhibition of Bax-induced cytochrome c release from neural cell and brain mitochondria by dibucaine and propranolol
    • POLSTER, B.M. & G. FISKUM. 2003. Inhibition of Bax-induced cytochrome c release from neural cell and brain mitochondria by dibucaine and propranolol. J. Neurosci. 23: 2735-2743.
    • (2003) J. Neurosci. , vol.23 , pp. 2735-2743
    • Polster, B.M.1    Fiskum, G.2
  • 23
    • 0035348408 scopus 로고    scopus 로고
    • Neuronal cell death in nervous system development, disease, and injury
    • MARTIN, L.J. 2001. Neuronal cell death in nervous system development, disease, and injury. Int. J. Mol. Med. 7: 455-478.
    • (2001) Int. J. Mol. Med. , vol.7 , pp. 455-478
    • Martin, L.J.1
  • 24
    • 0037164865 scopus 로고    scopus 로고
    • Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli
    • ARNOULT, D., P. PARONE, J.C. MARTINOU, et al. 2002. Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli. J. Cell Biol. 159: 923-929.
    • (2002) J. Cell Biol. , vol.159 , pp. 923-929
    • Arnoult, D.1    Parone, P.2    Martinou, J.C.3
  • 25
    • 0036788941 scopus 로고    scopus 로고
    • Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax
    • STARKOV, A.A., B.M. POLSTER & G. FISKUM. 2002. Regulation of hydrogen peroxide production by brain mitochondria by calcium and Bax. J. Neurochem. 83: 220-228.
    • (2002) J. Neurochem. , vol.83 , pp. 220-228
    • Starkov, A.A.1    Polster, B.M.2    Fiskum, G.3
  • 26
    • 0037101887 scopus 로고    scopus 로고
    • Effect of Bcl-X(L) overexpression on reactive oxygen species, intracellular calcium, and mitochondrial membrane potential following injury in astrocytes
    • OUYANG, Y., S. CARRIEDO & R. GIFFARD. 2002. Effect of Bcl-X(L) overexpression on reactive oxygen species, intracellular calcium, and mitochondrial membrane potential following injury in astrocytes. Free Radic. Biol. Med. 33: 544.
    • (2002) Free Radic. Biol. Med. , vol.33 , pp. 544
    • Ouyang, Y.1    Carriedo, S.2    Giffard, R.3
  • 27
    • 0034786019 scopus 로고    scopus 로고
    • BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis
    • CHENG, E.H., M.C. WEI, S. WEILER, et al. 2001. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol. Cell 8: 705-711.
    • (2001) Mol. Cell , vol.8 , pp. 705-711
    • Cheng, E.H.1    Wei, M.C.2    Weiler, S.3
  • 28
    • 0035478068 scopus 로고    scopus 로고
    • Estrogen and Bcl-2: Gene induction and effect of transgene in experimental stroke
    • ALKAYED, N.J., S. GOTO, N. SUGO, et al. 2001. Estrogen and Bcl-2: gene induction and effect of transgene in experimental stroke. J. Neurosci. 21: 7543-7550.
    • (2001) J. Neurosci. , vol.21 , pp. 7543-7550
    • Alkayed, N.J.1    Goto, S.2    Sugo, N.3
  • 29
    • 0036663014 scopus 로고    scopus 로고
    • In vivo delivery of a Bcl-xL fusion protein containing the TAT protein transduction domain protects against ischemic brain injury and neuronal apoptosis
    • CAO, G., W. PEI, H. GE, et al. 2002. In vivo delivery of a Bcl-xL fusion protein containing the TAT protein transduction domain protects against ischemic brain injury and neuronal apoptosis. J. Neurosci. 22: 5423-5431.
    • (2002) J. Neurosci. , vol.22 , pp. 5423-5431
    • Cao, G.1    Pei, W.2    Ge, H.3
  • 30
    • 0017348934 scopus 로고
    • Mitochondrial production of superoxide radical and hydrogen peroxide
    • BOVERIS, A. 1977. Mitochondrial production of superoxide radical and hydrogen peroxide. Adv. Exp. Med. Biol. 78: 67-82.
    • (1977) Adv. Exp. Med. Biol. , vol.78 , pp. 67-82
    • Boveris, A.1
  • 31
    • 18344366874 scopus 로고    scopus 로고
    • Role of mitochondria in oxidative stress and aging
    • LENAZ, G., C. BOVINA, M. D'AURELIO, et al. 2002. Role of mitochondria in oxidative stress and aging. Ann. N.Y. Acad. Sci. 959: 199-213.
    • (2002) Ann. N.Y. Acad. Sci. , vol.959 , pp. 199-213
    • Lenaz, G.1    Bovina, C.2    D'Aurelio, M.3
  • 32
    • 0020554522 scopus 로고
    • Respiratory activity of isolated rat brain mitochondria following in vitro exposure to oxygen radicals
    • HILLERED, L. & L. ERNSTER. 1983. Respiratory activity of isolated rat brain mitochondria following in vitro exposure to oxygen radicals. J. Cereb. Blood Flow Metab. 3: 207-214.
    • (1983) J. Cereb. Blood Flow Metab. , vol.3 , pp. 207-214
    • Hillered, L.1    Ernster, L.2
  • 33
    • 0035968183 scopus 로고    scopus 로고
    • Modulation of mitochondrial function by hydrogen peroxide
    • NULTON-PERSSON, A.C. & L.I. SZWEDA. 2001. Modulation of mitochondrial function by hydrogen peroxide. J. Biol. Chem. 276: 23357-23361.
    • (2001) J. Biol. Chem. , vol.276 , pp. 23357-23361
    • Nulton-Persson, A.C.1    Szweda, L.I.2
  • 34
    • 0037891051 scopus 로고    scopus 로고
    • Generation of reactive oxygen species by brain mitochondria mediated by alpha-ketoglutarate dehydrogenase
    • STARKOV, A. & G. FISKUM. 2002. Generation of reactive oxygen species by brain mitochondria mediated by alpha-ketoglutarate dehydrogenase. Soc. Neurosci. 194.17.
    • (2002) Soc. Neurosci. , pp. 19417
    • Starkov, A.1    Fiskum, G.2
  • 35
    • 0037155880 scopus 로고    scopus 로고
    • Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase
    • GAZARYAN, I.G., B.F. KRASNIKOV, G.A. ASHBY, et al. 2002. Zinc is a potent inhibitor of thiol oxidoreductase activity and stimulates reactive oxygen species production by lipoamide dehydrogenase. J. Biol. Chem. 277: 10064-10072.
    • (2002) J. Biol. Chem. , vol.277 , pp. 10064-10072
    • Gazaryan, I.G.1    Krasnikov, B.F.2    Ashby, G.A.3
  • 36
    • 0033990449 scopus 로고    scopus 로고
    • The alpha-ketoglutarate dehydrogenase complex in neurodegeneration
    • GIBSON, G.E., L.C. PARK, K.F. SHEU, et al. 2000. The alpha-ketoglutarate dehydrogenase complex in neurodegeneration. Neurochem. Int. 36: 97-112.
    • (2000) Neurochem. Int. , vol.36 , pp. 97-112
    • Gibson, G.E.1    Park, L.C.2    Sheu, K.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.